ライフサイエンスコーパス: cholinergic receptor

1 is inhibition was specific for the nicotinic cholinergic receptor.

2 n stimulated by the Gq-coupled M3 muscarinic cholinergic receptor.

3 a known candidate gene, the beta3 nicotinic cholinergic receptor.

4 sis via stimulation of endothelial nicotinic cholinergic receptors.

5 g direct effects on AC mediated by nicotinic cholinergic receptors.

6 exerts part of its actions through nicotinic cholinergic receptors.

7 ding the 5-hydroxytryptamine2 and muscarinic cholinergic receptors.

8 receptors, the nicotinic and the muscarinic cholinergic receptors.

9 y paralleling the concentration of nicotinic cholinergic receptors.

10 beta gamma subunit complex, or m1 muscarinic cholinergic receptors.

11 genes including GABAergic, melatonergic, and cholinergic receptors.

12 layer, express both nicotinic and muscarinic cholinergic receptors.

13 d in vitro(7), and expressed more inhibitory cholinergic receptors.

14 the laminar and subcellular localization of cholinergic receptors.

15 ver, lymphocytes also express adrenergic and cholinergic receptors.

16 e activation by agonist of the m1 muscarinic cholinergic receptor, a prototypical class I G(q)-couple

17 raphy to test the hypothesis that muscarinic cholinergic receptors activate G proteins in C57BL/6J (B

18 We examined how cholinergic receptor activation affects temporal and spa

19 The summation was unaffected by cholinergic receptor activation by carbachol.

20 suggests that concurrent beta-adrenergic and cholinergic receptor activation enhances LTP induction b

21 While cholinergic receptor activation has long been known to d

22 The creation of nitric oxide in response to cholinergic receptor activation may provide a mechanism

23 he effects of concurrent beta-adrenergic and cholinergic receptor activation on the induction of long

24 Previous studies have shown that nicotinic cholinergic receptor activation sharpens mitral cell che

25 n produced by concurrent beta-adrenergic and cholinergic receptor activation.

26 have on SC inputs in hippocampal CA1 during cholinergic receptor activation.

27 principal cells, are modulated similarly by cholinergic receptor activation.

28 triggered by depolarizing stimuli following cholinergic receptor activation.

29 e involved in the antinociceptive effects of cholinergic receptor activation.

30 asynchrony is related to an increase in the cholinergic receptor activity.

31 Reverse dialysis of the cholinergic receptor agonist carbachol (1 mM) into the S

32 receptor agonist isoproterenol (ISO) and the cholinergic receptor agonist carbachol had no effect on

33 We iontophoretically applied the general cholinergic receptor agonist carbachol onto neurons in d

34 ellular Ca2+ by ionophore or by a muscarinic cholinergic receptor agonist increases cAMP in cells tra

35 The centrally acting muscarinic cholinergic receptor agonist, arecoline, resulted in an

36 Central application of the non-selective cholinergic receptor agonist, carbachol, induces water i

37 drenergic receptor agonist, and carbachol, a cholinergic receptor agonist.

38 Cholinergic receptor agonists, including acetylcholine,

39 ed the selective expression of the nicotinic cholinergic receptor alpha2 (Chrna2) in mice to genetica

40 The alpha7-nicotinic cholinergic receptor (alpha7-nAChR) is a key mediator of

41 This neurotransmitter can bind to the alpha7 cholinergic receptor (alpha7R) expressed by nonneuronal

42 roblems is impaired following blockade of OB cholinergic receptors, although the relative contributio

43 rats showed unchanged cardiac adrenergic and cholinergic receptor and IKACh-subunit gene expression,

44 the protracted decrease in the expression of cholinergic receptors and acetylcholinesterase in specif

45 tagonist binding kinetics of both muscarinic cholinergic receptors and phorbol ester receptors.

46 ulation of signaling kinases associated with cholinergic receptors and provided mechanistic explanati

47 Blockade of muscarinic cholinergic receptors and selective cholinergic lesions

48 kes the need for structural proximity of the cholinergic receptors and the Ca2+ release channels in t

49 changes in beta-adrenergic and m2-muscarinic cholinergic receptors and their linkage to AC.

50 pesticides are agonists of insect nicotinic cholinergic receptors, and sub-lethal exposures are link

51 Cholinergic receptor antagonism also attenuated the norm

52 Perfusion of the cholinergic receptor antagonist atropine accentuated the

53 ptor antagonist scopolamine or the nicotinic cholinergic receptor antagonist dihydro-beta-erythroidin

54 s when it was co-infused with the muscarinic cholinergic receptor antagonist scopolamine or the nicot

55 mice were reduced by mecamylamine (nicotinic cholinergic receptor antagonist) and PPADS (P2X receptor

56 (NMDAR), dizocilpine (DZP), and a muscarinic cholinergic receptor antagonist, scopolamine (SCP).

57 insensitivity to the amnesic effects of the cholinergic receptor antagonist, scopolamine.

58 administration of scopolamine, a muscarinic-cholinergic receptor antagonist.

59 are not blocked by metabotropic glutamate or cholinergic receptor antagonists and are not produced by

60 Systemic infusions of the muscarinic cholinergic receptor antagonists atropine and scopolamin

61 hed by simultaneous reverse microdialysis of cholinergic receptor antagonists into BF.

62 mined by either intrahippocampal infusion of cholinergic receptor antagonists or knocking out choline

63 showed that NKCC1, Na+,K+-ATPase and the M3 cholinergic receptor are expressed on the basolateral me

64 fects on performance of cognitive tasks, and cholinergic receptors are being actively explored as pro

65 encoding-related activity may be reduced if cholinergic receptors are blocked by scopolamine.

66 These results demonstrate that cholinergic receptors are critical to establish attentio

67 These results show that muscarinic cholinergic receptors are involved in the learning of ne

68 A subset of muscarinic cholinergic receptors are linked to G-proteins that acti

69 Cholinergic receptors are localized to both presynaptic

70 GABA)ergic, N-methyl-d-aspartate (NMDA), and cholinergic receptors are thought to be involved in visu

71 hermore, both pharmacological stimulation of cholinergic receptors, as well as interference with GABA

72 contact-mediated, clustering of postsynaptic cholinergic receptors at the synaptic site requires tran

73 ynaptic inputs mediated by glutamatergic and cholinergic receptors, because co-application of the glu

74 cotinic (3H-cytisine) or muscarinic (3H-QNB) cholinergic receptor binding in the cortex or hippocampu

75 ng and after exposure, we assessed nicotinic cholinergic receptor binding in the midbrain, cerebral c

76 of cardiac beta-adrenergic and m2-muscarinic cholinergic receptor binding, and receptor linkages to a

77 ignaling, neurophysiological recordings, and cholinergic receptor blockade to delineate the cholinerg

78 transition duration and failure rate during cholinergic receptor blockade.

79 Ligation of cholinergic receptors blunts IC-triggered responses in t

80 Muscarinic and nicotinic cholinergic receptors both contributed specifically to g

81 determined by stimulation of the muscarinic/cholinergic receptor by the agonist pilocarpine, suggest

82 as well as stimulation of G-protein-coupled cholinergic receptors by carbachol and tyrosine kinase r

83 Stimulation of endothelial nicotinic cholinergic receptors causes endothelial cell proliferat

84 pled receptors, among which human muscarinic cholinergic receptors (CHRMs) have been prominently repo

85 ed neurological functions including synaptic cholinergic receptor (CHRNA) families, dopamine receptor

86 an amino acid change in the alpha5 nicotinic cholinergic receptor (CHRNA5).

87 decreased function of the alpha 7-nicotinic cholinergic receptor could underlie the physiological de

88 With repeated release of ACh from the GCs, cholinergic receptors could become desensitized, particu

89 ses integrating transcriptomic data indicate cholinergic receptors could control multiple traits.

90 tabotropic (M2 muscarinic) but not nicotinic cholinergic receptors decreases their output.

91 ynapses, it remains unclear how postsynaptic cholinergic receptors encode the firing patterns of CHIs

92 synaptic inputs and the distribution of key cholinergic receptors (encoded by the genes acr-18, acr-

93 found that repeated activation of nicotinic cholinergic receptors enhanced cocaine intake in rats bu

94 , which express the inhibitory m2 muscarinic cholinergic receptor, exhibit a large increase in forsko

95 Nicotinic cholinergic receptors expressed on macrophages detect th

96 mportantly, we document increased muscarinic cholinergic receptor expression in Alexander disease mod

97 erved in the optic tectum, in which nicotine cholinergic receptor expression is delayed until E8-12.

98 nAChRs are cholinergic receptors forming ligand-gated ion channels

99 assessing whether a reduction in muscarinic cholinergic receptor function would improve depressive s

100 by altering nicotinic rather than muscarinic cholinergic receptor function.

101 lity through acute changes in adrenergic and cholinergic receptor function.

102 chlear hair cells is mediated by 'nicotinic' cholinergic receptors functionally coupled to calcium-ac

103 al homologues); beta(1)-ARs, m(2)-muscarinic cholinergic receptors, Galpha(s), and cardiac types V/VI

104 xpressed genes included NeuroD and nicotinic cholinergic receptor gamma.

105 Association between the M2 cholinergic receptor gene (CHRM2) and SD has recently be

106 kage to the alpha-7 subunit of the nicotinic cholinergic receptor gene in families with schizophrenia

107 q25.1 region, which includes three nicotinic cholinergic receptor genes (CHRNA5-B4) and the cell prol

108 contained purified recombinant m1 muscarinic cholinergic receptor, Gq, and 2-4 mol % [3H]phosphatidyl

109 l models suggest that blockade of muscarinic cholinergic receptors impairs paired-associate learning

110 otent nicotinic antagonists at the nicotinic cholinergic receptor in PC-12 cells (IC(50) < or =37 nM)

111 inergic receptor antagonists or knocking out cholinergic receptors in excitatory neurons or interneur

112 ent feedback through alpha9alpha10 nicotinic cholinergic receptors in IHCs.

113 Neural regulation via cholinergic receptors in isolated pancreatic acini and t

114 Here, we stimulated cholinergic receptors in prefrontal cortex and examined

115 s suggest the involvement of GABA, NMDA, and cholinergic receptors in rapid experience-dependent plas

116 study, we determined the role of presynaptic cholinergic receptors in regulation of the inhibitory GA

117 al information regarding the distribution of cholinergic receptors in relation to this circuitry.

118 ften treated with medications that block the cholinergic receptors in the bladder (known as anticholi

119 cated changes in expression alpha7 nicotinic cholinergic receptors in the pathophysiology of traumati

120 eductal gray is mediated in part by NMDA and cholinergic receptors in the rostral ventromedial medull

121 To investigate whether noradrenergic and cholinergic receptor interactions regulate forms of syna

122 ety and antidepressant effects, although the cholinergic receptors involved are likely different for

123 The alpha7 nicotinic cholinergic receptor is a ligand-gated ion channel with

124 Stimulation of cholinergic receptors is being explored to create cognit

125 M15 cells, and, because annexins can act as cholinergic receptors, its conformation was tested in a

126 SIB-1663 exhibited modest affinities to cholinergic receptors (K(i) values displacing the bindin

127 uggesting that PX is one of the keratinocyte cholinergic receptors known to be targeted by disease-ca

128 ere both acetylcholinesterase activities and cholinergic receptors labeled with [(3)H]QNB.

129 Cholinergic receptors labeled with the ligands [(3)H]epi

130 ably including Alzheimer's disease, in which cholinergic receptor-linked signal transduction activity

131 e fSR/BA1 synapse is modulated by muscarinic cholinergic receptors located on gamma-aminobutyric acid

132 The functional significance of cholinergic receptors, located at the presynaptic nerve

133 ngths, "modes", of the human m(1) muscarinic cholinergic receptor, m(1)AChR.

134 3) loop of the G(q/11)-coupled M1 muscarinic cholinergic receptor (M1 mAChR; M1i3).

135 adrenergic receptor (beta2AR), m2 muscarinic cholinergic receptor (m2 mAChR), and rhodopsin.

136 In pancreatic beta cells, muscarinic cholinergic receptor M3 (M3R) stimulates glucose-induced

137 B/La, as well as the cell surface muscarinic cholinergic receptor (M3) are observed.

138 ivity to an allosteric site on M4 muscarinic cholinergic receptors (M4Rs) in vitro and shows a region

139 t, we found that the activated m2 muscarinic cholinergic receptor (MAChR) could facilitate the exchan

140 The internalization of the M(2) muscarinic cholinergic receptor (mAChR) proceeds through an atypica

141 neuroblastoma cells, we show that muscarinic cholinergic receptor (mAchR) stimulation triggers Arc sy

142 The muscarinic cholinergic receptor (mAChR) subtypes share high sequenc

143 in the rapid uncoupling of the m2 muscarinic cholinergic receptors (mAChR) from G-proteins and seques

144 The internalization of the M(2) muscarinic cholinergic receptors (mAChR) in HEK293 cells has been d

145 pressed human m1, m2 and chimeric muscarinic cholinergic receptors (MAChR) in tobacco plants and in c

146 choline release and activation of muscarinic cholinergic receptors (mAChRs) enhance synaptic plastici

147 oinositides in the endocytosis of muscarinic cholinergic receptors (mAChRs) has been investigated via

148 inergic receptors (nAChRs) and/or muscarinic cholinergic receptors (mAChRs).

149 tgrowth elicited by activation of muscarinic cholinergic receptors (mAChRs).

150 te via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).

151 its toxic effects may involve the muscarinic cholinergic receptors (mAChRs).

152 amine signaling, these data suggest that NAc cholinergic receptors may gate the expression of cue-mot

153 esynaptic and postsynaptic specificity of m2 cholinergic receptors may help explain the differential

154 Specific targeting of these cholinergic receptors may thus provide a therapeutic str

155 This suggested that non-cholinergic receptor-mediated mechanisms contributed to

156 lamine showed that uptake was not muscarinic cholinergic receptor-mediated.

157 esence of three (N-, L-, and B-) subtypes of cholinergic receptor mediating contraction of body wall

158 gest the potential for intervention based on cholinergic receptor modulation.

159 progress in the field, such as glutamate and cholinergic receptor modulators, circadian regulators, a

160 In addition, early intervention with cholinergic receptor muscarinic (ChRM)-3 blocker reverse

161 or (B2AR), the dopamine receptor D1, and the cholinergic receptor muscarinic 2 agonists.

162 the relative abundance of muscarinic CHRM3 (cholinergic receptor muscarinic 3), purinergic P2X1, and

163 ors: SSTR2 (somatostatin receptor 2), CHRM2 (cholinergic receptor, muscarinic 2), and RXFP1 (relaxin/

164 g of the chromosome 6 QTLs identified Chrm2 (cholinergic receptor, muscarinic 2, cardiac) as a candid

165 lop an array of alpha(7)-selective nicotinic cholinergic receptor (nAChR)-based imaging agents for PE

166 ates cell growth via activation of nicotinic cholinergic receptors (nAChRs) and/or muscarinic choline

167 P2X receptors and nicotinic cholinergic receptors (nAChRs) are linked in a mutually

168 Nicotinic cholinergic receptors (nAChRs) are present in ganglia in

169 mpared with neuronal nicotinic acetylcholine cholinergic receptors (nAChRs) assembled from alpha and

170 esult of nicotine interacting with nicotinic cholinergic receptors (nAChRs) during lung development,

171 e GABAergic neurons at RVM express nicotinic cholinergic receptors (nAChRs) is not known.

172 ly selective ligand at alpha3beta4 nicotinic cholinergic receptors (nAChRs) that was reported to decr

173 the autoantibodies: a GWAS signal within the cholinergic receptor nicotinic alpha 1 subunit (CHRNA1)

174 between acetylcholine from immune cells and cholinergic receptor nicotinic alpha 2 subunit (CHRNA2)

175 We found that cholinergic receptor nicotinic alpha 2 subunit (CHRNA2)

176 hages interact with beige adipocytes through cholinergic receptor nicotinic alpha 2 subunit (CHRNA2)

177 , HDAC9 (histone deacetylase 9), and CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) loci (wh

178 umor-initiating capacity by interacting with cholinergic receptor nicotinic alpha 7 subunit (CHRNA7)

179 bound sites mapped to sites flanking CHRNA7 (cholinergic receptor nicotinic alpha 7) encoding the cho

180 rong expression quantitative trait locus for cholinergic receptor nicotinic alpha2 subunit (CHRNA2);

181 1 genome-wide significant locus on 15q25.1 (cholinergic receptor nicotinic B4 subunit, or CHRNB4) fo

182 CHRNA1) gene and a TWAS association with the cholinergic receptor nicotinic beta 1 subunit (CHRNB1) g

183 The discovery of genetic variants in the cholinergic receptor nicotinic CHRNA5-CHRNA3-CHRNB4 gene

184 gic receptor nicotinic alpha 7) encoding the cholinergic receptor, nicotinic, alpha 7.

185 Activation of muscarinic cholinergic receptors on pyramidal cells of the cerebral

186 bicuculline, by ligands for D2 or muscarinic cholinergic receptors or by low calcium buffer, tetrodot

187 us be improved by more specific targeting of cholinergic receptors or nuclei.

188 Our study uncovers a hepatic nicotinic cholinergic receptor pathway that constitutes a cell-aut

189 Several cholinergic receptors predictive of state modulation in

190 Antibodies to muscarinic cholinergic receptor proteins m1 to m4 were used in stri

191 ch as frizzled and smoothened, the nicotinic cholinergic receptors, receptor tyrosine kinases, and cy

192 ggest that coactivation of noradrenergic and cholinergic receptors regulates LTP induction via conver

193 alternative approach is to directly activate cholinergic receptors responsible for learning and memor

194 netic linkage of poor P50 suppression to the cholinergic receptor's alpha7 nicotinic subunit.

195 Interactions between noradrenergic and cholinergic receptor signaling may be important in some

196 conditions are altered to promote sustained cholinergic receptor stimulation, it becomes evident tha

197 entration capable of blocking the effects of cholinergic receptor stimulation.

198 Some nicotinic cholinergic receptor subtypes are lost in AD, making the

199 The muscarinic cholinergic receptor system has been implicated in the p

200 Here, we examined the role of the NAc cholinergic receptor system in cue-motivated behavior us

201 nformation will help to understand how these cholinergic receptor systems might be regulating neurona

202 ut are due to alterations in D1 dopamine and cholinergic receptor systems.

203 ardiovascular system, such as the muscarinic cholinergic receptors that regulate heart rate, might be

204 essential macrophage acetylcholine-mediated (cholinergic) receptor that responds to vagus nerve signa

205 that contained purified Gq and m1 muscarinic cholinergic receptors, the most active tails increased a

206 reliably activate both pre- and postsynaptic cholinergic receptors, thereby controlling TRN neuronal

207 ligand galantamine (Gal) modulates nicotinic cholinergic receptors to increase acetylcholine release

208 their cell-surface nicotinic and muscarinic cholinergic receptors to mediate the autocrine and parac

209 er disease (AD) or Lewy body disorder (LBD), cholinergic receptors, transporters, or enzymes are invo

210 specific for serotonergic, noradrenergic and cholinergic receptors uncovered differences.

211 Nicotinic cholinergic receptors undergo desensitization upon repea

212 G(q) and m1 muscarinic cholinergic receptor were co-reconstituted into proteoli

213 rs, beta-adrenergic receptors and muscarinic cholinergic receptors were not involved in generating th

214 2a, or an antagonist of the alpha7 nicotinic cholinergic receptor, whereas it was induced at metestru

215 Antagonism of cholinergic receptors which typically impairs learning d

216 This ligand binds to the alpha 7 nicotinic, cholinergic receptor, which has been implicated in hippo

217 rences in expression of the alpha7 nicotinic cholinergic receptor, which may be generally expressed b

218 We also compare the expression of cholinergic receptors, which are thought to causally lin

219 ased in response to activation of muscarinic cholinergic receptors, which increases intracellular cal

220 e activity of an unusual class of ionotropic cholinergic receptor with that of nearby calcium-depende

221 ovo and was inhibited by blocking muscarinic cholinergic receptors with atropine.

222 tdTomato mice, pharmacological activation of cholinergic receptors with bath application of carbachol

223 ed iontophoretic pharmacological analysis of cholinergic receptors with single cell recordings in V1