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1 LCAT), which rapidly converts cholesterol to cholesteryl ester.
2 ne, phosphatidylserine, triacylglycerol, and cholesteryl ester.
3 ncrease in the synthesis of phospholipid and cholesteryl ester.
4 ture of steroidogenic luteal cells and store cholesteryl esters.
5 d from other condensed structures, including cholesteryl esters.
6 ompanied by a compensatory overproduction of cholesteryl esters.
7 two enzymes that convert free cholesterol to cholesteryl esters.
8 for neutral lipids such as triglycerides and cholesteryl esters.
9 cholines, quaternary amines, and cholesteryl/cholesteryl esters.
10 in the duodenal hydrolysis and absorption of cholesteryl esters.
11 ase, leading to a subsequent accumulation of cholesteryl esters.
12 gh arachidonic acid and low linoleic acid in cholesteryl esters.
13 gths-540 and 560 nm (calcification), 920 nm (cholesteryl ester), 1040 nm (phospholipids), 1180 nm (el
15 ipids, 23% for glycerophospholipids, 16% for cholesteryl esters, 15% for sphingolipids, and 9% for he
16 h as in atherosclerosis, excessive levels of cholesteryl ester accumulate in lysosomes for reasons th
17 ell formation assessed by lipid staining and cholesteryl ester accumulation compared with control cel
18 therosclerosis in LDLR(-/-) mice by reducing cholesteryl ester accumulation in atherosclerotic sites.
19 When fed a Western-type diet, hepatic TG and cholesteryl ester accumulation was significantly higher
20 osclerotic plaque macrophages, ACAT promotes cholesteryl ester accumulation, resulting in foam cell f
22 tected against hepatic neutral lipid (TG and cholesteryl ester) accumulation, with the greatest diffe
23 sphatidylcholines (LPCs), sphingolipids, and cholesteryl esters all showed delayed increases at day 7
25 in, markedly raises high-density lipoprotein-cholesteryl ester and has no effect on fecal cholesterol
26 R-mitochondrial communication-as measured by cholesteryl ester and phospholipid synthesis, respective
27 ing in quantifying two major neutral lipids: cholesteryl ester and triacylglycerol in cells and tissu
28 L gene-knockout (lal(-/-)) mice, blockage of cholesteryl ester and triglyceride metabolism led to abn
29 P) is a serum component responsible for both cholesteryl ester and triglyceride trafficking between h
30 s essential for the clearance of endocytosed cholesteryl ester and triglyceride-rich chylomicron remn
31 r protein (CETP) facilitates the transfer of cholesteryl ester and triglycerides between plasma lipop
34 Conditional genetic ablation of MTP reduces cholesteryl esters and enhances free cholesterol in the
35 e 1 (Acat1) converts cellular cholesterol to cholesteryl esters and is considered a drug target for t
37 (ARIC) Study analyzed plasma fatty acids in cholesteryl esters and phospholipids in whites residing
38 ent LAL activity accumulate large amounts of cholesteryl esters and triglycerides in multiple tissues
39 ase (LAL) is essential for the hydrolysis of cholesteryl esters and triglycerides to generate cholest
41 id lipase (LAL) is a key enzyme that cleaves cholesteryl esters and triglycerides to generate free fa
43 id accumulation and storage of oxidized LDL, cholesteryl esters and triglycerides were abolished in H
45 e LAL inhibitor increased the levels of TAG, cholesteryl ester, and RE in both rat and mouse HSCs.
47 copy for the quantitative analysis of waxes, cholesteryl esters, and glycerides in meibum lipid (ML).
48 lipids (including lyso- and ether- species), cholesteryl esters, and glycerolipids were associated wi
49 cylglycerols, 1,2-diol diesters, wax esters, cholesteryl esters, and hydrocarbons, from TLC and high-
50 such as oxidized phospholipids and oxidized cholesteryl esters, and mediate a variety of immune resp
53 hosphatidylcholine-lipid species and gaining cholesteryl esters, and proteomic changes, with losses i
55 ing di- and triacylglycerols, phospholipids, cholesteryl esters, and wax esters in OG-treated sebocyt
56 GD3 and GD1a), cardiolipin, cholesterol and cholesteryl esters are elevated in autophagic vacuole fr
59 rate stimulated the synthesis of unsaturated cholesteryl esters at the expense of saturated esters.
60 P) facilitates exchange of triglycerides and cholesteryl ester between high-density lipoprotein (HDL)
61 refore, MTP plays a novel role in regulating cholesteryl ester biosynthesis in cells that produce lip
63 or longer does not impair the hydrolysis of cholesteryl esters but partially impairs the transport o
65 ng 2 amino acids (citrulline and glycine), 4 cholesteryl esters (C18:2, C18:1, C16:0, C18:3), 8 phosp
66 l metabolism-associated lipids [arachidonoyl cholesteryl ester, C8-dihydroceramide, N-stearoyl-d-sphi
67 intima, contributes to massive intracellular cholesteryl ester (CE) accumulation in human vascular sm
71 eryl ester transfer protein (CETP) transfers cholesteryl ester (CE) and triglyceride (TG) between lip
72 ed O-stained foam cells and showed increased cholesteryl ester (CE) content when cocultured with LDL.
73 ticles or via selective uptake (SU), wherein cholesteryl ester (CE) enters cells without concomitant
74 cal activities of mmLDL were associated with cholesteryl ester (CE) hydroperoxides and were diminishe
75 quantification of free cholesterol (FC) and cholesteryl ester (CE) in mammalian samples is of great
76 l-CoA and cholesterol are two substrates for cholesteryl ester (CE) synthesis via the ACAT reaction.
77 tent CETP inhibitor that maximally inhibited cholesteryl ester (CE) transfer activity at an oral dose
78 pment of protocols for the direct measure of cholesteryl ester (CE) transfer activity resident in hum
79 ked selective high-density lipoprotein (HDL) cholesteryl ester (CE) transport and steroidogenesis.
80 by selective high density lipoprotein (HDL)-cholesteryl ester (CE) uptake, mediated by scavenger rec
84 e different CD1c conformations and suggested cholesteryl esters (CE) and acylated steryl glycosides (
86 otein liquid chromatography profiles, aortic cholesteryl esters (CE), and plaque sizes were determine
87 lipid mixture of triacylglycerols (TAG) and cholesteryl esters (CE), surrounded by a single monolaye
88 AD-patient iPSC-derived neurons and identify cholesteryl esters (CE), the storage product of excess c
89 ajor lipid classes, such as wax esters (WE), cholesteryl esters (CE), triacylglycerols, (O)-acylated
91 36:5, 38:5), lyso-PCs (16:1, 18:1, 22:4) and cholesteryl esters (CEs) (16:0, 18:0, 20:4) in fish from
92 hydrolysis of high-density lipoprotein (HDL) cholesteryl esters (CEs) after selective uptake by hepat
93 rvention on plasma fatty acid composition of cholesteryl esters (CEs) and phospholipids and estimated
94 lyzes the hydrolysis of intracellular stored cholesteryl esters (CEs) and thereby enhances free chole
95 sfer protein (CETP) mediates the transfer of cholesteryl esters (CEs) and triglycerides between diffe
97 binds HDL and mediates selective delivery of cholesteryl esters (CEs) to the liver, adrenals, and gon
98 of lipid species, that is, wax esters (WEs), cholesteryl esters (CEs), and diesters (DEs) were correc
99 major compounds, triacylglycerols (TAGs) and cholesteryl esters (CEs), inside lipid droplets (LDs).
101 el wherein after lysosomal hydrolysis of LDL-cholesteryl esters, cholesterol binds NPC2, which transf
107 l ester transfer protein mediates direct HDL cholesteryl ester delivery to the liver cells; adipose t
108 demonstrate the presence of cholesterol and cholesteryl ester deposits beneath the retinal pigment e
109 h as keto, hydroperoxide, hydroxy, and epoxy cholesteryl ester derivatives from cholesteryl linoleate
110 c acid (20:4n-6) in plasma phospholipids and cholesteryl esters differed between genotype groups (int
111 osed primarily of TG, with lesser amounts of cholesteryl esters, diglyceride and other phospholipids.
112 rption by the intestine and the secretion of cholesteryl ester-enriched very low density lipoproteins
115 RD4 has been shown to increase intracellular cholesteryl ester formation and is controlled at the tra
119 ze HDL particles and prevent the transfer of cholesteryl ester from HDL to atherogenic lipoproteins.
121 fer protein (CETP) catalyzes the transfer of cholesteryl ester from high-density lipoprotein (HDL) to
122 r protein inhibitors prevent the transfer of cholesteryl ester from high-density lipoprotein to trigl
123 ryl ester transfer protein (CETP) transports cholesteryl ester from the antiatherogenic high-density
124 otein (CETP), which mediates the transfer of cholesteryl esters from HDL to apolipoprotein B-containi
125 eryl ester transfer protein (CETP) transfers cholesteryl esters from high-density lipoproteins to apo
127 lular cholesterol esterification by removing cholesteryl esters from their site of synthesis and depo
130 olesterol acyltransferase, ACAT, the neutral cholesteryl ester hydrolase (nCEH) that catalyzes the re
133 us nCEH that can account for the majority of cholesteryl ester hydrolysis in transformed rat hepatic
135 ts with chronic inflammatory conditions, and cholesteryl ester hydroperoxides are present in plasma,
136 report that mmLDL and its active components, cholesteryl ester hydroperoxides, induce TLR4-dependent
137 up to 70-fold increases in specific oxidized cholesteryl esters, identical to those present in human
138 oscopy, we found an aberrant accumulation of cholesteryl ester in human pancreatic cancer specimens a
139 though esterification of free cholesterol to cholesteryl ester in the liver is known to be catalyzed
140 eeply within the protein, shifting the bound cholesteryl ester in the N-terminal pocket of the long h
143 wed excellent inhibition of the oxidation of cholesteryl esters in human low-density lipoprotein and
147 or-mediated uptake of LDL, hydrolysis of LDL-cholesteryl esters in lysosomes, and transfer of the lib
149 ive lipase (HSL) catalyzes the hydrolysis of cholesteryl esters in steroidogenic tissues and, thus, f
151 ficient animals synthesize lesser amounts of cholesteryl esters in vitro, but addition of purified MT
152 sease, where the accumulation of cholesterol/cholesteryl-esters in macrophages can elicit a maladapti
153 olecules with apoA-I residues indicates that cholesteryl esters interact with protein residues mainly
156 ice had larger plasma HDLs enriched in apoM, cholesteryl ester, lecithin:cholesterol acyltransferase,
157 nous HSL, with siRNAs, resulted in increased cholesteryl ester levels and decreased cholesterol conte
158 had significantly lower free cholesterol and cholesteryl ester levels in the brachiocephalic artery t
161 e numbers and diminished the cholesterol and cholesteryl ester load without causing detectable apopto
163 ere, we have studied endosomal and lysosomal cholesteryl ester metabolism in cultured mouse macrophag
165 esterol, which creates a hydrophobic core of cholesteryl ester molecules in the middle of the discoid
166 itionally, the average number of contacts of cholesteryl ester molecules with apoA-I residues indicat
167 (NES) = 2.01, P = 0.001, FDR P = 0.005], and cholesteryl esters (NES = -1.77, P = 0.005, FDR P = 0.02
168 lipids - cholesteryl esters, wax esters, and cholesteryl esters of (O)-acylated w-hydroxy fatty acids
169 xy fatty acids (OAHFA), cholesteryl sulfate, cholesteryl esters of OAHFA, and diacylated alpha,omega-
170 f oxidized phospholipids (OxPL) and oxidized cholesteryl esters (OxCE) was evaluated in 24 filters us
172 ated with ezetimibe showed a 173% higher LDL-cholesteryl ester plasma disappearance rate (P < 0.001 v
173 group, FA markers in total plasma TG, plasma cholesteryl esters, plasma phospholipids, and red blood
174 ase (LCAT) catalyzes the formation of plasma cholesteryl ester, plays a key role in high-density lipo
175 roups from triglycerides, phospholipids, and cholesteryl esters plus total cholesterol (i.e., both es
177 The objective was to study whether the serum cholesteryl ester proportion of palmitoleic acid [16:1n-
178 significantly altered lipoprotein lipase and cholesteryl ester protein mass or measures of insulin re
179 ) convert cholesterol into its storage form, cholesteryl esters, regulating a key step in cellular ch
180 high density lipoprotein (HDL) to spheroidal cholesteryl ester-rich HDL is a central step in reverse
182 the partial disproportionation of HDL into a cholesteryl ester-rich microemulsion (CERM) and a new HD
183 D approximately 8.5 nm) into a single, large cholesteryl ester-rich microemulsion (CERM; D > 100 nm),
188 existing literature on Wolman's disease and cholesteryl ester storage disease, and discuss available
190 plasmic reticulum, where it was converted to cholesteryl esters stored in lipid droplets when ORP1L w
191 ny organs, resulting in a marked increase in cholesteryl esters, suppression of C but not fatty acid
195 long-chain fatty acid to cholesterol to form cholesteryl esters that coalesce into cytosolic lipid dr
196 mixture of phospholipids, triglycerides, and cholesteryl esters that plays a major role in lipoprotei
197 m acyl-coenzyme A to cholesterol to generate cholesteryl ester, the primary form in which cholesterol
198 es enzymes of this family to readily oxidize cholesteryl esters, thus providing an additional source
199 eding an HCD supplemented with a fluorescent cholesteryl ester to optically transparent fli1:EGFP zeb
205 cholesterol (HDL-C) levels by inhibition of cholesteryl ester transfer protein (CETP) activity with
209 ockout mice, and human apolipoprotein (apo)B/cholesteryl ester transfer protein (CETP) double transge
214 is study was to identify associations of the cholesteryl ester transfer protein (CETP) gene with coro
215 xplore two HDL-C raising target modulations, Cholesteryl Ester Transfer Protein (CETP) inhibition and
216 ofuroquinoline derivatives exhibiting potent cholesteryl ester transfer protein (CETP) inhibition at
217 ne is consistent with a protective effect of cholesteryl ester transfer protein (CETP) inhibition on
220 te the efficacy and safety of torcetrapib, a cholesteryl ester transfer protein (CETP) inhibitor, in
227 cuses on the studies with niacin and the new cholesteryl ester transfer protein (CETP) inhibitors tor
228 mine the recent advances in our knowledge of cholesteryl ester transfer protein (CETP) inhibitors, he
229 is has been challenged by clinical trials of cholesteryl ester transfer protein (CETP) inhibitors, wh
244 Asp), apolipoprotein E (Apo E2, E3, and E4), cholesteryl ester transfer protein (TaqIB), and leptin r
246 ty, HDL ability to esterify cholesterol, and cholesteryl ester transfer protein activity), HDL antiox
247 ding expression of the emerging drug targets cholesteryl ester transfer protein and apolipoprotein (a
248 tigate the mechanisms of action, we measured cholesteryl ester transfer protein and indexes of plasma
250 identified a rare missense variant in CETP (cholesteryl ester transfer protein gene; rs1800777-A) th
253 s; adipose tissue-specific overexpression of cholesteryl ester transfer protein in mice reduces the p
254 Initial studies addressing the effect of cholesteryl ester transfer protein inhibition on cardiov
256 and low-density lipoprotein cholesterol, the cholesteryl ester transfer protein inhibitor torcetrapib
258 s after ACS to treatment with dalcetrapib (a cholesteryl ester transfer protein inhibitor) or placebo
259 te the safety and efficacy of anacetrapib, a cholesteryl ester transfer protein inhibitor, in patient
260 , 0.94-1.09) vs 0.90 (95% CI, 0.89-0.91) for cholesteryl ester transfer protein inhibitors (P = .002)
263 apeutic agents such as fibrates, niacin, and cholesteryl ester transfer protein inhibitors that are k
264 t should be possible to develop more optimal cholesteryl ester transfer protein inhibitors that do no
265 less, drugs that raise HDL-C concentrations, cholesteryl ester transfer protein inhibitors, are in la
267 specific and, since the crystal structure of cholesteryl ester transfer protein is now known, it shou
270 hat do not form a nonproductive complex with cholesteryl ester transfer protein on the high-density l
271 zed in the presence of PLA2 by the action of cholesteryl ester transfer protein or by guanidine hydro
273 holesterol concentration and adipocyte size; cholesteryl ester transfer protein TaqIB polymorphism is
275 for hepatic lipase, endothelial lipase, and cholesteryl ester transfer protein were analyzed, patien
276 lemia that were naturally deficient in CETP (cholesteryl ester transfer protein) and fed a Western-ty
277 RATIONALE: Therapies that inhibit CETP (cholesteryl ester transfer protein) have failed to demon
280 of coexpression of scavenger receptor BI or cholesteryl ester transfer protein, both of which promot
281 frequency for the TaqI B1/B2 polymorphism in cholesteryl ester transfer protein, consistent with the
282 lipoprotein-cholesterol, i.e. inhibition of cholesteryl ester transfer protein, is markedly effectiv
283 -cholesterol fractional esterification rate, cholesteryl ester transfer protein, phospholipid transfe
284 translocated through caveolae were detected (cholesteryl ester, triacylglycerol) and/or enriched (cho
285 se of nonpolar lipids, including wax esters, cholesteryl esters, triacylglycerols, and diesters, wher
286 cholesterol (HDL-C) metabolism in selective cholesteryl ester uptake and in free cholesterol cellula
289 ion by increasing the rate of HDL-associated cholesteryl ester uptake, possibly by optimizing SR-BI l
294 cetrapib markedly decreases clearance of HDL cholesteryl ester via an indirect pathway, but has no ef
295 ansferase (LCAT), a key enzyme that produces cholesteryl esters via transfer of acyl groups from phos
296 learance of HDL particles and HDL-associated cholesteryl esters was also similar between hLrp1(+/+) a
297 affected major classes of meibomian lipids - cholesteryl esters, wax esters, and cholesteryl esters o