ライフサイエンスコーパス: chromaffin

1 d fusion of purified synaptic and dense core chromaffin and insulin vesicles using a single vesicle-s

2 differed markedly in reporter expression in chromaffin and neuroblastoma cells, whereas site-directe

3 ation of filopodia-like structures in bovine chromaffin and PC12 cells driving the footprint expansio

4 y recording showed that during exocytosis in chromaffin and PC12 cells, fusion pores formed by smalle

5 e was measured from bovine adrenal medullary chromaffin cell (CC) cultures maintained over a period o

6 e via desensitization/down-regulation of the chromaffin cell alpha(2)-adrenergic receptors that norma

7 ssociated with the effects of CIH on adrenal chromaffin cell catecholamine secretion.

8 are increased by Sp and that elevate 5-HT in chromaffin cell cultures, suggesting direct metabolic si

9 of NGF signaling for sympathetic neural and chromaffin cell development.

10 l sympathetic neuroblast hyperplasia, blocks chromaffin cell differentiation, and ultimately triggers

11 ar mechanisms by which PGE(2) might modulate chromaffin cell function.

12 euroblastoma at single-cell level and find a chromaffin cell identity of neuroblastoma.

13 We provide evidence that chromaffin cell malfunction derives from altered Cav1.2

14 We show that loss of SDH activity in a chromaffin cell model does not perturb complex I functio

15 SDH deficiency based on epithelial cells, a chromaffin cell model retains aspects of metabolic "heal

16 exhibiting differential mobility shifting to chromaffin cell nuclear proteins during EMSA, binding of

17 Internalisation of PrP(d) from the chromaffin cell plasma membrane occurred in association

18 The bovine chromaffin cell procedure should yield approximately 10-

19 medullary slices that permit separating the chromaffin cell secretion from sympathetic input.

20 CG10 by synthetic siRNAs virtually abolished chromaffin cell secretion of a transfected CHGA-EAP chim

21 revented the effects of IH on hypoxia-evoked chromaffin cell secretion.

22 extraordinary accumulation of solutes inside chromaffin cell secretory vesicles, although this has ye

23 ndogenous proteins are expressed in separate chromaffin cell subpopulations.

24 eterogeneous release of catecholamine at the chromaffin cell surface.

25 ltered transmission at the preganglionic --> chromaffin cell synapse.

26 ificity for the diagnosis of adrenomedullary chromaffin cell tumors can be jeopardized by physiologic

27 grams down-regulate SCP-gene and up-regulate chromaffin cell-gene networks.

28 e mice, expressing Cre recombinase under the chromaffin cell-specific phenylethanolamine N-methyltran

29 In a chromaffin cell-transfected CHGA 3'-UTR/luciferase repor

30 ic vesicle, and a medium size vesicle in the chromaffin cell.

31 Adrenal chromaffin cells (ACCs), stimulated by the splanchnic ne

32 ty and reduced secretory activity in adrenal chromaffin cells (CCs).

33 Mouse chromaffin cells (MCCs) fire spontaneous action potentia

34 e changes in the surface membrane of adrenal chromaffin cells after stimulation of exocytosis with a

35 Ganglion neurons and adrenal chromaffin cells also show strong expressions.

36 In addition to the catecholamines, chromaffin cells also synthesize a range of peptides, in

37 onitoring of exocytotic events from cultured chromaffin cells and adrenal slices.

38 in the purified large dense-core vesicles of chromaffin cells and associated with synaptotagmin-1.

39 yme, phenyl-N-methyl transferase, by adrenal chromaffin cells and changes in cell cycle dynamics.

40 an directly affect the secretory capacity of chromaffin cells and contribute, in part, to elevated ca

41 nsmission on sympathetic neurons and adrenal chromaffin cells and elevates cytosolic ROS.

42 and vesicular catecholamine transporters of chromaffin cells and facilitates localization of the pri

43 investigated this question in mouse adrenal chromaffin cells and found that SNAP-25 inhibits Ca(2+)

44 nergic receptors are found on bovine adrenal chromaffin cells and have been implicated in the facilit

45 irst study of EP receptor signaling in mouse chromaffin cells and identifies a molecular mechanism fo

46 s, in vesicle docking and secretion in mouse chromaffin cells and in cell-free assays.

47 tory capacity measured amperometrically from chromaffin cells and in the expression of tyrosine hydro

48 nd [Ca2+]i responses in neonatal rat adrenal chromaffin cells and involves reactive oxygen species (R

49 ly, many imprinted genes are up-regulated in chromaffin cells and may play key roles in their develop

50 Using adrenal chromaffin cells and neurons, we now find that both over

51 th catecholamines from secretory vesicles in chromaffin cells and noradrenergic neurons.

52 repinephrine released from adrenal medullary chromaffin cells and norepinephrine released locally fro

53 mega-shaped structure in live neuroendocrine chromaffin cells and pancreatic beta-cells, visualized u

54 a restricted subset of cell types, including chromaffin cells and paraganglia.

55 ibitor of catecholamine release from adrenal chromaffin cells and postganglionic sympathetic axons.

56 protein released from secretory granules of chromaffin cells and sympathetic nerves, triggers endoth

57 Adrenal chromaffin cells and sympathetic neurons synthesize and

58 ed genes differentially expressed by adrenal chromaffin cells and sympathetic neurons.

59 entiation and increased apoptosis in adrenal chromaffin cells and sympathetic neurons.

60 hrough voltage-gated Ca2+ channels in bovine chromaffin cells and the domain of this receptor variant

61 n the development of sympathetic neurons and chromaffin cells and the mechanisms involved in Lin28B-i

62 proximity to the surface of adherent bovine chromaffin cells and to amperometrically record single e

63 at controls epinephrine release from adrenal chromaffin cells and, consequently, hepatic glucose prod

64 Adrenal chromaffin cells are an important part of the neuroendoc

65 Adrenal medullary chromaffin cells are innervated by the sympathetic splan

66 Chromaffin cells are known to express functional GABA(A)

67 onclude that sympathetic neurons and adrenal chromaffin cells are more vulnerable to diabetes than pa

68 findings demonstrate that the fetal adrenal chromaffin cells are the source for acute hypoxaemia-ind

69 y from neural crest precursors while adrenal chromaffin cells arise from neural crest-derived cells t

70 We demonstrate that large numbers of chromaffin cells arise from peripheral glial stem cells,

71 hromocytoma cells and bovine adrenomedullary chromaffin cells as detected by Northern blotting, Weste

72 ion did not evoke action potential firing in chromaffin cells but did cause a persistent subthreshold

73 or monitoring single vesicle exocytosis from chromaffin cells by constant potential amperometry as we

74 sponse element motif, an effect confirmed in chromaffin cells by site-directed mutagenesis on the tra

75 o shrink the Omega-profile in neuroendocrine chromaffin cells containing approximately 300 nm vesicle

76 tailed structure-function analysis in murine chromaffin cells demonstrates that linker motifs play a

77 describes the primary culture of individual chromaffin cells derived by enzymatic digestion from the

78 We used amperometric recordings from chromaffin cells derived from mice that overexpress A30P

79 evoked secretion simultaneously from several chromaffin cells directly cultured on the device surface

80 owever, unlike hypothalamic nerve terminals, chromaffin cells do not display syntilla activation by d

81 synapses lacking Munc13s, the corresponding chromaffin cells do not exhibit a vesicle docking defect

82 techolamine biosynthetic capacity of adrenal chromaffin cells during periods of sustained catecholami

83 rms, even upon high-frequency stimulation of chromaffin cells during stress responses.

84 Application of etomidate directly to the chromaffin cells elicited robust catecholamine secretion

85 ously reported that N-type current in bovine chromaffin cells exhibits very little voltage-dependent

86 evious studies have shown that naive adrenal chromaffin cells express a nominal Ca(v)3.2-dependent co

87 d secretion from Munc18-1-null mouse adrenal chromaffin cells expressing Munc18-1 mutants designed to

88 residues, single exocytotic events in bovine chromaffin cells expressing R198Q, R198E, K201Q, or K201

89 Single exocytotic events in chromaffin cells expressing this mutant were characteriz

90 arge dense core vesicle (LDCV) exocytosis in chromaffin cells follows a well characterized process co

91 Stimulation of bovine chromaffin cells for 5 min with 6 mum free intracellular

92 at the plasma membrane and in the cytosol in chromaffin cells from adrenal medulla.

93 ally occurring splice variants of CAPS2 into chromaffin cells from CAPS1/CAPS2 double-deficient mice

94 A30P or wild-type (WT) alpha-syn, as well as chromaffin cells from control and alpha-syn null mice, t

95 We show that adrenal chromaffin cells from CPX II knockout mice exhibit marke

96 Additionally, mRNA analyses of purified chromaffin cells from Gata3 mutants show that levels of

97 e have examined the kinetics of secretion in chromaffin cells from mice lacking phosphatidylinositol

98 ime and characterized in freshly dissociated chromaffin cells from mouse.

99 SCR-1 calcium-insensitive mutant or by using chromaffin cells from PLSCR-1(-)/(-) mice prevents outwa

100 ime-lapse imaging of Lifeact-GFP-transfected chromaffin cells in combination with fluorescent 70 kDa

101 small and different subpopulations of bovine chromaffin cells in culture.

102 -R(KT) mAb was observed in adrenal medullary chromaffin cells in murine and human tissue.

103 es and other hormones, released from adrenal chromaffin cells in response to Ca(2+) influx through vo

104 s on T-type Ca(v)3.2 calcium influx in mouse chromaffin cells in situ.

105 umor entity originating from adrenomedullary chromaffin cells in the adrenal medulla or in sympatheti

106 The number of chromaffin cells in the adrenal medulla was also decreas

107 catecholamines and a neuropeptide from mouse chromaffin cells in vitro.

108 0 were colocalized to the Golgi apparatus of chromaffin cells in vivo and shared localization with CH

109 ociated with distinctive membrane changes of chromaffin cells including increased electron density, a

110 pression of Ca(v)3.2 channels in MPC 9/3L-AH chromaffin cells induced low-threshold secretion that co

111 ominant calcium signal regulating release in chromaffin cells is generated by the cooperative action

112 heteromeric nAChR expressed by human adrenal chromaffin cells is the alpha3beta4* subtype (asterisk i

113 In chromaffin cells isolated from a PICK1 knockout (KO) mou

114 Chromaffin cells isolated from transgenic mice that over

115 analyzed their role in LDCV exocytosis using chromaffin cells lacking individual isoforms.

116 equently, the absence of Snapin in embryonic chromaffin cells leads to a significant reduction of cal

117 These findings suggest one way in which chromaffin cells may regulate cargo release is via diffe

118 Thus, chromaffin cells may regulate release of different trans

119 e docking, neither synchronized secretion in chromaffin cells nor Ca(2+)-triggered SUV-GUV fusion was

120 also expressed in neonatal adrenal medullary chromaffin cells of rats and mice whose hypoxia-evoked c

121 To specifically delete GRK2 in the chromaffin cells of the adrenal gland, we crossed PNMTCr

122 Chromaffin cells of the adrenal medulla (AM) represent t

123 Chromaffin cells of the adrenal medulla are a primary ne

124 Chromaffin cells of the adrenal medulla are innervated b

125 c neurons are severely depleted in CIPA, but chromaffin cells of the adrenal medulla are spared.

126 ium channels are expressed in neurosecretory chromaffin cells of the adrenal medulla.

127 opening of a narrow fusion pore, in adrenal chromaffin cells of wild-type and Rab3A(-/-) mice.

128 gs of quantal exocytosis from bovine adrenal chromaffin cells on the device.

129 By culturing chromaffin cells on the VAL-PVC/SiNW-FET, the conductanc

130 cement of exocytosis by PMA in either bovine chromaffin cells or the INS-1 insulin-secreting cell lin

131 suggest that PROG inhibits CA secretion from chromaffin cells predominantly by rapidly inhibiting nAC

132 Adrenal chromaffin cells release hormones and neuropeptides that

133 wise, inactivation of the V0 a1-I subunit in chromaffin cells resulted in a decreased frequency and p

134 comparable with those of bPAC1hop in bovine chromaffin cells resulted in acquisition by PC12-G cells

135 hat overexpression of neuronal AP-3 in mouse chromaffin cells results in a striking decrease in the n

136 rometric measurements of exocytosis in mouse chromaffin cells revealed that syb2 TMD mutations altere

137 We provide data to show that chromaffin cells selectively release catecholamine under

138 l firing rates, set by the sympathetic tone, chromaffin cells selectively release catecholamines at a

139 Neuroendocrine chromaffin cells selectively secrete a variety of transm

140 of this phenomenon in neuroendocrine adrenal chromaffin cells show that a single 2-ns, 16 MV/m unipol

141 Chromaffin cells stimulated with high KCl showed both sl

142 medulla gland and of cultured human adrenal chromaffin cells that demonstrated prominent expression

143 chains supported secretion in permeabilized chromaffin cells that had been allowed to rundown.

144 irectly activated GABA(A) receptors found in chromaffin cells thereby elevating [Ca(2+)](i).

145 hape of the bipolar pulse, Ca(2+) entry into chromaffin cells through electropores could be attenuate

146 Stimulation causes chromaffin cells to fire action potentials, leading to t

147 We used bovine chromaffin cells to investigate the effects of PROG on C

148 tentials delivered at 0.5 Hz) causes adrenal chromaffin cells to selectively release catecholamines t

149 hetic tone, basal synaptic excitation drives chromaffin cells to selectively secrete modest levels of

150 Exposing adrenal chromaffin cells to single 150 to 400 ns electric pulses

151 ies have demonstrated that adrenal medullary chromaffin cells transplanted into the spinal subarachno

152 ection of catecholamine release from adrenal chromaffin cells trapped in a microfluidic network.

153 s of exocytosis from populations of mast and chromaffin cells using chemoreceptive neuron MOS (CnuMOS

154 We investigated its role in chromaffin cells using Doc2b knock-out mice and high tem

155 Experiments on diI-stained bovine adrenal chromaffin cells using polarized TIRFM demonstrate rapid

156 strate that CIH increases the RRP in adrenal chromaffin cells via ROS-mediated activation of PKC and

157 punctate staining of norepinephrine-enriched chromaffin cells visualized using confocal microscopy in

158 ing of individual exocytotic fusion pores in chromaffin cells was imaged electrochemically with high

159 these mutations on the exocytotic process in chromaffin cells were assessed using capacitance measure

160 We show that bovine adrenal chromaffin cells were excited by etomidate at clinically

161 Bovine adrenal chromaffin cells were loaded into the microfluidic chann

162 Bovine adrenal chromaffin cells were superfused with a variety of GABA(

163 Small populations of chromaffin cells were trapped in the microfluidic device

164 y monitoring CME of single vesicles in mouse chromaffin cells with cell-attached capacitance measurem

165 Stimulation of chromaffin cells with lysophosphatidic acid, a nonsecret

166 Treatment of cultured bovine adrenal chromaffin cells with the catecholamine transport blocke

167 monstrate that electrostimulation of adrenal chromaffin cells with ultrashort pulses can be modulated

168 foundly impairs priming of granules in mouse chromaffin cells without altering catecholamine release

169 alogue enhances exocytosis in neuroendocrine chromaffin cells, altering the quantal release of catech

170 ed transcriptional mechanisms in transfected chromaffin cells, and concluded with observations on blo

171 e into melanocytes, parasympathetic neurons, chromaffin cells, and dental mesenchymal populations.

172 n of individual secretory granules in living chromaffin cells, and related their mobilities to postfu

173 When secretion was measured from chromaffin cells, brief depolarizations triggered peptid

174 nt from mature secretory vesicles in adrenal chromaffin cells, but localizes to a compartment near th

175 ls (a rat insulinoma cell line) and cultured chromaffin cells, but not in AtT-20 cells (derived from

176 ediating SNARE-dependent exocytosis in mouse chromaffin cells, but the role of a closely related calc

177 In chromaffin cells, CHGA and KLKB1 proteins co-localized i

178 s highly expressed in bovine adrenomedullary chromaffin cells, human pheochromocytoma tissue, PC12 ph

179 evealed decreased LDCV size in noradrenergic chromaffin cells, increased adrenal norepinephrine and e

180 ated exocytic function in Mecp2(-/y) adrenal chromaffin cells, indicating that the Mecp2 null mutatio

181 ially regulate fusion pore dynamics in mouse chromaffin cells, indicating TMD flexibility as a mechan

182 In chromaffin cells, inhibition of H(+)-ATPase diverted CHG

183 on of neurotransmitters and neuropeptides in chromaffin cells, is poorly understood.

184 letion of a gene highly expressed by adrenal chromaffin cells, NIK-related kinase, a gene on the X-ch

185 own to accumulate mainly in association with chromaffin cells, occasional nerve endings and macrophag

186 Pheochromocytomas, arising from chromaffin cells, produce catecholamines, epinephrine an

187 In cultured chromaffin cells, reducing endogenous CHGA expression by

188 est that a spontaneous syntilla, at least in chromaffin cells, releases Ca2+ into a cytosolic microdo

189 In summary, PAI-1 is expressed in chromaffin cells, sorted into the regulated pathway of s

190 gnals was severalfold faster than in adrenal chromaffin cells, suggesting profound differences in the

191 In Cplx 2-null adrenal chromaffin cells, we also find decreased and desynchroni

192 ophysiological measurements in mouse adrenal chromaffin cells, we show that PI(4,5)P2 uncaging potent

193 In individual chromaffin cells, we tracked conformational changes in S

194 red how alpha-syn overexpression in PC12 and chromaffin cells, which exhibit low endogenous alpha-syn

195 s to hypoxia by the carotid body and adrenal chromaffin cells, which regulate cardio-respiratory func

196 mice, we find that NPY is synthesized by all chromaffin cells.

197 es in a millisecond time resolution in mouse chromaffin cells.

198 successfully from multiple individual living chromaffin cells.

199 AP-25 x synaptotagmin-1 interaction in mouse chromaffin cells.

200 iNW-FET) to detect the K(+)-efflux from live chromaffin cells.

201 holamines released from small populations of chromaffin cells.

202 echolamines, exclusively, from fetal adrenal chromaffin cells.

203 iated fusion pore expansion in mouse adrenal chromaffin cells.

204 ippocampus, dorsal root ganglia, and adrenal chromaffin cells.

205 augmented T-type Ca2+ current in IH-treated chromaffin cells.

206 correlation, confirming similar findings in chromaffin cells.

207 stimulated catecholamine release in cultured chromaffin cells.

208 spatial distribution of calcium channels in chromaffin cells.

209 d released by exocytosis in PC12 and primary chromaffin cells.

210 adapted from a model for fast exocytosis in chromaffin cells.

211 matory effects that depend on NPY(+) adrenal chromaffin cells.

212 typical transmitter storage and release from chromaffin cells.

213 nd neuronal cells, including sympathoadrenal chromaffin cells.

214 on with a D1-like receptor on bovine adrenal chromaffin cells.

215 nced catecholamine loading of LDCVs in mouse chromaffin cells.

216 omosyn-syntaxin 1A complexes in live adrenal chromaffin cells.

217 type/reporter plasmids were transfected into chromaffin cells.

218 receptors on exocytosis from bovine adrenal chromaffin cells.

219 se frequency of catecholamine in dissociated chromaffin cells.

220 ant (>90%) mode of secretion in calf adrenal chromaffin cells.

221 calcium-triggered catecholamine release from chromaffin cells.

222 Ca) was produced by P2Y receptors in adrenal chromaffin cells.

223 motions related to the secretory response in chromaffin cells.

224 e in the Ca2+-cooperativity of exocytosis in chromaffin cells.

225 ficant reduction in DCG formation in adrenal chromaffin cells.

226 human embryonic kidney HEK293-S3 and adrenal chromaffin cells.

227 is a rare, but clinically important tumor of chromaffin cells.

228 18-1/syntaxin1A interaction in HEK293-S3 and chromaffin cells.

229 ive anion equilibrium potential, depolarizes chromaffin cells.

230 coupling after this peptidergic stimulus to chromaffin cells.

231 wo sequential priming steps in mouse adrenal chromaffin cells.

232 e nerve and form postsynaptic neuroendocrine chromaffin cells.

233 NPY(+) noradrenergic neurons and/or adrenal chromaffin cells.

234 nergic stimulated catecholamine release from chromaffin cells.

235 uptake at the synaptic terminals and adrenal chromaffin cells.

236 ventional active zones and in neuroendocrine chromaffin cells.

237 le priming and secretory amplitude in living chromaffin cells.

238 ion is severely inhibited in Ophn1 knock-out chromaffin cells.

239 hn1 knock-out mice and OPHN1-silenced bovine chromaffin cells.

240 ipid microdomains at the exocytotic sites in chromaffin cells.

241 he nAChR subtypes expressed by human adrenal chromaffin cells.

242 and is also essential for vesicle docking in chromaffin cells.

243 med during catecholamine exocytosis in mouse chromaffin cells.

244 nk exocytosis to compensatory endocytosis in chromaffin cells.

245 duced bulk endocytosis also occurs in bovine chromaffin cells.

246 tivator (tPA) (over many seconds) in adrenal chromaffin cells.

247 large, dense core vesicles (LDCVs) in mouse chromaffin cells.

248 Two Syt isoforms are expressed in chromaffin cells: Syt-1 and Syt-7.

249 CPE and PC activity in extracts of cultured chromaffin cells; total protein levels were unaltered fo

250 n of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels

251 erexpressed gene-3; stem (BMI1, nestin); and chromaffin (chromogranin A, tyrosine hydroxylase) marker

252 icate an essential role of CgA in regulating chromaffin DCG biogenesis and catecholamine storage in v

253 Moreover, examination of chromaffin granule abundance in PC12 cells exposed to ba

254 ation of catecholamine-containing dense-core chromaffin granule biogenesis in the adrenal gland and t

255 a coupled relationship between CHGA-mediated chromaffin granule biogenesis, necessary for catecholami

256 lation of the CHGA gene in the mouse reduced chromaffin granule cotransmitter concentrations by appro

257 reduction kinetics, similar to those of the chromaffin granule Cyt b(561).

258 le myosin II and cortical actin filaments in chromaffin granule exocytosis were studied by confocal f

259 al and non-neuronal cells, and into resealed chromaffin granule ghosts efficiently through passive di

260 Structure-activity studies with bovine chromaffin granule ghosts show that 3'-hydroxy-MPP(+) is

261 ibition of [3H]dopamine uptake into purified chromaffin granule ghosts showed IC50 values of approxim

262 ation of dopamine (DA) was studied in bovine chromaffin granule ghosts.

263 Analysis of [125I]TBZ-AIPP-labeled chromaffin granule membranes by SDS-PAGE and autoradiogr

264 Incubation of [125I]TBZ-AIPP-photolabeled chromaffin granule membranes in the presence of the glyc

265 synthesized and used to photoaffinity label chromaffin granule membranes.

266 phenotypic changes, including: (a) decreased chromaffin granule size and number; (b) elevated BP; (c)

267 Chromaffin granule ultrastructure revealed a approximate

268 associated with the Manduca sexta and bovine chromaffin granule V-ATPase.

269 reversible inhibitors for the bovine adrenal chromaffin granule vesicular monoamine transporter (VMAT

270 (f) increased catecholamine/ATP ratio in the chromaffin granule; and (g) increased plasma catecholami

271 Furthermore, a size mismatch between chromaffin granules ( approximately 300-nm diameter) and

272 transports electrons across the membrane of chromaffin granules (CG) present in the adrenal medulla,

273 individual natural secretory granules (i.e., chromaffin granules (CGs)) on the single-particle level

274 Using chromaffin granules and liposomes we now show that alpha

275 se model led to decreased size and number of chromaffin granules as well as hypertension in these ani

276 nophil granules match the residence times of chromaffin granules at the plasma membrane in intact cel

277 myosin II facilitate release from individual chromaffin granules by accelerating dissociation of cate

278 in L is the responsible cysteine protease of chromaffin granules for converting proenkephalin to the

279 t a full-length CgA/EAP chimera is sorted to chromaffin granules for exocytosis.

280 Our results show that liposomes and chromaffin granules fuse with GUVs containing activated

281 image analysis to determine the position of chromaffin granules immediately adjacent to the plasma m

282 Surprisingly, the size of chromaffin granules is reduced within few minutes of tre

283 Neuroendocrine chromaffin granules of adrenal medulla represent regulat

284 is concluded that a significant fraction of chromaffin granules re-seal after exocytosis, and retain

285 After exocytosis, chromaffin granules release essentially all their catech

286 be used to observe destaining of individual chromaffin granules upon exocytosis.

287 A decrease in the buoyant density of chromaffin granules was observed after downregulation of

288 s catecholamines for storage in the lumen of chromaffin granules, has been shown to be involved in DC

289 be biotinylated at the C-terminus in intact chromaffin granules, indicating that it is a transmembra

290 well within the physiological range found in chromaffin granules, we conclude that catecholaminergic

291 S leads to enhanced catecholamine content in chromaffin granules.

292 cytosis of neurosecretory vesicles including chromaffin granules.

293 cedure is to perform studies in a continuous chromaffin (pheochromocytoma) cell line, such as PC12, a

294 d CgB proteolytic fragments that function in chromaffin secretory vesicles for release of bioactive m

295 dent maintenance of pH gradients in isolated chromaffin vesicles and that the WT protein was signific

296 Chromaffin vesicles contain very high concentration of C

297 e electrochemical response to single adrenal chromaffin vesicles filled with catecholamine hormones a

298 constants 0.23 s (synaptic vesicles), 3.3 s (chromaffin vesicles), and 9.1 s (insulin vesicles) and c

299 enhanced insulin vesicle fusion, but not for chromaffin vesicles, correlating inversely with the pres

300 h of the catecholamine compared with adrenal chromaffin vesicles.