ライフサイエンスコーパス: cholesterol content

1 ions require precise regulation of lysosomal cholesterol content.

2 nctions some of which are independent of its cholesterol content.

3 cholesterol efflux and increase in cellular cholesterol content.

4 mechanistically linked to increased platelet cholesterol content.

5 lipidemia associated with increased platelet cholesterol content.

6 are sensitive to alterations in the membrane cholesterol content.

7 yperreactivity induced by increased platelet cholesterol content.

8 e in membranes with physiologically relevant cholesterol content.

9 at particle uptake has on the cell's overall cholesterol content.

10 -Gal A was less effective in normalizing the cholesterol content.

11 ol and increased hepatic free fatty acid and cholesterol content.

12 nificant increases in renal triglyceride and cholesterol content.

13 wed decreased extractability with increasing cholesterol content.

14 ect correlation with increased cellular free cholesterol content.

15 sponse that correlates with vesicle membrane cholesterol content.

16 (brown, not white) due to a 91% reduction in cholesterol content.

17 nifest the functional importance of membrane cholesterol content.

18 lesterol molecules vary as a function of the cholesterol content.

19 metabolism in cancer cells is independent of cholesterol content.

20 erol efflux consequently decreasing cellular cholesterol content.

21 tic cholesterol levels to changes in dietary cholesterol content.

22 shown to be affected by changes in cellular cholesterol content.

23 low in plant sterols and moderate to low in cholesterol content.

24 heightened in response to increases in cell cholesterol content.

25 sterol domains despite significantly reduced cholesterol content.

26 ain and is retarded by an elevated endosomal cholesterol content.

27 ule injury first lowers, then raises, tubule cholesterol content.

28 udied as a function of lipid phase state and cholesterol content.

29 idylcholine transfer with an increase in the cholesterol content.

30 rescence, irrespective of headgroup size and cholesterol content.

31 et, many people avoid it because of its high cholesterol content.

32 is very low in total fat, yet it has a high cholesterol content.

33 significantly enhanced by reducing membrane cholesterol content.

34 r membranes, in particular those with a high cholesterol content.

35 , whose activity has been linked to membrane cholesterol content.

36 reased in abundance as a function of bilayer cholesterol content.

37 , which is the retinal layer with the lowest cholesterol content.

38 r responses to these agents are regulated by cholesterol content.

39 ses changes in glioma cells that have higher cholesterol content.

40 C toward lower temperatures with increasing cholesterol content.

41 n its biological activity rather than in its cholesterol content.

42 e A reductase, and increased plasma membrane cholesterol content.

43 elis-Menten kinetics independent of membrane cholesterol content.

44 es for changes in polarity versus changes in cholesterol content.

45 changes in membrane fluidity from changes in cholesterol content.

46 ngial expansion, kidney weight, and cortical cholesterol content.

47 protein abundance and renal triglyceride and cholesterol contents.

48 p24 dimerization in membranes with increased cholesterol contents.

49 differences in surface monolayer protein and cholesterol contents.

50 f total surface area, P=.89) and analysis of cholesterol content (236+/-203 nmol/mg, 9.1+/-7.8 microg

51 He had exceptionally high cholesterol content (760 mg/dL; to convert to millimoles

52 subjects revealed double the normal hepatic cholesterol content, a markedly deficient rate of bile a

53 However, at high cholesterol content, a switch toward the C-terminus is o

54 Direct measurement of cholesterol content after beta-methyl-cyclodextrin treat

55 The plasma membrane cholesterol content also was altered by various biochemi

56 Cholesterol content alters cell membrane stiffness, and

57 f9 insect cells that typically have very low cholesterol content and a different phospholipid profile

58 timibe is a novel approach to reduce biliary cholesterol content and a promising strategy for prevent

59 ified in a sucrose gradient and measured for cholesterol content and cholesterol/phospholipid mole ra

60 The membrane cholesterol content and cholesterol/phospholipid mole ra

61 in octapeptide-induced contraction, membrane cholesterol content and cholesterol/phospholipid ratio,

62 the cell membrane appears to be regulated by cholesterol content and cytoskeleton integrity.

63 e delivery, significantly augments adipocyte cholesterol content and enhances fatty acid uptake.

64 e in membranes with physiologically relevant cholesterol content and in membranes without cholesterol

65 hat ATRA-mediated decrease in total cellular cholesterol content and increase in lysosomal acidificat

66 dy aimed to describe the fatty acid profile, cholesterol content and indexes of lipid quality.

67 ration and hydrophobicity but decreases with cholesterol content and lower temperature.

68 urons tolerate only slight alteration in the cholesterol content and plasma membrane tension.

69 Aortic tissue cholesterol content and platelet aggregation were also m

70 om lysosomes leads to a decrease of parasite cholesterol content and proliferation.

71 on was associated with a reduction in aortic cholesterol content and reduced platelet aggregability a

72 terol homeostasis, the combination of higher cholesterol content and reduced receptor activation asso

73 cholesterol restored granule morphology and cholesterol content and rescued insulin secretion in ABC

74 maintained elevated Src and plasma membrane cholesterol content and showed increased phosphorylation

75 B-100 dual transgenic mice and increased HDL cholesterol content and size comparable to torcetrapib (

76 s, accompanied with decreased pulmonary free cholesterol content and suppressed tumor cell proliferat

77 logical inhibition of RORgamma reduces tumor cholesterol content and synthesis rate while preserving

78 Both the cholesterol content and the cholesterol/phospholipid rat

79 -deficient mice with such a robust change in cholesterol content and the expression of cholesterol me

80 ating cholesterol in SCID mice increased the cholesterol content and the extent of protein tyrosine p

81 Cs - are composed of a high sphingolipid and cholesterol content and the protein caveolin-1 (Cav-1).

82 fferent properties such as water content and cholesterol content and thus perform a more comprehensiv

83 y pathogenic MDV-RB1B increases the cellular cholesterol content and upregulates the genes involved i

84 size is associated with a linear increase in cholesterol content and with accumulation of amorphous c

85 lation of HA depends on cellular or membrane cholesterol content and, potentially, intact cholesterol

86 onditions of pH, temperature, lipid content, cholesterol content, and buffer dimethylsulfoxide concen

87 decreased bile acid pool, increased hepatic cholesterol content, and lowered serum cholesterol in mi

88 investigate the influence of electrostatics, cholesterol content, and peptide palmitoylation, we also

89 th cholesterol or variations in unesterified cholesterol content appear to have little effect on the

90 n effective bending rigidity with increasing cholesterol content approaching a mole fraction of 50%.

91 erimental data we find that measures of cell cholesterol content are important in differentiating bet

92 of up to 25 and 60% reduction in chylomicron cholesterol content are seen with a 10-mg dose.

93 s illuminate targeted regulation of membrane cholesterol content as a host defense strategy.

94 s, the parameter tau depends linearly on the cholesterol content at 310 K and allows us to determine

95 protein cargo sorting through the control of cholesterol content at the endosomal compartment/MVBs.

96 c variation, as large as 50%, with liposomal cholesterol content at the theoretically predicted C(r),

97 fied, CE droplets accumulate and microdomain cholesterol content becomes poorly regulated.

98 hypothesized that the natural difference in cholesterol content between erythrocytes and leukocytes

99 utants p.E297G and p.R432T increased at high cholesterol content but did not reach the capacity of no

100 pools was unaffected by raising the cellular cholesterol content, but the size of the fast pool incre

101 s occurs through the maintenance of caveolae cholesterol content by cholesterol ester uptake from HDL

102 membrane, 8 mm in diameter, were assayed for cholesterol content by enzymatic fluorometry (n = 10, >7

103 After increasing the membrane cholesterol content by treatment of water-soluble choles

104 P, an antivascular drug, to demonstrate that cholesterol content can actually modulate the release an

105 otoxicity generated by lowering the membrane cholesterol content can be reversed by AbetaP calcium ch

106 hat these functions may be related; membrane cholesterol content can regulate receptor-mediated signa

107 of the membrane that do not change the total cholesterol content, can significantly affect how choles

108 among known organellar membranes in terms of cholesterol content, cholesterol dynamics, and response

109 s found to decrease by six times for 50 mol% cholesterol content compared with cholesterol-free lipos

110 A1(-A/-A) mice had a 2-fold increase in free cholesterol content compared with wild-type mice and fai

111 Increasing the SUV cholesterol content, concomitant with the presence of ne

112 t, saturated fat, protein, carbohydrate, and cholesterol content, consistent with former American Hea

113 GUVs of high cholesterol content containing the breakdown products of

114 variates (including high-density lipoprotein cholesterol content, coronary artery disease, and the in

115 A-I)-containing particles, and adrenal gland cholesterol content decreased by 42% and 72%, respective

116 The cholesterol content decreased significantly after cannin

117 ity directly depends on canalicular membrane cholesterol content, decreased BSEP presence in rafts ma

118 under ischemic conditions astrocyte membrane cholesterol content decreases, which could increase AQP4

119 have different phospholipid composition and cholesterol content, displaying a profile of fluidity th

120 Manipulations of membrane cholesterol content dramatically altered the diffusion p

121 L) did not substantially increase macrophage cholesterol content during in-vitro incubations, investi

122 be dramatically affected by changes in their cholesterol content during the development of atheroscle

123 sed mice to excrete up to 60% of their total cholesterol content each day.

124 However, cholesterol content exhibited significant variation and

125 of sPLA2 shows an alternating variation with cholesterol content, exhibiting a minimum at the critica

126 drating the head groups and as a function of cholesterol content for a fixed hydration level.

127 le for development-associated differences in cholesterol content for the differential responses of th

128 The dynamics are independent of cholesterol content from 10 to 35%.

129 the ultrastructure of the MVB by perturbing cholesterol content genetically through the use of a del

130 cells, we found that changes in the overall cholesterol content have a limited effect on the average

131 Changes in membrane cholesterol content have potent effects on cell signalli

132 is that DRMs of vastly different protein and cholesterol contents have been isolated from erythrocyte

133 Regardless of cholesterol content, high fat diets induced mineralizati

134 xamine how lipid phase, packing density, and cholesterol content impact SERM-membrane interactions.

135 ic activity of sPLA2 is found to change with cholesterol content in an alternating manner.

136 However, CsA treatment decreased cholesterol content in caveolae and displaced eNOS from

137 These data suggest that decreasing cholesterol content in caveolae by CsA is a potentially

138 ndothelial dysfunction is related to reduced cholesterol content in caveolae.

139 tivation in endothelial cells via decreasing cholesterol content in caveolae.

140 reatment with TO901317 resulted in increased cholesterol content in Dhcr7(-/-) embryos.

141 eta-(1-42) would differentially modify Golgi cholesterol content in DINTC1 astrocytes and that the ef

142 Cholesterol content in each well was measured using a fl

143 ance, fatty acid content and composition and cholesterol content in egg yolk has been evaluated durin

144 ll be very useful for the quality control of cholesterol content in food matrices and can be easily a

145 stone dissolution in mice and reduce biliary cholesterol content in human beings.

146 LDL-C was corrected (LDL-C(corrected)) for cholesterol content in lipoprotein(a).

147 6.7 to 59.6 mg/dl) and LDL-C [corrected for cholesterol content in lipoprotein(a)] predicted MACE.

148 eased cholesteryl ester levels and decreased cholesterol content in MA-10 cells.

149 Given that cholesterol content in plasma membranes varies with cell

150 zymatic product of CYP27A1, reduced cellular cholesterol content in prostate cancer cell lines by inh

151 nsfer by PLTP decreases with increasing free cholesterol content in rHDL and with decreasing HDL size

152 Increasing cholesterol content in target vesicles increased lipid-

153 rich domains is constant, independent of the cholesterol content in the bilayer.

154 otaxis to an SDF-1 gradient was dependent on cholesterol content in the cell membrane and on the inco

155 be nonhorizontal, indicating a difference in cholesterol content in the coexisting phases.

156 els, disrupted lysosomal function, decreased cholesterol content in the endoplasmic reticulum, and pr

157 that aged Abeta-(1-42) significantly reduced cholesterol content in the Golgi complex.

158 mitochondria with a significantly increased cholesterol content in the inner mitochondrial membrane.

159 he water permeability of AQP4 depends on the cholesterol content in the lipid bilayer, but it was not

160 embrane surface independently of the overall cholesterol content in the membrane.

161 Increasing cholesterol content in the membranes resulted in a reduc

162 ddition of linseed oil did not influence the cholesterol content in yolks (P=0.5200) while the only f

163 FA profile and cholesterol content in yolks were determined.

164 tion rates could be observed with increasing cholesterol contents in the vesicle membranes.

165 First, the total cellular cholesterol content increase was 2-3-fold and 3-5-fold i

166 However, high-density-lipoprotein-cholesterol content increased by 14.4% in the HFD rats t

167 TLR4), interleukin-1beta (IL-1beta), and the cholesterol content increased in the retina of patients

168 ce also exhibited higher plasma LDL and VLDL cholesterol content, increased circulating apolipoprotei

169 repulsive to attractive to repulsive as the cholesterol content increases.

170 xpression attenuated the increase in hepatic cholesterol content induced by consumption of a high cho

171 correlation between atherosclerosis, plasma cholesterol content, inflammation, and alpha1-AT rate of

172 holesterol synthesis inhibitor, lowered raft cholesterol content, inhibited Akt1 serine-threonine kin

173 also disrupted LRs, reduced plasma membrane cholesterol content, inhibited NADPH oxidase 4 transloca

174 , pomca, irs1); whole-body LDLc and/or total cholesterol content (irs2b and sh2b1); and pancreatic be

175 The increase in cholesterol content is associated with 1) increased expr

176 ty reaches a local minimum when the membrane cholesterol content is at or near the critical cholester

177 Since membrane cholesterol content is disturbed in the development of c

178 marks of atherogenic dyslipidemia, and their cholesterol content is hypothesized to drive atheroscler

179 Increasing macrophage cholesterol content is sufficient to trigger IL-1beta re

180 d in the inner mitochondrial membrane, where cholesterol content is very low.

181 because gPr80gag-negative M-MuLV has a lower cholesterol content, is less sensitive to inhibition of

182 Instead by considering the intracellular cholesterol content it is found that internalisation of

183 counterstained with filipin, an indicator of cholesterol content, MNV NS3 displayed a greater associa

184 Hence, changing membrane cholesterol content modulates BSEP and MRP2 transport ki

185 ity consistent with the increase in membrane cholesterol content observed after 4 h of DCA treatment

186 Fatty acid composition and cholesterol content of caveolae/lipid rafts before and a

187 tion that was preceded by an increase in the cholesterol content of cell membranes and increased acti

188 synthase inhibitor squalestatin reduced the cholesterol content of cells and prevented the accumulat

189 ression analysis of the relation between the cholesterol content of each DGUC fraction as the depende

190 sphocholine (POPC)), and the average GM1 and cholesterol content of each ND were determined.

191 Moves to reduce the cholesterol content of formula feeds below those of brea

192 henotypic differences in either the relative cholesterol content of gallbladder bile, bile acid pool

193 Similarly, reducing the cholesterol content of HBE cells with simvastatin or the

194 significant reduction in the lesion area and cholesterol content of high-fat, high-cholesterol diet-i

195 suggested that endo-CHOL contributes to the cholesterol content of late endosomes and controls its m

196 and size of LDL particles in addition to the cholesterol content of LDL.

197 s study, we tested whether alteration of the cholesterol content of lipid rafts in prostate cancer (P

198 asma membrane, likely through regulating the cholesterol content of lipid rafts.

199 ly lower, but no significant decrease in the cholesterol content of major lipoprotein fractions was m

200 goal of this experiment was to diminish the cholesterol content of Manchego, the most popular Spanis

201 ompares favourably with the fat, energy, and cholesterol content of many other meats and poultry.

202 ctions as a molecular machine to control the cholesterol content of membranes in mammalian cells.

203 While the cholesterol content of most tissues is normal in PEX2(-/

204 Increasing cholesterol content of PS liposomes also suppresses Abet

205 lity of RBC cholesterol was unrelated to the cholesterol content of RBCs or plasma, but was associate

206 Treatment with glucosamine-PI increased the cholesterol content of ScGT1 cell membranes and reduced

207 ibute significantly to the saturated fat and cholesterol content of the American diet.

208 When the cholesterol content of the diet was raised to 1.0%, hepa

209 in apoAI-Tg mice, independent of the fat or cholesterol content of the diet.

210 terol transfer was greatly influenced by the cholesterol content of the donor vesicles.

211 The cholesterol content of the endoplasmic reticulum (ER) an

212 However, the high cholesterol content of the envelope (ca. 40 to 50 mol%)

213 reduces the phosphatidylserine (PtdSer) and cholesterol content of the inner plasma membrane.

214 est hydrophobic characteristics; and (4) the cholesterol content of the membrane bilayer.

215 some of whose functions are affected by the cholesterol content of the membrane.

216 ted with low fluidity, low polarity, or high cholesterol content of the membranes, and a low GP is th

217 lts in increased chemotaxis dependent on the cholesterol content of the plasma membrane and receptor

218 Doubling the unesterified cholesterol content of the plasma membrane by incubation

219 In addition, results indicate that as the cholesterol content of the plasma membrane is increased,

220 The effect of the cholesterol content of the plasma membrane on the intrac

221 n TCR reorganization and is sensitive to the cholesterol content of the T cell membrane.

222 ly overlooked therapeutic consideration: the cholesterol content of the treated cell determines which

223 Although the cholesterol content of the treated cells increased after

224 suggest that carvacrol and thymol alter the cholesterol content of the viral membrane, blocking HIV-

225 ains, two properties that depend on the high cholesterol content of the viral membrane.

226 inhibited by EGTA, and is independent of the cholesterol content of these membranes.

227 Aortic lesions in D-HL swine had double the cholesterol content of those in N-HL swine, and incorpor

228 This implies that elevated cholesterol content of triglyceride-rich lipoprotein par

229 ospective epidemiological data pertaining to cholesterol content of TRLs and sdLDL in primary prevent

230 These findings signal that the cholesterol content of TRLs and sdLDL influence atheroge

231 es in lipid composition, particularly in the cholesterol content of very-low-density lipoproteinparti

232 n inducing a 3-5-fold increase in macrophage cholesterol content of which >60% is esterified.

233 gressively broadens and is not detectable at cholesterol contents of >40 mol%.

234 The cholesterol contents of major tissues were not altered.

235 Cell-type-specific effects of cholesterol content on function of human Pgp were detect

236 The influence of calcium and disc membrane cholesterol content on fusion between ROS membrane speci

237 The affects of cholesterol content on fusion were investigated by incre

238 We also examined the effect of varying cholesterol content on the cold Triton X-100 solubility

239 d a detailed study of the effect of membrane cholesterol content on the initial hydrolytic activity o

240 etion of ABCA1 and ABCG1 causes an increased cholesterol content on the inner leaflet of the PM, asso

241 d in vitro, but it had no effect on cellular cholesterol content or efflux.

242 We find that alteration of membrane cholesterol content or perturbation of lipid rafts regul

243 SCVD and all-cause mortality, and that their cholesterol content or remnant cholesterol likewise are

244 Partial restoration of membrane cholesterol content partially restored shear-induced pla

245 to approximately 2 x 10(-9) cm(2)/s in high-cholesterol-content phases, to approximately 2 x 10(-10)

246 he flip-flop rate is independent of membrane cholesterol content, phospholipid acyl saturation, and l

247 ion of VLC-ceramides reduced plasma membrane cholesterol content, reduced plasma membrane lipid packi

248 Cellular cholesterol content reflects a balance of lipid influx b

249 ld, respectively, whereas plasma and hepatic cholesterol content remained unchanged.

250 ophilic BS eliminated or increased vesicular cholesterol content, respectively.

251 by depleting phosphatidylserine (PtdSer) and cholesterol contents, respectively, at the inner PM leaf

252 ell CD36 receptors and by depleting caveolae cholesterol content, resulting in the disruption of eNOS

253 Temperature variation at constant cholesterol content revealed three of the eight combinat

254 High cholesterol content shifted E17betaG to Michaelis-Menten

255 indicate that a reduction in neuron-derived cholesterol content, similar to that observed in diabeti

256 thods produced 20-31% reductions in cellular cholesterol content, similar to the decrease in choleste

257 on oligomer size is independent of membrane cholesterol content, so one interpretation of the data i

258 As a regulator of plasma membrane cholesterol content, SR-B1 promotes the uptake of lipid

259 nduction of hepatic Abcg5/g8 and gallbladder cholesterol content, suggesting a role of FXR in the reg

260 minished and eventually disappeared over 15% cholesterol content, suggesting that the cholesterol ric

261 rs are reported as a function of the bilayer cholesterol content, temperature, and incubation time.

262 ces in mineral content, fatty acid profiles, cholesterol content, texture parameters and sensory acce

263 nes made from the same cells showed a higher cholesterol content than nondetergent lipid rafts but we

264 via small vesicles having lower GP and lower cholesterol content than the surface membrane.

265 abolism is a 46% increase in plasma membrane cholesterol content, the implications of which are discu

266 pecimens were analyzed for the percentage of cholesterol content, the percentage of calcium bilirubin

267 urrent studies show that cells control their cholesterol content through receptor-ligand interactions

268 ne transcription by increasing intracellular cholesterol content through the hydrolysis of cellular s

269 The mechanisms that regulate lysosomal cholesterol content to enable mTORC1 signalling are unkn

270 adrenocortical cells increases mitochondrial cholesterol content under conditions in which StAR is in

271 d by increasing and decreasing disc membrane cholesterol content using well established lipid exchang

272 In particular, membrane cholesterol content varies with aging and consequently w

273 ne out of four types of phospholipids plus a cholesterol content varying from 0 to 50 mol %.

274 Cellular cholesterol content was altered by incubating cells with

275 The activity variation with cholesterol content was correlated well with the area of

276 Liver TG content was unchanged, whereas cholesterol content was decreased.

277 The increase in biliary cholesterol content was dependent on expression of G5 an

278 Cellular cholesterol content was depleted by exposing the cells t

279 Cholesterol content was detected and the promotional fun

280 Liver cholesterol content was elevated in Sr-bI ko only (P < 0

281 l diets, whole liver and isolated hepatocyte cholesterol content was higher in the apoE knockout mice

282 efold in livers of the -/- mice, and hepatic cholesterol content was increased by 50%.

283 ore IAF and were more insulin resistant, the cholesterol content was increased in VLDL, intermediate-

284 e of lipid polarity, membrane curvature, and cholesterol content was investigated.

285 e mass spectroscopy revealed that esterified cholesterol content was markedly reduced.

286 the labeling studies; a decrease in cellular cholesterol content was observed in the 8-Br-cAMP-treate

287 Total and free cholesterol content was significantly higher in 25 RA CH

288 Lysosome cholesterol content was significantly lower after treatm

289 =0.5200) while the only factor affecting the cholesterol content was the hens age (P<0.0001).

290 , fatty acid profile, nutritional impact and cholesterol content were determined and compared with th

291 The highest losses of cholesterol content were found during thermal processing

292 Intracellular triacylglycerol and cholesterol contents were also decreased.

293 esis rate and the aortic free and esterified cholesterol contents were also higher in the LDLR:(-/-)A

294 nical properties of the cells with different cholesterol contents were compared by measuring the degr

295 and acetate increase the total intracellular cholesterol content, which is attenuated with lovastatin

296 We hypothesized that cholesterol content will modulate the recruitment of mon

297 Reducing cholesterol content with a cholesterol scavenger (beta-m

298 tent at 310 K and allows us to determine the cholesterol content with an accuracy of at least 5%.

299 Elevated cholesterol content within pancreatic beta-cells has bee

300 d at 4 degrees C vs. 60 degrees C; increased cholesterol content yielded more PDH and SSHH at 60 degr