ライフサイエンスコーパス: chew

1 tively accommodated by the universal adaptor CheW.

2 binds the histidine kinase CheA and adaptor CheW.

3 assays, despite similar binding to CheA and CheW.

4 mer in a trimer contacts kinase and only one CheW.

5 he chemoreceptor and kinase binding sites of CheW.

6 chemoreceptors, CheA and an adapter protein CheW.

7 s regulatory domain is homologous to that of CheW.

8 the His kinase CheA, and the adaptor protein CheW.

9 of the interaction between chemoreceptor and CheW.

10 t mimics that observed with the P5 homologue CheW.

11 A kinase via the scaffold or coupler protein CheW.

12 n interaction region where it binds CheA and CheW.

13 ivation both during resting state and during chewing.

14 icate brain regions involved with initiating chewing.

15 evaluate brain activity in humans during gum chewing.

16 groups, with no complications related to gum chewing.

17 gies is better adapted for either gnawing or chewing.

18 ic behaviours such as walking, breathing and chewing.

19 acking (a rhythmic facial expression) versus chewing.

20 z rhythm during lip-smacking, but not during chewing.

21 which entails swallowing food whole without chewing.

22 elivery that led to better perception during chewing.

23 unique palinal (longitudinal and backwards) chewing.

24 rough friction between teeth and food during chewing.

25 ely well suited to efficient (high-leverage) chewing.

26 ation of SF and SFN occurred during in vitro chewing.

27 of Lyme disease, has three cheW homologues (cheW(1) , cheW(2) and cheW(3) ).

28 In contrast to cheW(1) and cheW(3) , cheW(2) is dispensable for chemota

29 Collectively, our results indicate that CheW(1) and CheW(3) are incorporated into one chemosenso

30 ctron tomography studies suggested that both CheW(1) and CheW(3) are involved in the assembly of chem

31 rst, genetic studies indicated that both the cheW(1) and cheW(3) genes are essential for chemotaxis,

32 e three CheWs interact with different CheAs: CheW(1) and CheW(3) interact with CheA(2) whereas CheW(2

33 CI, 1.67-6.43) with >10 years paternal betel chewing, 1.62 (95% CI, 0.88-2.96) for 5 to 9 years, and

34 isease, has three cheW homologues (cheW(1) , cheW(2) and cheW(3) ).

35 1) and CheW(3) interact with CheA(2) whereas CheW(2) binds to CheA(1) .

36 In contrast to cheW(1) and cheW(3) , cheW(2) is dispensable for chemotaxis and assembly of th

37 three cheW homologues (cheW(1) , cheW(2) and cheW(3) ).

38 In contrast to cheW(1) and cheW(3) , cheW(2) is dispensable for chemotaxis and asse

39 ively, our results indicate that CheW(1) and CheW(3) are incorporated into one chemosensory pathway t

40 aphy studies suggested that both CheW(1) and CheW(3) are involved in the assembly of chemoreceptor ar

41 studies indicated that both the cheW(1) and cheW(3) genes are essential for chemotaxis, as the mutan

42 s interact with different CheAs: CheW(1) and CheW(3) interact with CheA(2) whereas CheW(2) binds to C

43 s with mature clusters containing about 1000 CheW(3) proteins.

44 To evaluate whether chewing a loading dose (LD) of ticagrelor, 180 mg, vs tr

45 rativity increases with increasing levels of CheW, a key adapter protein.

46 analyzed whether the new policy improved of chewing ability in the eligible population.

47 res for the older adults did not improve the chewing ability in the eligible population.

48 ry complexes with CheA histidine kinases and CheW adaptor proteins.

49 Gutka chewing alone, chewing among individuals with prediabete

50 wing among individuals with prediabetes, and chewing among healthy controls did not significantly inc

51 Gutka chewing alone, chewing among individuals with prediabetes, and chewing

52 Chewing an LD of ticagrelor, 180 mg, in patients with ST

53 atients with STEMI were randomized to either chewing an LD of ticagrelor, 180 mg, or standard oral ad

54 creases bilateral masseter activation during chewing, an effect driven by the expression of TeNT in S

55 or chemotaxis: CheW and CheV1, a hybrid of a CheW and a phosphorylatable receiver domain.

56 mers, each trimer binding a coupling protein CheW and a protomer of the kinase dimer.

57 with TlpD and the chemotaxis (Che) proteins CheW and CheA, enabling quantitative assays for potentia

58 n support of this possibility, we found that CheW and CheV1 interact with each other and with CheA in

59 nredundant coupling proteins for chemotaxis: CheW and CheV1, a hybrid of a CheW and a phosphorylatabl

60 bes have modified array formation to require CheW and CheV1.

61 ry pathways by controlling the expression of CheW and CheW*, which interact with the Tar (aspartate)

62 in interactions in the ternary complex, CheA-CheW and CheW-receptor interactions were studied previou

63 formed well-defined complexes with CheA and CheW and promoted a CheA kinase-off state.

64 uckle and swallow at birth, and subsequently chew and swallow solid foods, for optimal growth and hea

65 rto unknown, hydrophobic interaction between CheW and the homologous P5 domain of CheA in an adjacent

66 xis form high-order signaling complexes with CheW and the kinase CheA.

67 protein complex of known structure formed by CheW and the P4-P5 fragment of CheA, both from Thermotog

68 ugh a unique interface 2 interaction between CheW and the P5 domain of CheA.

69 icates a primary site of interaction between CheW and Tm14 that agrees well with previous biochemical

70 parent bone density in mandible under normal chewing and biting forces.

71 Leaf-chewing and leaf-mining herbivores, and predatory ants a

72 otably including ingestive behaviors such as chewing and nursing.

73 riodontal inflammatory conditions with gutka chewing and prediabetes.

74 Over the past two centuries, mammalian chewing and related anatomical features have been among

75 sity better explain plant resistance against chewing and sap-feeding herbivores than classic diversit

76 Longer duration of paternal betel quid chewing and smoking, prefatherhood, independently predic

77 salivary hypofunction exhibit difficulty in chewing and swallowing foods, tooth decay, periodontal d

78 ntainer, transporting it into the mouth, and chewing and swallowing it.

79 ding that cheek teeth function as guides for chewing and tools for fracturing allows us to characteri

80 ptors, which, along with an adaptor protein (CheW) and kinase (CheA), form large hexagonal arrays.

81 CheW* and Tsr* each contain a mutation at their protein-

82 vidual three-dimensional structures of CheA, CheW, and chemoreceptors have been determined, the inter

83 chemotaxis kinase CheA, the coupling protein CheW, and chemoreceptors.

84 ed interactions among the P5 domain of CheA, CheW, and chemoreceptors.

85 the chemotaxis scaffolding proteins CheV and CheW, and comparative genomic analysis indicates a likel

86 t-independent models were derived from bite, chew, and swallow features obtained from either video ob

87 chemoreceptor in a manner similar to that of CheW, and the receptor binding site of CheA's regulatory

88 generated by other people eating, drinking, chewing, and breathing [1-8].

89 mammals, e.g., walking, swimming, suckling, chewing, and breathing, inhibition is often hypothesized

90 to experience dry eyes and mouth, difficulty chewing, and mild dysphagia that worsened throughout the

91 activities of daily living (e.g., speaking, chewing, and swallowing).

92 r the effects of paternal smoking, areca nut chewing, and their duration prefatherhood on age of dete

93 mmal that displays decoupling of hearing and chewing apparatuses and functions.

94 Evidence shows that hearing and chewing apparatuses have evolved in a modular fashion.

95 ent, lower educational level, and pan masala chewing appear to be risk factors of GERD symptoms for t

96 that the kinase CheA and the adapter protein CheW are integral for receptor connectivity, the exact c

97 nate cultivar (intense sweetness and easy-to-chew arils); however, arils have pale pink colour and fl

98 o predict volatile induction: feeding guild (chewing arthropods > sap feeders), diet breadth (special

99 , histidine kinase CheA, and adaptor protein CheW, as well as a density map of the core-signaling uni

100 iations in the expression levels of CheA and CheW at a constant receptor density in the membrane.

101 with chemoreceptors and the coupling protein CheW at the poles of bacterial cells.

102 d to enable both gnawing at the incisors and chewing at the molars.

103 ever, cytoplasmic clusters comprise two CheA/CheW baseplates sandwiching two opposed receptor arrays.

104 ants, honeydew-producing membracids and leaf-chewing beetles on perennial host plants in field experi

105 g may reflect the close proximity of the two CheW binding surfaces near the receptor tip or further,

106 the receptor axis with respect to P3 and the CheW-binding P5 domains is bound by two limits differing

107 h receptor-CheW titrations, we estimate that CheW binds about four times tighter to its first binding

108 etric Morphometrics were employed to analyse chewing biomechanics and mandible morphology to, firstly

109 The results highlight the potential of chewed birch pitch as a source of ancient DNA.

110 iome sequenced from a 5700 year-old piece of chewed birch pitch from Denmark.

111 motor events associated with the end of the chew-block.

112 We also divided the 25-second chew-blocks into 5 segments of equal 5-second durations

113 udy of functional complexes of CF, CheA, and CheW bound to vesicles in native-like arrays reveals tha

114 feeding guilds (piercing aphids, generalist chewing caterpillars and specialist chewing caterpillars

115 neralist chewing caterpillars and specialist chewing caterpillars).

116 may not be a direct binding determinant for CheW/CheA at the trimer periphery.

117 ophobic amino acid replacement, may not bind CheW/CheA because they form conformationally frozen or d

118 ed dimerization domain of CheA and a variant CheW-CheR-like fusion protein that is critical for maint

119 xis system consisting of CheAY, three CheVs, CheW, CheY(HP) and the putative CheZ to colonize the hos

120 s issue in the network-driven, gastric mill (chewing) circuit in the crab stomatogastric nervous syst

121 provide distance restraints within the CheA:CheW complex in the absence and presence of a soluble re

122 The receptor-CheW complex shares a similar binding interface to that

123 vely, the receptor binding sites in the CheA-CheW complex suggest that conformational changes in CheA

124 alternating CheA regulatory domains (P5) and CheW couplers.

125 rray in concert with the CheA kinase and the CheW coupling factor.

126 eceptors, the CheA histidine kinase, and the CheW coupling protein assemble into signaling complexes

127 The chemoreceptor-CheA kinase-CheW coupling protein complex, with ancillary associated

128 rane receptors, histidine kinases (CheA) and CheW coupling proteins.

129 is latter situation, using the gastric mill (chewing) CPG in the crab (Cancer borealis) stomatogastri

130 s in early cladotherians that indicate their chewing cycles included significant transverse movement,

131 mprised one-third of the diet, the number of chewing cycles per year would have declined by nearly 2

132 ith increased yaw rotation of the jaw during chewing cycles.

133 This, in turn, mediated the reduction in chewing damage in mixed stands.

134 own defoliating herbivores and suggests that chewing damage on mountain birch foliage could significa

135 The RD analysis showed that in 2015, the chewing difficulty in aged above 65 was 2.2% lower than

136 The main outcome evaluated was self-reported chewing difficulty.

137 the core signaling complex, in which a CheA/CheW dimer bridges two adjacent receptor trimers via mul

138 vivo to simulate stresses during biting and chewing - dorsoventral (DV) shear and lateral transverse

139 , sex, duration and daily frequency of gutka chewing, duration of gutka placement in the mouth, and d

140 ividuals generally experience a reduced food-chewing efficiency.

141 In this issue of Developmental Cell, Chew et al. (2019) show that the pioneer factor DUX4 is

142 ar provides direct evidence of the effect of chewed food particles on tooth enamel surfaces and refle

143 ained two receptor trimers of dimers and two CheW for each CheA dimer, consistent with the approximat

144 Palaeolithic processing technologies affect chewing force production and efficacy in humans consumin

145 Tooth roots provide support to counter chewing forces and so it is advantageous to grow roots q

146 t of teeth(1), and has evolved to bear large chewing forces, resist mechanical fatigue and withstand

147 histidine kinase CheA, and coupling protein CheW form clusters of chemotaxis signaling complexes.

148 eria, transmembrane chemoreceptors, CheA and CheW form the core signalling complex of the chemotaxis

149 tidine kinase CheA, and the coupling protein CheW form transmembrane molecular arrays with remarkable

150 Previous studies on chewing frequency across animal species have focused on

151 e maximum force of muscle, so that the upper chewing frequency scales as the -1/3 power of body mass

152 xcess of saliva describes the lower limit of chewing frequency, scaling approximately as the -1/6 pow

153 roused without elucidating the variations in chewing frequency.

154 e the interaction modes of chemoreceptor and CheW from Thermotoga maritima.

155 Platelet reactivity in the chewing group was significantly reduced by 24% at 30 min

156 erwent an fcMRI scanning protocol while they chewed gum.

157 Patients in the intervention arm received chewing gum 4 times a day postoperatively.

158 Lastly, the role of vagal signaling or chewing gum as potential treatment strategies of allevia

159 amplitude was significantly decreased after chewing gum containing 4 mg of nicotine.

160 tude responses decreased significantly after chewing gum containing both 2 and 4 mg of nicotine.

161 Sham feeding with chewing gum has been shown to accelerate the return of g

162 ng diluted samples, computer keyboard swabs, chewing gum, and cigarette butts.

163 and could be used as an active component in chewing gums or mouthwashes for both caries and gingivit

164 ations and industrial products like candies, chewing gums, mouthwash and toothpaste.

165 tent of TiO(2) included candies, sweets, and chewing gums.

166 duals with prediabetes irrespective of gutka-chewing habit (P <0.05).

167 age, sex, duration of prediabetes, and gutka-chewing habits was collected using a questionnaire.

168 Although R62A CheW had essentially the same affinity for chemoreceptor

169 We report that CheV1 and CheW have largely redundant abilities to interact with c

170 ts only when phloem-feeders were present and chewing herbivore abundance was high.

171 alysis revealed that trophic position of the chewing herbivore and omnivore increased significantly w

172 e show that a specialist caterpillar (biting-chewing herbivore) and a specialist aphid (phloem feeder

173 lants were independently challenged with (1) chewing herbivores (Manduca sexta), (2) piercing-sucking

174 plant immune receptors in the perception of chewing herbivores and defense.

175 It is well known that plant damage by leaf-chewing herbivores can induce resistance in neighbouring

176 ng, which likely reduces plant resistance to chewing herbivores due to its negative cross-talk with J

177 Leaf-chewing herbivores fluxed 6.2 g m(-2) yr(-1) of frass an

178 a the salicylic acid pathway, whereas biting-chewing herbivores induce plant resistance mainly via th

179 Simultaneously, however, these chewing herbivores stimulated JA production, demonstrati

180 ivores increased with plant biomass; that of chewing herbivores tracked plant quality; and predator b

181 The growth of various chewing herbivores was not significantly affected by the

182 henorrhyncha, sucking herbivores, Acrididae, chewing herbivores, Tettigoniidae, omnivores, and Aranea

183 suite of proteins that defend maize against chewing herbivores.

184 e causative agent of Lyme disease, has three cheW homologues (cheW(1) , cheW(2) and cheW(3) ).

185 On multivariate analysis, heavy-areca nut chewing (HR = 2.18, 95% CI: 1.37-3.47), current smoking

186 postoperative oscillopsia that occurred upon chewing in 29 of 34 patients (85%) and upon walking in 8

187 nce for specific brain areas associated with chewing in humans and demonstrated that brain activation

188 ilized to investigate the roles of the three cheWs in chemotaxis of B. burgdorferi.

189 nds of diet-how often or how hard one had to chew-in human populations worldwide.

190 g is required for host plant resistance to a chewing insect herbivore.

191 nase that is a key defensive protein against chewing insect pests in maize (Zea mays).

192 syringae pv tomato DC3000, and larvae of the chewing insect tobacco hornworm (Manduca sexta).

193 may influence JA-dependent defenses against chewing insects and SA-dependent defenses against aphids

194 Here we provide evidence that chewing insects differentially alter the oxylipin profil

195 ws the elaborate behaviors exhibited by leaf-chewing insects that appear to function specifically to

196 ors of Nicotiana attenuata responses against chewing insects, a 26-nucleotide tag matching the HSPRO

197 complex responses against pathogens and leaf-chewing insects.

198 y impaired by both generalist and specialist chewing insects.

199 which they serve as toxic compounds against chewing insects.

200 pitation studies demonstrated that the three CheWs interact with different CheAs: CheW(1) and CheW(3)

201 eptor arrays that are known to form via CheA-CheW interactions.

202 CheW is a scaffold protein that mediates the association

203 e receptor, whereas the binding interface of CheW is placed between the beta-strand 8 of domain 1 and

204 d, the interaction between chemoreceptor and CheW is still unclear.

205 We conclude that a key feature of CheW is to maintain the specific geometry between the tw

206 In the present study we show that vigorous chewing is limited by the maximum force of muscle, so th

207 It is known that gutka chewing jeopardizes periodontal health; however, severit

208 gerprint analysis (OFA) to reconstruct their chewing kinematics; we also used various morphometric ap

209 n parasite systems and to the pocket gophers-chewing lice system, and demonstrate that both host shif

210 s and have played a minor role in the gopher-chewing lice system.

211 acial behaviors such as breathing, sniffing, chewing, licking, swallowing, vocalizing, and in rodents

212 a hybrid protein consisting of an N-terminal CheW-like adaptor domain and a C-terminal response regul

213 opment of orofacial dyskinesias, involuntary chewing-like movements that often accompany long-term ne

214 tion to quitting smoking, quitting areca nut chewing may also reduce the risk of first recurrence in

215 The findings suggest that areca nut chewing may jeopardize the defensive functions of neutro

216 the well-described chemotaxis elements CheY, CheW, MCP, and CheA.

217 ominins would have improved their ability to chew meat into smaller particles by 41%, reduced the num

218 OC) neurons trigger a specific gastric mill (chewing) motor pattern in the stomatogastric ganglion so

219 e other is a roachoid with long antennae and chewing mouthparts very similar in form to the most gene

220 such as tiny wingless body, head with strong chewing mouthparts, robust and short antennae having lon

221 quamosal jaw joint, which allows a posterior chewing movement, and must have evolved independently fr

222 Using vacuous chewing movements (VCMs) induced by chronic haloperidol

223 showed that speech movements are faster than chewing movements, and the functional coordination betwe

224 ted in mammals, architecture dynamics of the chewing muscles and their impact on muscle performance a

225 in having relatively smaller teeth, reduced chewing muscles, weaker maximum bite force capabilities,

226 l, we constructed and characterized CheA and CheW mutants with amino acid replacements at key interfa

227 derwent an immediate 1:1 subrandomization to chewed (n=21) or integral (n=21) tablets administration.

228 tes even after controlling for sex and gutka chewing (odds ratio = 13.2; 95% CI = 4.3 to 40.7).

229 Chewing of areca quid increases the prevalence of period

230 ascicle velocity) were observed when animals chewed on more mechanically resistant foods.

231 The effects of chewing on in vivo biofilm, microbial composition, and s

232 tional effects of paternal Areca catechu nut chewing on offspring metabolic syndrome (MetS) risk in h

233 t the patient had a long-standing history of chewing on toilet bowl deodorizing cakes.

234 variables, with a special focus on areca nut chewing, on disease recurrence and progression in patien

235 e the effects of paternal smoking, and betel chewing, on the risks of early MetS in human offspring.

236 ge as explanation for the recently suggested CheW-only linker structures.

237 r, tirofiban, and prasugrel, administered as chewed or integral loading dose, on IPA in patients unde

238 ceived gingival bleeding (P <0.001), pain on chewing (P <0.001), dry mouth (P <0.001), and oral burni

239 ller particles by 41%, reduced the number of chews per year by another 5%, and decreased masticatory

240 mia, smoking, alcohol consumption, betel nut chewing, physical activity, income, and education level,

241 ions of population and is related to certain chewing practices that involve direct exposure of the gi

242 Cangrelor or tirofiban were both superior to chewed prasugrel (IPA, 10.5+/-11.0; P<0.001 for both com

243 ed with chewed prasugrel, and superiority of chewed prasugrel as compared with integral prasugrel, ea

244 f both tirofiban and cangrelor compared with chewed prasugrel, and superiority of chewed prasugrel as

245 treatments yielded greater IPA compared with chewed prasugrel, which led to higher active metabolite

246 des the first experimental evidence that two CheW proteins coexist in one chemosensory pathway and th

247 ctions in the ternary complex, CheA-CheW and CheW-receptor interactions were studied previously, wher

248 n CheA are required for assembly of the CheA-CheW-receptor ternary complex and CheA activation.

249 array (HOMIM) analyses revealed a consistent chewing-related increase in the binding of Streptococcus

250 r behaviors, such as breathing, walking, and chewing, remains elusive.

251 oceptor neuron on the biphasic gastric mill (chewing) rhythm driven by the projection neuron modulato

252 asic (protraction, retraction) gastric mill (chewing) rhythm, triggered in the isolated stomatogastri

253 erved 12-nm hexagonal lattice linked by CheA/CheW rings.

254 rived from annotated video observation and a chewing sensor to predict mass and energy intake during

255 ent meals in a laboratory setting and wore a chewing sensor while being videotaped.

256 bservation or information extracted from the chewing sensor.

257 ns may dynamically change over the course of chewing sequences.

258 conservation patterns suggests that CheV and CheW share the same binding spot on the chemoreceptor st

259 ypothesis is that monkey lip-smacking versus chewing should also exhibit these differences.

260 vivo, during VCN-triggered and POC-triggered chewing, show that the lateral teeth protraction movemen

261 L., Bangla cultivar) oil, a widely consumed chewing stimulant and valuable flavouring agent.

262 We infer that the ancestral therian chewing stroke relied heavily on long-axis rotation, inc

263 describe the ancestral tribosphenic therian chewing stroke, as conserved in the short-tailed opossum

264 Notably, chewing, sucking and gall-making herbivores were more af

265 oximity of the CheA and Tsr binding sites on CheW suggests the formation of a composite CheW-Tsr surf

266 the affinity tag, we successfully identified CheW surfaces responsible for CheA-Tsr interaction.

267 She can smile, chew, swallow, and blow normally whereas pouting and kis

268 ons among activated brain areas during a gum-chewing task.

269 satisfaction with appearance, and ability to chew/taste.

270 that guinea pigs are more efficient at molar chewing than squirrels.

271 footprinting was used to map the surfaces of CheW that interact with the large multidomain histidine

272 istidine kinase, CheA, and a linker protein, CheW, that couples CheA activity to receptor control.

273 pth of 2.3x and find that the individual who chewed the pitch was female and that she was genetically

274 nge chemical shifts associated with receptor-CheW titrations, we estimate that CheW binds about four

275 into the five domains of the CheA dimer and CheW to provide distance restraints within the CheA:CheW

276 coli, but the ratios of the coupling protein CheW to the CheA dimer are nearly identical in the two o

277 to (i) measure saturable binding of CheA and CheW to the smallest kinase-activating groups of recepto

278 On the other hand, gentle chewing to mix food uniformly without excess of saliva d

279 tionary link documenting the transition from chewing to piercing mouthparts in relation to suction fe

280 any bacteria have more than one homologue of CheW, to our knowledge, this report provides the first e

281 f and only 61 cases and 96 controls had used chewing tobacco in the absence of cigarettes, precluding

282 ncy of use, and duration of use of snuff and chewing tobacco separately for never and ever cigarette

283 state of residence, applicator license type, chewing tobacco use, and total lifetime days of all pest

284 om India on cigarette smoking, bidi smoking, chewing tobacco, and secondhand smoke.

285 cavity, whereas associations were weaker for chewing tobacco.

286 th snuff being more strongly associated than chewing tobacco.

287 n CheW suggests the formation of a composite CheW-Tsr surface for the recruitment of the signaling ki

288 ovative saliva reactor, which imitated human chewing under temperature control.

289 ve inhibition of platelet aggregation in the chewing vs the standard group were 51% vs 10% (95% CI, 1

290 Chewing was associated with activations in the cerebellu

291 Although ever (versus never) tobacco chewing was weakly associated with HNC among never cigar

292 The hardest bread was Rye and the easiest to chew were Oat and Bavaria breads.

293 Further, those with a habit of pan masala chewing were more likely to develop GERD compared with t

294 ys by controlling the expression of CheW and CheW*, which interact with the Tar (aspartate) and Tsr*

295 anism Escherichia coli, the coupling protein CheW, which bridges the chemoreceptors and histidine kin

296 ling complexes with the CheA kinase and with CheW, which couples CheA to receptor control.

297 uperstructure depends on the adaptor protein CheW, which mediates a functionally important bridging i

298 terial chemotaxis systems replace or augment CheW with a related protein, CheV, which is less well un

299 rs by interaction of one CheA protomer and a CheW with each trimer, an organization for which specifi

300 The effects of replacing conserved Arg62 of CheW with other residues suggested that the scaffold pro