ライフサイエンスコーパス: chromosome-wide

1 s that establish and maintain gene silencing chromosome wide.

2 levels are shifted towards the euploid state chromosome-wide.

3 chromosome in cis to mediate gene silencing chromosome-wide.

4 position of histone H3 lysine 27 methylation chromosome-wide.

5 chromosomes while regulating gene expression chromosome-wide.

6 diterranei, that spacers are indeed acquired chromosome-wide, although a preference for integrated mo

7 However, chromosome-wide analyses indicated that the vast majorit

8 Chromosome-wide analysis showed hypermethylation hotspot

9 Both chromosome-wide and genome-wide statistical tests were c

10 Biological processes that function chromosome-wide are not well understood.

11 However, in a chromosome-wide assay of nucleotide variation in natural

12 performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidne

13 landscape of AD, we performed an in-depth X-Chromosome-Wide Association Study (XWAS) in 115,841 AD c

14 We performed an X-chromosome-wide association study (XWAS) of PD risk by m

15 Here, we conducted an X-chromosome-wide association study (XWAS) using whole-gen

16 number and distribution are controlled on a chromosome-wide basis at the level of DNA double-strand

17 is hypothesis has not yet been assessed on a chromosome-wide basis.

18 human genome by generating high-resolution, chromosome-wide binding maps of human nucleoporin 93 (Nu

19 first instance of a monocentric species with chromosome-wide CenH3 deposition.

20 transitions such as those from localized to chromosome-wide centromeres between monocentric and holo

21 Moreover, ectopic Xic action resulted in chromosome-wide changes that are characteristic of the X

22 centromeres in the context of a role for the chromosome-wide chromatin landscape in conferring centro

23 st molecules per Xi and contrasting with the chromosome-wide "coat" observed by deep sequencing and c

24 etion smaller than 1 kb with high-resolution chromosome-wide comparative genomic hybridization.

25 Chromosome-wide comparisons revealed a difference betwee

26 strong interactions that may contribute to X Chromosome-wide condensation in C. elegans hermaphrodite

27 t is widespread throughout the genome, lacks chromosome-wide coordination, and varies between cell ty

28 A robust, chromosome-wide crossover control system limits chromoso

29 ow the SC might act as a conduit to regulate chromosome-wide crossover distribution.

30 whose molecular organization contributes to chromosome-wide crossover regulation.

31 Animal Y chromosomes have undergone chromosome-wide degeneration in response to a lack of re

32 lls exposed to ionizing radiation, exhibit a chromosome-wide delay in replication timing (DRT) that i

33 genes at five of five tested loci result in chromosome-wide delayed replication and chromosomal inst

34 ure of DCC mutants, permitting analysis when chromosome-wide domain architecture was disrupted but mo

35 mechanism underlying the recognition of the chromosome-wide domain in the male germline.

36 The mechanism by which the chromosome-wide domain is recognized and gene silencing

37 sis, the establishment of DDR signals on the chromosome-wide domain of the sex chromosomes is impaire

38 ylated histone H2AX (gammaH2AX), defines the chromosome-wide domain, initiates meiotic sex chromosome

39 many species have evolved epigenetic-based, chromosome-wide dosage compensation (DC) mechanisms.

40 the complex regulatory mechanisms underlying chromosome-wide dosage compensation can evolve.

41 Our results also suggest that chromosome-wide dosage compensation does not occur in th

42 unterbalanced by the evolution of functional chromosome-wide dosage compensation in this species, whi

43 s an intermediate step in the evolution of a chromosome-wide dosage compensation system in this speci

44 It is not known how long it takes for a chromosome-wide dosage compensation system to evolve.

45 lies, thus defining a minimal RNA domain for chromosome-wide dosage compensation.

46 omorphic ZW chromosomes in rattlesnakes lack chromosome-wide dosage compensation.

47 We show that chromosome-wide downregulation initiates the processes o

48 llenging owing to the small magnitude of the chromosome-wide effect and the lack of an in vitro syste

49 The chromosome-wide effects of ASAR6 map to the antisense st

50 higher-order chromosome structure to achieve chromosome-wide effects.

51 Drosophila testes reflects a balance between chromosome-wide epigenetic transcriptional suppression a

52 imately 8% of the mutants profiled exhibited chromosome-wide expression biases, leading to spurious c

53 ruitment elements on X (rex sites) to reduce chromosome-wide gene expression by half.

54 ion proteins to the new task of regulating X-chromosome-wide gene expression points to the evolutiona

55 ting higher-order chromosome structure and X-chromosome-wide gene expression.

56 One paradigm of chromosome-wide gene regulation is Caenorhabditis elegan

57 Thus, the potential for chromosome-wide gene regulation is not intrinsic to X-ch

58 reads to neighboring X regions to accomplish chromosome-wide gene repression.

59 We have quantified chromosome-wide gene silencing kinetics at the level of

60 (XCI), the long noncoding RNA Xist mediates chromosome-wide gene silencing of one X Chromosome in fe

61 3 enrichment, and the stepwise regulation of chromosome-wide gene silencing.

62 There was no evidence of chromosome-wide genomic rearrangements between the chrom

63 by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquitylation, signaling

64 Our algorithm, cnvHap, jointly learns a chromosome-wide haplotype model of CNVs and cluster-base

65 tes, from five parasite clones, establishing chromosome-wide haplotypes and a dense map with one poly

66 eotide (SNV), and structural variations into chromosome-wide haplotypes in humans has been challengin

67 netic variant coordinates, genetic maps, and chromosome-wide haplotypes.

68 Chromosome-wide inactivation is an epigenetic signature

69 Xist-induced Jarid2 recruitment occurs chromosome-wide independently of a functional PRC2 compl

70 Five DE QTL, significant at a chromosome wide level (alpha = 0.05), were detected, wit

71 FourME QTL significant at the chromosome wide level were detected, with three signific

72 At the chromosome-wide level, a total 122 QTNs were associated

73 toire, and show that biases are evident on a chromosome-wide level.

74 that is apparent at both the nucleosome and chromosome-wide levels, and discuss the emerging importa

75 on of the results both at single-loci and at chromosome-wide levels.

76 Thus, the X(D) in D. recens appears to be in chromosome-wide linkage disequilibrium and in the early

77 In contrast, no analogous X-chromosome-wide mechanism balances transcription between

78 Both species appear to lack a Z chromosome-wide mechanism of dosage compensation, becaus

79 dosage compensation, and the DCC acts via a chromosome-wide mechanism to balance transcription betwe

80 Gene-specific and chromosome-wide mechanisms of transcriptional regulation

81 In addition, chromosome-wide median expression ratios of the premeiot

82 ill this gap, we conducted a comprehensive X-chromosome-wide meta-analysis including more than 43,000

83 We found increases in genome- and chromosome-wide methylation levels in the CpG, CHG, and

84 Chromosome-wide methylation patterns were similar among

85 e of our method is that it provides a global chromosome-wide nominal control level to clustering, as

86 Chromosome-wide, nucleosomes were characterized by high

87 te that a button-based mechanism can lead to chromosome-wide pairing.

88 hypothesis is qualitatively consistent with chromosome-wide patterns of recombination suppression ex

89 es using HiFi are the current gold standard, chromosome-wide phasing accuracy is comparable when usin

90 id de novo genome assembly that combines the chromosome-wide phasing and scaffolding capabilities of

91 omatin composition during XCI and generate a chromosome-wide profile of Xi and Xa (active X) at nucle

92 PAR or autosomes, culminating in an elevated chromosome-wide rate.

93 to both X chromosomes of hermaphrodites for chromosome-wide reduction of gene expression.

94 throughout Xi, providing direct evidence for chromosome-wide regulation of "junk" DNA transcription.

95 ena, including sex determination, epigenetic chromosome-wide regulation of gene expression, the distr

96 ues by modulating signaling pathways through chromosome-wide regulation of gene expression.

97 ng the importance of primary DNA sequence in chromosome-wide regulation.

98 In mammals, chromosome-wide regulatory mechanisms ensure a balance o

99 me gene expression between the sexes through chromosome-wide regulatory mechanisms that function in o

100 enome of males and females has led to unique chromosome-wide regulatory mechanisms with significant a

101 expression in C. elegans is controlled by a chromosome-wide regulatory process called dosage compens

102 In C. elegans, an X-chromosome-wide regulatory process compensates for the d

103 L1 antisense RNA plays a functional role in chromosome-wide replication timing of mammalian chromoso

104 ontain discrete cis-acting loci that control chromosome-wide replication timing, mono-allelic express

105 Our results further demonstrate that the chromosome-wide repression imposed by MSCI is limited to

106 omosome dosage compensation in the soma, and chromosome-wide repression of X in the germline.

107 e complex that achieves gene-specific versus chromosome-wide repression.

108 strong gene-specific repressor and a weaker chromosome-wide repressor.

109 Within this chromosome-wide reproductive barrier, linkage mapping in

110 ng the effects of linkage and selection on a chromosome-wide scale.

111 ur of DSBs controlled by the other allele at chromosome-wide scales.

112 Subsequent chromosome-wide searches revealed homologs of Wengen (Wg

113 ic regulatory elements, rather than a simple chromosome-wide separation from transcription machinery,

114 n chromosome 3 in both populations, reaching chromosome-wide significance in both the sire- and dam-b

115 occurred on chromosome 1q21.3-q32.1, with a chromosome-wide significant likelihood ratio Z score (Z(

116 s (P <= 5 x 10(-)(8)) but identified seven X-chromosome-wide significant loci (P <= 1.6 x 10(-)(6)).

117 A total of 7 genome- and 13 chromosome-wide significant SNPs were associated with ph

118 Genome-wide or chromosome-wide significant SNPs were positioned exonic,

119 omosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-di

120 Sex chromosomes are uniquely subject to chromosome-wide silencing during male meiosis, and silen

121 tivation center and the molecular aspects of chromosome-wide silencing has greatly improved recently.

122 escape gene activation in an environment of chromosome-wide silencing in murine germ cells.

123 d in differentiated neural cells can trigger chromosome-wide silencing of chromosome 21 in Down syndr

124 romosome inactivation, acts in cis to induce chromosome-wide silencing.

125 d at serine 139 (gammaH2AX), which initiates chromosome-wide silencing.

126 spread along the inactive X (Xi) to initiate chromosome-wide silencing.

127 SNPNB can efficiently handle genome-wide or chromosome-wide SNP data analysis in a PC or a workstati

128 The second step is the MDC1-dependent chromosome-wide spreading of DDR factors to the entire c

129 plication and leads to chromosome breaks and chromosome-wide, strand-biased occurrence of RPA-bound s

130 We carried out a chromosome-wide survey of ASM across 16 human pluripoten

131 Different chromosome-wide systems that rebalance gene expression a

132 of origin firing, allowing us to reconstruct chromosome-wide timing profiles from an asynchronous cul

133 In Drosophila flies, chromosome-wide transcription is doubled from the single

134 sion of the entire chromosome, demonstrating chromosome-wide transcription manipulation without chang

135 ctive X chromosomes with XIST expression and chromosome-wide transcriptional dampening and initiated

136 this genus and can be directly attributed to chromosome-wide transcriptional regulation that de-mascu

137 iggers stable heterochromatin modifications, chromosome-wide transcriptional silencing and DNA methyl

138 ent spermatocytes are profoundly impaired in chromosome-wide transcriptional silencing of genes linke

139 In wild-type testes, this sex chromosome-wide transcriptional suppression is generally

140 died as a hallmark of imprinted genes, and a chromosome-wide version of this phenomenon occurs, in a

141 Here we present a chromosome-wide view of the structure and evolution of t

142 ely correlated with the other X-linked genes chromosome-wide, which is consistent with the XIST-media

143 We conclude that chromosome-wide X silencing continues from meiosis to th