ライフサイエンスコーパス: chronological age

1 e variance in PhenoAge (after accounting for chronological age).

2 pal responses, despite minimal difference in chronological age.

3 es is typically linearly combined to predict chronological age.

4 brains were estimated to be older than their chronological age.

5 genes that are differentially expressed with chronological age.

6 have delayed neurocognitive age relative to chronological age.

7 res used in a regression analysis to predict chronological age.

8 th in the general population, independent of chronological age.

9 lected individual differences over and above chronological age.

10 es relative to an average person of the same chronological age.

11 etter predictors of the health outcomes than chronological age.

12 oA, but does add predictive power to that of chronological age.

13 brain-derived age estimate is close to their chronological age.

14 re correlated with cognitive performance and chronological age.

15 tent correlation between DNA methylation and chronological age.

16 e p16(INK4a) tumor suppressor increases with chronological age.

17 posity rather than a consequence of advanced chronological age.

18 are a function of physiological rather than chronological age.

19 ell as longer duration of epilepsy and older chronological age.

20 is significantly (P = 0.01) correlated with chronological age.

21 which patients appear much older than their chronological age.

22 ted individuals appear much older than their chronological age.

23 hich affected humans appear older than their chronological age.

24 analysis to ascertain the relationship with chronological age.

25 noglycoside clearance estimation compared to chronological age.

26 ation and better discriminated survival than chronological age.

27 logical age (from both clocks separately) on chronological age.

28 ation is estimated as residuals regressed on chronological age.

29 from regressing estimated epigenetic age on chronological age.

30 e between epigenetic age (Horvath clock) and chronological age.

31 ions to the human genome effectively predict chronological age.

32 ns exhibiting significant relationships with chronological age.

33 ge" and "epigenetic clocks" that can predict chronological age.

34 as the difference between predicted age and chronological age.

35 nital cataract surgery between 1-6 months of chronological age.

36 s significantly among individuals of similar chronological age.

37 chronological age, expressed as a percent of chronological age.

38 BAG was defined as estimated brain age minus chronological age.

39 as computed as the gap between predicted and chronological age.

40 showed a systematic offset in predictions of chronological age.

41 Children were followed up until 2 years of chronological age.

42 nd older CHARTER subgroups, and unrelated to chronological age.

43 ased biomarkers of aging accurately estimate chronological age.

44 lculated as the developmental age divided by chronological age.

45 linear regression model of epigenetic age on chronological age.

46 variation in fluid cognition over and above chronological age.

47 of disease onset that clearly increased with chronological age.

48 fying cognitive control tasks and predicting chronological age.

49 ences emerged, primarily with biological and chronological age.

50 ealth Timeline) clock, a strong predictor of chronological age.

51 ator of biological age, as opposed to merely chronological age.

52 ge of fetal retina is highly correlated with chronological age.

53 edict neurological disease risk than patient chronological age.

54 of variance in PhenoAge after adjustment for chronological age.

55 scribes a person's immune status better than chronological age.

56 and female samples and were correlated with chronological age.

57 on (DNAm) age and pubertal stage relative to chronological age.

58 itting models included both reproductive and chronological age.

59 munities that develop in the human host with chronological age.

60 Children's Hospital of New York, to predict chronological age.

61 acceleration in biological age, relative to chronological age.

62 f women's reproductive stage, independent of chronological age.

63 detected in a published prediction model for chronological age.

64 by the sizes of the lesion or the patients' chronological ages.

65 lecting the disparity between biological and chronological aging.

66 onsistent with a linear model, indicative of chronological aging.

67 the interpretation and design of studies on chronological aging.

68 of 1 year of biological aging per 1 year of chronological aging.

69 the more variable splicing changes seen with chronological aging.

70 tions that uncouple physiological aging from chronological aging.

71 lthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volum

72 ers with minimal or no spoken language (mean chronological age = 30.20, SD = 7.07), and 15 neurotypic

73 Genome-wide DNAm was assessed at visit 1 (chronological age, 30-64 years) and visit 2.

74 c preschoolers who use spoken language (mean chronological age = 34.38, SD = 8.16), 15 autistic presc

75 SD = 7.07), and 15 neurotypical peers (mean chronological age = 36.73, SD = 6.51) using novel eye-tr

76 Neurodevelopmental assessments at chronological age 4.5 years included motor (Movement Ass

77 In this cohort, all chronological age 45 years, brainAGE was measured reliab

78 pigenetic changes have been used to estimate chronological age across the lifespan, and some studies

79 into quiescence, and cellular health during chronological aging, across genetic background and indep

80 Comparisons based on chronological age alone failed to reveal a reliable diff

81 It is controversial whether chronological age alone should be used in making healthc

82 Many oncologists recognize that chronological age alone should not be the determinant wh

83 against classifying patients on the basis of chronological age alone, most studies and published guid

84 son, >80% of children had it by 24 months of chronological age, although this observation differed by

85 nd the resulting difference (Deltaage = BA - chronological age)-an index of biological aging-was test

86 inAGE), a composite index of the gap between chronological age and a machine learning algorithm-estim

87 ividual's brainAGE is the difference between chronological age and age predicted from machine-learnin

88 widely used to identify differences between chronological age and biological age in health and disea

89 we did observe an association between donor chronological age and CGD (P=0.018).

90 ion (EAA), defined as the difference between chronological age and epigenetically predicted age, was

91 d insulator regions that associate with both chronological age and gene expression levels.

92 methylation-based prediction of age exceeds chronological age and has been associated with increased

93 ential exists to modify the relation between chronological age and health.

94 l biomarkers capable of precisely estimating chronological age and identifying novel factors influenc

95 ess than 1 year to over 3 years depending on chronological age and neurocognitive domain.

96 ase and myocardial infarction independent of chronological age and other well-known cardiovascular ri

97 of myeloma patients has focused primarily on chronological age and performance status as markers of f

98 d with exceptional longevity irrespective of chronological age and prioritized drugs with repurposing

99 Grim2Age exhibits a strong correlation with chronological age and shows accelerated AA in frail indi

100 The two groups were matched in chronological age and socioeconomic status.

101 ovarian failure long before death because of chronological age and subsequently develop many of the s

102 completely mediate the relationship between chronological age and survival, suggesting that chronolo

103 rs, we observe a direct relationship between chronological age and temporal-rate tuning, unconfounded

104 the strongest correlation was found between chronological age and the formation of the germ of the s

105 productive hormones-LH, FSH, SHBG and AMH-by chronological age and time around the menopause (reprodu

106 HD or MI after multifactorial adjustment for chronological age and well-known cardiovascular risk fac

107 tion of IL-1beta is strongly associated with chronological age and with elevated IL-1beta transcripti

108 cognitive reserve, because even at the same chronological age and with the same number of illnesses,

109 we test whether differences between people's chronological ages and estimated ages, DNA methylation a

110 resistance in addition to implying roles in chronological aging and cell size determination, since S

111 of genes is coordinately altered both during chronological aging and in the transition from the repro

112 reducing yeast histone proteins accelerates chronological aging and increasing histone supply extend

113 skin morphology and function associated with chronological aging and photoaging.

114 cture and function are prominent features of chronological aging and solar UV irradiation-induced pre

115 from the residuals of a model of GrimAge and chronological age, and any GrimAge acceleration (positiv

116 education, household income, as well as sex, chronological age, and cognitive level of the participan

117 alitative transcriptional state of HSCs than chronological age, and transcriptional consequences of m

118 tal and superior temporal cortices than both chronological age- and reading age-matched controls.

119 t differences between transcriptomic age and chronological age are associated with biological feature

120 Age adjusted for gestation and chronological age are important risk factors for glaucom

121 heir ovaries intact and examined at the same chronological age as the 19-month post-OVX group, estrog

122 ts, brain age was significantly greater than chronological age at baseline (+3.36 years) and progress

123 Gap between estimated neuroanatomical vs chronological age at MRI scan (brain age gap estimation

124 Among 470 participants, the mean (SD) chronological age at visit 1 was 48.7 (8.7) years.

125 er tissue-independent or designed to predict chronological age based on blood or saliva samples.

126 Recent studies have identified biomarkers of chronological age based on DNA methylation levels.

127 etailed and global mechanisms underlying the chronological age-based differences in the ability of CP

128 ls can be upregulated in normal mice at this chronological age, because 24-h food deprivation increas

129 elations were observed, after adjustment for chronological age, between the biological age indicators

130 e difference between brain-predicted age and chronological age (brain-predicted age difference [brain

131 Differences between brain age and chronological age ("brain age gap") and between schizoph

132 found a large overlap between Brain Age and chronological age: Brain Age could uniquely add only aro

133 withhold from patients solely based on their chronological age but rather be based on the patient's p

134 tates the shift from thinking not just about chronological age but the health status and disease seve

135 ARCH is associated not just with chronological aging but also with several other, age-rel

136 Normally BioAge increases with chronological age, but in AD it is prematurely expressed

137 resulting 'epigenetic clock' closely tracks chronological age, but individuals are predicted to be s

138 ) indicating a consistent underestimation of chronological age by FDG/PET in parkinsonism.

139 ng age-associated systemic inflammation from chronological aging by using transgenic Nfkb1KO mice, we

140 its comparison with the participants' actual chronological age (CA) and their predisposition to perio

141 Brain age (BA), distinct from chronological age (CA), can be estimated from MRIs to ev

142 etween uterine and ovarian measurements with chronological age (CA), TS and GA (p < 0.0001).

143 t health risks among individuals of the same chronological age (CA).

144 system integrity that occurs with advancing chronological age, causing morbidity and disability.

145 me distribution change with replicative age, chronological age, cell differentiation state, and/or ov

146 These studies are relevant to chronological aging, cell cycle, and genome evolution, a

147 ific decelerations up to 7 years in multiple chronological age clocks.

148 After adjusting for chronological age, comorbidities, and other characterist

149 s were predicted to be twice as old as their chronological age compared to nonsmokers, whereas male s

150 d to be one and a half times as old as their chronological age compared to nonsmokers.

151 5.3% of predictions were within 24 months of chronological age compared with 91.6% for GPDL-BAAM (P =

152 lower metabolic brain age-relative to their chronological age-compared with the male brain.

153 by one's metabolome, as compared with one's chronological age, confers an increased risk on future c

154 Reproductive and chronological age contribute to changes in LH, FSH, SHBG

155 At baseline, a decade of chronological aging correlated with a decrease in Ao-A,

156 To understand how chronological age could impact the cryptococcal capsule

157 fference between this metabolic estimate and chronological age (delta) was then computed, where delta

158 ere recent work has found its deviation from chronological age ("delta age") to be associated with mo

159 nces between calculated 'biological' age and chronological age (DeltaAge) appear to reflect an indivi

160 e difference between DNA methylation age and chronological age (Deltaage) was calculated in four long

161 ated the acceleration of GrimAge relative to chronological age, denoted "AgeAccelGrim" in combat trau

162 ucted another deep-learning model to predict chronological age directly from raw images and their fea

163 er buccal telomeres, independently from sex, chronological age, educational level, zygosity and chori

164 clinical research and deviations of EA from chronological age [epigenetic age acceleration (EAA)] ha

165 Individuals of the same chronological age exhibit disparate rates of biological

166 predicted from geometric phenotypes and the chronological age, expressed as a percent of chronologic

167 d-type mice in response to hypoxia or during chronological aging, fission arrest may represent fundam

168 BBAGs predicted chronological age, followed by regional and exposomal fa

169 y, time left becomes a better predictor than chronological age for a range of cognitive, emotional, a

170 xample, the equivalent of almost 12 years of chronological age for those CMV seropositive.

171 k with differences between the predicted and chronological ages for the second group identified signi

172 ng DeepBrainNet, a model trained to estimate chronological age from 14 468 structural MRIs from healt

173 o train a deep neural network to predict the chronological age from CT scout views.

174 s defined as the differences between PHA and chronological age >5 years.

175 en who were predicted to be older than their chronological age had twice as much violence exposure as

176 Although chronological age has been linked to changes in DNA meth

177 onological age and survival, suggesting that chronological age has no direct effect on ILD survival.

178 iological age, distinct from an individual's chronological age, has been studied extensively through

179 igenetic Clocks have been trained to predict chronological age, healthspan and lifespan.

180 quantify discrepancies between brain age and chronological age, hold promise for understanding brain

181 atched using two strategies: (a) matching by chronological age (human sample size: n = 562), or (b) m

182 clinical practice, we usually only consider chronological age (i.e., is the patient under or above 6

183 When controlling for chronological age in addition to mental age, there were

184 age and has been used to accurately estimate chronological age in children and adults.

185 ECG-age was highly correlated with chronological age in FHS.

186 ical approaches, have the ability to predict chronological age in healthy people.

187 as a highly accurate molecular correlate of chronological age in humans and other vertebrates.

188 al barrier dysfunction is more accurate than chronological age in identifying individual flies with s

189 Predicted age was 8 years greater than chronological age in individuals with schizophrenia in t

190 f amyloid-beta deposition by controlling for chronological age in our analyses.

191 MPAR expression occurred 2-3 days earlier by chronological age in Sprague Dawley rats compared with L

192 fractional anisotropy for the prediction of chronological age in the same individuals.

193 l for the joint analysis of generational and chronological age in the transmission dynamics of a mole

194 differs from the rate of decline found with chronological age in this same group, which shows a stea

195 the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term

196 Chronological aging independent of biological markers of

197 Robust effects of chronological age, independent of ovarian hormone status

198 gnitive age based on performance relative to chronological age, indicated that 22q11DS participants l

199 om PWV, most patients exhibited values below chronological age indicating a counterintuitive healthie

200 Intravenous IL-15 treatment rescued chronological aging-induced healing defects and restored

201 This investigation determines how chronological age influences the phenotypic characterist

202 Regardless of chronological age, intestinal barrier dysfunction predic

203 Concordance was high between all methods and chronological age (intraclass coefficient > 0.93).

204 Chronological age is a particularly well-known indicator

205 Chronological age is a powerful epidemiologic risk facto

206 Chronological age is a risk factor for SARS-CoV-2 infect

207 Chronological age is an imperfect estimate of molecular

208 Chronological age is no longer viewed as an absolute bar

209 Increasing chronological age is the most significant risk factor fo

210 c cancer increases with age, suggesting that chronological aging is a significant risk factor for thi

211 the MRI-based predicted age with respect to chronological age, is associated with risk for neurodege

212 i.e. the dependence of the biological age on chronological age, is then a universal stochastic functi

213 We have identified that chronological age leads to telomeric shortening in CPCs,

214 erated biological aging when controlling for chronological age, lifestyle, health-related, and demogr

215 Brain estimates of chronological age may inform mechanisms of the associati

216 The differential response of TG mice to chronological age may result from preservation of functi

217 e using magnetic resonance imaging (MRI) and chronological age may serve as a biomarker for early-sta

218 discrepancies between CNN-predicted age and chronological age may serve as a physiological measure o

219 ascular disease and IADL impairment, but not chronological age, may be involved in the etiology of sh

220 ted with greater biological age, relative to chronological age, measured by DNA methylation (positive

221 stability using the Saccharomyces cerevisiae chronological aging model.

222 ording to what they were trained to predict: chronological age, mortality, mitotic divisions, or telo

223 ntially methylated regions, correlating with chronological aging, occurred preferentially at both tra

224 the molecular clock model, we use the known chronological age of each individual and fit the methyla

225 etic age", which is in contrast to the known chronological age of each individual.

226 because the fossil record is scarce and the chronological age of many key specimens remains uncertai

227 There was no difference between the chronological age of the four groups, and the SLI and ty

228 we found that RS could be used to track the chronological age of the mice.

229 ls with MS regardless of disease duration or chronological age of the patient.

230 these processes will be proportional to the chronological age of the person.

231 We conclude that chronological aging of NHFs contributes to PDAC progress

232 In this study, we investigated whether the chronological aging of normal human fibroblasts (NHFs),

233 le-genome analysis of gene expression during chronological aging of the worm provides a rich database

234 mentation and DNA degradation, and premature chronological aging of yeast cells.

235 ted age difference (brain-PAD: predicted age-chronological age) of the HCs and 318 patients with epil

236 were derived using a transformed version of chronological age on DNA methylation at specific sites u

237 With the effect of chronological age on white matter microstructure taken i

238 current study is to understand the impact of chronological aging on mitochondrial function in respons

239 riable, after controlling for mental age and chronological age, only the Rivermead Picture Recognitio

240 hondrial dysfunction are directly related to chronological age or are related to age-related changes

241 ge of the plaques, independent of the mice's chronological age or disease stage.

242 hether these deleterious effects result from chronological age or lifestyle-related factors such as a

243 calculated using 4 clocks trained on either chronological age or physiological dysregulation.

244 to the FMP: a linear model, consistent with chronological aging, or a piecewise linear model, consis

245 (37.34 [95% CI, 17.4-41.0] years) older than chronological age (P = .004) and had lower sex hormone p

246 rationality compared with younger subjects, chronological age per se did not correlate with rational

247 n age (0 indicates a brain age equivalent to chronological age; positive and negative values represen

248 rresponding CpGs and genes associated with a chronological age prediction model.

249 For a given chronological age, PTB patients with longer telomeres at

250 ECG-age was correlated to chronological age (r=0.81; mean absolute error, 9+/-7 ye

251 espectively, were positively correlated with chronological ages (r = 0.88/0.91), elevated in bipolar

252 y help to distinguish between biological and chronological age-related change in arterial health in h

253 Further, we tested whether chronological age remained a unique predictor of inflamm

254 Generalized linear models that adjusted for chronological age, sex, and race/ethnicity and applied a

255 imated using linear regression, adjusted for chronological age, sex, ethnicity, and study centre.

256 Thus, chronological age should not be considered to represent

257 ility to benefit from treatment, rather than chronological age, should be used to develop policies th

258 A crude estimate showed that, at the same chronological age, social renters, for example, were nin

259 aortic age" was calculated from the baseline chronological age-stiffness relationship.

260 rfeit of follicles is maintained in advanced chronological age, such that 20-22-month-old female Bax-

261 number of previous flights taken instead of chronological age, suggesting a learning process adapted

262 as associated with disability independent of chronological age, suggesting that biological aging may

263 of biological age completely attenuated the chronological age-survival association and better discri

264 and peripheral blood telomere length on the chronological age-survival relationship.

265 for weight, body mass index (BMI), bone age, chronological age, Tanner breast stage, and socioeconomi

266 bserved correlation between RTE activity and chronological age, the expression of most RTE classes an

267 as in vitro surrogate end point markers for chronological age, the extent of GAG modifications was d

268 hormones (outcomes) by reproductive age and chronological age (these age variables being the key exp

269 t regression is trained on FI components for chronological age to generate the FRIGHT (Frailty Inferr

270 the LensAge index by contrasting LensAge and chronological age to reflect the aging rate relative to

271 ges of "vascular age" are available for most chronological ages to assist with risk communication.

272 sectary to different known physiological and chronological ages to evaluate if MALDI-TOF MS could be

273 f considering reproductive stage, not simply chronological age, to identify neuronal and cognitive ch

274 Deviations from chronological age towards an increased epigenetic age ha

275 mic structures that change dramatically with chronological aging under prolonged stationary-phase gro

276 Remarkably, chronological aging under stationary-phase growth condit

277 d that many eye diseases not associated with chronological age undergo accelerated molecular aging of

278 All ratings were compared with chronological age using mean absolute error (MAE), and s

279 Young individuals of the same chronological age varied in their "biological aging" (de

280 flecting aging-related health decline beyond chronological age, varies among individuals.

281 he average ECG age for patients of a similar chronological age was associated with an increase in mor

282 difference between predicted "brain age" and chronological age was calculated to indicate brain-predi

283 Deviation from chronological age was defined as "delta age".

284 A correlation between the dental age and chronological age was established.

285 difference between the predicted and actual chronological age was less than 2.0 years was statistica

286 Conversely, chronological age was significantly associated with visu

287 (positive GrimAA: having GrimAge older than chronological age) was associated with significantly hig

288 ich represents the deviation of GrimAge from chronological age, was derived from the residuals of a m

289 e elevated inflammatory environment, and not chronological age, was responsible for the decrease in S

290 comprehensive evaluation that extends beyond chronological age, we explore alternative aging metrics

291 Using the yeast model, in conditions of chronological aging, we concluded that cells expressing

292 The mean epigenetic age and chronological age were 56.1 +/- 11.1 and 36.7 +/- 12.3 y

293 Predicted and chronological age were not different in BD.

294 mations (BrainAGEs; predicted age minus true chronological age) were calculated as indices of relativ

295 sted age should be considered in addition to chronological age when determining age of cataract surge

296 osphorylated Ser238 on Bmh1 increases during chronological aging, which is delayed by CR or by reduce

297 of the triplets was 6-10 years younger than chronological age, while it was 9 years older in the off

298 ng known as epigenetic clocks, which predict chronological age with remarkable accuracy and show prom

299 His height was at the 25th percentile for chronological age, with decline from the 50th percentile

300 hippocampus are particularly susceptible to chronological aging, with many aged animals (including h