ライフサイエンスコーパス: chromosome condensation

1 uggesting that these cells undergo premature chromosome condensation.

2 ster-chromatid resolution and contributes to chromosome condensation.

3 ion of transcription is coupled with mitotic chromosome condensation.

4 ure of DNA and is consequently essential for chromosome condensation.

5 ay be the consequence of problems in mitotic chromosome condensation.

6 t overproduction of MukBEF results in marked chromosome condensation.

7 its of MukBEF play only an auxiliary role in chromosome condensation.

8 earlier meiosis-linked H3 S10ph involved in chromosome condensation.

9 tilis LrpC is a global regulator involved in chromosome condensation.

10 mark event in mitosis and is associated with chromosome condensation.

11 kpoint activation, chromosome stability, and chromosome condensation.

12 suggested role for this class of kinesins in chromosome condensation.

13 logy of the nuclear envelope and no signs of chromosome condensation.

14 tes correlated with timing of additional sex chromosome condensation.

15 int that negatively targets the APC prior to chromosome condensation.

16 that have been implicated in the process of chromosome condensation.

17 g that is associated with a delay in mitotic chromosome condensation.

18 nscription activity of the chromatin DNA and chromosome condensation.

19 delay in replication timing/delay in mitotic chromosome condensation.

20 stortion phenotype that differs from mitotic chromosome condensation.

21 somes and important for establishing mitotic chromosome condensation.

22 ocytes arrest at the stage of pachytene-like chromosome condensation.

23 in vitro, and both are required for mitotic chromosome condensation.

24 and Orc2, respectively, results in aberrant chromosome condensation.

25 MC interacting proteins that are involved in chromosome condensation.

26 l interplay between condensin and topo II in chromosome condensation.

27 human condensin complex required for mitotic chromosome condensation.

28 g meiosis I, although both processes require chromosome condensation.

29 d a mitotic block in HeLa cells and inhibits chromosome condensation.

30 units of the condensin complex essential for chromosome condensation.

31 role in DNA replication, transcription, and chromosome condensation.

32 efective X chromosome gene silencing and sex chromosome condensation.

33 related closely to chromatin remodeling and chromosome condensation.

34 ole for the 13S condensin complex in mitotic chromosome condensation.

35 complex that plays a central role in mitotic chromosome condensation.

36 n gene expression, chromatin remodeling, and chromosome condensation.

37 is, and Xenopus protein functions in mitotic chromosome condensation.

38 necessary for sister chromatid cohesion and chromosome condensation.

39 r functions, including nuclear integrity and chromosome condensation.

40 and an increased ability to induce premature chromosome condensation.

41 correlates closely with mitotic and meiotic chromosome condensation.

42 affect prophase timing or the initiation of chromosome condensation.

43 cence, suggesting that this process involves chromosome condensation.

44 h influence gene regulation, DNA repair, and chromosome condensation.

45 rientation, gene regulation, DNA repair, and chromosome condensation.

46 about the role of checkpoints in monitoring chromosome condensation.

47 in action and to propose a model for mitotic chromosome condensation.

48 rs delay both the initiation and the rate of chromosome condensation.

49 id entanglements and thereby ensure accurate chromosome condensation.

50 ial for proper sister chromatid cohesion and chromosome condensation.

51 /M, massive DNA damage, and improper mitotic chromosome condensation.

52 3 Ser 10 (H3S10p) drives gene activation and chromosome condensation.

53 N-terminal domain homologous to regulator of chromosome condensation 1 (RCC1), a guanine nucleotide e

54 ds on the regulated activity of regulator of chromosome condensation 1 (RCC1), Ran's nucleotide excha

55 in a divergent ortholog of the regulator of chromosome condensation 1 (RCC1), which is critical for

56 ine nucleotide exchange factor, regulator of chromosome condensation 1 (RCC1).

57 rity to those that characterize regulator of chromosome condensation 1 (RCC1, a guanine nucleotide ex

58 asite that contains a divergent regulator of chromosome condensation 1 (TgRCC1) that is required for

59 included cell cycle regulators (regulator of chromosome condensation 1 [RCC1], murine double minute 2

60 rminal methylation level of the regulator of chromosome condensation 1 and SET proteins in HCT116 cel

61 The binding of RCC1 (regulator of chromosome condensation 1) to chromatin is critical for

62 specific exchange factor, RCC1 (regulator of chromosome condensation 1), with chromatin.

63 entify two novel ISWI partners, regulator of chromosome condensation 1-like protein (RCCP) and phenyl

64 particular, condensin promotes both meiotic chromosome condensation after crossover recombination an

65 deletion mutant was defective in inhibiting chromosome condensation after Taxol treatment.

66 scriptional activation, DNA replication, and chromosome condensation all require changes in chromatin

67 e chromosome breaks as measured by premature chromosome condensation, an increased yield of acentric

68 ultiple mitotic defects, including disrupted chromosome condensation and abnormal spindles.

69 Here we have analyzed the dynamics of chromosome condensation and cell cycle progression in MC

70 N-terminal tail of histone H3 is crucial for chromosome condensation and cell-cycle progression durin

71 a minor effect on wapl-associated defects in chromosome condensation and centromere association.

72 Chromosome condensation and centrosome assembly is impai

73 Here we elucidate a role for dCAP-G in chromosome condensation and cohesion in Drosophila.

74 Aurora B also has additional functions in chromosome condensation and cohesion.

75 gy to the SMC family of proteins involved in chromosome condensation and cohesion.

76 Inhibitors that cause severe defects in chromosome condensation and congression on the metaphase

77 spects of nucleic acid metabolism, including chromosome condensation and daughter chromosome separati

78 ell line exhibits chromosome instability and chromosome condensation and decatenation defects similar

79 the Drosophila gene greatwall cause improper chromosome condensation and delay cell cycle progression

80 ring meiosis, micronuclei underwent abnormal chromosome condensation and failed to faithfully transmi

81 ion before segregation as a prerequisite for chromosome condensation and faithful genome separation.

82 SMC protein is required for chromosome condensation and for the faithful segregation

83 ent approaches, including membrane blebbing, chromosome condensation and fragmentation, DNA laddering

84 an interaction with Mcm2 is not required for chromosome condensation and heterochromatic silencing bu

85 ion domain is required both for coordinating chromosome condensation and human brain development.

86 m H3 in a number of key residues involved in chromosome condensation and in transcription, potentiall

87 e Protein, Survivin, and Borealin, regulates chromosome condensation and interaction between kinetoch

88 tion of histone H3 serine 10 correlates with chromosome condensation and is required for normal chrom

89 mplex also is known to have mitotic roles in chromosome condensation and is required in some systems

90 ) and displays mitotic phenotypes, including chromosome condensation and missegregation.

91 g factors that promote spindle organization, chromosome condensation and movement, and cytokinesis.

92 nuclear and chromatin-associated RNAs after chromosome condensation and nuclear envelope breakdown i

93 Chromosome condensation and nuclear envelope breakdown o

94 is in ncc-1 mutants, as indicated by lack of chromosome condensation and nuclear envelope breakdown.

95 eoid-associated proteins (NAPs) to assist in chromosome condensation and organization.

96 male and female sterile and show defects in chromosome condensation and pairing beginning at leptone

97 RAD21-like proteins play essential roles in chromosome condensation and pairing during both meiosis

98 ny processes, including the DNA replication, chromosome condensation and precisely regulated partitio

99 e breakdown (NEB) characterized by defective chromosome condensation and prometaphase arrest.

100 is also required for maintenance of meiotic chromosome condensation and proper spindle formation.

101 The formation of a tight bivalent involves chromosome condensation and restructuring around the cro

102 Both chromosome condensation and SC disassembly are likely cr

103 They function in chromosome condensation and segregation and in DNA repai

104 enzymes that perform important functions in chromosome condensation and segregation and in regulatin

105 , and overexpression of SRF rescues impaired chromosome condensation and segregation defects in aneup

106 translational modification required for both chromosome condensation and segregation during mitosis)

107 ance of topoisomerase II activity for proper chromosome condensation and segregation during mitosis.

108 s could be partially because of the delay in chromosome condensation and segregation during mitosis.

109 sin complex is a major molecular effector of chromosome condensation and segregation in diverse organ

110 Topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and m

111 conserved protein complex that helps mediate chromosome condensation and segregation in mitotic cells

112 ine 10 phosphorylation is causally linked to chromosome condensation and segregation in vivo and is r

113 the SMC protein family required for mitotic chromosome condensation and segregation in yeast and fro

114 that human KIF4A is a novel component of the chromosome condensation and segregation machinery functi

115 hat perform important intracellular roles in chromosome condensation and segregation, and in regulati

116 ve in DNA replication and also show abnormal chromosome condensation and segregation.

117 rEF-deficient E. coli cells are defective in chromosome condensation and segregation.

118 ction in G(2)-M to mediate processes such as chromosome condensation and segregation.

119 diverse functions in chromatin packaging and chromosome condensation and segregation.

120 essential to resolve strain imparted during chromosome condensation and segregation.

121 disrupted nuclear divisions with defects in chromosome condensation and segregation.

122 A replication stress, resulting in defective chromosome condensation and segregation.

123 ight foci accompanied sporulation-associated chromosome condensation and septation.

124 ce of chromosomes (SMC) proteins function in chromosome condensation and several other aspects of DNA

125 RAD21-like proteins, which are required for chromosome condensation and sister chromatid cohesion du

126 n complexes, condensin and cohesin, regulate chromosome condensation and sister chromatid cohesion, r

127 ssential gene in mitosis and is required for chromosome condensation and sister chromatid cohesion.

128 mbers of this protein family are involved in chromosome condensation and sister chromatid cohesion.

129 diate diverse chromosomal functions, such as chromosome condensation and sister chromatid cohesion.

130 Mutant brn1 cells show a defect in mitotic chromosome condensation and sister chromatid separation

131 In females, Brwd1 ablation caused severe chromosome condensation and structural defects associate

132 nd pericentromeric regions are essential for chromosome condensation and the fidelity of segregation.

133 Chromosome condensation and the global repression of gen

134 ht to be responsible for H3 phosphorylation, chromosome condensation and the subsequent segregation o

135 ion has been suggested to play roles in both chromosome condensation and transcriptional regulation.

136 that subsequently results in delayed mitotic chromosome condensation and ultimately in chromosomal in

137 topological simplification concomitant with chromosome 'condensation', and explains how enzymes a fe

138 Overexpression of SMC2, a gene necessary for chromosome condensation, and a homologue of the XCAP-E c

139 e maintenance including DNA damage, aberrant chromosome condensation, and crossover defects in mouse

140 ust be simultaneously maintained for correct chromosome condensation, and destroyed to complete siste

141 tosis-including phosphatidylserine exposure, chromosome condensation, and DNA fragmentation-when face

142 th broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair.

143 resumption of meiosis from prophase arrest, chromosome condensation, and kinetochore-microtubule att

144 g kinetics further varies with the extent of chromosome condensation, and more surprisingly, varies i

145 d genes associated with necrotic cell death, chromosome condensation, and mRNA processing.

146 from defective spindle formation, incomplete chromosome condensation, and premature mitotic exit lead

147 e coordination of sister chromatid cohesion, chromosome condensation, and recombination.

148 er until mitosis, condensin (Smc2+4) acts in chromosome condensation, and Smc5+6 performs currently e

149 plays an important role in an early stage of chromosome condensation, and that this function of topo

150 ith a mutant nuclear export sequence induced chromosome condensation, and thus overcame the CHFR chec

151 poorly understood cellular function-mitotic chromosome condensation-and experimentally validated the

152 Sister chromatid cohesion and chromosome condensation are both essential to the succes

153 Defects in DNA replication and chromosome condensation are common phenotypes in cancer

154 Cells in early stages of chromosome condensation are very vulnerable, and many st

155 hanism for microcephaly, implicating mitotic chromosome condensation as a key process ensuring mammal

156 associated with nuclear fusion and premature chromosome condensation as well as severe ATP depletion

157 This is in part because of a failure of chromosome condensation at mitosis that blocks normal an

158 Condensin mediates genome-wide chromosome condensation at the onset of mitosis and is c

159 a causal role for NCAPG2, we found abnormal chromosome condensation, augmented anaphase chromatin-br

160 In the presence of ZM, chromosome condensation began on schedule but then faile

161 eiosis entry (germinal vesicle breakdown and chromosome condensation), but are required for the compl

162 tion does not alter the onset or kinetics of chromosome condensation, but dramatically lengthens the

163 icated in both sister chromatid cohesion and chromosome condensation, but has never been observed dir

164 Remarkably, defective mitotic chromosome condensation by a condensin mutation, cut3-47

165 Furthermore, the chromosome condensation by MukB did not rescue the tempe

166 ABC-ATPases in DSBR, membrane transport, and chromosome condensation by SMC proteins.

167 demonstrate a critical role for RB in proper chromosome condensation, centromeric function, and chrom

168 east and animal systems, where they modulate chromosome condensation, chromatid separation, and dosag

169 delay in replication timing/delay in mitotic chromosome condensation chromosomes frequently display h

170 delay in replication timing/delay in mitotic chromosome condensation chromosomes that persist for as

171 undergo premeiotic DNA replication, meiotic chromosome condensation, cohesion, synapsis and recombin

172 t mitochondrial membrane potential collapse, chromosome condensation, cytochrome C release, and caspa

173 uggest that SET is an important regulator of chromosome condensation/decondensation and that disrupti

174 In condensin-depleted cells, a chromosome condensation defect was most striking at meio

175 In addition, chromosome condensation defects and mis-segregation were

176 scc2 phosphomimetic mutants exhibit dramatic chromosome condensation defects that are likely responsi

177 Chromosome condensation depends on the ability of ASF1a

178 velope breakdown, centrosome separation, and chromosome condensation did not take place.

179 delay in replication timing/delay in mitotic chromosome condensation display chromosomal instability.

180 ssociated with a subsequent delay in mitotic chromosome condensation (DMC).

181 ) that is associated with a delay in mitotic chromosome condensation (DMC).

182 plex required for sister chromatid cohesion, chromosome condensation, DNA damage repair, and regulati

183 ne phosphorylation influences transcription, chromosome condensation, DNA repair and apoptosis.

184 such as promoting sister chromatid cohesion, chromosome condensation, DNA repair, and transcriptional

185 thereby promoting sister chromatid cohesion, chromosome condensation, DNA repair, and transcriptional

186 y kinase domain as well as to a regulator of chromosome condensation domain (RCC1), which is also pre

187 artic/serine (DS)-domain, a regulator of the chromosome condensation domain and myc-type helix-loop-h

188 verse range of chromosome dynamics including chromosome condensation, dosage compensation and recombi

189 ltisubunit protein complex, is essential for chromosome condensation during cell division and functio

190 tions act as a critical intermediate step in chromosome condensation during cell division, transcript

191 1 to be mandatory for the premature onset of chromosome condensation during G2 and the maintenance of

192 Condensin complexes play vital roles in chromosome condensation during mitosis and meiosis.

193 Despite chromosome condensation during mitosis visible by micros

194 H1 ensures the proper temporal activation of chromosome condensation during mitosis, by acting as a n

195 ate cyclin-dependent kinase-1 activation and chromosome condensation during mitosis, with MCPH1 mutat

196 H3K9me3/S10ph), which has been implicated in chromosome condensation during mitosis.

197 dence that Pin1 has an important function in chromosome condensation during mitosis.

198 Ser10 phosphorylation, which correlates with chromosome condensation during mitosis.

199 y gene expression, chromatin remodeling, and chromosome condensation during mitosis.

200 To allow chromosome condensation during prophase, the connections

201 in fiber in living yeast cells, we show that chromosome condensation entails two temporally and mecha

202 he overproduction of MukB leads to a similar chromosome condensation, even in the absence of MukE and

203 ability of cells to progress past G2, global chromosome condensation failure, aberrant centrosome amp

204 ease complexes, as well as untimely onset of chromosome condensation followed by nuclear lamina disas

205 ls take much longer to transit the period of chromosome condensation from late G2 through nuclear env

206 bridization on cells in which stress-induced chromosome condensation had been induced, a procedure th

207 In vivo analysis of chromosome condensation has therefore revealed unsuspect

208 acterization of a mutation affecting mitotic chromosome condensation in a metazoan.

209 Rather, cells lacking Wapl display increased chromosome condensation in both interphase and mitosis.

210 int gene inactivated in human cancer, delays chromosome condensation in cells treated with microtubul

211 s is involved in the reinitiation of mitotic chromosome condensation in conjunction with phosphorylat

212 ylation at serine 28 is coupled with mitotic chromosome condensation in diverse mammalian cell lines.

213 nother major SMC protein complex that drives chromosome condensation in eukaryotic cells [11].

214 lack of H4K20me1 also resulted in defects in chromosome condensation in interphase nuclei.

215 eries regulating DNA methylation and mitotic chromosome condensation in mammalian cells.

216 In contrast, dCAP-G is essential for chromosome condensation in metaphase of single, unreplic

217 They reach their greatest compaction during chromosome condensation in mitosis.

218 ays in S-phase entry and metaphase exit) and chromosome condensation in mitosis.

219 The mitotic block occurs after chromosome condensation in prophase, before spindle asse

220 way that functions early in mitosis to delay chromosome condensation in response to microtubule poiso

221 cently, and its activation causes a delay in chromosome condensation in response to mitotic stress.

222 causes arrest of cells in prophase prior to chromosome condensation in response to spindle poisons.

223 as two activities that contribute to meiotic chromosome condensation in Saccharomyces cerevisiae.

224 conformation capture (Hi-C) to study mitotic chromosome condensation in the fission yeast Schizosacch

225 Although chromosome condensation in the yeast Saccharomyces cerev

226 acronuclei divide amitotically without overt chromosome condensation in this organism, suggesting tha

227 mplex termed condensin, required for mitotic chromosome condensation in vitro.

228 Barren is an essential protein required for chromosome condensation in vivo and that it is likely to

229 ble mechanism to explain the role of CspE in chromosome condensation in vivo by CspE binding to dista

230 ic acid-binding protein that plays a role in chromosome condensation in vivo.

231 in vitro and plays a central role in mitotic chromosome condensation in Xenopus egg cell-free extract

232 ubunit protein complex essential for mitotic chromosome condensation in Xenopus egg extracts.

233 improper disassembly of the SC and aberrant chromosome condensation, independently of the condensin

234 ound HP1 proteins does not detectably affect chromosome condensation into SAHF.

235 lude that the mechanism by which CHFR delays chromosome condensation involves inhibition of accumulat

236 Increased chromosome condensation is a common feature of cells iso

237 delay in replication timing/delay in mitotic chromosome condensation is associated with aneuploidy.

238 Mitotic chromosome condensation is chiefly driven by the condens

239 ction during a period of the cell cycle when chromosome condensation is established and maintained.

240 The mechanism of mitotic chromosome condensation is poorly understood, but even l

241 Chromosome condensation is required for the physical res

242 Our study demonstrates that chromosome condensation is uncoupled from cell cycle pro

243 nterdependent manner and coordinately direct chromosome condensation, kinetochore assembly, and chrom

244 nal effects of Drosophila mitotic mutants on chromosome condensation, kinetochore forces, and the pol

245 diphosphate kinase III protein, regulator of chromosome condensation-like protein, and amino acid per

246 he condensation of newly replicated DNA by a chromosome condensation machine located at the cell 1/4

247 iochemical and functional dissection of this chromosome condensation machinery.

248 nerally accepted model, we find that neither chromosome condensation nor chromosomal targeting of con

249 osphorylation of histone H3 that accompanies chromosome condensation nor condensin recruitment to mit

250 ults show that transcription interferes with chromosome condensation, not the reverse.

251 us in ago-2 embryos and there are defects in chromosome condensation, nuclear kinesis, and assembly o

252 NA interference (RNAi) partially rescues the chromosome condensation of H3.3 KD embryos and allows de

253 ication and centrosome proliferation without chromosome condensation or mitotic segregation.

254 letion has little effect on DNA replication, chromosome condensation or sister chromatid cohesion in

255 delay in replication timing/delay in mitotic chromosome condensation participate in frequent secondar

256 the MCPH1 N terminus leads to the premature chromosome condensation (PCC) phenotype.

257 recessive primary microcephaly and premature chromosome condensation (PCC) syndrome.

258 quency of G2-like cells displaying premature chromosome condensation (PCC).

259 delay in replication timing/delay in mitotic chromosome condensation phenotype and that this phenotyp

260 to SET and fail to fully rescue the abnormal chromosome condensation phenotype in Mcph1(-/-) mouse em

261 Condensin II knockdown rescued the abnormal chromosome condensation phenotype in SET-depleted cells.

262 delay in replication timing/delay in mitotic chromosome condensation phenotype occurs predominantly o

263 delay in replication timing/delay in mitotic chromosome condensation phenotype, and that the delay in

264 As chromosome condensation poses significant constraints to

265 The logic behind this phenomenon is that chromosome condensation prevents the activity of RNA pol

266 entry into mitosis, mitotic spindle defects, chromosome condensation problems, and a Chk2-dependent b

267 ion, mel-28(RNAi) embryos exhibit defects in chromosome condensation, pronuclear migration, kinetocho

268 tic protein highly homologous to the Xenopus chromosome condensation protein XCAP-G, designated hCAP-

269 ed by the chromatin-bound RCC1 (regulator of chromosome condensation) protein, which recruits Ran to

270 nce to PHMB has not been reported, selective chromosome condensation provides an unanticipated paradi

271 protein A), which displays four regulator of chromosome condensation (RCC) repeats, homologous to tho

272 Regulator of chromosome condensation (RCC1) binding to chromatin is h

273 Here, we report that regulator of chromosome condensation (RCC1) rapidly associates and di

274 Chromosome condensation, repetitive DNA stability, and D

275 ncluding DNA replication, transcription, and chromosome condensation, require enzymes that can regula

276 tranded DNA molecules that are essential for chromosome condensation, resolution, and segregation.

277 oteins have been demonstrated to function in chromosome condensation, segregation and global gene reg

278 tenance of Chromosomes) proteins function in chromosome condensation, segregation, and other aspects

279 mportant roles in sister chromatid cohesion, chromosome condensation, sex-chromosome dosage compensat

280 y of factors includes proteins important for chromosome condensation, signal transduction, and ion ch

281 omes) family members play essential roles in chromosome condensation, sister chromatid cohesion and D

282 Mitotic chromosome condensation, sister chromatid cohesion, and

283 s are large coiled-coil proteins involved in chromosome condensation, sister chromatid cohesion, and

284 rates, two condensin complexes ensure timely chromosome condensation, sister chromatid disentanglemen

285 ex protein INCENP is required in mitosis for chromosome condensation, spindle attachment and function

286 its establishment in S phase and adjusts the chromosome condensation status.

287 bacteria displayed cell division arrest and chromosome condensation, suggesting DNA binding as an al

288 lay, a failure to arrest in mitosis prior to chromosome condensation, supernumerary centrosomes, and

289 me translocations display a delay in mitotic chromosome condensation that is associated with a delay

290 PR-Set7 also showed a defect in chromosome condensation that was enhanced in the double

291 nger domain, we tested whether Chfr inhibits chromosome condensation through an ubiquitin (ubiquitin)

292 stem cells and orchestrates DNA replication, chromosome condensation, transcription, telomeric silenc

293 Cohesin also functions in chromosome condensation, transcriptional regulation, and

294 Defects in H1M dynamics and chromosome condensation were rescued by adding back wild

295 Strikingly, human condensin can induce chromosome condensation when added back into a Xenopus e

296 tracts prevented such extracts from inducing chromosome condensation when added to S phase nuclei.

297 matin was not observed in the early phase of chromosome condensation when histone H3 phosphorylation

298 Condensin mediates chromosome condensation, which is essential for proper c

299 has a role in heterochromatic silencing and chromosome condensation, while the analysis of a novel C

300 ndensin II participates in an early stage of chromosome condensation within the prophase nucleus.