ライフサイエンスコーパス: chromosomal loci

1 -outs, knock-ins, and single-base editing at chromosomal loci.

2 are also clustered on six cancer-associated chromosomal loci.

3 es and epigenetic gene silencing at specific chromosomal loci.

4 annotated gene expression levels to specific chromosomal loci.

5 coordinately controlled by several unlinked chromosomal loci.

6 tion of tRNA gene position effects at native chromosomal loci.

7 probes that hybridize to the 14q32 and 11q13 chromosomal loci.

8 m myositis and anti-Mi-2 autoantibodies at 4 chromosomal loci.

9 es may be most effective at highly expressed chromosomal loci.

10 omain is not primarily used to direct SCM to chromosomal loci.

11 structural functions by binding to specific chromosomal loci.

12 ences in the dynamic properties of different chromosomal loci.

13 ns (ctn) contain copies of CTRT1 at multiple chromosomal loci.

14 c recombination and targeted modification of chromosomal loci.

15 cessibility and remodeling within endogenous chromosomal loci.

16 with the discrete positioning of particular chromosomal loci.

17 between introduced DNA and the corresponding chromosomal loci.

18 etween asthma-associated traits and specific chromosomal loci.

19 in each of these ethnic groups differ at two chromosomal loci.

20 causative gene in any of the NCLs at defined chromosomal loci.

21 ine retinal disease, others because of their chromosomal loci.

22 h the invasive carcinoma at some but not all chromosomal loci.

23 fragility of four, and apparently only four, chromosomal loci.

24 he known fluctuating and elastic dynamics of chromosomal loci.

25 expression site (ES) promoters, into various chromosomal loci.

26 parison of an approximately random sample of chromosomal loci.

27 at 43 polymorphic autosomal loci and seven X chromosomal loci.

28 to distinguish genetic groups at plasmid and chromosomal loci.

29 cases, the multiple forms arise from single chromosomal loci.

30 mly repeated in plant genomes at one or more chromosomal loci.

31 pendent on genes located in several adjacent chromosomal loci.

32 al activities and connecting disparate inter-chromosomal loci.

33 ich enabled precise localization of specific chromosomal loci.

34 nflicts and replication stress compared with chromosomal loci.

35 n of DSB repair pathway choice at endogenous chromosomal loci.

36 s, targeting co-located genes within defined chromosomal loci.

37 requires genetic alteration at their native chromosomal loci.

38 rvation of spatiotemporal aspects of damaged chromosomal loci.

39 nsport of plasmids, protein machineries, and chromosomal loci.

40 oorganisms may arise by mutations at certain chromosomal loci.

41 g transgenic elements from precisely defined chromosomal loci.

42 ision impact recombinants formed at multiple chromosomal loci.

43 and insertion/deletion polymorphisms at five chromosomal loci.

44 ry genomic map of Rpd3L- and Rpd3S-regulated chromosomal loci.

45 introducing double-strand breaks at selected chromosomal loci.

46 reaks (DSBs) to be introduced into specified chromosomal loci.

47 ells and to target modifications of specific chromosomal loci.

48 leukin-6 (IL-6) STAT3-dependent promoters on chromosomal loci.

49 g, parSI stretches far away from neighboring chromosomal loci.

50 uage phenotypes was established at two novel chromosomal loci, 15q23-26 and 16p12.

51 of 18 UC specimens with instability at other chromosomal loci (17%) showed TGF-beta 1RII poly A tract

52 rs associated with tumor suppressor genes at chromosomal loci 1p, 3p, 5q, 9p, 10q, 17p, 17q, 18q, 21q

53 e have identified three vitamin D-responsive chromosomal loci (1p36, 19q13, and 6p25) and show the in

54 are recurrent copy number variants (CNVs) at chromosomal loci 22q11.2 and 16p11.2 are genetic disorde

55 These translocation breakpoints involve six chromosomal loci: 4p16.3 (two lines and the one tumor);

56 ive of but not limited to genes localized to chromosomal loci 8p, 9p, 11q, and 13q.

57 Chromosomal loci adjacent to the integrated vector were

58 assess the overall genomic instability, and chromosomal loci affected by genomic alterations were de

59 ery that despite the disparate nature of the chromosomal loci affected by senescence in fibroblasts a

60 t shock and translocates from nucleoplasm to chromosomal loci after heat shock.

61 c complementation studies suggested that two chromosomal loci, agr and sar, are involved in the upreg

62 Here, by imaging several chromosomal loci and 16 distinct plasmids, we show that

63 particle tracking, we quantify the motion of chromosomal loci and cytoplasmic tracer particles.

64 covered one novel human PTP gene and defined chromosomal loci and exon structure of the additional 37

65 ransition pathways, spatial repositioning of chromosomal loci and hysteresis loop of contact evolutio

66 Chromosomal loci and many protein complexes are position

67 nts, which are encoded by plasmid as well as chromosomal loci and mediate plasmid and genomic island

68 cription factors is discussed in relation to chromosomal loci and other nuclear domains.

69 s further demonstrated by imaging endogenous chromosomal loci and proteins.

70 ly our analysis to experimental data sets of chromosomal loci and RNA-protein particles in Escherichi

71 merase-II activity is concentrated at single chromosomal loci and that cleavage sites extend over app

72 ne strain is genetically heterogeneous at 46 chromosomal loci and that heterogeneity was maintained u

73 chromosomal abnormalities, including several chromosomal loci and the genes coding for p53, p57, and

74 has a strong impact on interactions between chromosomal loci, and appears to explain the tendency of

75 es affected with TAA have identified several chromosomal loci, and further mapping of familial TAA ge

76 ing loss of heterozygosity (LOH) at multiple chromosomal loci, and these aberrations are strongly ass

77 h H3K27Me2 and Ago2-2 concurrently enrich at chromosomal loci; and an established silencing phase in

78 Moreover, chromosomal loci are redirected toward the nucleolus and

79 3 (miR-133), which are clustered on the same chromosomal loci, are transcribed together in a tissue-s

80 Chromosomal loci associated with 49 DCPs were confirmed

81 been made in the identification of genes and chromosomal loci associated with several types of motor

82 interacts with adenine and thymine (AT)-rich chromosomal loci, associates with the promoter regions o

83 d which places the replication machinery and chromosomal loci at defined locations that change during

84 es to partition and place many, if not most, chromosomal loci at defined subcellular sites.

85 r-dimensional fluorescence imaging of tagged chromosomal loci at high spatio-temporal resolution in b

86 Tracking the motion of chromosomal loci at short timescales provides informatio

87 Centromeres are the chromosomal loci at which spindle microtubules attach to

88 During S phase in Saccharomyces cerevisiae, chromosomal loci become mobile in response to DNA double

89 the same gene expression state at individual chromosomal loci before and after DNA replication.

90 early activation of late origins at internal chromosomal loci but did not alter the initiation timing

91 as powerful tools to alter genomes and mark chromosomal loci, but an inexpensive method for generati

92 roducing the target gene into pre-determined chromosomal loci, but recombination between the availabl

93 DNA was analyzed in duplicate for LOH at 10 chromosomal loci by PCR and polyacrylamide gel electroph

94 ication in metazoans initiates from multiple chromosomal loci called origins.

95 Functional silencing of chromosomal loci can be induced by transgenes (cosuppres

96 dered to function by targeting regulators to chromosomal loci carrying specific histone modifications

97 idence for vitamin D regulation of two human chromosomal loci, Chr17q12-21.1 and Chr17q21.2, reliably

98 bes the relative probabilities that pairs of chromosomal loci collide with one another in living cell

99 was twice that of the X rDNA array with both chromosomal loci containing regions where the rate of el

100 rosophila ovarian follicle cells amplify the chromosomal loci containing the chorion gene clusters up

101 To map chromosomal loci contributing to DAT susceptibility, we

102 As a first step toward identification of chromosomal loci contributing to genetic predisposition

103 To identify chromosomal loci contributing to vulnerability, we have

104 phila Rabs with YFP(MYC) at their endogenous chromosomal loci, determined their expression and subcel

105 s hybridization of transcripts to homologous chromosomal loci distinct from their site of synthesis.

106 y, we use single-particle tracking of tagged chromosomal loci during interphase in live yeast cells t

107 Centromeres are the chromosomal loci essential for faithful chromosome segre

108 -tagged proteins expressed from their native chromosomal loci, examining cytosolic dynamics and inter

109 of rare but ubiquitous 'rapid movements' of chromosomal loci exhibiting near-ballistic dynamics.

110 To ascertain whether distinct chromosomal loci existed that were linked to severe obes

111 When integrated at either of two chromosomal loci, expansion rates were 1 x 10(-5) to 4 x

112 llin genes that are uniquely arranged in two chromosomal loci, flaABCDE and flaF.

113 V. cholerae flagellin genes, arranged in two chromosomal loci, flaAC and flaEDB; all five genes have

114 Our linkage data suggest specific chromosomal loci for future fine-mapping genetic analysi

115 ow Rnf20 is recruited to its specific target chromosomal loci for the establishment of H2Bub1.

116 smokers and nonsmokers that were located at chromosomal loci frequently altered in non-small cell lu

117 nactivation of several of the genes at their chromosomal loci had no effect on the intracellular grow

118 Linkage to several chromosomal loci has been established for other forms of

119 gments containing the ade6-M26 gene to other chromosomal loci has previously demonstrated that the he

120 The direct visualization of specific chromosomal loci has revealed that bacteria condense, mo

121 er in up to 19% of patients, and a number of chromosomal loci have been identified for the condition.

122 Different chromosomal loci have been linked with three autosomal d

123 However, conflicting chromosomal loci have been reported in human genomic dat

124 Early reports of linkage to chromosomal loci have fallen into doubt; however they ha

125 We find that supercoiled chromosomal loci have overall higher Hi-C contact freque

126 in the vicinity of the Pitx2, Wnt8 and Wnt11 chromosomal loci identified five novel lncRNAs with diff

127 The 15 reproducible chromosomal loci identified here are good candidates to

128 g(2+), forms feedforward loops that regulate chromosomal loci identified through a motif search over

129 sk genes in brain, 28 of which map to linked chromosomal loci; (ii) delineated six biological process

130 complex rearrangements occur at one or a few chromosomal loci in a single catastrophic event.

131 hypothesized that subcellular positioning of chromosomal loci in bacteria may be influenced by gene f

132 0.1-10 s) dynamics of fluorescently labelled chromosomal loci in Escherichia coli at different growth

133 e protein expression affects the position of chromosomal loci in Escherichia coli.

134 omplex, as it is associated with hundreds of chromosomal loci in euchromatin of salivary gland polyte

135 genomes supported the involvement of various chromosomal loci in glycan metabolism.

136 emonstrate simultaneous imaging of up to six chromosomal loci in individual live cells and document l

137 Our approach first labels and tracks chromosomal loci in live cells with the CRISPR-Cas9 syst

138 do not suppress the aberrant positioning of chromosomal loci in mukB cells, despite suppressing the

139 Here we report the imaging of 3,660 chromosomal loci in single mouse embryonic stem (ES) cel

140 ntified the mobility of a pair of homologous chromosomal loci in the interphase nuclei of Caenorhabdi

141 d fractional Brownian motion simulations for chromosomal loci in the nucleoplasm and interacting with

142 romosome segregation by visualizing specific chromosomal loci in the presence and absence of the Tus

143 olving the juxtaposition of otherwise distal chromosomal loci in the three-dimensional nuclear space(

144 We examined the arrangement of chromosomal loci in the very large, highly polyploid, un

145 Whether instability was present at other chromosomal loci in these lesions was determined.

146 By tracking fluorescently labeled chromosomal loci in thousands of cells throughout the en

147 ) are widely used to monitor the behavior of chromosomal loci in various systems.

148 track and analyze the movements of specific chromosomal loci in vivo using four-dimensional microsco

149 We identified several chromosomal loci in which many (sometimes more than 20)

150 IgH) translocations that involve 5 recurrent chromosomal loci, including 11q13 (cyclin D1), 6p21 (cyc

151 re U snRNPs but also associate with specific chromosomal loci, including gene clusters that encode U

152 shown to play diverse functions at multiple chromosomal loci, including telomeres.

153 antibody stained coiled bodies and specific chromosomal loci, including terminal granules, axial gra

154 dividual residuals, grouped or aggregated by chromosomal loci, indicate problematic samples and poten

155 Chromosomal loci involved in the recombination were foun

156 Loss of heterozygosity (LOH) at several chromosomal loci is a common feature of the malignant pr

157 The linear order of chromosomal loci is maintained in the axial cores, whose

158 eems likely that the cellular positioning of chromosomal loci is the outcome of the formation of two

159 Chromosomal loci jiggle in place between segregation eve

160 These systems can be encoded in specific chromosomal loci, known as defense islands, and in mobil

161 has been recognized previously and highlight chromosomal loci likely to contain oncogenes or tumor su

162 rential expression of six genes localized to chromosomal loci linked to forms of human hereditary myo

163 tem, which allows inducible amplification of chromosomal loci linked to the SV40 origin.

164 The first model is a dissection of chromosomal loci linked to the variance in airway respon

165 rays in vivo and brings spatial proximity of chromosomal loci marked with those arrays back to the wi

166 on of the R and C subunit genes to different chromosomal loci, mechanisms exist that coordinately reg

167 nduce H3K27Me2 deposits at both episomal and chromosomal loci, mediating gene silencing.

168 stance to quinolones was assigned to several chromosomal loci, mostly encoding transport systems that

169 H locus and a diverse but nonrandom array of chromosomal loci occur in most multiple myeloma (MM) tum

170 Sequence variation was determined in 10 chromosomal loci of 231 strains that predominantly origi

171 The chromosomal loci of both proviruses were determined in t

172 gy, similar genomic structure, and identical chromosomal loci of hKID, MIP, and AQP-2 suggest a MIP f

173 ociation of genotypes at plasmid-encoded and chromosomal loci of native Rhizobium, the nitrogen-fixin

174 As test cases, the chromosomal loci of the C. glabrata genes encoding amino

175 transgenic mouse lines, irrespective of the chromosomal loci of the insertion sites.

176 omatin structure by mapping contacts between chromosomal loci on a genome-wide scale.

177 the genome or is concentrated at just a few chromosomal loci or on plasmids.

178 (with the exception of some autosomal and X-chromosomal loci) or for the time of separation between

179 tion to the three known essential cis-acting chromosomal loci, origins, centromeres, and telomeres, w

180 chromatid cohesion and localize to the same chromosomal loci over the same cell cycle window.

181 r PRDM13 and by duplications in two distinct chromosomal loci, overlapping DNase I hypersensitive sit

182 induced dynamically between intra- or inter-chromosomal loci pairs, including the ones with very low

183 apping deletions are only available at a few chromosomal loci, partly due to drawbacks of existing me

184 recombination intermediates at interstitial chromosomal loci, perhaps through the noncrossover branc

185 achomatis, glgA and other plasmid-responsive chromosomal loci (PRCLs) were transcriptionally responsi

186 Nucleotide sequence analysis of chromosomal loci previously identified through insertion

187 Common fragile sites are chromosomal loci prone to breakage and rearrangement, hy

188 ontaneous, loss-of-function mutations at two chromosomal loci (pyrF and pyrE) enabled the first molec

189 Several chromosomal loci reflect potential adaptation to the inf

190 The present study identified the possible chromosomal loci regulating fear conditioning in BXD rec

191 y which this complex is targeted to specific chromosomal loci remains unknown.

192 Centromeres are chromosomal loci required for accurate segregation of si

193 Although 6 chromosomal loci responsible for autosomal dominant FDCM

194 evious studies of intraspecific variation at chromosomal loci, revealing that lacY has unusually low

195 rvation in the context of the defined murine chromosomal loci ROSA26 and TIGRE.

196 n frequencies and rates were measured at two chromosomal loci, rpoB and gyrA, and base substitution a

197 Four chromosomal loci showed suggestive evidence of linkage:

198 none of the ARD QTLs was homologous to human chromosomal loci so far implicated in age-related macula

199 Of thousands of chromosomal loci studied, the same locus had the stronge

200 our model using live-imaging measurements of chromosomal loci tagged with the MS2 and PP7 nascent RNA

201 ion initiation proteins assemble at specific chromosomal loci termed replication origins and direct l

202 Two distinct chromosomal loci, termed major (chromosome 3) and minor

203 ikely to undergo homologous recombination at chromosomal loci than parental cells.

204 Chromosomal loci that are enriched sources of microDNA i

205 s frequently contain fragments from multiple chromosomal loci that are fused to form new open reading

206 essed the stability of common fragile sites, chromosomal loci that are prone to breakage in cells und

207 Two S. flexneri chromosomal loci that are required for these processes w

208 kage studies have attempted only to identify chromosomal loci that cause or increase the risk of deve

209 Centromeres are chromosomal loci that direct segregation of the genome d

210 We screened chromosomal loci that encode known and predicted Tat-dep

211 eneral screen for tetracycline (Tet)-induced chromosomal loci that exhibited Tet-activated or Tet-rep

212 Centromeres are the chromosomal loci that facilitate segregation, and, in mo

213 9 genetic variants in 128 candidate genes or chromosomal loci that had at least three data sources.

214 nction and found mutations in three separate chromosomal loci that had this phenotype.

215 the disorder, the authors sought to identify chromosomal loci that harbor the genes influencing this

216 Cytogenetic studies have targeted candidate chromosomal loci that may be perturbed during cardiac li

217 covered one significant and three suggestive chromosomal loci that modulate tau phosphorylation.

218 We also identified several chromosomal loci that possess pagC-type genes without th

219 Centromeres are unique chromosomal loci that promote the assembly of kinetochor

220 We first identified chromosomal loci that were strongly associated with coro

221 DNA sequences of four chromosomal loci (the 16S rRNA gene, flaB, gyrB, and glp

222 microarrays identified a conserved group of chromosomal loci, the expression of which was similarly

223 r positional identity, are clustered in four chromosomal loci; the Hox genes are expressed in nested

224 introducing double-strand breaks at specific chromosomal loci, thereby increasing the recombination f

225 otobleaching show a rapid exchange of HSF at chromosomal loci under non-heat-shock conditions but a v

226 of matings among SWR and SJL inbred mice for chromosomal loci underlying tumor susceptibility.

227 fragments specific for three M. tuberculosis chromosomal loci used for the identification of W-Beijin

228 RSS or the insertion of signal circles into chromosomal loci via a V(D)J recombination-like mechanis

229 Amplification bias among eight chromosomal loci was less than 3-fold in contrast to 4-6

230 brain and transcribed from three independent chromosomal loci, we designed and validated different gu

231 To identify chromosomal loci, we performed a genome scan on 939 F(2)

232 Individual chromosomal loci were detected by expression of a protei

233 0 genetic variants in 754 different genes or chromosomal loci were eligible for inclusion.

234 A copy of bacteriophage HP1 and 46 further chromosomal loci were identified in the BPF but not in t

235 Multiple chromosomal loci were identified, including an insertion

236 The cellular positions of other chromosomal loci were in the wild-type order relative to

237 eous patterns of allelic loss at one or more chromosomal loci were observed in adjacent DCIS foci.

238 Nucleolus organizer regions (NORs) are chromosomal loci where hundreds of rRNA genes are cluste

239 olus organizer regions (NORs) are eukaryotic chromosomal loci where ribosomal RNA (rRNA) genes are cl

240 Centromeres, the chromosomal loci where spindle fibers attach during cell

241 ellite analysis for allelic loss at 10 major chromosomal loci which have been defined previously.

242 lative probabilities that different pairs of chromosomal loci will collide with one another in vegeta

243 GFP provides an improved system for studying chromosomal loci with a low pairing background.

244 transgene can be inserted into predetermined chromosomal loci with high efficiency (up to 40%), and f

245 nt types of mutations can be introduced into chromosomal loci with high fidelity and without genotoxi

246 can be efficiently mobilized from a range of chromosomal loci with high inducibility and low backgrou

247 Common fragile sites (CFSs) are chromosomal loci with inherent characteristics that make

248 This analysis revealed 3 chromosomal loci with multiple markers demonstrating evi

249 f AN and BMI loci revealed variants at three chromosomal loci with potential joint impact.

250 associated with at least 24 genes and seven chromosomal loci, with RET and EDNRB as its major genes.