ライフサイエンスコーパス: chronological

1 Reconstructing the chronological activity of each mutational signature, we

2 s defined as the differences between PHA and chronological age >5 years.

3 Differences between brain age and chronological age ("brain age gap") and between schizoph

4 lthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volum

5 t health risks among individuals of the same chronological age (CA).

6 e difference between DNA methylation age and chronological age (Deltaage) was calculated in four long

7 atched using two strategies: (a) matching by chronological age (human sample size: n = 562), or (b) m

8 clinical practice, we usually only consider chronological age (i.e., is the patient under or above 6

9 Concordance was high between all methods and chronological age (intraclass coefficient > 0.93).

10 hormones (outcomes) by reproductive age and chronological age (these age variables being the key exp

11 Neurodevelopmental assessments at chronological age 4.5 years included motor (Movement Ass

12 In this cohort, all chronological age 45 years, brainAGE was measured reliab

13 pigenetic changes have been used to estimate chronological age across the lifespan, and some studies

14 Many oncologists recognize that chronological age alone should not be the determinant wh

15 inAGE), a composite index of the gap between chronological age and a machine learning algorithm-estim

16 ividual's brainAGE is the difference between chronological age and age predicted from machine-learnin

17 widely used to identify differences between chronological age and biological age in health and disea

18 we did observe an association between donor chronological age and CGD (P=0.018).

19 d insulator regions that associate with both chronological age and gene expression levels.

20 methylation-based prediction of age exceeds chronological age and has been associated with increased

21 ential exists to modify the relation between chronological age and health.

22 ess than 1 year to over 3 years depending on chronological age and neurocognitive domain.

23 ase and myocardial infarction independent of chronological age and other well-known cardiovascular ri

24 of myeloma patients has focused primarily on chronological age and performance status as markers of f

25 The two groups were matched in chronological age and socioeconomic status.

26 rs, we observe a direct relationship between chronological age and temporal-rate tuning, unconfounded

27 the strongest correlation was found between chronological age and the formation of the germ of the s

28 productive hormones-LH, FSH, SHBG and AMH-by chronological age and time around the menopause (reprodu

29 HD or MI after multifactorial adjustment for chronological age and well-known cardiovascular risk fac

30 tion of IL-1beta is strongly associated with chronological age and with elevated IL-1beta transcripti

31 cognitive reserve, because even at the same chronological age and with the same number of illnesses,

32 t differences between transcriptomic age and chronological age are associated with biological feature

33 heir ovaries intact and examined at the same chronological age as the 19-month post-OVX group, estrog

34 ts, brain age was significantly greater than chronological age at baseline (+3.36 years) and progress

35 Recent studies have identified biomarkers of chronological age based on DNA methylation levels.

36 withhold from patients solely based on their chronological age but rather be based on the patient's p

37 tates the shift from thinking not just about chronological age but the health status and disease seve

38 ific decelerations up to 7 years in multiple chronological age clocks.

39 s were predicted to be twice as old as their chronological age compared to nonsmokers, whereas male s

40 d to be one and a half times as old as their chronological age compared to nonsmokers.

41 5.3% of predictions were within 24 months of chronological age compared with 91.6% for GPDL-BAAM (P =

42 Reproductive and chronological age contribute to changes in LH, FSH, SHBG

43 To understand how chronological age could impact the cryptococcal capsule

44 Individuals of the same chronological age exhibit disparate rates of biological

45 xample, the equivalent of almost 12 years of chronological age for those CMV seropositive.

46 en who were predicted to be older than their chronological age had twice as much violence exposure as

47 Although chronological age has been linked to changes in DNA meth

48 When controlling for chronological age in addition to mental age, there were

49 age and has been used to accurately estimate chronological age in children and adults.

50 ical approaches, have the ability to predict chronological age in healthy people.

51 as a highly accurate molecular correlate of chronological age in humans and other vertebrates.

52 al barrier dysfunction is more accurate than chronological age in identifying individual flies with s

53 Predicted age was 8 years greater than chronological age in individuals with schizophrenia in t

54 f amyloid-beta deposition by controlling for chronological age in our analyses.

55 fractional anisotropy for the prediction of chronological age in the same individuals.

56 differs from the rate of decline found with chronological age in this same group, which shows a stea

57 This investigation determines how chronological age influences the phenotypic characterist

58 Chronological age is a powerful epidemiologic risk facto

59 Increasing chronological age is the most significant risk factor fo

60 e using magnetic resonance imaging (MRI) and chronological age may serve as a biomarker for early-sta

61 discrepancies between CNN-predicted age and chronological age may serve as a physiological measure o

62 the molecular clock model, we use the known chronological age of each individual and fit the methyla

63 etic age", which is in contrast to the known chronological age of each individual.

64 because the fossil record is scarce and the chronological age of many key specimens remains uncertai

65 ls with MS regardless of disease duration or chronological age of the patient.

66 these processes will be proportional to the chronological age of the person.

67 were derived using a transformed version of chronological age on DNA methylation at specific sites u

68 With the effect of chronological age on white matter microstructure taken i

69 hondrial dysfunction are directly related to chronological age or are related to age-related changes

70 rationality compared with younger subjects, chronological age per se did not correlate with rational

71 rresponding CpGs and genes associated with a chronological age prediction model.

72 Thus, chronological age should not be considered to represent

73 t regression is trained on FI components for chronological age to generate the FRIGHT (Frailty Inferr

74 Deviations from chronological age towards an increased epigenetic age ha

75 All ratings were compared with chronological age using mean absolute error (MAE), and s

76 Young individuals of the same chronological age varied in their "biological aging" (de

77 difference between predicted "brain age" and chronological age was calculated to indicate brain-predi

78 Deviation from chronological age was defined as "delta age".

79 A correlation between the dental age and chronological age was established.

80 The mean epigenetic age and chronological age were 56.1 +/- 11.1 and 36.7 +/- 12.3 y

81 Predicted and chronological age were not different in BD.

82 ted age difference (brain-PAD: predicted age-chronological age) of the HCs and 318 patients with epil

83 e variance in PhenoAge (after accounting for chronological age).

84 education, household income, as well as sex, chronological age, and cognitive level of the participan

85 alitative transcriptional state of HSCs than chronological age, and transcriptional consequences of m

86 Normally BioAge increases with chronological age, but in AD it is prematurely expressed

87 system integrity that occurs with advancing chronological age, causing morbidity and disability.

88 me distribution change with replicative age, chronological age, cell differentiation state, and/or ov

89 by one's metabolome, as compared with one's chronological age, confers an increased risk on future c

90 ated the acceleration of GrimAge relative to chronological age, denoted "AgeAccelGrim" in combat trau

91 gnitive age based on performance relative to chronological age, indicated that 22q11DS participants l

92 Regardless of chronological age, intestinal barrier dysfunction predic

93 i.e. the dependence of the biological age on chronological age, is then a universal stochastic functi

94 erated biological aging when controlling for chronological age, lifestyle, health-related, and demogr

95 ascular disease and IADL impairment, but not chronological age, may be involved in the etiology of sh

96 ording to what they were trained to predict: chronological age, mortality, mitotic divisions, or telo

97 riable, after controlling for mental age and chronological age, only the Rivermead Picture Recognitio

98 A crude estimate showed that, at the same chronological age, social renters, for example, were nin

99 as associated with disability independent of chronological age, suggesting that biological aging may

100 f considering reproductive stage, not simply chronological age, to identify neuronal and cognitive ch

101 e elevated inflammatory environment, and not chronological age, was responsible for the decrease in S

102 of the triplets was 6-10 years younger than chronological age, while it was 9 years older in the off

103 His height was at the 25th percentile for chronological age, with decline from the 50th percentile

104 etailed and global mechanisms underlying the chronological age-based differences in the ability of CP

105 lower metabolic brain age-relative to their chronological age-compared with the male brain.

106 y help to distinguish between biological and chronological age-related change in arterial health in h

107 aortic age" was calculated from the baseline chronological age-stiffness relationship.

108 itting models included both reproductive and chronological age.

109 munities that develop in the human host with chronological age.

110 Children's Hospital of New York, to predict chronological age.

111 acceleration in biological age, relative to chronological age.

112 f women's reproductive stage, independent of chronological age.

113 detected in a published prediction model for chronological age.

114 pal responses, despite minimal difference in chronological age.

115 es is typically linearly combined to predict chronological age.

116 brains were estimated to be older than their chronological age.

117 genes that are differentially expressed with chronological age.

118 have delayed neurocognitive age relative to chronological age.

119 res used in a regression analysis to predict chronological age.

120 th in the general population, independent of chronological age.

121 lected individual differences over and above chronological age.

122 es relative to an average person of the same chronological age.

123 etter predictors of the health outcomes than chronological age.

124 oA, but does add predictive power to that of chronological age.

125 brain-derived age estimate is close to their chronological age.

126 re correlated with cognitive performance and chronological age.

127 tent correlation between DNA methylation and chronological age.

128 s significantly among individuals of similar chronological age.

129 ealth Timeline) clock, a strong predictor of chronological age.

130 ator of biological age, as opposed to merely chronological age.

131 ge of fetal retina is highly correlated with chronological age.

132 edict neurological disease risk than patient chronological age.

133 of variance in PhenoAge after adjustment for chronological age.

134 scribes a person's immune status better than chronological age.

135 and female samples and were correlated with chronological age.

136 on (DNAm) age and pubertal stage relative to chronological age.

137 n age (0 indicates a brain age equivalent to chronological age; positive and negative values represen

138 identify functional interactions among yeast chronological ageing genes, we conducted a haploproficie

139 ageing may be superimposed on the effects of chronological ageing in atherosclerosis.

140 espectively, were positively correlated with chronological ages (r = 0.88/0.91), elevated in bipolar

141 we test whether differences between people's chronological ages and estimated ages, DNA methylation a

142 k with differences between the predicted and chronological ages for the second group identified signi

143 by the sizes of the lesion or the patients' chronological ages.

144 reducing yeast histone proteins accelerates chronological aging and increasing histone supply extend

145 skin morphology and function associated with chronological aging and photoaging.

146 ARCH is associated not just with chronological aging but also with several other, age-rel

147 ng age-associated systemic inflammation from chronological aging by using transgenic Nfkb1KO mice, we

148 At baseline, a decade of chronological aging correlated with a decrease in Ao-A,

149 Chronological aging independent of biological markers of

150 c cancer increases with age, suggesting that chronological aging is a significant risk factor for thi

151 stability using the Saccharomyces cerevisiae chronological aging model.

152 We conclude that chronological aging of NHFs contributes to PDAC progress

153 In this study, we investigated whether the chronological aging of normal human fibroblasts (NHFs),

154 current study is to understand the impact of chronological aging on mitochondrial function in respons

155 mic structures that change dramatically with chronological aging under prolonged stationary-phase gro

156 Remarkably, chronological aging under stationary-phase growth condit

157 d-type mice in response to hypoxia or during chronological aging, fission arrest may represent fundam

158 to the FMP: a linear model, consistent with chronological aging, or a piecewise linear model, consis

159 Using the yeast model, in conditions of chronological aging, we concluded that cells expressing

160 Intravenous IL-15 treatment rescued chronological aging-induced healing defects and restored

161 tions that uncouple physiological aging from chronological aging.

162 lecting the disparity between biological and chronological aging.

163 onsistent with a linear model, indicative of chronological aging.

164 ortant role during myogenic differentiation, chronological alterations in DNA methylation and gene ex

165 Chronological analyses have attributed megafaunal extinc

166 tralia are highly contested because standard chronological analyses rely on scarce data of varying qu

167 the Grotte du Renne through biomolecular and chronological analysis.

168 Here we show, using stratigraphic, chronological and archaeological data, that a fragment o

169 First published in 2016, predictors of chronological and biological age developed using deep le

170 sites in the human genome are predictive of chronological and biological age.

171 A series of chronological and biological aging parameters in XRCC1 h

172 rstanding of the immune response to TBI in a chronological and compartment-based manner, highlighting

173 The two factors, chronological and developmental time, are closely entang

174 Chronological and endocrinological aging are associated

175 rovide insights into the complex dynamics of chronological and endocrinological bioenergetic aging in

176 mean predicted age difference (PAD) between chronological and estimated brain age of 4.66 years (+/-

177 Our data fill a chronological and geographical gap that is relevant for

178 o unvaccinated mothers, after adjustment for chronological and gestational age and receipt of diphthe

179 d, researchers have been able to disentangle chronological and ovarian aging with respect to CVD risk

180 We define individuals' differences in chronological and predicted structural "brain age," and

181 astocyst-derived HSCs, despite the extensive chronological and proliferative age of the former.

182 Systematic analysis reveals characteristic chronological and regional differences in reported globa

183 Chronological approaches revealing human presences in th

184 This chronological arc establishes that bison first entered N

185 iate the two forms of aging, replicative and chronological, are highly conserved.

186 Current chronological, behavioral, and biological models of this

187 hic art evolution and challenged traditional chronological benchmarks.

188 tudies have revealed a disparity between the chronological brain age and the 'data-driven' brain age

189 We showed that the gap between predicted and chronological brain age is a biomarker, complimentary to

190 Chronological by publication of the earliest solved stru

191 is review gives a comprehensive and strictly chronological (by date of first online publication) trea

192 The purpose of this study was to investigate chronological changes after radiofrequency-renal denerva

193 We systemically analysed chronological changes in biochemical and physiological s

194 This study presents a unique chronological characterization of SNV infection and prov

195 Chronological ChIP assays demonstrated the occupancy of

196 The tight chronological clustering of the eight kill localities at

197 The results provide chronological context for the early occupation of Europe

198 local farming groups within their different chronological contexts.

199 coherent isotope cycles that provide annual chronological control and paleoclimate information.

200 od is reasonably well-known, relatively poor chronological control has precluded precise alignment of

201 0 radiocarbon and luminescence dates provide chronological control, and genetic, palaeoenvironmental

202 We gathered chronological data on the implementation of NPIs for sev

203 ve sea level curve adds valuable spatial and chronological data to the relative sea level record of N

204 using stratigraphic, paleoenvironmental, and chronological data, AH 3 is ascribed to the onset of Gre

205 Archaeological evidence and chronological dating shows the site was well utilized as

206 In this review, we present a chronological description of the results of the studies

207 alis constant KM of (67 +/- 13)muM while the chronological development of the relative transport coef

208 red in parallel across southwest Asia, or if chronological differences existed between regions.

209 The geographical and chronological emergence of Bd at these localities also i

210 However, knowledge of chronological events in prion spread during early infect

211 Our results show the chronological events leading to cell death and the tempo

212 To investigate the chronological events of early prion pathogenesis, we exp

213 these new age constraints provide compelling chronological evidence for the significance of the combi

214 Here we report new stratigraphic and chronological evidence from Liang Bua that does not supp

215 nged regions, this information can provide a chronological examination of the selective events that h

216 days generates cell populations that develop chronological expression of marker genes of non-neural e

217 We provide a new, high-resolution chronological framework for this key agricultural develo

218 ge modelling approach, and use the resulting chronological framework to elucidate spatiotemporal patt

219 e "precolonization" theory, accord it a firm chronological framework, and demonstrate that the quest

220 portant to construct a detailed and reliable chronological framework.

221 nce and the inability to establish a precise chronological framework.

222 A chronological gap of over 3,000 years separates the MP o

223 We find major chronological gaps between periods of high evolutionary

224 The chronological improvements enabled by the radiocarbon "e

225 iods of climatic warming within the LGM, but chronological information from many of these sites are c

226 of yeast SNF1 in mediating the extension of chronological life span (CLS) by caloric restriction (CR

227 quantitative trait loci (QTLs) that control chronological life span (CLS) in calorie-rich and calori

228 h medium, which extends both replicative and chronological life span (CLS).

229 We sought to identify pathways that regulate chronological life span by controlling intracellular his

230 onse to inositol starvation is correlated to chronological life span extension but is Sir2p-independe

231 The shortened chronological life span of the pah1Delta mutant along wi

232 This led us to suggest that chronological life span, and not cell type, determines t

233 uently, the pah1Delta mutant had a shortened chronological life span.

234 nsitivity to oxidative stress, and decreased chronological life span.

235 o promote histone gene expression and extend chronological life span.

236 tone gene transcription and maintains normal chronological life span.

237 aging and increasing histone supply extends chronological life span.

238 Studies of replicative and chronological lifespan in Saccharomyces cerevisiae have

239 Chronological lifespan in this species is defined as the

240 We find that a reduction in Pol III extends chronological lifespan in yeast and organismal lifespan

241 y plays an important role in extending yeast chronological lifespan under calorie-unrestricted condit

242 P), and that deletion of these genes reduces chronological lifespan, impairs transcriptional reprogra

243 vival of yeast in stationary phase, known as chronological lifespan, led to the identification of mol

244 mands of promoting cell growth and extending chronological lifespan.

245 conditions that shortened or extended yeast chronological lifespan.

246 hase, canonically defined as an extension of chronological lifespan.

247 efects in quiescence entry and shortening of chronological lifespan.

248 ls were advantageous, resulting in prolonged chronological lifespan.

249 es in nonmammalian species that exhibit long chronological lifespans.

250 This finding provides a high-precision chronological link to mid-latitude terrestrial and marin

251 nsufficiency in mammals has little effect on chronological longevity and many key biological markers

252 rough this protocol, they express genes in a chronological manner similar to that described during in

253 onal regulation mechanisms was captured in a chronological model of the JA gene regulatory network.

254 Bayesian chronological modeling was applied to 354 dates from 23

255 ate specific cellular processes in a defined chronological order and describe the role of two key sec

256 The different descriptions are presented in chronological order and their relevance is discussed.

257 al methods has been introduced, which in the chronological order of development are 2D sum-frequency-

258 g of enrollment, 4 groups were identified in chronological order of recruitment: years 1983 to 1989,

259 me-series data contain information about the chronological order of regulatory events and genetics da

260 nary interface of chemistry and biology in a chronological order to show the evolution of my research

261 We provide a detailed chronological order to these changes, giving an overview

262 Cs) generate various cell types in a precise chronological order, but how exactly cone photoreceptor

263 In chronological order, I have a B.A. in Scandinavian langu

264 s tended to recall the events of the walk in chronological order, the order in which patients recalle

265 s reported the events of the walk in correct chronological order, whereas the order in which patients

266 se is fully induced and (ii) are executed in chronological order, with TLS coming first, followed by

267 c potentials, and chemical compound space in chronological order.

268 patterning to generate diverse neurons in a chronological order.

269 ss involves three elementary steps, i.e., by chronological order: Myers-Saito cycloaromatization (M-S

270 In particular, the duration of chronological overlap between the two groups is much deb

271 treated by laparoscopic TME in the immediate chronological period.

272 ations and permit fuller exploitation of the chronological potential of the CI tephra marker.

273 d an approach from graph theory to establish chronological precedence in the acquisition of different

274 The chronological precision and high resolution of our recor

275 Methylation450 BeadChip array, we obtained a chronological profile of the genome-wide DNA methylation

276 , which is clearly comparable in spatial and chronological profile to the mouse CL.

277 e space extracted by this network revealed a chronological progression of morphological changes that

278 ted tissue was performed to characterize the chronological progression of the radiofrequency lesions.

279 irus, to the conserved stalk, and to a broad chronological range of H3s consistent with original anti

280 nlike blood and urine samples, it contains a chronological record of medication use.

281 The data indicate, therefore, that chronological resistance arterial aging is a prominent f

282 d nitrogen isotopes and an increasingly high chronological resolution obtained on a large sample of d

283 from Taiwan ~4000 years ago (4 ka), but the chronological resolution of existing control-region data

284 geological context of hominin fossils, poor chronological resolution, and a lack of well-preserved e

285 Next, we present a thorough chronological review of state-of-the-art fMRI studies th

286 ssociated with modern maize breeding through chronological sampling of 350 elite inbred lines represe

287 We suggest a chronological scheme of cognitive impairments along the

288 rosstalk signaling), which follows a similar chronological sequence and R-Smad specificity as induced

289 Detailed analysis of chronological sequences between aggression and matings r

290 ferent types of neurons and glia in specific chronological sequences, but this process remains poorly

291 our results support (182)Hf homogeneity and chronological significance of the (182)Hf-(182)W clock.

292 ults presented here, along with other recent chronological studies on Chinese Middle Pleistocene homi

293 Recent chronological studies suggest a possible overlap between

294 degree of contingency in succession requires chronological study of replicate ecosystems.

295 Our study shows how subtle chronological submolecular changes within calcium bindin

296 This article will be a chronological summary of how we rapidly validated tests

297 A stochastic model incorporated chronological surface contacts, pathogen concentrations

298 The YDIH fails the critical chronological test of an isochronous event at the YD ons

299 tion with BF levels and association with the chronological time from initial propagation.

300 vidual trisomies often acquired in different chronological windows during evolution, and with a prefe