ライフサイエンスコーパス: chromosomal instability

1 evelopmental impairment, embryonic death and chromosomal instability.

2 s, hypersensitivity to genotoxic agents, and chromosomal instability.

3 evaluation of tumors revealed characteristic chromosomal instability.

4 levels and promoted checkpoint weakness and chromosomal instability.

5 ng of telomeres, seems to be associated with chromosomal instability.

6 VHL with increased miR-28-5p expression and chromosomal instability.

7 mis-segregate whole chromosomes and display chromosomal instability.

8 oplastic tissue, is attributed to continuous chromosomal instability.

9 bipolar spindle assembly and a high rate of chromosomal instability.

10 r and promotes tumor growth, metastasis, and chromosomal instability.

11 atumor heterogeneity, genetic diversity, and chromosomal instability.

12 ploidy single-handedly triggered cancer-like chromosomal instability.

13 cellular cholesterol homeostasis also causes chromosomal instability.

14 he development of HGSOC, and associated with chromosomal instability.

15 nes associated with cancer proliferation and chromosomal instability.

16 in and heterochromatin, and cause widespread chromosomal instability.

17 Human cells lacking RECQL5 display chromosomal instability.

18 cterized by progressive fatal BM failure and chromosomal instability.

19 nt human tumors and strongly correlates with chromosomal instability.

20 kinase A (AURKA) drives tumor aneuploidy and chromosomal instability.

21 em cells, uncoupling cell cycle defects from chromosomal instability.

22 pone DSB repair without accumulating massive chromosomal instability.

23 essive disorders characterized by cancer and chromosomal instability.

24 nd processing, HR-type DSB repair, and overt chromosomal instability.

25 and led to concomitant telomerase-dependent chromosomal instability.

26 No evidence was found of G-CSF-induced chromosomal instability.

27 umor development to drive the acquisition of chromosomal instability.

28 ted MEK1-tubulin in spindle organization and chromosomal instability.

29 s chromosome content, two characteristics of chromosomal instability.

30 61 is associated with higher cancer risk and chromosomal instability.

31 tic event associated with gene silencing and chromosomal instability.

32 evoid of RECQL1 and RECQL5 display increased chromosomal instability.

33 resence of extra centrosomes correlates with chromosomal instability.

34 lium and is characterized by a high level of chromosomal instability.

35 intraepithelial lesions, yet did not exhibit chromosomal instability.

36 sease characterized at the cellular level by chromosomal instability.

37 ve double-strand break repair, and increased chromosomal instability.

38 llular superoxide, to the acute induction of chromosomal instability.

39 ochastic model, driven by the observation of chromosomal instability.

40 arities involving anaphase bridges and gross chromosomal instability.

41 y of p53 lesions, and display high levels of chromosomal instability.

42 a gene expression signature associated with chromosomal instability.

43 to mitomycin C and exhibited high levels of chromosomal instability.

44 ersensitivity to DNA crosslinking agents and chromosomal instability.

45 uence motifs, predispose the human genome to chromosomal instability.

46 radiosensitivity, increased micronuclei, and chromosomal instability.

47 repair pathway that protects the genome from chromosomal instability.

48 severely compromised DSB repair resulting in chromosomal instability.

49 eukemia (AML) is frequently characterized by chromosomal instability.

50 onical Hh signaling through the induction of chromosomal instability.

51 repton reduced liver overgrowth and signs of chromosomal instability.

52 histomorphologic parameters associated with chromosomal instability.

53 checkpoint activity and the potentiation of chromosomal instability.

54 cell cycle checkpoint, resulting in profound chromosomal instability.

55 , but was a potent inducer of aneuploidy and chromosomal instability.

56 centromeres are altered in cancer cells with chromosomal instability.

57 ts in sensitivity to DNA-damaging agents and chromosomal instabilities.

58 athway to propagate structural and numerical chromosomal instabilities.

59 -positive ALT cells were found to have gross chromosomal instabilities.

60 ulation of Bub1 mediated by LANA resulted in chromosomal instability, a hallmark of cancer.

61 hindered in p27-deficient cells, leading to chromosomal instability, a hallmark of cancers with poor

62 These diseases are associated with chromosomal instability, a hallmark of human cancer.

63 y defects have recently been associated with chromosomal instability, a hallmark of human cancer.

64 ubule attachments during mitosis can lead to chromosomal instability, a hallmark of human cancers.

65 auses polyploidy, which in turn can generate chromosomal instability, a hallmark of many cancers.

66 essing tissues with age, consistent with the chromosomal instability accompanying a polzeta defect.

67 data implicate MAK in both AR activation and chromosomal instability, acting in both early and late p

68 In contrast, we discovered that chromosomal instability activates cGAS/STING signaling b

69 odification may contribute to the prevention chromosomal instability and aneuploidy which frequently

70 meres are associated with the development of chromosomal instability and aneuploidy, the latter being

71 he top 25 genes overexpressed in tumors with chromosomal instability and aneuploidy.

72 are implicated in hereditary human disease, chromosomal instability and cancer, and underlie the cli

73 disrupted by BRCA2 mutations, which lead to chromosomal instability and cancer.

74 rly or late stages of tumorigenesis promotes chromosomal instability and carcinogenesis in telomerase

75 When making synthetic hybrids, chromosomal instability and cell size increase dramatica

76 down-regulation of such homologs resulted in chromosomal instability and chromatid cohesion defects i

77 been implicated as an important mediator of chromosomal instability and colon cancer triggered by En

78 Acquired chromosomal instability and copy number alterations are

79 pt management of small melanoma might reduce chromosomal instability and could improve overall patien

80 ly, loss of TRAIP function leads to enhanced chromosomal instability and decreased cell survival afte

81 of FA including DNA crosslinker sensitivity, chromosomal instability and defective FA pathway activat

82 ks whose unfaithful repair may contribute to chromosomal instability and disease progression to blast

83 The aneuploid cells display increased chromosomal instability and DNA damage, a mutator phenot

84 efine genomic heterogeneity of PLC linked to chromosomal instability and evasion of immune surveillan

85 ons disturb mitosis and cytokinesis, causing chromosomal instability and greatly increased susceptibi

86 UBE2C is an important marker of chromosomal instability and has been associated with mal

87 ) is a rare genetic disease characterized by chromosomal instability and impaired DNA damage repair.

88 -deficient B cells also exhibited pronounced chromosomal instability and impaired proliferation capac

89 t CDK inhibitors may have use in suppressing chromosomal instability and in synthetic lethal drug com

90 iferation, while prolonged expression caused chromosomal instability and in vivo tumor suppression.

91 eat shock protein Hsp72 was shown to promote chromosomal instability and increase radiation sensitivi

92 es provide valuable information for studying chromosomal instability and its consequences in cancer.

93 to the vast size of tumour cell populations, chromosomal instability and its potential for phenotypic

94 esulting from these interactions may promote chromosomal instability and leave the hepatocyte unable

95 Chromosomal instability and mitotic errors may contribut

96 , they demonstrate that MSH2-MSH3 suppresses chromosomal instability and modulates the tumor spectrum

97 Though not mutually exclusive, chromosomal instability and pathogenic variants affectin

98 s (ICL), a highly toxic lesion that leads to chromosomal instability and perturbs normal transcriptio

99 bishield emergency program drives evasion of chromosomal instability and phagocytosis checkpoints by

100 gests a possible causal relationship between chromosomal instability and premature aging.

101 lular transformation through accumulation of chromosomal instability and premature progression of the

102 , with seemingly opposing roles in promoting chromosomal instability and protecting genome integrity.

103 ct as posttranscriptional safeguards against chromosomal instability and replication stress by integr

104 In addition to chromosomal instability and replication stress, Gcna mut

105 , tumors overexpressing Shh exhibited marked chromosomal instability and Smoothened-independent upreg

106 r that plays a key role in the prevention of chromosomal instability and suppresses the acquisition o

107 ntribute to tumor formation by both inducing chromosomal instability and suppressing the DDR pathway.

108 e report that LANA promoted the induction of chromosomal instability and the formation of micronuclei

109 Chromosomal instability and the subsequent genetic mutat

110 Chromosomal instability and the subsequent genetic mutat

111 DNA replication stress can cause chromosomal instability and tumor progression.

112 shorter telomeres have been associated with chromosomal instability and tumor progression.

113 nificant differences in mutational patterns, chromosomal instability, and gene expression that correl

114 ignaling pathway results in excessive ssDNA, chromosomal instability, and hypersensitivity to replica

115 phases of cellular transformation, exhibited chromosomal instability, and promoted increase in nuclea

116 ted hypersensitivity to DNA damage reagents, chromosomal instability, and reduced ATM-dependent phosp

117 Loss of cell-cell adhesion and chromosomal instability are cardinal events that drive t

118 Incorrect chromosome number and chromosomal instability are hallmarks of tumor cells.

119 These results underscore the role of chromosomal instability as a result of mitotic checkpoin

120 VirD5 promotes chromosomal instability as seen by the high-frequency lo

121 syndrome, respectively, and associated with chromosomal instability as well as premature aging.

122 useful strategy in cancer therapy, although chromosomal instability associated with pol zeta deficie

123 al to preserve genomic integrity and prevent chromosomal instability-associated diseases including ca

124 uggest that KIF5B is critical in suppressing chromosomal instability at the early stages of female me

125 ongly associated with tumor stage, a mitotic chromosomal instability attractor strongly associated wi

126 a striking association between the degree of chromosomal instability, both numerical and structural,

127 bute to tumor formation not only by inducing chromosomal instability but also by suppressing the func

128 n increases tumor initiation by induction of chromosomal instability, but that initiated tumors need

129 the absence of NORAD, PUMILIO proteins drive chromosomal instability by hyperactively repressing mito

130 that LMW-E expression primes cells to accrue chromosomal instability by shortening the length of mito

131 tastrophe and apoptosis; and 4) induction of chromosomal instability by telomere aggregate formation.

132 We show that R-loop-associated chromosomal instability can be induced by the loss of DI

133 Chromosomal instability can result from defective contro

134 mouse Mcm4(Chaos3) mutation associated with chromosomal instability, cancer, and decreased intersubu

135 ity in mouse thymi and small intestines, the chromosomal instability caused by Atf3 deficiency was la

136 rt that Spartan insufficiency in mice causes chromosomal instability, cellular senescence and early o

137 tellite stable but most are characterized by chromosomal instability (CIN pathway).

138 omes at kinetochores is a major mechanism of chromosomal instability (CIN) [1, 2].

139 and anaphase bridges, which are hallmarks of chromosomal instability (CIN) and Bub1 insufficiency.

140 rives aggressive cellular phenotypes such as chromosomal instability (CIN) and invasiveness.

141 lterations in pathways that characterize the chromosomal instability (CIN) and the genomically stable

142 to defects in kinetochore biorientation and chromosomal instability (CIN) and these phenotypes are s

143 air (HDR) is essential to limit mutagenesis, chromosomal instability (CIN) and tumorigenesis.

144 The mechanisms that safeguard cells against chromosomal instability (CIN) are of great interest, as

145 Myc upregulation and increasing chromosomal instability (CIN) characterized the evolutio

146 Chromosomal instability (CIN) comprises continual gain a

147 Chromosomal instability (CIN) contributes to cancer evol

148 d that the rate of chromosome missegregation/chromosomal instability (CIN) determines the effect of a

149 oup related to drug resistance that contains chromosomal instability (CIN) genes.

150 ds to global changes in gene expression, and chromosomal instability (CIN) in the host cell.

151 Chromosomal instability (CIN) in tumors is characterized

152 ness of cells with constitutional trisomy or chromosomal instability (CIN) in vivo using hematopoieti

153 euploidy, Separase overexpression results in chromosomal instability (CIN) including premature chroma

154 Chromosomal instability (CIN) increases a tumor cell's a

155 Although chromosomal instability (CIN) is a common phenomenon in

156 Chromosomal instability (CIN) is a hallmark of cancer th

157 Chromosomal instability (CIN) is a hallmark of human neo

158 Chromosomal instability (CIN) is a hallmark of many tumo

159 Chromosomal instability (CIN) is a major driving force o

160 Chromosomal instability (CIN) is associated with poor ou

161 Chromosomal instability (CIN) is one of the major forms

162 Chromosomal instability (CIN) is widely considered a hal

163 Besides acquired T790M mutation, chromosomal instability (CIN) related genes, including A

164 Cancer chromosomal instability (CIN) results in an increased ra

165 egregation events in aneuploid cells promote chromosomal instability (CIN) that may contribute to the

166 ve increased segregation errors and elevated chromosomal instability (CIN), but the genetic defects r

167 Whole chromosomal instability (CIN), manifested as unequal chr

168 hways in colorectal cancer pathogenesis: the chromosomal instability (CIN), microsatellite instabilit

169 Chromosomal instability (CIN), the persistent inability

170 chromosome segregation, can be causative of chromosomal instability (CIN), which is a hallmark of ma

171 Polyploid cancer cells exhibit chromosomal instability (CIN), which is associated with

172 loss of BRCA1 in human cancer cells leads to chromosomal instability (CIN), which is defined as a per

173 -cycle checkpoints, allowing accumulation of chromosomal instability (CIN), which resulted in aneuplo

174 Segregation errors lead to chromosomal instability (CIN), with deleterious conseque

175 euploidy, chromothripsis, and other forms of chromosomal instability (CIN), yet how this occurs remai

176 g cell division are strongly associated with chromosomal instability (CIN).

177 es at high rates, a phenotype referred to as chromosomal instability (CIN).

178 the other is subclonal aneuploidy caused by chromosomal instability (CIN).

179 mosome missegregation in a phenomenon called chromosomal instability (CIN).

180 d-disease phenotypes, notably metastasis and chromosomal instability (CIN).

181 mosomes at high rates in a phenomenon called chromosomal instability (CIN).

182 mosomes at high rates in a phenomenon called chromosomal instability (CIN).

183 hromosome missegregation in a process called chromosomal instability (CIN).

184 ate whole chromosomes in a phenomenon called chromosomal instability (CIN).

185 genes are overexpressed in tumors exhibiting chromosomal instability (CIN).

186 scale genomic rearrangements, referred to as chromosomal instability (CIN).

187 mosome missegregation in a phenomenon called chromosomal instability (CIN).

188 o evidence to support that [PSI (+)] induces chromosomal instability (CIN).

189 s having microsatellite instability (MSI) or chromosomal instability (CIN); herein termed microsatell

190 o search for gene signatures associated with chromosomal instability (CIN); we investigated associati

191 ouble knockout splenocytes displayed reduced chromosomal instability compared with Atm null mice.

192 that macroevolutionary shifts (the onset of chromosomal instability) contribute to the evolution of

193 nd disruption of these complexes can lead to chromosomal instability culminating in cell death or mal

194 Fanconi anaemia is a chromosomal instability disorder associated with cancer

195 Fanconi anemia (FA) is an inherited chromosomal instability disorder characterized by childh

196 FA is a chromosomal instability disorder characterized by multip

197 Fanconi anemia (FA) is a chromosomal instability disorder in which DNA-damage pro

198 uster DNA helicase genetically linked to the chromosomal instability disorder Warsaw breakage syndrom

199 Fanconi anemia (FA) is a rare chromosomal-instability disorder associated with a varie

200 nd Bloom's syndrome (BS) are rare hereditary chromosomal instability disorders.

201 tically stable epithelial cells can initiate chromosomal instability, DNA damage, cell transformation

202 summary, we propose that Hus1 loss leads to chromosomal instability during DNA replication, triggeri

203 imply that multiple oncogenic pathways drive chromosomal instability during osteosarcoma evolution an

204 Since chromosomal instability emerges when BRCA1 HR function i

205 Chromosomal instability enables tumor development, enabl

206 aling via a DNA-bound form, the induction of chromosomal instability, enhancement of DNA damage sensi

207 during childhood, which along with intrinsic chromosomal instability, favor clonal evolution and the

208 f; that is, whether aneuploidy per se causes chromosomal instability, for example, in patients with i

209 Together, these data identify RanBP2 as a chromosomal instability gene that regulates Topo IIalpha

210 as been no systematic exploration of whether chromosomal instability generated as a result of deregul

211 The overall consequences of this chromosomal instability have been largely unexplored in

212 New models of aneuploidy and chromosomal instability have shed light on the diverse e

213 s) are highly toxic lesions that can lead to chromosomal instability if they are not repaired correct

214 hypersensitivity to DNA cross-linker-induced chromosomal instability in association with developmenta

215 e repair, that may explain in part the whole-chromosomal instability in BRCA2-deficient tumors.

216 What specific defects can cause chromosomal instability in cancer cells?

217 Chromosomal instability in cancer consists of dynamic ch

218 hila epithelial cells to address the role of chromosomal instability in cancer development as they ha

219 dy identifies p120 loss as a driver event of chromosomal instability in cancer.

220 e to replication stress and are hotspots for chromosomal instability in cancer.

221 progress has been made to identify causes of chromosomal instability in colorectal cells and to deter

222 A rapidly assessable biomarker of chromosomal instability in CTC is associated with poor o

223 of repair of DNA interstrand cross-links and chromosomal instability in FA cells.

224 and provides a novel molecular mechanism for chromosomal instability in HL.

225 increases chromosome missegregation to cause chromosomal instability in human tumors.

226 eveal a previously unrecognized mechanism of chromosomal instability in leukemia progenitors because

227 chromosomal aneuploidy accompanying ongoing chromosomal instability in mice resulting from reduced l

228 We tested our hypothesis that targeting chromosomal instability in MM would improve response to

229 how that overexpression of Cyclin B1 induces chromosomal instability in mouse embryonic fibroblasts l

230 mirus provide a second example of prolonged chromosomal instability in natural neoallopolyploid popu

231 omal aberrations, suggesting the presence of chromosomal instability in the cancer stem cells.

232 eres produce apoptosis, cell senescence, and chromosomal instability in tissue culture and animal mod

233 romosome mis-segregation, a leading cause of chromosomal instability in tumors.

234 e constitutional MdnCNV phenomenon resembles chromosomal instability in various cancers.

235 By identifying a potential mediator of chromosomal instability in VHL-associated cancers, our w

236 cancer cells with a growth advantage, caused chromosomal instability in vitro, and promoted tumor dev

237 Despite considerable chromosomal instability, in most cases the evolution fro

238 evel of somatic mosaicism, a proxy marker of chromosomal instability, in patients with constitutional

239 rylation leads to multiple manifestations of chromosomal instability including increased levels of DN

240 sed replication forks, as well as in various chromosomal instabilities, including loss of heterozygos

241 ot only reduced but the cells also exhibited chromosomal instability, including binucleation and aneu

242 ing from primary causes that do not generate chromosomal instability, including loss of the INK4a tum

243 Cell proliferation and chromosomal instability increased in colon crypt cells o

244 Chromosomal instability index as measured by changes in

245 ation of nucleoplasmic bridges and increased chromosomal instability, indicating that inaccurate endo

246 from undergoing programmed cell death (PCD), chromosomal instability induces neoplasic overgrowth.

247 Underlying the chromosomal instability is a failure to up-regulate the

248 Chromosomal instability is a hallmark of cancer, but mit

249 Chromosomal instability is a hallmark of many tumor type

250 We find that chromosomal instability is a major driver of RNA-ITH, an

251 Interestingly, p53 loss induced chromosomal instability leading to features of transform

252 We first show that chromosomal instability leads to an apoptotic response.

253 rs harboring Rsf-1 amplification, can induce chromosomal instability likely through DDR.

254 pericentric heterochromatin, with consequent chromosomal instability manifested by increased micronuc

255 Thus, early chromosomal instability may be responsible for tumour re

256 Chromosomal instability may enable the continuous select

257 cies suggests that substantial and prolonged chromosomal instability might be common in natural popul

258 The chromosomal instability model proposed here suggests a c

259 ecimens and 37 tumor cell lines derived from chromosomal instability neoplasia and microsatellite ins

260 revealed no evidence of aneuploidy or gross chromosomal instability (no difference to adenomas from

261 mb features, and backbone demethylation with chromosomal instability, NSD1 and TP53 mutations, 5q and

262 It corrected the DNA repair defect and the chromosomal instability observed after exposure to a DNA

263 cancer mouse models with persistent mitotic chromosomal instability, observing a decrease in prolife

264 ncer is aneuploidy, which is a result of the chromosomal instability of cancer cells and is thought t

265 alteration of FAM190A may contribute to the chromosomal instability of cancer.

266 ncy did not modify the checkpoint defects or chromosomal instability of Mre11 complex mutants; howeve

267 s are found in many tumors, and the enhanced chromosomal instability of polyploid cells in culture su

268 cer cells, was significantly associated with chromosomal instability on 13q and 15q.

269 th in CAFs was significantly associated with chromosomal instability on 4q and 13q and lymphocyte tel

270 bsequent cell divisions, resulting in either chromosomal instabilities or cell cycle arrest.

271 r DNA strand separation is the basis for the chromosomal instability or collision of RNA polymerases.

272 early-stage tumors induced by oncoproteins, chromosomal instability, or DNA damage is associated wit

273 ession is a hallmark of cancer cells showing chromosomal instability, particularly in certain breast

274 High module scores of chromosomal instability, phosphatase and tensin homolog

275 This hereditary disease is associated with chromosomal instability, premature aging and cancer pred

276 e precise mechanism underlying LANA-mediated chromosomal instability remains uncharted.

277 ross 22 tumour types to show that continuous chromosomal instability results in pervasive SCNA hetero

278 ndensation defects that underlie the ongoing chromosomal instability seen in aneuploid hPSCs.

279 widespread heterogeneity, alongside a strong chromosomal instability signature.

280 e same patient samples suggesting a field of chromosomal instability surrounding the tumor.

281 Fanconi anemia (FA) is an inherited chromosomal instability syndrome characterized by bone m

282 Fanconi anemia (FA) is an inherited chromosomal instability syndrome that is characterized b

283 The DCIS had a lower degree of chromosomal instability than the IDC.

284 ency program and the accumulation of genomic/chromosomal instability that leads to tumorigenesis.

285 Telomere shortening induces chromosomal instability that, in the absence of function

286 e the proteome, the proteins associated with chromosomal instability, the sets of signaling pathways

287 sing disease progression in MPDs by inducing chromosomal instability through the production of DSBs a

288 Overexpression of Mad1 causes aneuploidy and chromosomal instability through weakening mitotic checkp

289 LANA also induces chromosomal instability, thus promoting oncogenesis.

290 Previous studies showed that chromosomal instability was common in esophageal squamou

291 Chromosomal instability was prevalent in nonhypermutated

292 fork stalling in FAN1-deficient cells causes chromosomal instability, we reasoned that the key functi

293 To address the question of chromosomal instability, we used FISH to evaluate the pe

294 To test how caspase-2 protects against chromosomal instability, we utilized an ex vivo system f

295 Genome doubling and ongoing dynamic chromosomal instability were associated with intratumor

296 osable elements (TEs) generate mutations and chromosomal instability when active.

297 ing during mitosis to prevent aneuploidy and chromosomal instability, which are hallmarks of tumor ce

298 Most human cancers are aneuploid and have chromosomal instability, which contrasts to the inabilit

299 es mitophagy and results in the promotion of chromosomal instability, which enables tumor cells to ef

300 he reported Fanconi anemia (FA) mouse model, chromosomal instability with radial changes can be detec