ライフサイエンスコーパス: chromosome break

1 mistakenly joined to an end from a different chromosome break.

2 ational repair of a programmed double-strand chromosome break.

3 ans, the COL6A4 gene has been disrupted by a chromosome break.

4 mology-directed repair of an I-Sce I-induced chromosome break.

5 s an end joining pathway (TMEJ) that repairs chromosome breaks.

6 +/-), Ku86(-/-), and DNA ligase IV(+/-)) for chromosome breaks.

7 als did not show significant accumulation of chromosome breaks.

8 om Ku86(-/-) mice have even higher levels of chromosome breaks.

9 are formed; two opposing nicks could lead to chromosome breaks.

10 ed with elevated uracil misincorporation and chromosome breaks.

11 acil into human DNA (4 million per cell) and chromosome breaks.

12 and display a high level of double-stranded chromosome breaks.

13 eplication timing, and replication-dependent chromosome breaks.

14 as well as the effect of altered mobility of chromosome breaks.

15 modifications and DNA repair in response to chromosome breaks.

16 eficient in PCNA unloading exhibit increased chromosome breaks.

17 A for its ability to reduce the frequency of chromosome breaks.

18 t and indirect acquisition of DNA damage and chromosome breaks.

19 is in suppressing the oncogenic potential of chromosome breaks.

20 ng replication fork integrity and preventing chromosome breaks.

21 (NHEJ) is essential for efficient repair of chromosome breaks.

22 ight on how eukaryotes utilize RNA to repair chromosome breaks.

23 s, as well as elevated levels of spontaneous chromosome breaks.

24 p 378 molecular markers, which detected 2312 chromosome breaks.

25 10 groups of RH plants reflecting different chromosome breaks.

26 complex that is central to the metabolism of chromosome breaks.

27 or the trend was .0348 for bleomycin-induced chromosome breaks, .0036 for BPDE-induced chromosome bre

28 patients display a high level of spontaneous chromosome breaks and an increased frequency of intragen

29 er, results in over-replication and leads to chromosome breaks and chromosome-wide, strand-biased occ

30 quadruplex (G4) stabilizing compounds induce chromosome breaks and cohesion defects which are strongl

31 rvival in a TP53-dependent manner and causes chromosome breaks and cohesion defects, independent of t

32 V3L are necessary for preventing spontaneous chromosome breaks and conferring resistance to UV radiat

33 age-fusion-bridge (BFB) cycle is a series of chromosome breaks and duplications that could lead to th

34 h partially re-replicated DNA that generates chromosome breaks and fusions [5].

35 nt mouse embryonic fibroblasts show elevated chromosome breaks and fusions after methyl methane sulfo

36 emonstrates that loss of p73 exacerbates the chromosome breaks and fusions observed in Mdm2(Tg) cells

37 ended FA phenotype, which included increased chromosome breaks and G2/M accumulation upon exposure to

38 centric chromosomes, chromatid exchanges and chromosome breaks and gaps.

39 the standard objective functions of obligate chromosome breaks and maximum likelihood, software for t

40 te hallmarks of genome instability including chromosome breaks and micronuclei.

41 Nonhomologous end joining (NHEJ) repairs chromosome breaks and must remain effective in the face

42 rved that irofulven induces the formation of chromosome breaks and radials and the activation and foc

43 LKB1 depletion induced the formation of chromosome breaks and radials.

44 teractions with recA and recB suggested that chromosome breaks and regressed forks accumulate in obgE

45 nce and a telomere, suggesting the dicentric chromosome breaks and repairs by recombination between d

46 ls use homology-dependent DNA repair to mend chromosome breaks and restore broken replication forks,

47 t of broken replication forks, the repair of chromosome breaks and the exchange of genetic material d

48 in G1 phase cells and their progression into chromosome breaks and translocations after cellular prol

49 rved at the cytogenetic level in the form of chromosome breaks and translocations and at the molecula

50 a method for the sensitive detection of rare chromosome breaks and translocations in interphase cells

51 t with high sensitivity and specificity rare chromosome breaks and translocations in the anaplastic l

52 ed chromosome breaks, .0036 for BPDE-induced chromosome breaks, and .0397 for BPDE-induced DNA damage

53 elevated rates of sister chromatid exchange, chromosome breaks, and CIN.

54 pathway is used in diverse species to repair chromosome breaks, and is defined in part by a requireme

55 Exogenous TGF-beta1 can suppress aneuploidy, chromosome breaks, and malignant transformation of the T

56 aks demonstrated hybridization adjoining the chromosome breaks, and occasionally the hybridization si

57 sitivity to cross-linking agents, diminishes chromosome breaks, and reverses defective homologous rec

58 omies and trisomies, to predict the sites of chromosome breaks, and to identify chromosomal aberratio

59 eplication timing, and replication-dependent chromosome breaks are determined primarily by the genomi

60 Importantly, caspase-independent chromosome breaks are observed in ATR(-/-) cells prior t

61 Here, we show that the observed spontaneous chromosome breaks are partially suppressed by reducing t

62 and inert chromosome ends, whereas internal chromosome breaks are potent stimulators of the DNA dama

63 NA-PKcs-deficient mice, in which G1-specific chromosome breaks are present, did not exhibit synergy w

64 We find CSR is reduced and that Igh locus chromosome breaks are reduced in the MMR/XRCC4 double-de

65 levated micronucleus frequency (a measure of chromosome breaks) are reversed by folate administration

66 These studies demonstrate that chromosome breaks arise frequently and that NHEJ is requ

67 However, chromosome breaks arising from biological sources often

68 restitution of radiation-induced interphase chromosome breaks as measured by premature chromosome co

69 telosome 2CcL of Ae. cylindrica only induced chromosome breaks at a low frequency.

70 s, reduced bivalents at diakinesis, numerous chromosome breaks at anaphase I, and that >33% of quarte

71 Consistent with this, chromosome breaks at RSSs increase markedly in the prese

72 s contribute to the accumulation of multiple chromosome breaks at the same moment in time.

73 ion potential is impacted by the location of chromosome breaks both within chromatin and within the n

74 Among the structures that can lead to chromosome breaks, breakage frequency is inversely corre

75 (TMEJ) has been implicated in the repair of chromosome breaks, but its cellular mechanism and role r

76 gest that HSRs and DMs both are initiated by chromosome breaks, but that cell types differ in how the

77 in response to ionizing radiation and repair chromosome breaks by homologous recombination at wild-ty

78 Repair of chromosome breaks by non-homologous end joining requires

79 n DNA polymerase mu, implicated in repair of chromosome breaks by nonhomologous end joining (NHEJ), h

80 and likely derived from imprecise repair of chromosome breaks by nonhomologous end-joining.

81 human and chicken over major parts of large chromosomes, broken by lineage-specific chromosome fusio

82 Double-strand chromosome breaks can arise in a number of ways, by ioni

83 se IV(+/-) mice have elevated frequencies of chromosome breaks compared with those from wild-type mic

84 abnormalities, including a preponderance of chromosome breaks, consistent with a defect in resolving

85 of the sources and the cellular responses to chromosome breaks contribute to the accumulation of mult

86 ly repaired, by single-strand annealing, the chromosome break created by liberating the fragment.

87 g a tobacco test system, we demonstrate that chromosome breaks created by zinc-finger nucleases great

88 s end joining (NHEJ) can effectively resolve chromosome breaks despite diverse end structures; howeve

89 ombination and the recombinational repair of chromosome breaks, DNA molecules become linked at points

90 ways, by ionizing radiation, by spontaneous chromosome breaks during DNA replication, or by the prog

91 t simple repeat sequences may be involved in chromosome breaks during evolution.

92 ng of the cell cycle occurs as the result of chromosome breaks during the first mitosis.

93 We also show that H2AX prevents chromosome breaks emanating from unrepaired RAG endonucl

94 Mitotic chromosome breaks encounter problems related to structur

95 ene in Chinese hamster cells is initiated by chromosome breaks, followed by bridge-breakage-fusion cy

96 Excision by transposons is associated with chromosome breaks; generally, host-cell proteins repair

97 The absence of evidence for chromosome breaks has led to speculation that infecting

98 omosome breaks; however, the source of these chromosome breaks has remained undefined.

99 d joining [NHEJ]) have increased spontaneous chromosome breaks; however, the source of these chromoso

100 distributed to the two sperm or resulted in chromosome breaks in 9S, occasionally producing new tran

101 omosome healing is a mechanism for repair of chromosome breaks in mammalian cells.

102 06 melanoma cases to derive graph models for chromosome breaks in melanoma.

103 The highly condensed chromosomes and chromosome breaks in mitotic cells of a Drosophila mutan

104 , perturbations in DNA replication result in chromosome breaks in regions termed "fragile sites." Usi

105 how impaired cell cycle arrest and increased chromosome breaks in response to ionizing radiation.

106 fragments suggests that the Gc genes induce chromosome breaks in the G1 phase prior to DNA synthesis

107 We show that most etoposide-induced chromosome breaks in the MLL locus and the overall genot

108 m homology directed repair of I-SceI-induced chromosome breaks in transfected CHO cells.

109 We found that dicentric chromosomes break in mitosis, and the broken fragments c

110 any micronutrients cause DNA damage, such as chromosome breaks, in cultured human cells or in vivo.

111 kout cells proceed to mitosis but do so with chromosome breaks, indicating that ATR provides a key ge

112 yonic fibroblasts were highly susceptible to chromosome breaks induced by the DNA replication inhibit

113 t gross PTEN mutations, involving intragenic chromosome breaks, inversions, deletions and micro copy

114 Translocations arise when an end of one chromosome break is mistakenly joined to an end from a d

115 We also discuss the important role for chromosome break location; how translocation potential i

116 can be used with the graph models including chromosome breaks, losses or gains of large DNA regions,

117 These chromosome breaks may be induced by mutagenic agents suc

118 We reasoned that spontaneous chromosome breaks may facilitate vector integration and

119 or rearrangements, (b) the high frequency of chromosome breaks measured after "fertilization" by the

120 tion of PrimPol induces phenotypes including chromosome breaks, micronuclei, and decreased survival a

121 A Ku-modulated two-ended versus one-ended chromosome break model is presented to explain these res

122 se the accumulation of uracil in DNA induces chromosome breaks, mutagenic lesions, we suggest that, a

123 We find that AID-dependent IgH locus chromosome breaks occur at high frequency in primary H2A

124 Pathologic chromosome breaks occur in human dividing cells ~10 time

125 to site-specific I-CreI endonuclease-induced chromosome breaks on cell-cycle progression in wild-type

126 ations or deletions through the formation of chromosome breaks or the dissociation of broken ends.

127 llele to prevent biallelic recombination and chromosome breaks or translocations.

128 ble chromosomal rearrangements produced by a chromosome-breaking pair of Ac and Ds elements situated

129 t that AAV vectors can integrate at existing chromosome breaks rather than causing breaks themselves,

130 Similar to mei-41, mus304 is required for chromosome break repair and for genomic stability.

131 ssion improved the kinetics of double-strand chromosome break repair and reduced DNA damage-related n

132 DNA end resection is critical for chromosome break repair by homologous recombination and

133 ian pol X family and reduces deletion during chromosome break repair by nonhomologous end joining (NH

134 me separation during anaphase, while another chromosome break repair pathway, non-homologous end join

135 l viability and genome stability by rescuing chromosome break repair when resection is misregulated o

136 Over half of the chromosome break sites are conserved between Ascaris and

137 In this study, we map chromosome break sites of dicentrics in Saccharomyces ce

138 on of MIR intermediates propagates secondary chromosome breaks that frequently cause additional rearr

139 ntified in yeast, is thought to generate the chromosome breaks that initiate meiotic recombination.

140 n cells are capable of efficiently repairing chromosome breaks through nonhomologous processes, the r

141 of RecA may stimulate annealing by allowing chromosome breaks to persist.

142 Repair of chromosome breaks was impaired in lymphocytes from affec

143 d G(2)/M arrest, gamma-H2AX persistence, and chromosome breaks were elevated in mre11-3 mutants.

144 Chromosome breaks were significantly increased in the hi

145 Chromosome breaks, which form spontaneously in bovine em

146 First, pairs of TEs cause chromosome breaks with frequencies inversely related to

147 eling with next generation sequencing to map chromosome breaks with improved sensitivity and resoluti

148 gestion, which digests DNA from the ends and chromosome breaks, with next-generation sequencing (NGS)

149 ck replication in an rrm3 mutant, leading to chromosome breaks within Ty1 sequences.