ライフサイエンスコーパス: chromatin assembly

1 H1 in compacting DNA under force and during chromatin assembly.

2 ting more histones than what is required for chromatin assembly.

3 Only D17Z1 has been linked to CENP-A chromatin assembly.

4 nection between lagging-strand synthesis and chromatin assembly.

5 synchronous culture and altered higher order chromatin assembly.

6 to metaphase centromeres and inhibits CENP-A chromatin assembly.

7 CAF-1 in DNA replication- and repair-coupled chromatin assembly.

8 inate DNA replication with transcription and chromatin assembly.

9 transcription, chromosome organization, and chromatin assembly.

10 c histone chaperone required for centromeric chromatin assembly.

11 me do recruit Pho4 but are still delayed for chromatin assembly.

12 ns between Sir3 and the nucleosome in silent chromatin assembly.

13 tinct from their previously reported role in chromatin assembly.

14 a key substrate for replication-independent chromatin assembly.

15 rried by newly synthesized histones prior to chromatin assembly.

16 ses including transcription, DNA repair, and chromatin assembly.

17 systems that Kap114p inhibits Nap1p-mediated chromatin assembly.

18 nate link between histone nuclear import and chromatin assembly.

19 ferases (HATs) is involved in the process of chromatin assembly.

20 gion is not required for histone binding and chromatin assembly.

21 etween type B histone acetyltransferases and chromatin assembly.

22 and 12 that accompanies replication-coupled chromatin assembly.

23 unctions and is a valuable tool for in vitro chromatin assembly.

24 istone deacetyl ase involved in higher order chromatin assembly.

25 -strand break repair through Asf1p-dependent chromatin assembly.

26 itted to the DNA template upon initiation of chromatin assembly.

27 FA exposure, suggesting that FA compromises chromatin assembly.

28 inks the nuclear transport of H2A and H2B to chromatin assembly.

29 en proposed to play a role in the process of chromatin assembly.

30 ase, suggesting a potential role for p300 in chromatin assembly.

31 omplex is active for DNA replication-coupled chromatin assembly.

32 holm oak are enriched in abiotic stress and chromatin assembly.

33 implicated in transcriptional silencing and chromatin assembly.

34 es, a result having implications for in vivo chromatin assembly.

35 nt for histone nuclear import and subsequent chromatin assembly.

36 of FA exposure on histone modifications and chromatin assembly.

37 ing that a variant of RNase P regulates H3.3 chromatin assembly.

38 e role of murine HAT1 in replication-coupled chromatin assembly.

39 ategories of the nucleosome organization and chromatin assembly.

40 histone modifications that are important for chromatin assembly.

41 both replication-dependent and -independent chromatin assembly.

42 rtant chromatin modifications that accompany chromatin assembly.

43 se MafK binding sites in mediating repressed chromatin assembly.

44 , sumoylation in response to DNA damage, and chromatin assembly.

45 nd 12, which accompanies replication-coupled chromatin assembly.

46 n of histone gene expression for concomitant chromatin assembly.

47 a diverse class of proteins that facilitate chromatin assembly.

48 specificity in the role of motor proteins in chromatin assembly.

49 regulating the availability of histones for chromatin assembly.

50 proteins are able to catalyze ATP-dependent chromatin assembly.

51 nd utilized for replication-independent (RI) chromatin assembly.

52 ata into an updated overview of yeast silent chromatin assembly.

53 ns that are important for nuclear import and chromatin assembly.

54 statin-A (TSA) addition, prior to and during chromatin assembly, activated chromatin transcription in

55 ts completely lacked DNA replication-coupled chromatin assembly activity, suggesting that CAF-1 is re

56 lex reconstituted in vitro is sufficient for chromatin assembly activity, without requiring additiona

57 We find that Asf1 contributes toward chromatin assembly after DSB repair by promoting acetyla

58 osynthetic processes, protein synthesis, and chromatin assembly all contribute to circadian regulatio

59 Because motor proteins in chromatin assembly also function as chromatin remodeling

60 ays were performed to examine the changes in chromatin assembly and accessibility after FA exposure.

61 I-binding regions that are important for the chromatin assembly and ATPase activities of ACF.

62 s directly proportional to the efficiency of chromatin assembly and cannot be explained only by DNA c

63 stigated the relationship between ATP-driven chromatin assembly and chromatin remodeling in the gener

64 lated processes, including DNA repair, where chromatin assembly and disassembly are of primary releva

65 75 (Vps75) histone chaperone participates in chromatin assembly and disassembly at both active and in

66 one chaperone function and play key roles in chromatin assembly and disassembly pathways.

67 Histone chaperones function in chromatin assembly and disassembly, suggesting they have

68 lex essential in transcriptional regulation, chromatin assembly and DNA damage repair.

69 Chromatin assembly and DNA replication are temporally co

70 ne, highlight in particular the link between chromatin assembly and DNA replication control.

71 The effects of chromatin assembly and DNA supercoiling on the communica

72 lays both structural and regulatory roles in chromatin assembly and dynamics in addition to being an

73 zed DNA into nucleosomes, to inhibit S phase chromatin assembly and found that this induced S phase a

74 ly synthesized histone H4 and is involved in chromatin assembly and genome maintenance.

75 The factors that control chromatin assembly and guide transcription regulation du

76 mice, while expression of genes involved in chromatin assembly and histone modification were express

77 sponse, and suppression of genes involved in chromatin assembly and induction of ubiquitin-related ge

78 erstanding the processes of DNA replication, chromatin assembly and maturation, and the replication s

79 ranging from Okazaki fragment maturation to chromatin assembly and mismatch repair.

80 Although chromatin assembly and modification undoubtedly play maj

81 are also subject to the regulatory impact of chromatin assembly and modifications.

82 sf1 as an important component of a number of chromatin assembly and modulation complexes.

83 st two distinct, separable functions, one in chromatin assembly and one in regulating RAS function.

84 t a role of torsional stresses in regulating chromatin assembly and organization.

85 ne lysine residues at the sites critical for chromatin assembly and prevents these sites from physiol

86 rochromatin is incompatible with centromeric chromatin assembly and propagation.

87 ies advance our understanding of centromeric chromatin assembly and provide a framework for investiga

88 Thus, chromatin assembly and remodeling by ACF can occur in th

89 Chromatin assembly and remodeling complexes alter histon

90 lity of the adenosine triphosphate-utilizing chromatin assembly and remodeling enzyme ACF to mobilize

91 mbinant system with Drosophila ATP-utilizing chromatin assembly and remodeling factor (ACF), Drosophi

92 e histone chaperone NAP-1, and ATP-dependent chromatin assembly and remodeling factor (ACF).

93 ACF1 (ATP-utilizing chromatin assembly and remodeling factor 1) and an ISWI

94 stent upregulation of the ACF (ATP-utilizing chromatin assembly and remodeling factor) ATP-dependent

95 ACF (ATP-utilizing chromatin assembly and remodeling factor) catalyzes the

96 in conjunction with NAP-1 and ATP-utilizing chromatin assembly and remodeling factor; this effect wa

97 4 with the regulation of gene expression and chromatin assembly and remodeling, in effect constitutin

98 The ATP-dependent chromatin assembly and remodelling factor (ACF) function

99 ucleosome remodelling by human ATP-dependent chromatin assembly and remodelling factor (ACF), an ISWI

100 mes in low salt, providing new insights into chromatin assembly and revealing an unexpected mechanism

101 We have used an in vitro chromatin assembly and transcription system to compare t

102 biochemical approach, including an in vitro chromatin assembly and transcription system, to examine

103 biochemical approach, including an in vitro chromatin assembly and transcription system, to examine

104 The chromatin assembly and transcriptional activation functi

105 al role of NAP-1-p300 complexes in promoting chromatin assembly and transcriptional activation.

106 RAS/cAMP/protein kinase A signaling pathway, chromatin assembly and transcriptional co-repression.

107 l roles in promoting cell cycle progression, chromatin assembly, and activation of DNA repair pathway

108 y nuclear processes including transcription, chromatin assembly, and DNA damage repair.

109 connection between transcription elongation, chromatin assembly, and messenger RNP complex biogenesis

110 e, suppression of de novo telomere addition, chromatin assembly, and mismatch repair, have been ident

111 mportant for replication, genomic stability, chromatin assembly, and the response to and recovery fro

112 in hormone signaling and replication-coupled chromatin assembly are discussed.

113 We identified chromatin assembly as an important regulator of divergen

114 plasmids in one-cell embryos also exhibited chromatin assembly, as determined by a supercoiling assa

115 Here, using proximity ligation assay-based chromatin assembly assays and DNA fiber analysis, we ana

116 is functional as NASP is active in in vitro chromatin assembly assays using histone substrates deple

117 tion; therefore, we examined replication and chromatin assembly at centromeres in Drosophila cells.

118 e now demonstrate that cell cycle-restricted chromatin assembly at centromeres is unique to CENP-A nu

119 s-4 methylation is also necessary for silent chromatin assembly at telomeres and ribosomal DNA.

120 portion of the cell cycle prior to mediating chromatin assembly at the centromere.

121 to facilitate transcription at a step after chromatin assembly but before transcript elongation.

122 Distal (-850) binding of p53 during chromatin assembly, but not post-assembly, reverses tran

123 Chromatin assembly by ACF is also impaired upon mutation

124 se results suggest that acrolein compromises chromatin assembly by reacting with histone lysine resid

125 erase (met1), histone deacetylase (hda6), or chromatin assembly (caf1) mutants that disrupt silencing

126 Host chromatin assembly can function as a barrier to viral in

127 r completion of S phase and that a defect in chromatin assembly can itself induce DNA damage.

128 biosynthesis and metabolism; nucleosome and chromatin assembly; carboxylic and organic acid metaboli

129 ermore, the model allowed us to identify the chromatin assembly complex CAF-1 as a context-specific r

130 We found that depletion of the chromatin assembly complex-1 (CAF-1) complex, a histone

131 air pathways, as well as factors involved in chromatin assembly/condensation, chromosome segregation,

132 Our data suggest that chromatin assembly defects are sensed by an ATM-dependen

133 Lastly, we observed modest chromatin assembly defects on mutation of other conserve

134 y synthesized histones during the process of chromatin assembly, definitive evidence linking these en

135 role of Rtt109p or H3 Lys(56) acetylation in chromatin assembly/disassembly (and hence gene expressio

136 one H3 eviction, thus providing insight into chromatin assembly/disassembly and hence gene expression

137 ers to study in real time chaperone-mediated chromatin assembly/disassembly at the level of single ch

138 at Hat1 is transiently recruited to sites of chromatin assembly, dissociating prior to the maturation

139 A methyltransferase, and replication-coupled chromatin assembly DNA replication provides a window of

140 ide the NH2-tail domains in the processes of chromatin assembly, DNA repair, and transcriptional sile

141 ion for elucidating the mechanisms of silent chromatin assembly during development.

142 assembly factor (RCAF) complexes function in chromatin assembly during DNA replication and repair and

143 assembly factor (RCAF) complexes function in chromatin assembly during DNA replication and repair and

144 esponse and that Rad53 may directly regulate chromatin assembly during DNA replication and repair.

145 tions suggesting similar mechanisms of viral chromatin assembly during the different infection types

146 ear histone stores and provides histones for chromatin assembly during times of high demand.

147 center of this locus, confirmed by in vitro chromatin assembly experiments, appears to cooperate wit

148 (an H3 variant), which mimics inhibition of chromatin assembly, facilitated FA-mediated anchorage-in

149 The ATP-dependent chromatin assembly factor (ACF) forms such structures in

150 The ATP-dependent chromatin assembly factor (ACF) spaces nucleosomes to pr

151 ion with the remodeling enzyme ATP-dependent chromatin assembly factor (ACF).

152 Here we show that chromatin assembly factor (CAF)-1 subunit A (CHAF1A), th

153 Chromatin assembly factor 1 (CAF-1) and Rtt106 participa

154 Anti-silencing function 1 (Asf1) and Chromatin Assembly Factor 1 (CAF-1) chaperone histones H

155 wn that the histone H3-H4 chaperone known as chromatin assembly factor 1 (CAF-1) contributes to trans

156 The heterotrimer chromatin assembly factor 1 (CAF-1) couples DNA replicat

157 Chromatin assembly factor 1 (CAF-1) deposits histones du

158 Chromatin assembly factor 1 (CAF-1) deposits histones H3

159 The histone chaperone Chromatin Assembly Factor 1 (CAF-1) deposits tetrameric

160 erones anti-silencing function 1 (Asf1p) and chromatin assembly factor 1 (CAF-1) in global transcript

161 erones anti-silencing function 1 (Asf1p) and chromatin assembly factor 1 (CAF-1) in vivo.

162 Chromatin assembly factor 1 (CAF-1) is a H3-H4 histone c

163 Chromatin assembly factor 1 (CAF-1) is a highly conserve

164 Chromatin assembly factor 1 (CAF-1) is a histone H3-H4 c

165 Chromatin assembly factor 1 (CAF-1) is the histone chape

166 The histone chaperone chromatin assembly factor 1 (CAF-1) mediates histone H3-

167 chaperone anti-silencing factor 1 (Asf1) to chromatin assembly factor 1 (CAF-1), another histone cha

168 ent upon Cac1p, the largest subunit of yeast chromatin assembly factor 1 (CAF-1), as well as upon the

169 that MBD1 partners with the p150 subunit of chromatin assembly factor 1 (CAF-1), forming a multiprot

170 Here we show that the histone chaperone Chromatin Assembly Factor 1 (CAF-1), which is recruited

171 efficiency of nucleosome loading mediated by chromatin assembly factor 1 (CAF-1).

172 ication-coupled histone assembly mediated by CHROMATIN ASSEMBLY FACTOR 1 (CAF-1).

173 th a mutation in Cac1p, the large subunit of chromatin assembly factor 1 (CAF-1).

174 es with a past history of a mutation for the chromatin assembly factor 1 (CAF1) complex causes rapid

175 Here, we report that yeast chromatin assembly factor 1 (CAF1), a conserved histone

176 HAF1A is a subunit of the chromatin modifier chromatin assembly factor 1 and it regulates H3K9 trimet

177 n vivo, whereas the histone chaperone CAF-1 (chromatin assembly factor 1) in humans and Caf1 in Droso

178 nd spindle-associated protein 1 (NuSAP1) and chromatin assembly factor 1, subunit B (p60; CHAF1b) as

179 all cell cycle stages, whereas knockdown of chromatin assembly factor 1b (CAF-1b) revealed derepress

180 or for the import of histones H2A and H2B, a chromatin assembly factor and a mitotic factor involved

181 A replication, and Tlk can phosphorylate the chromatin assembly factor Asf.

182 Here we demonstrate that chromatin assembly factor Asf1 also affects DNA replicat

183 Here we report that overproduction of the chromatin assembly factor Asf1 can suppress the Ts pheno

184 e, the SAS complex is found to interact with chromatin assembly factor Asf1p, and asf1 mutants show s

185 hway that includes replication factor C, the chromatin assembly factor Asf1p, and the K56-specific ac

186 The chromatin assembly factor Asf1p, as well as the acetylat

187 in histone deacetylase modifier SPOP and in chromatin assembly factor BAZ1A, in nearly two thirds of

188 An unexpected new role for the chromatin assembly factor CAF-1 and the histone-regulati

189 th mutations in cac2, a subunit of the yeast chromatin assembly factor CAF-I.

190 enotypes are shared with mutants lacking the chromatin assembly factor complex CAF1.

191 recombination mediator Rad22 (Sc Rad52), the chromatin assembly factor Hip1 (Sc Hir1), and the Msc1 p

192 whose assembly into nucleosomes requires the chromatin assembly factor HJURP.

193 ovel role for the histone deposition complex chromatin assembly factor I (CAF-I) in building centrome

194 Chromatin assembly factor I (CAF-I) is a conserved histo

195 iated protein 48 (RbAp48), is a component of chromatin assembly factor I (CAF-I), a complex that asse

196 Sir1 bound to Cac1, a subunit of chromatin assembly factor I (CAF-I), and helped to retai

197 s and nucleosome assembly proteins Asf1p and chromatin assembly factor I (CAF-I, encoded by the CAC1-

198 Instead, the CAF-1(chromatin assembly factor I) subunit Cac2 level decrease

199 nd the locus encoding the largest subunit of chromatin assembly factor I.

200 s further indicate that ACF/CHRAC is a major chromatin assembly factor in Drosophila.

201 We found that the chromatin assembly factor p55/dCAF-1 is essential for th

202 in a dynamic functional manner with Asf1, a chromatin assembly factor recently shown to mediate depo

203 Further, the DNA replication-associated chromatin assembly factor, CAF-1, binds to and specifica

204 Hif1p is also a chromatin assembly factor, promoting the deposition of h

205 further investigate mutants dysfunctional in chromatin assembly factor-1 (CAF-1) (fas1 and fas2 mutan

206 d by conserved assembly complexes, including chromatin assembly factor-1 (CAF-1) and the Hir proteins

207 Subunits of the chromatin assembly factor-1 (CAF-1) complex, including C

208 Chromatin assembly factor-1 (CAF-1) is a three-subunit p

209 omes in vitro, demonstrating that HJURP is a chromatin assembly factor.

210 ATP-dependent chromatin-assembly factor (ACF) uses the energy of ATP h

211 ribosyl)ation (PARylation) in regulating the chromatin-assembly factor HIRA in ALT cancer cells.

212 The chromatin-assembly factor I (CAF-I) and replication-coup

213 The chromatin-assembly factor I (CAF-I) and the replication-

214 Here, we show the involvement of two chromatin assembly factors (CAFs), Asf1 and CAF-1, in tu

215 the silencing defect of pol30 mutants to the chromatin assembly factors Asf1p and CAF-1, we found pol

216 int proteins Mec3, Rad24, Rad9, or Rfc5, the chromatin assembly factors Cac1 or Asf1, and the DNA hel

217 cycle are shown here to be distinct from the chromatin assembly factors previously shown to load othe

218 as an escort that hands off CENP-A(Cnp1) to chromatin assembly factors, allowing its incorporation i

219 onto newly synthesized DNA by the action of chromatin assembly factors, including anti-silencing fun

220 e into chromatin is likely to be mediated by chromatin assembly factors, including histone chaperones

221 cognition protein (HJURP) coupled with other chromatin assembly factors.

222 of histones with other important factors in chromatin assembly/fluidity.

223 involved in the reorganization of actin and chromatin assembly, followed by translocation of transcr

224 eritance of states of gene expression and in chromatin assembly following DNA repair.

225 sociates with the replisome and orchestrates chromatin assembly following DNA synthesis.

226 ei undergoing genome-wide decondensation and chromatin assembly from becoming abnormally stretched or

227 Prior to CENP-A(Cnp1) chromatin assembly, Hap2 facilitates transcription from

228 roducts, including other factors involved in chromatin assembly, have been found to participate in bo

229 and regulates nuclear activities, including chromatin assembly, histone modifications, replication,

230 s representing glucocorticoid receptor (GR), chromatin assembly/histone acetyltransferase, and inflam

231 ously, we reported that acrolein compromises chromatin assembly; however, underlying mechanisms have

232 hown to be essential for either viability or chromatin assembly in any model organism.

233 l divisions, the role of replication-coupled chromatin assembly in controlling cell differentiation d

234 We also examined the role of defective chromatin assembly in FA-mediated transcription and cell

235 These findings implicate chromatin assembly in the process of regulating var gene

236 assays, addition of p300 promoted efficient chromatin assembly in vitro in conjunction with NAP-1 an

237 romatin, consistent with a role for CAF-1 in chromatin assembly in vivo.

238 hromatin remodeling, and suggest a model for chromatin assembly in which randomly-distributed nucleos

239 fects of H1 on naked DNA in buffer or during chromatin assembly in Xenopus egg extracts.

240 ed with erythroid proteins in the absence of chromatin assembly, indicating that sensitivity to nucle

241 Chromatin assembly involves the combined action of ATP-d

242 Chromatin assembly involves the combined action of histo

243 It has been known for nearly 20 years that chromatin assembly is an ATP-dependent process.

244 esting that the RNA signal is amplified when chromatin assembly is blocked and attenuated by nucleoso

245 ion site in a genetic background in which RI chromatin assembly is blocked, we have been able to deci

246 tes contain multiple core histone genes, how chromatin assembly is controlled, and how these processe

247 bit MMR, we were interested to learn whether chromatin assembly is differentially regulated on hetero

248 Although replication-coupled chromatin assembly is known to be important for the main

249 Chromatin assembly is required for the duplication of ch

250 Further analyses suggested that chromatin assembly is strongly modified after fertilizat

251 generation of LCR HS sites in the absence of chromatin assembly leads to the formation of S1- and KMn

252 ons in genes involved in DNA replication and chromatin assembly led to LOH predominantly via reciproc

253 De novo chromatin assembly maintains histone density on the daug

254 Thus, ASF1-dependent chromatin assembly may mediate the role of the SAS compl

255 ating replication forks, suggesting distinct chromatin assembly mechanisms surrounding activated and

256 llels between centromeric and noncentromeric chromatin assembly mechanisms.

257 postulated that the balance between MMR and chromatin assembly might be governed by proliferating ce

258 Using the frog oocyte as a model system for chromatin assembly mimicking that in somatic cells, we d

259 Chromatin assembly mRNAs were expressed throughout the O

260 We propose that errors in chromatin assembly, occurring spontaneously or caused by

261 When chromatin assembly occurs at other times, the histone H3

262 atin structure are seen depending on whether chromatin assembly occurs in the presence of somatic H1s

263 ric but not catalytic inhibitors prevent the chromatin assembly of functional replisomes.

264 itment of specific E2Fs to their targets and chromatin assembly of the host cell factor 1 (HCF-1)-MLL

265 perone Daxx to modulate histone mobility and chromatin assembly on the EBV genome during the early st

266 tegument protein BNRF1 functions to regulate chromatin assembly on the viral genome during early infe

267 luding lysines 5 and 12, sites important for chromatin assembly, on histone H4 in vitro and in vivo A

268 Disrupting chromatin assembly or lagging-strand polymerase processi

269 by an established cell-cycle-coupled CENP-A chromatin assembly pathway, but how centromeres are inhe

270 In opposition to the CAF-I chromatin assembly pathway, H3K56 hyperacetylation, toge

271 ough the activity of the replication-coupled chromatin assembly pathway.

272 cation-independent and replication-dependent chromatin assembly pathways.

273 Cellular chromatin assembly plays an important role in regulating

274 of Cac2p, another CAF-1 component, and other chromatin assembly proteins (Hir3p, Nap1p, and Asf1p).

275 his issue of Molecular Cell demonstrates how chromatin assembly proteins HIRA/Asf1 help enforce trans

276 Further, we propose a model for the chromatin assembly reaction it mediates, including a ste

277 issection of the role of each subunit in the chromatin assembly reaction.

278 Ap48, a highly abundant component of various chromatin assembly, remodeling, and modification complex

279 DA2-A, ADA3, STAF36, and WDR5), cofactors of chromatin assembly/remodeling and DNA replication machin

280 We propose that the inhibition of chromatin assembly represents a novel mechanism of cell

281 onfers phenotypes consistent with defects in chromatin assembly such as sensitivity to DNA damaging a

282 This minimal chromatin assembly system comprises the Drosophila nucle

283 anism of nucleosome assembly with a purified chromatin assembly system containing the histone chapero

284 mine Tax transactivation in vitro, we used a chromatin assembly system that included recombinant core

285 Using a linker histone-dependent in vitro chromatin assembly system that spontaneously aligns nucl

286 enhanced chromatin formation in an in vitro chromatin assembly system.

287 in the categories related to nucleosome and chromatin assembly; the genes harboring the distant eQTN

288 These results indicate that coupling of chromatin assembly to DNA replication and DNA repair is

289 and unique histone modification that couples chromatin assembly to DNA synthesis, cell proliferation

290 synthesis with provision of new histones for chromatin assembly to ensure chromosomal stability.

291 vity of HJURP is responsible for centromeric chromatin assembly to maintain the epigenetic mark.

292 BNRF1 alters the host cellular chromatin assembly to prevent antiviral repressive chrom

293 Thus, checkpoint pathways directly regulate chromatin assembly to promote survival in response to DN

294 ons increases the DNA compaction rate during chromatin assembly under 2-pN force and decreases it dur

295 Thus, Acf1 facilitates chromatin assembly via an N-terminal DNA-binding region

296 in nonoverlapping ways that are required for chromatin assembly, viability, and DNA damage response s

297 n of RNAs associated with the cell cycle and chromatin assembly was repressed during prenatal lung ma

298 By using a purified ACF-dependent system for chromatin assembly, we found that ACF hydrolyses about 2

299 inhibition of remodeling and spacing factor chromatin assembly, which requires acetylated histones f

300 yeast, human CAF-1 is necessary for coupling chromatin assembly with DNA replication.