ライフサイエンスコーパス: cholesterol acyltransferase

1 DGAT1 gene family (i.e. related to acyl-CoA:cholesterol acyltransferases).

2 aining particles by incubation with lecithin:cholesterol acyltransferase.

3 f cholesterol 7alpha-hydroxylase or acyl-CoA:cholesterol acyltransferase.

4 ribute to the optimum activation of lecithin:cholesterol acyltransferase.

5 he intracellular esterifying enzyme acyl-CoA:cholesterol acyltransferase.

6 viously characterized antagonist of acyl-CoA cholesterol acyltransferase.

7 Macrophage acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) and apolipoprotein

8 Acyl-CoA:cholesterol acyltransferase 1 (Acat1) converts cellular

9 Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) is a resident endo

10 Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is a resident enzy

11 The enzyme acyl coenzyme A:cholesterol acyltransferase 1 (ACAT1) mediates sterol es

12 Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1), a resident enzyme

13 ly active against the related MBOAT acyl-CoA:cholesterol acyltransferase 1 (ACAT1), yet a single-resi

14 Human acyl-coenzyme A:cholesterol acyltransferase 1 (hACAT1) esterifies choles

15 Acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2) co

16 pression of Niemann Pick C1 Like 1, Acyl-CoA:Cholesterol acyltransferase 1, and microsomal triglyceri

17 Acyl-CoA:cholesterol acyltransferases 1 and 2 (ACAT1/2) convert c

18 ecimens and cell lines, mediated by acyl-CoA cholesterol acyltransferase-1 (ACAT-1) enzyme.

19 In addition to acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1), an enzyme in the

20 idic acid acyltransferase (LAT), or acyl-CoA cholesterol acyltransferase 2 (ACAT-2).

21 Targeted deletion of acyl-CoA:cholesterol acyltransferase 2 (ACAT2) (A2), especially i

22 Deficiency of acyl CoA:cholesterol acyltransferase 2 (ACAT2) in mice results in

23 The role of liver acyl-CoA:cholesterol acyltransferase 2 (ACAT2), earlier shown to

24 ryl-coenzyme A reductase and acyl-coenzyme A:cholesterol acyltransferase 2 in infected cells.

25 is 32% identical to the vertebrate lecithin:cholesterol acyltransferase, a secreted phospholipase.

26 Acyl coenzyme A:cholesterol acyltransferase (ACAT) (EC 2.3.1.26) is an e

27 Acyl CoA:cholesterol acyltransferase (ACAT) 2 is the major choles

28 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in the intes

29 efflux to apoA-I was independent of acyl-CoA:cholesterol acyltransferase (ACAT) activity.

30 r cholesterol esterification enzyme acyl-CoA:cholesterol acyltransferase (ACAT) are present in the no

31 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) catalyzes intracellul

32 Acyl-COA:cholesterol acyltransferase (ACAT) converts cholesterol

33 e of cholesterol ester synthesis by acyl CoA:cholesterol acyltransferase (ACAT) enzymes in intestinal

34 The enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) esterifies cholestero

35 thophysiological conditions, acyl-coenzyme A:cholesterol acyltransferase (ACAT) has attracted much at

36 Inhibition of acyl-CoA:cholesterol acyltransferase (ACAT) has direct anti-carci

37 Inhibitors of acyl CoA:cholesterol acyltransferase (ACAT) have attracted consid

38 The rationale was that the acyl-coenzyme A:cholesterol acyltransferase (ACAT) in homogenates should

39 s LDL cholesterol from lysosomes to acyl-CoA/cholesterol acyltransferase (ACAT) in the endoplasmic re

40 derived cholesterol is catalyzed by acyl-CoA:cholesterol acyltransferase (ACAT) in the endoplasmic re

41 25HC-mediated activation of acyl coenzyme A: cholesterol acyltransferase (ACAT) in the ER creates an

42 e have found previously that acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibition led to imp

43 Although originally designed as acyl CoA: cholesterol acyltransferase (ACAT) inhibitors, compariso

44 Esterification of cholesterol by acyl-CoA:cholesterol acyltransferase (ACAT) is a key element in m

45 Acyl-CoA:cholesterol acyltransferase (ACAT) is a key enzyme in ce

46 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is a membrane protein

47 Acyl-CoA:cholesterol acyltransferase (ACAT) is a membrane-bound e

48 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an enzyme involved

49 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an integral membra

50 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an intracellular e

51 Acyl-CoA:cholesterol acyltransferase (ACAT) mediates cellular cho

52 Acyl-coenzyme A:cholesterol acyltransferase (ACAT) plays important roles

53 Acyl-CoA:cholesterol acyltransferase (ACAT) plays important roles

54 Acyl-CoA:cholesterol acyltransferase (ACAT) plays important roles

55 The 25HC-mediated activation of acyl-CoA:cholesterol acyltransferase (ACAT) triggered rapid inter

56 Cholesterol trafficking to acyl-coenzyme A:cholesterol acyltransferase (ACAT) was also defective in

57 sion by activating the ER-localized acyl-CoA:cholesterol acyltransferase (ACAT) which leads to the de

58 used our studies on the activity of acyl-CoA:cholesterol acyltransferase (ACAT), a key enzyme for mai

59 ) synthase, squalene epoxidase, and acyl-CoA:cholesterol acyltransferase (ACAT), ACAT2, small heterod

60 ous studies have identified acyl-coenzyme A: cholesterol acyltransferase (ACAT), an enzyme that regul

61 as activator for the enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT), by monitoring the ac

62 terification reaction, catalyzed by acyl-CoA:cholesterol acyltransferase (ACAT), competes for the inc

63 sterol esterification, catalyzed by acyl-CoA:cholesterol acyltransferase (ACAT), plays a central role

64 The inhibition of macrophage acyl coenzyme A:cholesterol acyltransferase (ACAT), which catalyzes the

65 he sterol esterifying enzyme acyl-coenzyme A-cholesterol acyltransferase (ACAT), which likely occurs

66 teraction of the major SOAT, acyl-coenzyme A:cholesterol acyltransferase (ACAT)-related enzyme (Are)2

67 olesteryl ester synthesis by acyl coenzyme A:cholesterol acyltransferase (ACAT).

68 enerated in a reaction catalyzed by acyl CoA:cholesterol acyltransferase (ACAT).

69 ity to a human cDNA encoding acyl-coenzyme A:cholesterol acyltransferase (ACAT).

70 L)-receptor, HMG CoA reductase, and acyl-CoA:cholesterol acyltransferase (ACAT).

71 ery of several potent inhibitors of acyl CoA:cholesterol acyltransferase (ACAT).

72 to a deficiency in the activity of acyl-CoA:cholesterol acyltransferase (ACAT).

73 synthesis of cholesterol esters by acyl-CoA:cholesterol acyltransferase (ACAT, EC 2.3.1.26) is an im

74 The microsomal enzyme acyl-CoA:cholesterol acyltransferase (ACAT; EC 2.3.1.26) catalyze

75 o be catalyzed by the enzyme acyl-coenzyme A:cholesterol acyltransferase, ACAT, the neutral cholester

76 olesterol-esterifying enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT1), but not lecithin-ch

77 Acyl-CoA:cholesterol acyltransferases (ACAT1 and ACAT2) are two e

78 glycerol acyltransferase (DGAT) and acyl-CoA:cholesterol acyltransferases (ACAT1 and ACAT2) provided

79 cyltransferase 1 (also named acyl-coenzyme A:cholesterol acyltransferase, ACAT1) transfers a long-cha

80 A second form of the enzyme acyl-CoA:cholesterol acyltransferase, ACAT2, has been identified.

81 erase (MBOAT) enzyme family, acyl-coenzyme A:cholesterol acyltransferases (ACATs) catalyse the transf

82 id binding, cholesterol efflux, and lecithin-cholesterol acyltransferase activities of the lipoprotei

83 SRBI cells was not due to increased acyl-coA:cholesterol acyltransferase activity and was observed ev

84 a-helicity, cholesterol efflux, and lecithin-cholesterol acyltransferase activity of the recombinant

85 ctivity and approximately 90% lower lecithin-cholesterol acyltransferase activity relative to circula

86 espite an increase in hepatic mRNA; lecithin:cholesterol acyltransferase activity toward endogenous E

87 orm with 88.1 +/- 8.5% reduction in lecithin-cholesterol acyltransferase activity, a finding corrobor

88 ol delivery to hepatocytes, support lecithin:cholesterol acyltransferase activity, and suppress infla

89 flux, and also had markedly reduced lecithin cholesterol acyltransferase activity.

90 t shared regions of similarity with acyl CoA:cholesterol acyltransferase, an enzyme that also uses fa

91 Lecithin:cholesterol acyltransferase analysis, using reconstitute

92 Only in the absence of both lecithin cholesterol acyltransferase and apolipoprotein E is para

93 he presence of normal activities of acyl-CoA:cholesterol acyltransferase and glycerol phosphate acylt

94 There were no significant lecithin:cholesterol acyltransferase and lysophospholipase activi

95 gests the possible interaction with lecithin-cholesterol acyltransferase and may shed light on the mo

96 ression on the microsomal levels of acyl-CoA:cholesterol acyltransferase and neutral cholesterol este

97 LDL-cholesterol to be esterified by acyl-CoA:cholesterol acyltransferase and stored in lipid droplets

98 logous to enzymes called glycerophospholipid-cholesterol acyltransferases and, following translocatio

99 nriched in apoM, cholesteryl ester, lecithin:cholesterol acyltransferase, and S1P.

100 e chemoattractant protein-1, acyl coenzyme A:cholesterol acyltransferase, and tissue factor, in lesio

101 s of diacylglycerol acyltransferase and acyl cholesterol acyltransferase are expressed in the lumen o

102 r-activated receptor modulators and lecithin-cholesterol acyltransferase-based therapy, hold great pr

103 associates more and activates human lecithin-cholesterol acyltransferase better than mouse apoA-I.

104 ., paraoxonase, apolipoprotein A-I, lecithin:cholesterol acyltransferase, cholesterol ester transfer

105 ce and the roles of plasma factors (lecithin-cholesterol acyltransferase, cholesterol ester transfer

106 (p = 0.0008, CI 95%: 1.58, 5.33); lecithin: cholesterol acyltransferase concentration (p = 0.024, CI

107 l particles reminiscent of those in lecithin/cholesterol acyltransferase deficiency and cholestasis).

108 Patients with lecithin: cholesterol acyltransferase deficiency have both prebeta

109 (adrenocortical lipid depletion in acyl-CoA:cholesterol acyltransferase-deficient (Acact-/-) mice an

110 sc-associated apoA-I that binds the lecithin-cholesterol acyltransferase enzyme is well structured an

111 Cholesteryl ester synthesis by the acyl-CoA:cholesterol acyltransferase enzymes ACAT1 and ACAT2 is,

112 spholipases A (PLAs) and glycerophospholipid:cholesterol acyltransferases (GCATs), may target host ce

113 ted DGAT1), which is related to the acyl CoA:cholesterol acyltransferase gene family, or to any other

114 Administration of lecithin-cholesterol acyltransferase has the potential to reduce

115 ment-binding proteins and activated acyl-CoA:cholesterol acyltransferase in a normal fashion.

116 ting enzyme inhibitor, or an acyl coenzyme A-cholesterol acyltransferase inhibitor.

117 Lecithin-cholesterol acyltransferase is a rate-limiting enzyme in

118 Plasma lecithin:cholesterol acyltransferase is unchanged despite an incr

119 storage form by the enzyme acyl-coenzyme A: cholesterol acyltransferase, is a critical component of

120 residues and domains implicated in lecithin:cholesterol acyltransferase (LCAT) activation or lipid b

121 Interestingly, lecithin:cholesterol acyltransferase (LCAT) activation results co

122 f responsible for lipid binding and lecithin:cholesterol acyltransferase (LCAT) activation.

123 holipid transfer protein (PLTP) and lecithin cholesterol acyltransferase (LCAT) activities were decre

124 Lecithin:cholesterol acyltransferase (LCAT) activity was measured

125 Total endogenous plasma lecithin:cholesterol acyltransferase (LCAT) activity was reduced

126 ltered secondary structure affected lecithin:cholesterol acyltransferase (LCAT) activity.

127 than other acyltransferases such as lecithin cholesterol acyltransferase (LCAT) and acyl CoA acyltran

128 laboratory previously reported that lecithin:cholesterol acyltransferase (LCAT) and LDL receptor doub

129 lesterol binding, esterification by lecithin/cholesterol acyltransferase (LCAT) and transfer by chole

130 pacity and 37% capacity to activate lecithin:cholesterol acyltransferase (LCAT) as compared to the WT

131 osomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT) belong to a structura

132 on dramatically reduces the rate of lecithin:cholesterol acyltransferase (LCAT) catalyzed cholesterol

133 Lecithin-cholesterol acyltransferase (LCAT) catalyzes the formati

134 Lecithin:cholesterol acyltransferase (LCAT) catalyzes the formati

135 revious studies have indicated that lecithin-cholesterol acyltransferase (LCAT) contributes significa

136 Lecithin:cholesterol acyltransferase (LCAT) deficiencies represen

137 udy was to test the hypothesis that lecithin:cholesterol acyltransferase (LCAT) deficiency would acce

138 e been made in our understanding of lecithin-cholesterol acyltransferase (LCAT) function.

139 ng cassette transfer protein A1 and lecithin cholesterol acyltransferase (LCAT) gene loci.

140 Expression of human lecithin cholesterol acyltransferase (LCAT) in mice (LCAT-Tg) lea

141 had diminished capacity to activate lecithin/cholesterol acyltransferase (LCAT) in vitro.

142 Lecithin:cholesterol acyltransferase (LCAT) is a key plasma enzym

143 and interfacial binding activity of lecithin-cholesterol acyltransferase (LCAT) is affected different

144 Lecithin cholesterol acyltransferase (LCAT) is an enzyme involved

145 Although the major function of lecithin-cholesterol acyltransferase (LCAT) is cholesterol esteri

146 fied cholesterol (UC) by the enzyme lecithin:cholesterol acyltransferase (LCAT) is cholesteryl ester

147 Lecithin:cholesterol acyltransferase (LCAT) is the major determin

148 We recently reported that lecithin:cholesterol acyltransferase (LCAT) knock-out mice, parti

149 Lecithin:cholesterol acyltransferase (LCAT) plays a key role in r

150 Because lecithin:cholesterol acyltransferase (LCAT) possesses intrinsic P

151 be a physiological inhibitor of the lecithin-cholesterol acyltransferase (LCAT) reaction.

152 Further, plasma lecithin:cholesterol acyltransferase (LCAT) substrate reactivity

153 or protein-protein interaction with lecithin-cholesterol acyltransferase (LCAT) the enzyme for which

154 Lecithin:cholesterol acyltransferase (LCAT) then drives the conve

155 Binding of lecithin cholesterol acyltransferase (LCAT) to lipoprotein surfac

156 asma but reduces atherosclerosis in lecithin cholesterol acyltransferase (LCAT) transgenic (Tg) mice,

157 on in blood is closely regulated by lecithin-cholesterol acyltransferase (LCAT) which is produced in

158 The interaction of lecithin-cholesterol acyltransferase (LCAT) with apolipoprotein A

159 pear to show that the reactivity of lecithin:cholesterol acyltransferase (LCAT) with the mutant is sl

160 ue T. gondii homologue of mammalian lecithin:cholesterol acyltransferase (LCAT), a key enzyme that pr

161 Lecithin:cholesterol acyltransferase (LCAT), an important enzyme

162 G esters (PE) by the plasma enzyme lecithin: cholesterol acyltransferase (LCAT), and by other enzyme(

163 ol acyltransferase (ACAT1), but not lecithin-cholesterol acyltransferase (LCAT), and to differ from h

164 apoA-I) activates the plasma enzyme lecithin:cholesterol acyltransferase (LCAT), catalyzing the rapid

165 ns, and had minimal reactivity with lecithin-cholesterol acyltransferase (LCAT), compared with rHDL p

166 l ester transfer protein (CETP) and lecithin:cholesterol acyltransferase (LCAT), on chromosome 16q; a

167 hydroxylase, Scavenger receptor B1, lecithin:cholesterol acyltransferase (LCAT), or apoA-I in the liv

168 show that certain proteins such as lecithin cholesterol acyltransferase (LCAT), phospholipid transfe

169 aturally occurring mutants of human lecithin-cholesterol acyltransferase (LCAT), T123I and N228K, wer

170 f cholesterol-containing r-HDL with lecithin-cholesterol acyltransferase (LCAT), to form cholesteryl

171 N-ethylmaleimide, an inhibitor of lecithin: cholesterol acyltransferase (LCAT), whereas CUC was enha

172 Human lecithin-cholesterol acyltransferase (LCAT), which is normally sp

173 pathway is critically dependent on lecithin:cholesterol acyltransferase (LCAT), which rapidly conver

174 ted HDL and plasma from control and lecithin-cholesterol acyltransferase (LCAT)-deficient subjects to

175 and agonizing a circulating enzyme lecithin cholesterol acyltransferase (LCAT).

176 oA-I structure, and reactivity with lecithin:cholesterol acyltransferase (LCAT).

177 poprotein particles is catalyzed by lecithin:cholesterol acyltransferase (LCAT).

178 tect the esterification activity of lecithin:cholesterol acyltransferase (LCAT).

179 ger receptor B-1 (SRB-1) and plasma lecithin-cholesterol acyltransferase (LCAT).

180 erol esterifying enzymes, ACAT1 and lecithin:cholesterol acyltransferase (LCAT).

181 quences identical to those of human lecithin:cholesterol acyltransferase-like lysophospholipase (LLPL

182 In this work, the functions of lecithin:cholesterol acyltransferase-like PLAs (LCAT-PLAs) in HFA

183 es, due primarily to an increase in lecithin:cholesterol acyltransferase-mediated (LCAT-mediated) cho

184 -term pharmacological inhibition of acyl-CoA:cholesterol acyltransferase-mediated cholesterol esterif

185 ates LDL uptake and degradation and acyl-CoA:cholesterol acyltransferase-mediated esterification of L

186 lesteryl ester transfer protein and lecithin:cholesterol acyltransferase only function optimally in h

187 lesteryl ester transfer protein and lecithin-cholesterol acyltransferase (phosphatidylcholine-sterol

188 cholesteryl ester transfer protein, lecithin:cholesterol acyltransferase (phosphatidylcholine-sterol

189 he first molecular probe of acyl-coenzyme A: cholesterol acyltransferase provided a key to understand

190 e of similar size, composition, and lecithin:cholesterol acyltransferase reactivity when compared to

191 apoA-I(-/-) HDL in the presence of lecithin cholesterol acyltransferase reorganized the large hetero

192 long-chain acyl-CoA synthetase and acyl-CoA:cholesterol acyltransferase, respectively.

193 types toward a major plasma enzyme, lecithin:cholesterol acyltransferase responsible for the HDL matu

194 eletion of LRO1, a homolog of human lecithin cholesterol acyltransferase, resulted in a dramatic redu

195 phimurium translocates a glycerophospholipid:cholesterol acyltransferase (SseJ) into the host cytosol

196 mation, apoA-I activates the enzyme lecithin:cholesterol acyltransferase stimulating the formation of

197 MEDI6012 is a recombinant human lecithin-cholesterol acyltransferase that increases high-density

198 nzymes that esterify cholesterol (lecithin : cholesterol acyltransferase), transfer cholesterol (chol

199 Lecithin cholesterol acyltransferase treatment alone or addition

200 ester formation in tissues, acyl coenzyme A:cholesterol acyltransferase types 1 and 2 (ACAT1 and ACA

201 a cholesterol esterification enzyme lecithin:cholesterol acyltransferase was also compared.

202 Lecithin-cholesterol acyltransferase was unaffected by psyllium i

203 ver, apoA-V was a poor activator of lecithin:cholesterol acyltransferase where the activity was 8.5 +

204 parameters of the lipophilic enzyme lecithin:cholesterol acyltransferase, which binds to phosphatidyl