ライフサイエンスコーパス: chromosome arm

1 the centromere polymerized outward along the chromosome arm.

2 epaired to create at least one crossover per chromosome arm.

3 de I (GI) IDCs and ILCs often lost the whole chromosome arm.

4 number increase of a restricted region of a chromosome arm.

5 ned to a specific micronuclear chromosome or chromosome arm.

6 re amplified and used to map each clone to a chromosome arm.

7 igins, and map protein-binding sites along a chromosome arm.

8 es are entirely homozygous for a mutagenized chromosome arm.

9 ase in recombination rates along the average chromosome arm.

10 ial proximity of homologous sites throughout chromosome arms.

11 plicon pairs, even those located on opposing chromosome arms.

12 he centromere after it disassembles from the chromosome arms.

13 ity regions, and phased variants across full chromosome arms.

14 ub1 inactivation delocalizes cohesin-Sgo1 to chromosome arms.

15 sated by increased recombination activity in chromosome arms.

16 lus end-directed motor proteins that bind to chromosome arms.

17 able to map most of our H-probes to specific chromosome arms.

18 number of 2n = 44 but vary in the number of chromosome arms.

19 ated by PLK1, leading to SA2 dissociation at chromosome arms.

20 centromeric histone variant Cse4 to sites on chromosome arms.

21 y reduced from those of genes located on the chromosome arms.

22 g 181 SNP markers spanning two of five major chromosome arms.

23 spread in tandem to ectopic locations on the chromosome arms.

24 ed to unique and shared sites along polytene chromosome arms.

25 cohesin's alpha-kleisin subunit (Rec8) along chromosome arms.

26 ons over cohesin-associated regions (CAR) on chromosome arms.

27 -7 gets redistributed and upregulated on the chromosome arms.

28 encompasses multiple genetic loci and whole chromosome arms.

29 due to the retention of cohesin on undamaged chromosome arms.

30 eres interact before pairing commences along chromosome arms.

31 polar ejection forces by severing vertebrate chromosome arms.

32 absolute) positions within their respective chromosome arms.

33 with occasional alterations in 13 additional chromosome arms.

34 spread in tandem to ectopic locations on the chromosome arms.

35 es of sCNAs, including those spanning entire chromosome arms.

36 mplicons, or "firestorms," limited to single chromosome arms.

37 and frequently extending the length of whole chromosome arms.

38 acterization has often lagged behind that of chromosome arms.

39 the speed and force of the PEFs developed on chromosome arms.

40 he chromosome, between centromeres and along chromosome arms.

41 11,390 transcriptionally active sites on the chromosome arms.

42 ard higher densities in the distal halves of chromosome arms.

43 al halves than on the proximal halves of the chromosome arms.

44 association of cohesin with centromeres and chromosome arms.

45 h at centromeres and at discrete sites along chromosome arms.

46 n, provided by the cohesin complex along the chromosome arms.

47 e regions of high-mapped-EST density on both chromosome arms.

48 as many as 2694 genes, most of which are at chromosome arms.

49 ve in Ndc10p binding, are also present along chromosome arms.

50 nd the gradient of recombination rates along chromosome arms.

51 entric regions and causes reduced binding on chromosome arms.

52 ervention in order to reconstruct individual chromosome arms.

53 cruitment and activity of Aurora B kinase on chromosome arms.

54 separase and thereby destroys cohesion along chromosome arms.

55 e species occur within, rather than between, chromosome arms.

56 tochore proximal centromeres and the core of chromosome arms.

57 nished binding of the chromokinesin Kif4A to chromosome arms.

58 tified mega-haplotypes that encompass entire chromosome arms.

59 regions and a banded distribution along the chromosome arms.

60 is required for the juxtaposition of the two chromosome arms.

61 ion by promoting the loading of condensin on chromosome arms.

62 9 (H3K9me3)-modified chromatin sites on the chromosome arms.

63 to the postanaphase retention of cohesin on chromosome arms.

64 tends progressively along the full length of chromosome arms.

65 the cross section, balanced by the parallel chromosome arms.

66 n of variation at the most distal regions of chromosomes arms.

67 ts (S/I) is significantly lower than that of chromosome arms (1.62).

68 GFR amplification, loss of chromosome 10 and chromosome arm 10q, gain of chromosome 7, and hypermethy

69 n this sample set were uniparental disomy of chromosome arms 11p, 1q, 14q, and 15q and a novel area o

70 Gains of chromosome arm 12p and aneuploidy are nearly universal i

71 rable frequency within the telomere of mouse chromosome arm 14q.

72 d to a gene-rich region at the distal end of chromosome arm 1DS of bread wheat (Triticum aestivum L.)

73 n the basis of histology, diploid DNA index, chromosome arm 1p or 11q loss of heterozygosity (LOH) st

74 ed for the cannabis problems factor score on chromosome arm 1p.

75 during tumorigenesis, such as co-deletion of chromosome arms 1p and 19q (1p/19q codeletion) and mutat

76 ons in IDH, TP53, and ATRX and codeletion of chromosome arms 1p and 19q (1p/19q codeletion) have been

77 romoter, mutations in IDH, and codeletion of chromosome arms 1p and 19q (1p/19q codeletion).

78 d by IDH mutation but without co-deletion of chromosome arms 1p/19q, and further converged with acqui

79 20 paired families that involved one of the chromosome arms 1S, 1L, 4L, 5S, and 10L.

80 containing the tenacious glume gene Tg-D1 on chromosome arm 2 DS from Aegilops tauschii, the D genome

81 mapped to a sub-cM genetic interval on wheat chromosome arm 2BS, which includes a single collinear ge

82 Burs124 on chromosome arm 2L contains exons 1, 2, and 4, while burs

83 site (line 1198; insertion near the base of chromosome arm 2L) has been investigated in detail.

84 locations, which included the involvement of chromosome arms 2L, 3L, 5L, 6L, and 7L.

85 is located in the centric heterochromatin of chromosome arm 2R and is identical to a previously ident

86 lation genetic data from several loci across chromosome arm 2R in Drosophila simulans.

87 the PCNA and RpS18 genes at position 56F on chromosome arm 2R.

88 Most chromosome arms (35 out of 43) show a gradient of dwindl

89 ping, we identified several small regions on chromosome arms 3L and 3R that contribute to differences

90 Somatically acquired alterations at chromosome arms 3p and 11q are highly correlated with ac

91 nome, characterized by frequent deletions of chromosome arms 3p and 6q.

92 es of loss (at any one locus) were noted for chromosome arms 3p, 6q, 8p, 17q, 18p, 21q, and 22q (40-6

93 omas almost invariably carry extra copies of chromosome arm 3q, resulting in a gain of the human telo

94 The gene on chromosome arm 4HL encodes the previously identified pro

95 ct colinearity with the genetic map of wheat chromosome arm 5AL.

96 o ToxA is governed by the Tsn1 gene on wheat chromosome arm 5BL.

97 ensitivity/susceptibility gene identified on chromosome arm 5BS, which we designated as Snn3.

98 n to be recognized by the wheat gene Snn3 on chromosome arm 5BS.

99 s correlated with copy number alterations of chromosome arm 6p, suggesting a link between arm-level e

100 n SAMD9L, a tumor suppressor gene located on chromosome arm 7q.

101 enes that may mediate the effects of gain of chromosome arm 8q in human colon, liver, and pancreatic

102 One site near the centromere on chromosome arm 9L was identified by a majority of the co

103 ted across the genome and most prevalent for chromosome arms 9p, 17p, and 18q (>60%), sites of the kn

104 nactivation of ELP1 owing to somatic loss of chromosome arm 9q.

105 condensin mediates the axial contraction of chromosome arms, a process peaking later in anaphase.

106 the conservation of genes within homologous chromosome arms across species, the karyotypes of these

107 rigins are maintained at opposite poles with chromosome arms adjacent to each other, in an ori-ter co

108 homologs through recombinational exchange of chromosome arms after sister-chromatid cohesion is estab

109 Release of SSC along chromosome arms allows first a reductional segregation o

110 ents whose tumors had five or more predicted chromosome-arm alterations had 5.3 times higher odds of

111 knockdown results in a loss of Plk1 from the chromosome arm and an increase in highly disorganized "w

112 ated by Aurora B and that Aurora B-dependent chromosome arm and centromere localization is regulated

113 ics by measuring the histone turnover of the chromosome arm and the pericentromere during metaphase i

114 to identify the junction between the unique chromosome arm and the pericentromeric repeats.

115 nrepaired DSB leads to removal of the broken chromosome arm and to break-induced replication of the i

116 Cohesin binds near centromeres and chromosome arms and also close to telomeres, but its rol

117 some structure include duplication of entire chromosome arms and aneuploidy where chromosomes are dup

118 have distinct localizations, for example on chromosome arms and at kinetochores.

119 allelic homologous recombination (HR) along chromosome arms and between different ectopic locations.

120 Active genes in chromosome arms and centers have very similar histone ma

121 d histone modification were revealed between chromosome arms and centers, with similarly prominent di

122 omposition between the autosomes and between chromosome arms and centers.

123 e that the stepwise loss of cohesion between chromosome arms and centromeres is caused by local regul

124 However, the relative contributions of chromosome arms and centromeres/kinetochores in this pro

125 re highly continuous, include fully resolved chromosome arms and close persistent gaps in these refer

126 eading to release of acetylated cohesin from chromosome arms and loss of cohesion.

127 bring about the lateral interaction between chromosome arms and MTs in vitro to directly measure the

128 tumor cells maintain cohesion in mitosis at chromosome arms and telomeres.

129 on is not simply a consequence of compacting chromosome arms and that overall rDNA compaction is nece

130 cations showing their distribution among the chromosome arms and the 163 cytologically defined chromo

131 ell division, condensation and resolution of chromosome arms and the assembly of a functional kinetoc

132 opose that KLP3A acts on MTs associated with chromosome arms and the central spindle to organize ipMT

133 studies showed that the removal of SYN1 from chromosome arms and the centromeres is inhibited in the

134 hromosomes by controlling the positioning of chromosome arms and the dynamics of microtubules, respec

135 ct pathways dissociate cohesins, one acts on chromosome arms and the other on centromeres.

136 functions require localization first to the chromosome arms and then centromeres in mitosis and subs

137 slocations have been used to locate genes to chromosome arms and to study the dosage effects of speci

138 romosomes to generate embryos lacking entire chromosome arms and, thus, all zygotic gene products der

139 rosomes and kinetochores, 3) centrosomes and chromosome arms, and 4) centrosomes and cell cortex to u

140 Cohesin binds to discrete sites along chromosome arms, and is especially enriched surrounding

141 Most alien wheat lines carry whole chromosome arms, and it is notable that these lines show

142 965 singletons from 37 cDNA libraries on 146 chromosome, arm, and sub-arm aneuploid and deletion stoc

143 investigated in three scales: whole-genome, chromosome/arm, and focal regions.

144 Chromosome arm aneuploidies (CAAs) are pervasive in canc

145 r and orientation of sequence scaffolds into chromosome arm assemblies.

146 o be essential for cell division, only a few chromosome arm-associated motors have been described.

147 e essential for mitotic function, only a few chromosome arm--associated motors have been described.

148 inhibited dissociation of HP1alpha from the chromosome arms at the G2-M transition.

149 improper attachments by pushing mal-oriented chromosome arms away from spindle poles.

150 on, which is required to remove cohesin from chromosome arms but not centromeres.

151 in rsc mutants Mcd1p fails to associate with chromosome arms but still binds to centromeres, and that

152 one H3 at serine-10 (H3S10ph) by Aurora B on chromosome arms but, in Aurora B reactivation assays, re

153 f Drosophila genes have remained on the same chromosome arm, but within each arm gene order has been

154 chromatid cohesion and its dissolution along chromosome arms, but its protection at centromeric regio

155 etion of Plk1 rescues the cohesion along the chromosome arms, but not at the centromeres.

156 Cohesin association on chromosome arms, but not pericentromeric regions, is red

157 during mitosis most cohesin is stripped from chromosome arms by early prophase, while the remaining c

158 phosphorylation and removal of cohesin from chromosome arms by mitotic kinases, including Plk1, duri

159 ecessary for the removal of shugoshin-2 from chromosome arms by the Aurora B/C kinase, an event cruci

160 The pattern of exchanges along this chromosome arm can be represented by a counting model in

161 Chromosome arm cohesion was weakened, and the fraction o

162 ed" configuration, consistent with a loss of chromosome arm cohesion.

163 Instead, H3K9 methylation is enriched on chromosome arms, coincident with zones of elevated meiot

164 ssembles a coaxially paired channel for each chromosome arm comprised of one hexamer in each cell to

165 is centromere depolarization were homologous chromosome arms connected, as observed by the alignment

166 When RE is inactive, the two chromosome arms constitute separate domains inaccessible

167 0 of 26 Mb, a length that encompasses entire chromosome arms, contains 95% of expected single copy or

168 had a high frequency of whole chromosome or chromosome arm copy number alterations and were associat

169 Validation of the observed gene and chromosome arm copy number changes in a larger cohort of

170 xhibited poleward movement, long and tangled chromosome arms could not be segregated in anaphase.

171 gly, in the absence of the distal homologous chromosome arm dnTA is further increased, with nearly ha

172 We show that in mukB mutant cells, the two chromosome arms do not separate into distinct cell halve

173 suggesting that sequences elsewhere on these chromosome arms drive nucleolar association.

174 rise solely from the polymeric nature of the chromosome arms due to entropic interactions and nuclear

175 ble to visualize linear condensation of this chromosome arm during G2/M phase.

176 Cohesins are removed from chromosome arms during meiosis I but are maintained arou

177 ic heterochromatin, and also localizes along chromosome arms during meiosis.

178 cleoplasm during interphase and on condensed chromosome arms during mitosis.

179 an cells a good part of them dissociate from chromosome arms during mitotic prophase.

180 ated H3 T118ph occurs at pericentromeres and chromosome arms during prophase and is lost upon chromos

181 osomes during interphase and from neuroblast chromosome arms during prophase is blocked by translatio

182 d that WAPL-mediated removal of cohesin from chromosome arms during prophase is required for the diss

183 at facilitates cohesin's timely release from chromosome arms during prophase.

184 gins near the telomeres and progresses along chromosome arms during zygotene.

185 rge fraction of sequences in the euchromatic chromosome arms exhibits a heterochromatic chromatin sig

186 idate tumour suppressor genes located on the chromosome arms frequently deleted in oligodendrogliomas

187 construction of a completely synthetic 91-kb chromosome arm from Saccharomyces cerevisiae.

188 on lines (CS-B) with specific chromosomes or chromosome arms from G. barbadense L. substituted into G

189 per case), predominantly whole chromosome or chromosome arm gains and losses, whereas malignant melan

190 iptome profiling that allowed us to identify chromosome-arm gains and losses in 333 primary prostate

191 Using this technology, we identified which chromosome arm harbors the virus genome and obtained a h

192 ction to kinetochores and repulsion from the chromosome arms have to be proportional to each other.

193 ylated forms partitioned together within the chromosome arms; however, the mono- and dimethylated mod

194 t "wanderer" genes (present in a euchromatic chromosome arm in one species and on the dot chromosome

195 sed distinguishable amplifications in the 3q chromosome arm in squamous cell carcinomas and pointed t

196 prophase when most cohesin dissociates from chromosome arms in a process dependent on the regulatory

197 mally localized together along the metaphase chromosome arms in Aurora-B/AIM-1-depleted cells.

198 I hypothesize that autosomal chromosome arms in C. elegans undergo frequent local gen

199 this model by asking how newly evolving sex chromosome arms in Drosophila miranda acquired dosage co

200 tion rates are greatest in the middle of the chromosome arms in M. polymorpha like in most vascular p

201 s recruited to centromeres, kinetochores and chromosome arms in mid-meiosis I, and that MCAK depletio

202 his, the majority of cohesin is removed from chromosome arms in prophase and prometaphase in a manner

203 Removal of cohesin/Pol II from chromosome arms in prophase is important for accurate ch

204 aphase because of the loss of cohesion along chromosome arms in prophase.

205 presenting the telomeres of their respective chromosome arms in the P036 assay, were frequently ampli

206 no defect in pairing in embryos lacking any chromosome arm, indicating that no zygotic gene product

207 a common genetic alteration in ESCC and that chromosome arm instability is related to both telomere a

208 ngth in cancer cells was not associated with chromosome arm instability, telomere attrition in cancer

209 l crossover patterning processes, both along chromosome arms (interference and the centromere effect)

210 ormal chromosome 10 (Ab10) converts knobs on chromosome arms into neocentromeres, causing their prefe

211 We report that lack of crossover along one chromosome arm is associated with high-frequency occurre

212 urora B, although their association with the chromosome arm is not.

213 ge in oscillation amplitude and the amount a chromosome arm is shortened, we are able to map the dist

214 Here, we show that the binding of MCAK to chromosome arms is also regulated by Aurora B and that A

215 is enriched for repetitive sequences, and on chromosome arms is anticorrelated with centromeres.

216 original centromere-telomere polarity of the chromosome arms is maintained in the new chromosome.

217 Loss of cohesins from chromosome arms is necessary for homologous chromosomes

218 at the distribution of cohesins on mammalian chromosome arms is not driven by transcriptional activit

219 uited by Shugoshin (Sgo1), whereas SA2 along chromosome arms is phosphorylated by PLK1, leading to SA

220 MCAK association with chromosome arms is promoted by phosphorylation of T95 on

221 Execution of this screen on two chromosome arms led to the identification of mutations i

222 somatic feature of GCTs is highly recurrent chromosome arm level amplifications and reciprocal delet

223 ell cycle, we examined the DNA mutations and chromosome arm-level aneuploidy within tumours with low,

224 gration methods, assembly contiguity reached chromosome-arm-levels.

225 d exemplified by Caulobacter crescentus, the chromosome arms lie side-by-side, with the replication o

226 th recombination events spaced along a yeast chromosome arm, mapping trait variation, and then target

227 A similar type of polymeric structure on chromosome arms may mediate other chromosome-spindle int

228 Released kinetochores with attached chromosome arms moved poleward at rates at least two tim

229 ptions to the general rule of maintenance of chromosome arm (Muller element) association for most Dro

230 During mitosis, the longest chromosome arm must be shorter than half of the mitotic

231 microtubule (MT)-based motor proteins on the chromosome arms, namely chromokinesins, and (ii) the pol

232 r microirradiation to damage mitotic TIPs or chromosome arms (non-TIPs) in PtK2 kidney epithelial cel

233 icentromeres from either centromeres or from chromosome arms, nor did we identify an epigenetic signa

234 in Ambystoma is not strongly correlated with chromosome arm number.

235 phase and prometaphase, cohesin release from chromosome arms occurs under the control of Polo-like ki

236 st always found at a similar location on the chromosome arm of two different chromosome pairs, sugges

237 y 'octasomes', which are observed in vivo on chromosome arms only when Cse4 (yeast cenH3) is overprod

238 Depletion of hKID caused abnormal chromosome arm orientation, delayed chromosome congressi

239 imum one chiasma per chromosome (PC) and per chromosome arm (PA).

240 t of at least one chiasma per chromosome (or chromosome arm) per meiosis.

241 that gradients of recombination rates along chromosome arms promote more rapid rates of genome evolu

242 g around the chromosome center and dynein on chromosome arms provides a minus-end force.

243 al centromere and octamer-sized particles on chromosome arms, reconcile seemingly conflicting in vivo

244 s distributed over an approximately 1 microm chromosome arm region to determine positioning reproduci

245 with the large majority located on autosomal chromosome arms, regions characterized by higher genetic

246 loci is the outcome of the formation of two chromosome arms (replichores) by replication, followed b

247 ructures with the left (L) and the right (R) chromosome arms (replichores) on opposite cell halves an

248 Escherichia coli ("left-ori-right"), the two chromosome arms reside in separate cell halves, on eithe

249 equently, inhibition of Bub1 kinase impaired chromosome arm resolution but exerted only minor effects

250 Each autosomal chromosome arm responded to 2L trisomy similarly, but th

251 osity, phased haplotypes extending to entire chromosome arms, retrotransposon insertions and structur

252 mutants, following DNA damage in interphase, chromosome arm segregation fails due to an aberrant pers

253 gs reveal an essential role for telomeres in chromosome arm segregation.

254 nonessential in meiosis II for telomere and chromosome arm separation.

255 ent but appears dispensable for telomere and chromosome arm separation.

256 tachment but also by regulating telomere and chromosome arm separation.

257 We find that 26 of 39 autosomal chromosome arms show consistent large-scale copy-number

258 The distal regions of chromosome arms showed higher numbers of loci than the p

259 by loss of the CTD are primarily located in chromosome arms, similar to loci dependent CLSY1/2 or SH

260 entirely concentrated at kinetochores and on chromosome arms, sites where the APC/C, a target of Nup9

261 nt events, including 16-18 broad events near chromosome-arm size and 16-21 focal events.

262 horoidal chromosomal abnormalities including chromosome-arm-sized as well as focal events of amplific

263 On chromosome arms, small regions of chromatin locally inte

264 red tumor and cfDNA clustered in a number of chromosome arms, some of which harbor genes with oncogen

265 Chromosome arm-specific telomere lengths were measured b

266 les, leading to centromere rupture and whole-chromosome arm splitting.

267 cale phased haplotypes often spanning entire chromosome arms, structural variants (SVs), including sm

268 t the kinetochore, not at damage sites along chromosome arms, such that the APC is fully inhibited wi

269 The deletions usually involve whole chromosome arms, suggesting a t(1;19)(q10;p10).

270 an genes in the 1.5 Mb left and 2.3 Mb right chromosome arms, supporting the notion of the core versu

271 We applied SCRaMbLE to yeast synthetic chromosome arm synIXR (43 recombinase sites) and then us

272 A-based duplications and duplications within chromosome arms tend to produce longer duplication tract

273 At the level of the chromosome arm, the MSI-CIN- cancers had significantly f

274 seven showed heterogeneity for at least one chromosome arm; the most frequently heterogeneous chromo

275 ing the loading of cohesin specifically onto chromosome arms, thereby ensuring sister chromatid cohes

276 nsin also acts within the mostly euchromatic chromosome arms to suppress conditionally expressed gene

277 -shaped assemblies tether the left and right chromosome arms together while traveling from the origin

278 prometaphase chromosome movements by pushing chromosome arms toward the spindle equator.

279 tromere seeding was usually confined to long chromosome arms, transforming acrocentric chromosomes to

280 tal disorders, where isolated chromosomes or chromosome arms undergo massive local DNA breakage and r

281 n mechanisms, shed light on the dual role of chromosome arm volume, and compare well with experimenta

282 osome arm; the most frequently heterogeneous chromosome arm was 6p.

283 A molecular-ruler clone panel for each chromosome arm was developed and used for the design of

284 The distribution of ESTs along chromosome arms was nonrandom with EST clusters occurrin

285 on; however, the spreading of H3K9me2 to the chromosome arms was unaffected, strongly indicating that

286 ssing over, which can lead to LOH of a whole chromosome arm, was not observed, implying that there ar

287 of embryos deficient for each chromosome or chromosome arm, we were able to map most of our H-probes

288 Certain chromosome arms were critical for clinical outcome.

289 taining two homeologous segments on opposite chromosome arms were synthesized to increase their combi

290 Most cohesin dissociates from chromosome arms when the cell enters mitotic prophase, l

291 centromeres, as well as discrete sites along chromosome arms where transcription positions the comple

292 ntitative trait loci (QTL) located on the 2L chromosome arm, which is homologous to the 3R of D. mela

293 required for efficient cohesin removal from chromosome arms, which is a prerequisite for meiosis I c

294 berrations are extensive, encompassing whole chromosome arms, which makes identification of candidate

295 n was further promoted in the hypomethylated chromosome arms while it was inhibited in heterochromati

296 matological and solid cancers initially gain chromosome arms, while only solid cancers subsequently p

297 CRs including translocations and deletion of chromosome arms with associated de novo telomere additio

298 of low density in the proximal region of the chromosome arms, with the exception of 3DS and 3DL.

299 hyl H3K9 and HP1 to ectopic locations on the chromosome arms, with the most pronounced increase on th

300 the general attenuation of transcription on chromosome arms, yet how the cell regulates nuclear and