ライフサイエンスコーパス: chromosome

1 bly to generate a 15.87 Mb assembly of the Y chromosome.

2 ding kinetics and affinity for the bacterial chromosome.

3 ences as they are homologous to the bovine Y chromosome.

4 cking the replication of Chr2, the secondary chromosome.

5 s on isolation and sequencing of the ovine Y chromosome.

6 ss, telomere-to-telomere assembly of a human chromosome.

7 arger than the main body of their respective chromosomes.

8 eveal a remarkable flexibility of interphase chromosomes.

9 ow they topologically interact in replicated chromosomes.

10 ed virus genome were comparable to the other chromosomes.

11 coverage depth between viruses and bacterial chromosomes.

12 rst telomere-to-telomere assemblies of whole chromosomes.

13 n size, of which 80% has been anchored to 13 chromosomes.

14 altered allelic imbalance patterns between X chromosomes.

15 sive histone methylation marks on eukaryotic chromosomes.

16 lative positions and movement of segregating chromosomes.

17 e associations between EBV episomes and host chromosomes.

18 retaining their orientation within 3 mum of chromosomes.

19 n loop that is distinct from the rest of the chromosomes.

20 encompassing vast regions of the mating-type chromosomes.

21 expression and DNAm levels in fetal brain at chromosomes 1 and 17 that were associated with ADHD and

22 ed a uniform pattern of insertion in all the chromosomes (1-5) without any preference for a particula

23 Phosphatase and tensin homolog located on chromosome 10 (PTEN) is a tumor suppressor gene and one

24 identify the parental origin of each copy of chromosome 10 in the materials using oligonucleotide-bas

25 We previously identified a 210 kb region on chromosome 11 (50.37-50.58 Mb, mm10) containing two prot

26 hived at the MRC Harwell Institute lacks the chromosome 11 modifier but instead harbors an ~37 Mb reg

27 as shown to carry a non-B6-derived region of chromosome 11 that protected against B6.Y (POS) sex reve

28 C8 was characterized by copy losses on chromosome 11, having also the lowest lymphocytic infilt

29 pter protein-coding gene, SHANK2, located on Chromosome 11q13, was disrupted by SVs in 14% of MYCN no

30 The strong conserved synteny between mouse chromosome 12aF1 and human chromosome 14q32 has enabled

31 g Intergenic Co-Induced transcript (NICI) on chromosome 12p13.31 which is regulated by hypoxia via HI

32 5 x 10(-8) at chromosome 6p24.1 in PHACTR1, chromosome 12q13.3 in LRP1, and in females-only, at chro

33 region containing non-B6-derived segments on chromosome 13.

34 tic leukaemia (including trisomy 12, loss of chromosomes 13q and 13q, and copy-neutral loss of hetero

35 eny between mouse chromosome 12aF1 and human chromosome 14q32 has enabled the use of mouse models to

36 POLG, located on nuclear chromosome 15, encodes the DNA polymerase gamma(Pol gamm

37 temporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) and can contribute to Alzheimer'

38 Trans-Omics for Precision Medicine Freeze 5 chromosome 17 haplotypes.

39 support for the role of genetic variants on chromosome 18q23 in regulating neural connectivity and a

40 ABBR2, RUFY3, and in an intergenic region on chromosome 2 replicated with the same direction of effec

41 with both length and weight were detected on chromosomes 2, 6 and 9 in multiple datasets.

42 exchange of DNA segments between homologous chromosomes(2).

43 ders, three significant associations, all on chromosome 20, were identified: rs4809706 (p-value: 2.8

44 duals with DS supports the identification of chromosome 21 genes that protect against cancer when ove

45 S, involving trisomy of all or part of human chromosome 21 or orthologous mouse genomic regions, are

46 ng gene for a human T1D associated region on chromosome 21.

47 reponderance of MLH1-less homologs involving chromosomes 21 or 22.

48 ome 12q13.3 in LRP1, and in females-only, at chromosome 21q22.11 near LINC00310.

49 condition caused by a hemizygous deletion on chromosome 22-is associated with an elevated risk of psy

50 hin the epidermal differentiation complex on chromosome 25; (2) within a feather, micro-regional spec

51 of the feather beta-keratin gene cluster on chromosome 27.

52 One region on chicken chromosome 28 contains the LRRTM4 gene.

53 .2 M SNP dataset, major QTLs were located on chromosomes 3 and 7 for Mn containing six candidate gene

54 including Rec114 and Mer2, which assemble on chromosomes(3-7) and are nearly universal in eukaryotes(

55 nant trait is conferred by the SSt1 locus on chromosome 3B.

56 e to Phytophthora crown rot were detected on chromosome 4 (QtlPC-C04), 11 (QtlPC-C11) and 14 (QtlPC-C

57 ssociations with PD, including cg06690548 on chromosome 4.

58 T1: dormancy cycling) is physically close on chromosome 5, but is distinct from DOG1.

59 m a conserved mouse pachytene piRNA locus on chromosome 6 (pi6) produce sperm with defects in capacit

60 C4 was represented by copy losses on chromosome 6, and had the highest number of metastatic s

61 C7 was represented by copy gains on chromosome 6, and had the highest upregulation in mitoch

62 ent at the major histocompatibility locus on chromosome 6, consistent with admixture-enabled selectio

63 entified associations with P < 5 x 10(-8) at chromosome 6p24.1 in PHACTR1, chromosome 12q13.3 in LRP1

64 al activity of HMAs in AML/MDS patients with chromosome 7 deletions and other monosomal karyotypes.Se

65 9B, and MYD88), losses of 17p13 and gains of chromosome 7, 11q12.3-q25, whereas DLBCL, NOS was predom

66 mapping revealed a single critical locus on chromosome 7.

67 ns (sensitivity = 0.94, specificity = 0.92), chromosome 7/10 aneuploidies (sensitivity = 0.90, specif

68 ) identified one novel genomic risk locus on chromosome 8 (lead SNP rs17052966, p = 4.53 x 10(-9), od

69 low DNA damage (low genomic scar score with chromosome 9 gain) and a superior outcome (100% overall

70 carriers (n=185) of a pathogenic mutation in chromosome 9 open reading frame 72 (C9orf72), progranuli

71 Sequence variation at chromosome 9p21.3 accounts for 20% of myocardial infarct

72 monstrated that Grh remains bound to mitotic chromosomes, a property shared with other pioneer factor

73 ocated at 11q23, are among the most frequent chromosome aberrations in acute myeloid leukemia (AML).

74 on mitotic chromosomes, defects in metaphase chromosome alignment, and elevated rates of chromosome m

75 ession of meiotic DSBs and crossovers at the chromosome and fine scales.

76 igned epigenetic states simultaneously along chromosomes and across cell types, precisely and compreh

77 iderable fraction of events involve multiple chromosomes and additional structural alterations.

78 assemble the 1.07 Gb genome sequence into 24 chromosomes and annotate 32,690 protein-coding genes.

79 Crossover frequency varies along chromosomes and crossover interference limits the coinci

80 egabase-pair scale haplotypes for individual chromosomes and identify 23 genomic regions that have re

81 alpha (TOP2A) is a core component of mitotic chromosomes and important for establishing mitotic chrom

82 ructure that assembles on the centromeres of chromosomes and provides the major attachment point for

83 Additional genomic analysis of sex chromosomes and sex-determining genes of other blow flie

84 ed progeny exhibited aneuploidy for multiple chromosomes and showed improved fertility with both pare

85 dients most important to align and segregate chromosomes and simultaneously assemble a bipolar spindl

86 ultiple modes of organization in prokaryotic chromosomes and yield insights into the evolution of euk

87 tly lower for segmental as compared to whole-chromosome aneuploidies (70.8% versus 97.18%, respective

88 ary to the prevalent meiotic origin of whole-chromosome aneuploidies, we show that sub-chromosomal ab

89 ing high-resolution descriptions of archaeal chromosome architectures, our data provide evidence of m

90 Neo-sex chromosomes are found in many taxa, but the forces drivi

91 However, even in nucleosome-free regions, chromosomes are highly decorated with associated protein

92 nactivation of ELP1 owing to somatic loss of chromosome arm 9q.

93 Using this technology, we identified which chromosome arm harbors the virus genome and obtained a h

94 functions require localization first to the chromosome arms and then centromeres in mitosis and subs

95 matological and solid cancers initially gain chromosome arms, while only solid cancers subsequently p

96 the general attenuation of transcription on chromosome arms, yet how the cell regulates nuclear and

97 tochore proximal centromeres and the core of chromosome arms.

98 patitis B virus (HBV) integration in the HCC chromosome, as a circulating biomarker for this clinical

99 trand break (DSB) introduced on the paternal chromosome at the EYS locus, which carries a frameshift

100 nment at metaphase plates as well as lagging chromosomes at anaphase.

101 ted by the three-dimensional organization of chromosomes at multiple levels, including compartments(1

102 physical basis for the folding of individual chromosomes at the nanoscale.

103 This could help protect chromosome attachments from transient forces while allow

104 Thus, the integration of chromosome-autonomous signaling and a nucleus-wide cross

105 between PRDM9-bound hotspots and the nascent chromosome axis through its component cohesin pREC8.

106 The chromosome-based genome analysis enabled us to establish

107 We develop a new X-chromosome-based maximum likelihood method for estimatin

108 d how mutations in these regions may lead to chromosome breakage syndromes in humans.

109 The chromosome breakage-fusion-bridge (BFB) cycle is a mutat

110 t as genes become silenced on the paternal X chromosome but linger in regions that escape X chromosom

111 leads to reduced spreading of roX2 on the X chromosome, but surprisingly also to relocalization to s

112 The healing of broken chromosomes by de novo telomere addition, while a normal

113 1-cohesin, which in mitosis is released from chromosomes by Wapl and separase.

114 ads to complete destruction of the bacterial chromosome, causing cell death prior to completion of ph

115 se from cells entering anaphase with lagging chromosomes, cellular mechanisms allowing late-segregati

116 participate in the two opposing functions of chromosome centering versus off-centering.

117 n Petunia inflata using bacterial artificial chromosome clones collectively containing all 17 SLF gen

118 exit the brushes collapse and Ki-67 promotes chromosome clustering.

119 The genome contains a large sex chromosome composed primarily of repetitive sequences wi

120 nuclear and chromatin-associated RNAs after chromosome condensation and nuclear envelope breakdown i

121 Condensin mediates chromosome condensation, which is essential for proper c

122 somes and important for establishing mitotic chromosome condensation.

123 d by chromatin structure, through the use of Chromosome Conformation Capture (3C), we identified sequ

124 Here we employ circular chromosome conformation capture (4C) analysis to identif

125 High-resolution chromosome conformation capture (Hi-C) analysis revealed

126 Chromosome conformation capture (Hi-C)(1,2) analysis has

127 ing an optimized single-cell high-throughput chromosome conformation capture (HiC) protocol(12,13), d

128 Recent advances in chromosome conformation capture experiments provide part

129 ld insights into the evolution of eukaryotic chromosome conformation.

130 Here, we use high-resolution chromosome-conformation-capture carbon-copy sequencing (

131 Chromosome conformational capture techniques such as Hi-

132 n increase in the size of individual mitotic chromosomes, consistent with de-condensation.

133 ble to predict experimentally observed inter-chromosome contacts.

134 Mammalian sex chromosomes contain multiple palindromic repeats across

135 It was demonstrated that the two chromosomes could be fused by deliberate genome engineer

136 g meiosis, which leads to crossovers between chromosomes critical for production of healthy offspring

137 se microfluidic systems to probe the growth, chromosome cycle and division mechanism of Bacillus subt

138 on, it is required for efficient HR-mediated chromosome damage repair.

139 on, in which dosage compensation occurs by X-chromosome dampening (XCD).

140 cumulation of SAF-A-RNA complexes on mitotic chromosomes, defects in metaphase chromosome alignment,

141 iviral chromatin silencing machinery for sex chromosome dosage compensation.

142 specific structure formed between homologous chromosomes during prophase that promotes DSB formation

143 idline structure located between segregating chromosomes) during anaphase.

144 ound to control mitotic spindle assembly and chromosome dynamics.

145 , pharmacological activation of the murine X chromosome-encoded receptor proteins Toll-like receptor

146 All new Ascaris somatic chromosome ends are recapped by de novo telomere healing

147 eic acid-protein complexes that help protect chromosome ends from DNA damage.

148 Telomeres protect chromosome ends from inappropriately activating the DNA

149 howed that ecDNAs preferentially tether near chromosome ends, where they re-integrate when DNA damage

150 res, the structures that protect the ends of chromosomes, eventually triggering cellular senescence.

151 rgene does not follow standard models of sex chromosome evolution, in which distinct evolutionary str

152 is enabled us to establish a model of spurge chromosome evolution, since the common paleopolyploid ev

153 The human X and Y chromosomes evolved from a pair of autosomes approximate

154 hich is consistent with the observation that chromosomes exhibit no unique fold.

155 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (

156 thods have provided remarkable insights into chromosome folding in vivo.

157 dying model bacteria has revealed aspects of chromosome folding that are applicable to many species.

158 odal chromosome number 33 instead of 2n = 20 chromosomes for Ornithodoros spp. ticks.

159 sovers must be properly placed along meiotic chromosomes for their accurate segregation.

160 atory regions and in telomers at the ends of chromosomes frequently contain tandem repeats of guanine

161 tic approaches, we evaluated influences of X chromosome genomic imprinting and hormone replacement th

162 randomly distributed across eight homologous chromosome groups.

163 hnique revealed that the telomere lengths of chromosomes harboring the integrated virus genome were c

164 We then show that the same chromosome has recently formed a neo-W that has spread t

165 The origin and early evolution of sex chromosomes have been hypothesized to involve the linkag

166 Unfortunately, chromosome identification has been a major challenge for

167 lot, quantitative polymerase chain reaction, chromosome immunoprecipitation, cell invasion, and lucif

168 Assessment of Y chromosome in NSCLC tissue microarrays and expression of

169 Sex chromosomes in cells have the potential to affect protei

170 maternal alleles were detected on 5 (of 12) chromosomes in high-fitness individuals of both reciproc

171 uce 3D maps of 36 genomic targets across six chromosomes in hundreds to thousands of cells, implying

172 Sex chromosomes in males of most eutherian mammals share onl

173 ange of genetic information between parental chromosomes in meiosis is an integral process for the cr

174 otubule spindle for the proper separation of chromosomes in mitosis and meiosis.

175 Genomic imprinting and X-chromosome inactivation (XCI) are classic epigenetic phe

176 early X chromosome inactivation-imprinted X chromosome inactivation prevents biallelic X silencing.

177 X-chromosome inactivation ratios were determined in genomi

178 protein 1 (SMCHD1) has been implicated in X-chromosome inactivation, imprinting, and DNA damage repa

179 he hypothesis that-in organisms with early X chromosome inactivation-imprinted X chromosome inactivat

180 romosome but linger in regions that escape X chromosome inactivation.

181 characterised by TP53 mutation and extensive chromosome instability (CIN).

182 one deleterious hot-spot mutation increased chromosome instability in a wild-type (WT) background, s

183 atid recombination events leading to rampant chromosome instability.

184 t these CNVs appear to arise via a dicentric chromosome intermediate and breakage-fusion-bridge cycle

185 ow that subtelomeric DNA replication, unlike chromosome-internal DNA replication, is sensitive to hyd

186 We find that the X chromosome is most enriched (2.5-fold) for inversions, o

187 he Escherichia coli SMC complex, MukBEF, the chromosome is organized as a series of loops around a th

188 The structural organization of chromosomes is a crucial feature that defines the functi

189 an nuclei, positioning of all 10 acrocentric chromosomes is dictated by nucleolar association.

190 crossover (CO) formation between homologous chromosomes is essential for faithful segregation.

191 The spatial configuration of chromosomes is essential to various cellular processes,

192 6.49%, indicating the success in the ovine Y chromosome isolation and the high quality of the Y chrom

193 Hi-C scaffolding produces highly contiguous, chromosome-length scaffolds, and we identify hundreds of

194 A chromosome-level genome assembly and annotation were est

195 Here, we report a chromosome-level genome assembly of L. japonica, compris

196 With long-read sequencing, we obtained chromosome-level genome sequences of four Clade 2 isolat

197 Children and adults with Philadelphia chromosome-like B cell acute lymphoblastic leukemia (Ph-

198 This perturbation impairs sister chromosome linkage, advances the timing of genome replic

199 analyzed transcriptional induction kinetics, chromosome looping, and enhancer RNA production to under

200 ually high expression located at the apex of chromosome loops protruding from the nuclear periphery i

201 e importance of the RadD protein for general chromosome maintenance and repair.

202 ta point to a role for TOP2A as a structural chromosome maintenance enzyme locking in condensation st

203 De novo mutations arising on the paternal chromosome make the largest known contribution to autism

204 shortest length assay (TeSLA), we show that chromosome mis-segregation due to imperfect DDR signalin

205 meiotic resumption in oocytes can result in chromosome missegregation and infertility.

206 chromosome alignment, and elevated rates of chromosome missegregation in anaphase.

207 orces while allowing spindle remodeling, and chromosome movements, over longer timescales.

208 s moubata cell line OME/CTVM22 had the modal chromosome number 33 instead of 2n = 20 chromosomes for

209 osomes resulting in 2n = 4x = 168, a revised chromosome number for A. digitata.

210 peciation (HHS), which involves no change in chromosome number, is an important mechanism of speciati

211 ll lines IRE/CTVM19 and IRE/CTVM20 had modal chromosome numbers 48, 23 and 48, respectively.

212 eir large genome sizes, complexity, and high chromosome numbers.

213 monstrate that under conditions of increased chromosome occupancy of the Escherichia coli SMC complex

214 genomic integrity and coding accuracy of the chromosomes of all living organisms.

215 ich was successfully applied to flow-sorting chromosomes of sheep, with a focus on isolation and sequ

216 We reveal that chromosomes of Sulfolobus archaea are organized into CID

217 gative correlation between the loss of the Y chromosome or linc-SPRY3-2/3/4 and overall survival.

218 pecies that present extensive differences in chromosome organization, phenotype, evolutionary history

219 ing oligonucleotide-based haplotype-specific chromosome painting.

220 Meiotic chromosome pairing between homoeologous chromosomes was

221 The genetic exchange between homologous chromosomes plays a major role in evolution by breaking

222 The three-dimensional structure of chromosomes plays an important role in gene expression r

223 vels-ranging from cell cycle organization to chromosome ploidy to replication mode and nature of the

224 Using our improved chromosome preparation technique, we were able to unequi

225 A chromosome Pv03 dirigent-like gene, involved in lignin b

226 ht and length were detected on a total of 18 chromosomes, reflecting the polygenic nature of growth.

227 1-5) without any preference for a particular chromosome region.

228 sely with distance to nuclear speckles, with chromosome regions of unusually high expression located

229 esults indicated that 68.90% of reads were Y chromosome-related sequences as they are homologous to t

230 er-counting mechanism partitions holocentric chromosomes relative to the crossover site, which ultima

231 The unpaired chromosome remains tethered to centrosomes by lengthenin

232 istinct chromosome subdomains during meiotic chromosome remodeling.

233 has examined mutations in genes involved in chromosome remodelling (for example, PBRM1, BAP1 and SET

234 Mitotic chromosome reorganization is marked by the general atten

235 A ring-shaped helicase unwinds DNA during chromosome replication in all organisms.

236 que, we were able to unequivocally count the chromosomes resulting in 2n = 4x = 168, a revised chromo

237 inetochore-fibers pivot around poles but not chromosomes, retaining their orientation within 3 mum of

238 ology have made the creation of high quality chromosome scale assemblies feasible and low cost.

239 Here, we report a chromosome-scale assembly of the T. sinense genome.

240 d laboratory and used the data to generate a chromosome-scale draft genome sequence.

241 Analysis of chromosome-scale mango genome sequences reveals photosyn

242 ons between single-molecule observations and chromosome-scale organization.

243 We demonstrate the importance of chromosome-scale phased assemblies for the discovery of

244 rates through genomic comparisons with a new chromosome-scale sequence of the invertebrate chordate a

245 derived cohesin mutations in the fidelity of chromosome segregation and aneuploidy.

246 Centromeres are essential for accurate chromosome segregation and are marked by centromere prot

247 gous recombination, which facilitates proper chromosome segregation and enables the reciprocal exchan

248 However, mutations in genes that control chromosome segregation are rare in human tumors as these

249 olar body and be fertilised, despite chaotic chromosome segregation at the first meiotic division.

250 nsitive and systematic quantitation of these chromosome segregation defects in cells undergoing mitos

251 Accurate chromosome segregation depends on the proper attachment

252 ite, which ultimately defines the pattern of chromosome segregation during meiosis I.

253 on of the mitotic spindle to ensure faithful chromosome segregation during mitosis, cell polarization

254 e expression, recombination, DNA repair, and chromosome segregation during mitosis.

255 condensation, which is essential for proper chromosome segregation during mitosis.

256 ells go through the complex process of equal chromosome segregation into daughter cells.

257 Proper chromosome segregation is essential for faithful cell di

258 a demonstrate that Cdc23 is required for the chromosome segregation through regulating the spindle as

259 r the study of polyploidy, genome stability, chromosome segregation, and bioenergy.

260 plex, involved in sister chromatid cohesion, chromosome segregation, and DNA repair.

261 induces centromere instability and abnormal chromosome segregation.

262 sist microtubule-mediated forces for mitotic chromosome segregation.

263 icrotubule nucleation, which is critical for chromosome segregation.

264 portant for accurate spindle positioning and chromosome separation.

265 some isolation and the high quality of the Y chromosome sequences.

266 ge by the MUS81 nuclease, leading to massive chromosome shattering.

267 induced super-Mendelian inheritance of the X-chromosome-shredding I-PpoI nuclease by coupling this to

268 m the PacBio sequencing platform and shorter chromosome size from the hybrid Oxford Nanopore-Illumina

269 Detailed analyses indicate striking chromosome-specific differences, with a preponderance of

270 KNL-1 and KNL-3 are required for preanaphase chromosome stretching, suggesting a role in pulling forc

271 e-fibers remain tightly coupled, restricting chromosome stretching.

272 an exciting era of discovery in the field of chromosome structure and nuclear organization.

273 Theory predicts that chromosome structures are fluid and can only be describe

274 O directly affects the formation of distinct chromosome subdomains during meiotic chromosome remodeli

275 been a major challenge for plants with small chromosomes, such as the Citrus species.

276 e encoding phosphatase and tensin homolog on chromosome ten (PTEN) are diagnosed with PTEN hamartoma

277 are located in different regions within the chromosome territories.

278 nomalies in their gene arrays coded on the X chromosome that result in significantly decreased spectr

279 re we show that RNA is evicted from prophase chromosomes through Aurora-B-dependent phosphorylation o

280 nuclear envelope assembly by the movement of chromosomes to a dense cluster.

281 ellular mechanisms allowing late-segregating chromosomes to rejoin daughter nuclei remain underexplor

282 us revealed that distances of the homologous chromosomes to the center of nucleus are almost the same

283 ified factors that revealed the link between chromosome translocation and peptidoglycan remodeling.

284 In Emu-Myc mice, which model the MYC/IGH chromosome translocation in Burkitt's lymphoma, homozygo

285 ence shows that DSBs are a primary source of chromosome translocations or deletions, making them a ma

286 a ring that encircled and cohered replicated chromosomes until its cleavage triggered the metaphase-t

287 ns for each parental genome (including the X chromosome), using an optimized single-cell high-through

288 f the significance of maternally inherited X chromosome variants in males with neurocognitive phenoty

289 n of fission yeast DNA inserted into a mouse chromosome was previously observed to adopt a mitotic or

290 A dominant karyotype with three aneuploid chromosomes was observed in 25 cells, while two differen

291 otic chromosome pairing between homoeologous chromosomes was reported in many nascent allopolyploids.

292 properties of gene-flanking regions on the X Chromosome, we find evidence that adaptive cis-regulator

293 a depth of coverage as low as 0.5x on the X-chromosome when contamination is below 25%.

294 d correct segregation of multiple homologous chromosomes, which can form complex multivalent configur

295 id de novo genome assembly that combines the chromosome-wide phasing and scaffolding capabilities of

296 Because small chromosomes would be at risk of missegregation if recomb

297 report that elevated expression of CXorf67 (chromosome X open reading frame 67), which frequently oc

298 In addition, the complete chromosome X, combined with the ultra-long nanopore data

299 The inactive X chromosome (Xi) is inherently susceptible to genomic abe

300 tegration of viral genomic DNA into the host chromosomes, yet remarkably, the timing and cellular loc