ライフサイエンスコーパス: chromatid

1 h, with both effects independent of a sister chromatid.

2 hains, and entrap proximal strands of sister chromatids.

3 l core, which may physically separate sister chromatids.

4 iases repair of DSBs to homologs over sister chromatids.

5 required to promote bi-orientation of sister chromatids.

6 ring mitosis to capture and segregate sister chromatids.

7 information between two homologous nonsister chromatids.

8 chanisms comprise complete sets of nonsister chromatids.

9 ng mitosis depend on cohesion between sister chromatids.

10 r global recombination repair between sister chromatids.

11 intaining close parallel alignment of sister chromatids.

12 plication and faithful segregation of sister chromatids.

13 cription take place in the context of sister chromatids.

14 hat form separately within individual sister chromatids.

15 hes cohesion between newly replicated sister chromatids.

16 eractions between and along identical sister chromatids.

17 oth compaction and disentanglement of sister chromatids.

18 ith non-disjunction and catenation of sister chromatids.

19 c content between the loops formed on sister chromatids.

20 ugh rampant unequal exchanges between sister chromatids.

21 mes rather than the equally available sister chromatid, a bias that in Saccharomyces cerevisiae depen

22 clin B, leading to the dissolution of sister chromatids and anaphase onset [1].

23 taining the REC8 kleisin subunit bind sister chromatids and anchor chromosomes to the axis.

24 The mechanism by which chromatids and chromosomes are segregated during mitosis

25 g that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate gene e

26 sociated with faithful segregation of sister chromatids and has been identified as dysfunctional in n

27 o S phase of the cell cycle to repair broken chromatids and prevent iHR.

28 es are differentially incorporated by sister chromatids, and how epigenetically distinct sister chrom

29 that each SC layer may connect two nonsister chromatids, and present a 3D model of the Drosophila SC

30 DSB repair occurs as replicated sister chromatids are connected to a polymerized axis.

31 Sister chromatids are held together by cohesin, a tripartite ri

32 arase-mediated cleavage ensuring that sister chromatids are kept together until their separation in m

33 Along arms, sister chromatids are less precisely aligned, with inter-sister

34 that the structural axes of separated sister chromatids are linked by evenly spaced "mini-axis" bridg

35 In these cells, sister chromatids are not properly paired, and binding of Rad21

36 , Pebble nuclear sequestration when trailing chromatids are present at the midzone.Chromatid segregat

37 ination during cell cycle phases when sister chromatids are present.

38 While sister chromatids are segregated from one another in mitosis an

39 tids, and how epigenetically distinct sister chromatids are specifically recognized and segregated.

40 During recombination, sister chromatids are tethered as loops to a polymerized chromo

41 Sister chromatids are tethered together by the cohesin complex

42 he centromere as cohesion is released on the chromatid arms when the homologs segregate at anaphase I

43 ation of cohesins along the length of sister chromatid arms.

44 nzyme that resolves catenanes between sister chromatids as well as supercoils associated with the ove

45 We find precise alignment of sister chromatids at centromeres.

46 ion at meiosis I but also the fate of sister chromatids at meiosis II.

47 , which ensures proper segregation of sister chromatids at mitosis by mediating the interaction betwe

48 H3T3ph signals occur between cohered sister chromatids at prometaphase.

49 rast to G2/M, Top2 removes SCIs from cohesed chromatids at the anaphase onset.

50 etric components, which ensure biased sister chromatid attachment and segregation during ACD of Droso

51 Sister chromatid attachment during meiosis II (MII) is maintain

52 DSB repair pathway choice directly to sister chromatid availability.

53 phosphorylated at S/T18 decorated the inter-chromatid axial DNA on mitotic chromosomes.

54 ole for DNA ligase 1 in the fusion of sister chromatids bearing targeted double strand DNA breaks tha

55 recocious DSB strand exchange between sister chromatids before homologs have completed pairing.

56 i, micronuclei, and chromosomal aberrations (chromatid breaks and radials) relative to Rev3L(+/-) cel

57 ulted in remarkably increased chromosome and chromatid breaks in Mcph1(-/-)p53(-/-) lymphomas and MEF

58 reased levels of spontaneous and MMC-induced chromatid breaks.

59 ity to ensure accurate segregation of sister chromatids, but, as in centromere localization, they do

60 lation locks cohesin rings around the sister chromatids by counteracting an activity associated with

61 n implicated in the alignment of four sister chromatids by forming parallel guanine quadruplexes duri

62 The tethering together of sister chromatids by the cohesin complex ensures their accurate

63 sential for mitosis since it resolves sister chromatid catenations.

64 Along sister chromatids, cohesin results in the formation of loops of

65 rodimeric ATPase, the kleisin subunit sister chromatid cohesion 1 (Scc1) that links the two ATPase he

66 The sister chromatid cohesion 2 and 4 (Scc2-Scc4) complex loads coh

67 of genome architecture with roles in sister chromatid cohesion and chromosome compaction.

68 autosomes leads to premature loss of sister chromatid cohesion and chromosome missegregation, wherea

69 Despite key roles in sister chromatid cohesion and chromosome organization, the mech

70 regulated to prevent the untimely release of chromatid cohesion and disastrous chromosome distributio

71 ial roles in chromosome condensation, sister chromatid cohesion and DNA repair.

72 ns is important for establishing both sister chromatid cohesion and enhancer-promoter communication.

73 SA and DNA replication help establish sister chromatid cohesion and facilitate enhancer-promoter comm

74 gically around chromosomes to mediate sister chromatid cohesion and facilitate long-range control of

75 chromatin-bound complex that mediates sister chromatid cohesion and facilitates long-range interactio

76 ut the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin structure.

77 ong-range DNA interactions to mediate sister chromatid cohesion and other aspects of chromosome struc

78 lication, to promote establishment of sister chromatid cohesion and possibly other post-replicative p

79 merase and PARP inhibitors, defective sister chromatid cohesion and reduced DNA replication fork spee

80 case domain of DDX11 is essential for sister chromatid cohesion and resistance to G4 stabilizers.

81 , but their relative contributions to sister chromatid cohesion are unknown.

82 he centromere region until release of sister-chromatid cohesion at the metaphase II/anaphase II trans

83 associated SA2 mutation that supports sister chromatid cohesion but is unable to repress transcriptio

84 for an lncRNA in the establishment of sister chromatid cohesion by modulating DDX11 enzymatic activit

85 e by extruding DNA loops and mediates sister chromatid cohesion by topologically entrapping DNA.

86 otor proteins, microtubule crosslinking, and chromatid cohesion can modulate spindle size and shape,

87 Sister chromatid cohesion conferred by entrapment of sister DNA

88 ere, we show that Ctf18-RFC's role in sister chromatid cohesion correlates with PCNA loading but is s

89 HyperD-ALL cells show chromatid cohesion defects and an impaired spindle assem

90 lly interacts with Naa50, rescues the sister-chromatid cohesion defects and the resulting mitotic arr

91 Cohesins establish sister chromatid cohesion during S phase and are removed when c

92 y cohesin's Smc3 subunit to establish sister chromatid cohesion during S phase, but differ in their N

93 st that Pds5's role in maintenance of sister chromatid cohesion during the mitotic prophase-analogous

94 Sister chromatid cohesion essential for mitotic chromosome segr

95 ates replication fork progression and sister chromatid cohesion establishment.

96 Timely resolution of sister chromatid cohesion in G2/M is essential for genome integ

97 USP13 was dispensable for sister chromatid cohesion in HCT116 and HeLa cells, whereas it

98 eviously been shown to play a role in sister-chromatid cohesion in metazoans.

99 dify different effectors and regulate sister-chromatid cohesion in opposing ways.

100 Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2 mutated but not in wild-type

101 rm-null females are sterile [13], and sister chromatid cohesion is abolished on all chromosomes, lead

102 Sister chromatid cohesion is essential for tension-sensing mech

103 Sister-chromatid cohesion is established by Eco1-mediated acety

104 and transcriptional enhancers, or how sister chromatid cohesion is established.

105 Sister chromatid cohesion is intact in FACT-depleted cells, alt

106 ase in securin that ultimately causes sister chromatid cohesion loss.

107 an unexpected link between stress and sister chromatid cohesion loss.

108 Sister chromatid cohesion mediated by the cohesin complex is es

109 In vertebrates, sister chromatid cohesion requires the activity of the ESCO2 ac

110 During the cell cycle, sister-chromatid cohesion tethers sister chromatids together fr

111 The cohesin protein complex mediates sister chromatid cohesion to ensure accurate chromosome segrega

112 se is accompanied by establishment of sister chromatid cohesion to ensure faithful chromosome segrega

113 Thus, STAG1 and STAG2 support sister chromatid cohesion to redundantly ensure cell survival.

114 In addition, defective sister chromatid cohesion was observed in five HNSCC cell lines

115 es DNA-DNA interactions both between (sister chromatid cohesion) and within chromosomes (DNA looping)

116 recombination, DNA repair, DNA replication, chromatid cohesion, and chromosome segregation.

117 Mitotic chromosome condensation, sister chromatid cohesion, and higher order folding of interpha

118 tabolism modules, DNA replication and sister chromatid cohesion, and inactivated a third, the DNA dam

119 segregation, chromosome maintenance, sister chromatid cohesion, and mitotic chromosome compaction, i

120 Pds5 is required for sister chromatid cohesion, and somewhat paradoxically, to remov

121 Cohesin mediates sister chromatid cohesion, but this is not always perturbed in

122 onserved protein complex required for sister chromatid cohesion, chromosome condensation, DNA damage

123 The cohesin complex regulates sister chromatid cohesion, chromosome organization, gene expres

124 nt of the Smc5/6 complex, involved in sister chromatid cohesion, chromosome segregation, and DNA repa

125 tin organization that is critical for sister chromatid cohesion, DNA repair and transcriptional regul

126 me organization includes functions in sister chromatid cohesion, DNA repair, and transcriptional regu

127 subunit protein complex essential for sister chromatid cohesion, gene expression and DNA damage repai

128 hat regulates 3D genome organization, sister chromatid cohesion, gene expression, and DNA repair.

129 rophase chromosome axis that mediates sister chromatid cohesion, homologous recombination and chromos

130 al major mitotic processes, including sister chromatid cohesion, kinetochore-microtubule attachment a

131 s SOLO, SUNN, and ORD is required for sister-chromatid cohesion, localizes to the centromeres and is

132 s, aberrations of the centrosome, and failed chromatid cohesion, mirroring findings from cancer biolo

133 leted of CONCR show severe defects in sister chromatid cohesion, suggesting an essential role for CON

134 which load during S phase and mediate sister-chromatid cohesion, usually occur as individual complexe

135 -like protein and ORD is required for sister-chromatid cohesion, we tested the hypothesis that these

136 ferating cells, cohesin also mediates sister chromatid cohesion, which is essential for chromosome se

137 Sister chromatid cohesion, which is mediated by the cohesin com

138 point activation and establishment of sister chromatid cohesion.

139 ng homologous recombination linked to sister-chromatid cohesion.

140 istry may occur before dissolution of sister chromatid cohesion.

141 on as antagonists to regulate meiotic sister chromatid cohesion.

142 tinct sites on chromosomes to mediate sister chromatid cohesion.

143 ivity, is required for Chl1's role in sister chromatid cohesion.

144 y, assembly, and the establishment of sister chromatid cohesion.

145 a stable complex may be required for sister-chromatid cohesion.

146 icase involved in DNA replication and sister chromatid cohesion.

147 to promote chromosome compaction and sister-chromatid cohesion.

148 cedes the S-K entrapment required for sister chromatid cohesion.

149 r DNA replication but dispensable for sister chromatid cohesion.

150 lling, while simultaneously promoting sister chromatid cohesion.

151 by the combination of crossovers and sister chromatid cohesion.

152 role in mediating DNA repair through sister chromatid cohesion.

153 tudy of the complex interplay between sister chromatid compaction and their segregation during mitosi

154 inside TADs and is required to focus sister-chromatid contacts at TAD boundaries.

155 equence, making recombination between sister chromatids difficult to detect.

156 re they are the consequence of failed sister chromatid disentanglement during chromosome compaction.

157 nsure timely chromosome condensation, sister chromatid disentanglement, and maintenance of mitotic ch

158 RA SPINDLE POLES, ESP) plays a major role in chromatid disjunction and cell expansion in Arabidopsis

159 rases are large proteins that mediate sister chromatid disjunction in all eukaryotes.

160 ssembly checkpoint (SAC) ensures that sister chromatids do not separate until all chromosomes are att

161 M by Top2-dependent concatenation of cohesed chromatids due to their physical proximity.

162 in the dissolution of cohesion among sister chromatids during chromosome segregation.

163 rs are randomly distributed between daughter chromatids during DNA replication, rare occurrences of a

164 1D2 alleles prevent the segregation of the Y chromatids during meiosis II, causing female-biased sex

165 broken DNA replication forks, and cross over chromatids during meiosis in eukaryotes.

166 it SMC3 to regulate the separation of sister chromatids during mitosis and meiosis.

167 To separate replicated sister chromatids during mitosis, eukaryotes and prokaryotes ha

168 essential for faithful segregation of sister chromatids during mitosis.

169 partitioning epigenetically distinct sister chromatids during stem cell ACDs, which opens new direct

170 etric tethering of plasmid sisters to sister chromatids embodies the replication-dependent component.

171 ndogenous genomic loci by combining a sister chromatid exchange (SCE) assay with fluorescent in situ

172 d Strand-seq, that can be used to map sister chromatid exchange (SCE) events genome-wide in single ce

173 multaneous high-resolution mapping of sister chromatid exchange (SCE), facilitating the study of this

174 (C62A/C65A) cells exhibited increased sister-chromatid exchange and chromosome abnormalities.

175 At bulky adducts, PrimPol promotes sister chromatid exchange and genetic recombination.

176 eric CO-FISH patterns consistent with sister chromatid exchange at the frequency of 5% in primary tis

177 ic but causes DNA breaks and elevates sister chromatid exchange in mammalian cells.

178 interhomolog recombination and intra/sister chromatid exchange in the CUP1 locus.

179 ns, TERRA expression levels, telomere sister chromatid exchange or telomere length.

180 be induced display elevated levels of sister chromatid exchange, gross chromosomal aberrations, 53BP1

181 ccur by replication slippage, unequal sister chromatid exchange, homologous recombination, and aberra

182 cogenic selection and fine mapping of sister-chromatid-exchange events.

183 eukemia (PML) bodies (APBs), telomere sister chromatid exchanges (T-SCEs), and extrachromosomal telom

184 RECQ5 is significant in suppressing sister chromatid exchanges during homologous recombination but

185 Sister chromatid exchanges, a surrogate measure of iHR, was sig

186 d-seq data, to enable fine-mapping of sister chromatid exchanges, germline inversion and to support g

187 n its absence cells display increased sister chromatid exchanges, replication origin firing and chrom

188 age signaling, telomere fragility and sister chromatid exchanges.

189 and reduced RAD51 response, and fewer sister chromatid exchanges.

190 n) mutants during meiosis II when the sister chromatids exhibit random distribution.

191 o collapse of stalled replication forks into chromatid fragments that require resolution through the

192 Cohesin stably holds together the sister chromatids from S phase until mitosis.

193 Here we report that cells clear trailing chromatids from the cleavage site by undergoing two phas

194 e the authors show that cells clear trailing chromatids from the cleavage site in a two-step cell elo

195 d genomic recombinations initiated by sister chromatid fusion are predominantly mediated by alternati

196 s(3-7), but the identical sequence of sister chromatids has made it difficult to determine how they t

197 A single DNA link between chromatids has the potential to disrupt cell cycle progr

198 Along these chromatids, heterozygosity is maximal at the centromeres

199 ange with the homolog rather than the sister chromatid (homolog bias).

200 re thought to bind by encircling both sister chromatids in a topological embrace.

201 e resection needed for repair between sister chromatids in G-2 arrested cells of random, radiation-in

202 hat monitor bipolar attachment of replicated chromatids in metaphase.

203 ndensin complexes compact and resolve sister chromatids in mitosis and by which cohesin generates top

204 stem prevents premature separation of sister chromatids in mitosis and thus ensures the fidelity of c

205 stem prevents premature separation of sister chromatids in mitosis and thus ensures the fidelity of c

206 espite a loss in centromere cohesion, sister chromatids in STAG2 mutant tumor cells maintain cohesion

207 me fails to condense and resolve into sister chromatids in synchrony with the maternal genome.

208 Trailing chromatids induce a delay in nuclear envelope reassembly

209 Sister chromatid intertwines (SCIs), or catenanes, are topologi

210 ns as circular "loop outs" to convert sister chromatid intertwines into catenated circles.

211 d by drastic changes in the degree of sister chromatid intertwines.

212 ansition and ensures accurate segregation of chromatids into daughter cells.

213 nd G2 phases of the cell cycle when a sister chromatid is present(2).

214 Formation of individualized sister chromatids is essential for their accurate segregation.

215 Homologous recombination involving sister chromatids is the most accurate, and thus most frequentl

216 pairing, the homolog, rather than the sister chromatid, is used as repair partner for crossing over.

217 ct." During meiosis, cohesion between sister chromatids keeps recombinant homologs physically attache

218 coordinates the correct attachment of sister chromatid kinetochores to the mitotic spindle with activ

219 ism to enable formation of asymmetric sister-chromatid loops.

220 This requires that sister chromatids maintain cohesion at the centromere as cohesi

221 displacement loops (D-loops) between sister chromatids, Mph1(FANCM) ensures high levels of crossover

222 All physical connections between sister chromatids must be broken before cells can divide, and e

223 res it persists during anaphase, when sister chromatids must transit into daughter cells uninterrupte

224 F-193-treated PICH(-/-) cells undergo sister chromatid non-disjunction in anaphase, and frequently ab

225 Furthermore, whilst Pa ESP can rescue the chromatid nondisjunction phenotype of Arabidopsis ESP mu

226 rial cells, the process of separating sister chromatids occurs concomitantly with ongoing transcripti

227 ng hermaphrodite spermatogenesis, the sister chromatids of the X chromosomes separate during meiosis

228 mation of DNA intermediates, in which sister chromatids or homologous chromosomes are covalently link

229 junctions (HJs) that physically link sister chromatids or homologous chromosomes are formed as inter

230 Ring-shaped cohesin keeps sister chromatids paired until cleavage of its Scc1/Rad21 subun

231 specific cohesin member, required for sister chromatid pairing and for preventing telomere shortening

232 delays mitotic progression until all sister chromatid pairs achieve bi-orientation, and while the SA

233 g of a dynamic cohesin pool separates sister-chromatid pairs inside TADs and is required to focus sis

234 maps of human chromosomes reveal that sister-chromatid pairs interact most frequently at the boundari

235 mosomes once each cell cycle produces sister chromatid pairs, which separate accurately at anaphase.

236 f ESCO2 to establish cohesion between sister chromatids precisely as they are born during DNA replica

237 iosis II, and premature separation of sister chromatids (PSSC) and reverse segregation (RS) in meiosi

238 gh-fidelity homologous recombination, sister chromatid recombination (SCR), and break-induced replica

239 the extended repair synthesis during sister chromatid recombination (SCR).

240 sequences at metaphase and increased sister chromatid recombination events leading to rampant chromo

241 The rate of intra/sister chromatid recombination exceeded the rate of interhomolo

242 n rate of both interhomolog and intra/sister chromatid recombination in the CUP1 array; recombination

243 Despite its importance, sister chromatid recombination is not easily studied because it

244 tromeres is protected by shugoshin-2, sister chromatids remain attached through centromeric/pericentr

245 Sister chromatid resolution during mitosis required the evictio

246 segregate to opposite poles; and (3) sister chromatids segregate to opposite poles.

247 separate during meiosis I, and homologous X chromatids segregate to the functional sperm to create d

248 sis of cyclin B and securin initiates sister chromatid segregation and anaphase.

249 defects in apc8-1, including abnormal sister chromatid segregation and microtubule morphology.

250 d for appropriate cell cycle progression and chromatid segregation during mitosis, possibly in a nont

251 link centromeres to microtubules for sister chromatid segregation in mitosis.

252 ules of the mitotic spindle, enabling sister chromatid segregation in mitosis.

253 Chromatid segregation must be coordinated with cytokines

254 ailing chromatids are present at the midzone.Chromatid segregation must be coordinated with cytokines

255 bule activities results in randomized sister chromatid segregation.

256 response mechanism ensuring accurate sister chromatid segregation.

257 Here we describe sister-chromatid-sensitive Hi-C (scsHi-C), which is based on la

258 H2AThr133ph on maize lines containing sister chromatids separate precociously in anaphase I revealed

259 its chromosome axes elongate and the sister chromatids separate.

260 lowed by equational meiosis II, where sister chromatids separate.

261 er kinetochore distance and premature sister chromatid separation (PSCS), suggesting aberrant separas

262 emonstrate that the roles of ESP in daughter chromatid separation and cell expansion are conserved be

263 Hos1 depletion significantly delayed sister chromatid separation and segregation.

264 n through its prevention of premature sister-chromatid separation and the formation of DNA loops.

265 art of the cellular response triggered by a "chromatid separation checkpoint" that delays nuclear env

266 Removal of cohesin is necessary for sister chromatid separation during anaphase, and this is regula

267 Precise control of sister chromatid separation during mitosis is pivotal to mainta

268 Crucially, sister chromatid separation must be delayed until all the chrom

269 sures genomic stability by preventing sister chromatid separation until all chromosomes are attached

270 Timely sister chromatid separation, promoted by separase, is essential

271 segregation depends on the precise timing of chromatid separation, which is enforced by checkpoint si

272 us chromosome segregation followed by sister chromatid separation; cells then underwent additional ro

273 o confer cohesion but can bind to individual chromatids, suggesting a mechanism to enable formation o

274 ative involvement of these ligases in sister chromatid telomere fusion through a precise genetic diss

275 Sister chromatids that arrested with a lateral attachment to on

276 es, are topological links between replicated chromatids that interfere with chromosome segregation.

277 ributed relatively uniformly across the four chromatids that make up each chromosome pair is poorly u

278 Rather than contact spindles directly, the chromatids then bind to membrane-based kinetochores on t

279 g that it controls the segregation of sister chromatids through heterochromatin modification.

280 in the cell cycle when the lack of a sister chromatid to serve as a homologous template prevents com

281 regation requires kinetochores on duplicated chromatids to biorient by attaching to dynamic microtubu

282 polar spindle, which moves one set of sister chromatids to each nascent daughter cell.

283 facilitates the equal segregation of sister chromatids to each of the nascent daughter cells.

284 P1 function, routing only DSBs within sister chromatids to HR.

285 a ring-shaped structure that embraces sister chromatids to promote their cohesion.

286 that mediate the physical coupling of sister chromatids to spindle microtubule bundles (called kineto

287 ng almost the entire poleward surface of the chromatids, to which spindle fibers attach.

288 The ability of cohesin to tether sister chromatids together depends on acetylation of its Smc3 s

289 le, sister-chromatid cohesion tethers sister chromatids together from S phase to the metaphase-anapha

290 diated cleavage, in order to maintain sister chromatids together until their separation in meiosis II

291 cohesin, the protein complex holding sister chromatids together, first from arms in meiosis I and th

292 ied through its major role in holding sister chromatids together.

293 ent of high levels of cohesin to link sister chromatids together.

294 The rich pattern of sister-chromatid topologies and our scsHi-C technology will mak

295 symmetric incorporation of CENP-A on sister chromatids via HASPIN knockdown or overexpression of CEN

296 npaired X precociously separates into sister chromatids, which co-segregate with the autosome set to

297 tin that connects oppositely attached sister chromatids, which may then act as a mechanical signal to

298 c fidelity as evidenced by unresolved sister chromatids with marked accumulation of H1S/T18ph and cen

299 ngle chromosomes, arriving at individualized chromatids with morphology observed in vivo.

300 onsistent with cohesin embracing both sister chromatids within silent chromatin domains.