ライフサイエンスコーパス: cilia

1 dynamically show the same trends observed in cilia.

2 tors and complexes in the proximal region of cilia.

3 l bodies, and synchronized beating of motile cilia.

4 embled in the cytoplasm before deployment to cilia.

5 llow for the efficient assembly of very long cilia.

6 Bardet-Biedl syndrome 4 (BBS4) entrance into cilia.

7 omeric polycystin channel complex on primary cilia.

8 hat localize and move around centrosomes and cilia.

9 ase links of satellites with centrosomes and cilia.

10 their maturation and trafficking to primary cilia.

11 e critical for the integrity and function of cilia.

12 ion zone, a diffusion barrier at the base of cilia.

13 nd coordinated beating of hundreds of motile cilia.

14 or the formation and cortical positioning of cilia.

15 d diminished EYS protein near the connecting cilia.

16 3B is a regulatory GTPase highly enriched in cilia.

17 and their functions outside centrosomes and cilia.

18 Rs is required for their regulated exit from cilia.

19 of GPR161, SSTR3, and Smoothened (SMO) from cilia.

20 an be uncoupled from its function outside of cilia.

21 nknown association between KIF11 and primary cilia.

22 t mice was performed to evaluate for primary cilia.

23 sed structures that assemble centrosomes and cilia.

24 syndrome that results from defects in motile cilia.

25 o the extracellular surface of Chlamydomonas cilia.

26 am components, NPHP3 is redistributed within cilia.

27 ery necessary for the degradation of primary cilia.

28 se of decreased Kif19a protein levels in the cilia.

29 ing anterograde (base to tip) trafficking in cilia.

30 ypes and can be motile or non-motile primary cilia.

31 nd SHH, only to receiving cells with primary cilia.

32 ired for assembly and maintenance of primary cilia.

33 naling mechanism regulating growth of motile cilia.

34 ciliopathy caused by dysfunction of primary cilia.

35 oskeleton and microtubule-based transport in cilia.

36 eptors (Drd1), which are expressed in motile cilia.

37 mice specifically lacking beta-cell primary cilia, a cellular organelle that has been implicated in

38 In motile cilia, a mechanoregulatory network is responsible for co

39 creased cilia disassembly, shortened primary cilia, a retrograde IFT defect for IFT and BBS proteins,

40 Cytoplasmic cilia, a specialized type of cilia in which the axoneme

41 Our study demonstrates that cilia activity combined with muscle contractions sustain

42 Among the multiple possibilities to achieve cilia actuation, magnetic fields present an opportunity

43 nerated locally by caudally-polarized motile cilia along the ventral wall of the central canal.

44 Thm1-mutant cilia also show a retrograde transport defect for the He

45 iated with the aberrant formation of primary cilia, an organelle essential for canonical Hh signaling

46 Our findings demonstrate how primary cilia and autophagy are involved in the translation of m

47 evealed proteins that are important for both cilia and BC biology.

48 oot proteins in cells with primary or motile cilia and discover a hybrid cilium with a unique assembl

49 Cilia and flagella are microtubule-based cellular projec

50 Here, we describe a deficiency of cilia and flagella associated protein 45 (CFAP45) in hum

51 CFAP45-deficient cilia and flagella show normal morphology and axonemal u

52 es that are responsible for the formation of cilia and flagella, and for organizing the microtubule n

53 totic spindle and, as basal bodies, nucleate cilia and flagella.

54 L2A, a gene essential for normal function of cilia and flagella.

55 tion, these ectopic photoreceptors possessed cilia and formed synapses but failed to produce robust o

56 cilium emerges independently of other motile cilia and functions in regulating basal body alignment.

57 nk between KIF11 and the dynamics of primary cilia and further support non-mitotic functions for this

58 tralization in Ankmy2 knockout requires both cilia and Gli2 activation.

59 ggest that EVs may mediate signaling between cilia and glia to shape sensory organ compartments.

60 Role of cilia and IFT80 protein in intervertebral disc (IVD) dev

61 demonstrate novel roles for PRK1 and PRK2 at cilia and in BC biology and in the case of PRK2 in parti

62 Here we demonstrate novel roles for them at cilia and in cancer biology.

63 Although signaling by primary cilia and interstitial inflammation both play a critical

64 a, Arl13b(V358A/V358A) cells displayed short cilia and lacked ciliary ARL3 and INPP5E.

65 function largely depended on the presence of cilia and on smoothened, the obligate transducer of Shh

66 ytryptamine (HT)(2C) receptor (5-HT(2C)R) to cilia and plasma membrane, respectively.

67 gehog ligand, patched-1 (Ptch1) localizes to cilia and prevents ciliary accumulation and activation o

68 ht the architectural differences with motile cilia and provoke a reassessment of the relationship bet

69 ndrome, also suffer from infertility because cilia and sperm flagella share several characteristics.

70 ccounts for hydrodynamic screening of packed cilia and the chemomechanical energy efficiency of the f

71 RK1/pPRK2 localise to the transition zone of cilia and their co-depletion results in reduced cilia si

72 ed the abilities to form tight junctions and cilia and to differentiate at the air-liquid interface l

73 y epithelial cells correlated with elongated cilia and vice versa.

74 rafficking of G-protein-coupled receptors to cilia and whose aberrant expression is associated with s

75 Upon ligand binding, Ptch1 is removed from cilia, and Smo is derepressed and accumulates in cilia w

76 ral MT pairs were missing in the majority of cilia, and the polarity of the basal bodies was disorgan

77 ation, Smo is ubiquitinated and removed from cilia, and this process is dependent on Ift27 and BBSome

78 Complete loss of Arl13b disrupts cilia architecture, protein trafficking and Sonic hedgeh

79 Motile cilia are cellular beating machines that play a critical

80 Cilia are complex microtubule-based organelles essential

81 Cilia are dynamic microtubule-based organelles present o

82 Cilia are essential for Shh signal transduction and the

83 Double homozygous cilia are generally intact and display a normal morpholo

84 Motile cilia are hairlike structures that line the respiratory

85 Motile cilia are highly complex hair-like organelles of epithel

86 Cilia are important cell structures found on nearly all

87 Our study suggests that primary cilia are important for neuronal maturation and function

88 Primary cilia are important organizing centers that control dive

89 The physical means by which cilia are lost are poorly understood but are thought to

90 Primary cilia are lost during cancer development, but the mechan

91 Primary cilia are microtubule-based organelles that play importa

92 Defects in flagella/cilia are often associated with infertility and disease.

93 Primary cilia are organelles necessary for proper implementation

94 ulin secretion, and found that the beta-cell cilia are required for glucose sensing, calcium influx,

95 Primary cilia are sensory organelles crucial for cell signaling

96 Primary cilia are sensory organelles that are essential for euka

97 g multiciliated cell differentiation, motile cilia are templated from basal bodies, each extending a

98 Primary cilia are vital signaling organelles that extend from mo

99 Motile cilia are widespread across the animal and plant kingdom

100 Cilia arise from centrosomes and their formation and fun

101 However, in contrast to wild type cilia, Arl13b(V358A/V358A) cells displayed short cilia a

102 stdevelopmental ablation of Pkd1, Stat3, and cilia, as well as cultures of cilia-deficient or STAT3-d

103 plasma membrane protrusions, such as primary cilia, as well as extracellular vesicles derived thereof

104 mTOR hyperactivation interfered with primary cilia assembly (scenario also observed in other ciliopat

105 Cilia assembly is under strict transcriptional control d

106 We propose that cytoplasmic cilia assembly requires the precise localization of mRNA

107 Thm1 regulates cilia assembly, and alone and together with Thm2, regula

108 Thm1-mutant MEF show decreased cilia assembly, increased cilia disassembly, shortened p

109 erm), very little is known about cytoplasmic cilia assembly.

110 size, impaired planer polarity and impaired cilia associated signalling.

111 led to develop therapeutic interventions for cilia-associated disorders.

112 In summary, we report a set of motile cilia-associated genes that helps shape our understandin

113 Accordingly, many cilia-associated proteins have been described, while tho

114 ch tissue, genes coexpressed with the motile cilia-associated transcriptional factor, FOXJ1, were ide

115 at CS impaired barrier formation and reduced cilia beat activity.

116 n, indicated by calcium elevation, increased cilia beat frequency, and increased fluid and cytokine s

117 We study here the entrainment of cilia beat in multiciliated cells from brain ventricles.

118 leting their seed sites on Drd1 mimicked the cilia-beating and ventricular deficits.

119 The cilia-beating deficit observed in brain slices and in vi

120 ver, the fundamental mechanisms underpinning cilia biogenesis and functions remain only partly unders

121 se findings provide new insights into motile cilia biology and may lead to novel ciliopathy treatment

122 targeting a UbK63-specific deubiquitinase to cilia blocks the exit of GPR161, SSTR3, and Smoothened (

123 Cilia both receive and send information, the latter in t

124 d modular architecture in primary and motile cilia, but showing distinct features reflecting its spec

125 hese data indicate that ARL13B's role within cilia can be uncoupled from its function outside of cili

126 a similar frequency to the actively beating cilia can entrain cilia oscillations.

127 Defects in the ependymal cilia can result in hydrocephalus, defects in the cilia

128 cellular junctions, focal adhesions, primary cilia, caveolae, clathrin-coated pits, and plaques play

129 knockout airway epithelial cells have longer cilia compared with the WT cells because of decreased Ki

130 lin secretion, cell polarity, cell junction, cilia, cytoskeleton, vesicular trafficking, and regulati

131 Cilia defects underlie a growing list of human disorders

132 Furthermore, these data imply that the cilia defects upon complete absence of ARL13B do not und

133 skinesia (PCD), a condition caused by motile cilia defects.

134 d1, Stat3, and cilia, as well as cultures of cilia-deficient or STAT3-deficient tubular cell lines.

135 ation promotes tumor progression via primary cilia degeneration and aberrant Hh signaling.

136 er development, but the mechanism regulating cilia degeneration is not determined.

137 These findings indicate that cilia-dependent adenylyl cyclase signaling represses the

138 The cellular mechanisms of polycystin- and cilia-dependent cyst progression in ADPKD remain incompl

139 This cilia-dependent predatory mechanism is evolutionarily co

140 e failure to correctly establish or maintain cilia-dependent signaling pathways.

141 processes and reveals additional targets of cilia-dependent signaling.

142 Overall, our analyses reveal how primary cilia determine neuronal subtype composition of the cort

143 Our findings indicate that, although primary cilia directly modulate STAT3 activation in vitro, the b

144 We have previously shown that primary cilia directly regulate insulin secretion.

145 r, Thm1;Thm2 double-mutant MEF show enhanced cilia disassembly, and increased impairment of INPP5E ci

146 and alone and together with Thm2, regulates cilia disassembly, ciliary entry of membrane-associated

147 MEF show decreased cilia assembly, increased cilia disassembly, shortened primary cilia, a retrograde

148 length and an attenuation in the kinetics of cilia disassembly.

149 he organism level, the deletion of beta-cell cilia disrupts circulating hormone levels, impairs gluco

150 ive) can be entrained at flows comparable to cilia-driven flows, in contrast with what was recently o

151 es highly polarized to the distal end of the cilia during cytoplasmic ciliogenesis in Drosophila sper

152 termined that KIF11 has a role in regulating cilia dynamics.

153 ns (OSNs) in chordates usually have multiple cilia, each with a centriole at its base.

154 We use direct cilia electrophysiology, cryogenic electron microscopy,

155 ystems where the interplay between ependymal cilia, embryonic CSF flow dynamics and brain development

156 demonstrate that at this early stage, motile cilia ensure the proper formation of the central canal.

157 n was expressed but could not be detected in cilia, even when retrograde ciliary transport was blocke

158 3B is required within cilia, we knocked in a cilia-excluded variant of ARL13B (V358A) and showed it r

159 transport (LIFT) pathways are essential for cilia/flagella biogenesis, motility, and sensory functio

160 which is unexpected given the requirement of cilia for Shh transduction.

161 ent data identifying KIF14 as a regulator of cilia formation and Hedgehog (HH) signaling.

162 In developing POMC neurons, abnormal cilia formation disrupts axonal projections through impa

163 ome (TBS), a rare disease linked to abnormal cilia formation in human fibroblasts, we uncovered the l

164 , we show that ccdc32 is required for normal cilia formation in zebrafish embryos and mammalian cell

165 NRF2 also suppresses primary cilia formation through p62-dependent inclusion body for

166 ls of MyosinVa at the centrosome and primary cilia formation.

167 cell polarization and migration, and primary cilia formation.

168 ch in turn seems relevant for the process of cilia formation.

169 at transcriptome related to ciliogenesis and cilia function is significantly impaired during differen

170 onal program responsible of ciliogenesis and cilia function is significantly impaired in CRSwNP epith

171 tic mechanisms regulating the CPA and motile cilia function.

172 insights into the biogenesis of a functional cilia gate remain elusive.

173 Transition fibers (TFs) regulate cilia gating and make the primary cilium a distinct func

174 he homolog of ANKRD26, to orchestrate proper cilia gating.

175 onnections of Alzheimer's disease, aging and cilia genes.

176 Using cilia-GFP mice, we found presence of cilia on growth pla

177 nning to understand the mechanisms governing cilia growth, maintenance and function.

178 al. reveal new details about the control of cilia growth.

179 Motile cilia, hairlike structures present on the cell surface,

180 Moreover, cilia have been described as crucial for neurogenesis, n

181 ng of the crosstalk between NRF2 and primary cilia/Hh signaling could not only open new avenues for c

182 complex that plays a central role in primary cilia homeostasis.

183 Primary cilia host numerous signaling pathways affected in disea

184 n of adenylyl cyclase III in neuroepithelial cilia, implicating deficient pathway repression.

185 lfactory and nasal respiratory epithelia and cilia in animals.

186 Here, we investigate the role of primary cilia in controlling the decision between forming neuron

187 dult adiposity, which is mediated by primary cilia in developing hypothalamic neurons.

188 ZikV-NS5 persists at the base of the motile cilia in ependymal cells, which also exhibit a severe ci

189 t out to define genes associated with motile cilia in humans based on their transcriptional signature

190 In addition, we show that primary cilia in KIF14-depleted cells are defective in response

191 toreceptor cells bearing both microvilli and cilia in larva of the annelid Malacoceros fuliginosus.

192 dendritic input of proteins to chemosensory cilia in living Caenorhabditis elegans.

193 Primary cilia in many cell types contain a periaxonemal subcompa

194 ut led to incomplete dissociation of DAs and cilia in mitosis.

195 F11 localized to the basal bodies of primary cilia in multiple cell types, including neoplastic and n

196 ith host proteins at the base of the primary cilia in neural progenitor cells, causing an atypical no

197 lic tissues, thus providing a unique role of cilia in nutrient metabolism and insight into the pathop

198 et al. (2020b) demonstrates loss of primary cilia in Spitzoid melanoma compared with Spitz nevi and

199 provide clear evidence that xenopsin enters cilia in the eye of the larval bryozoan Tricellaria inop

200 can result in hydrocephalus, defects in the cilia in the fallopian tubes or in sperm flagella can ca

201 However, cilia in the visual relay center remain to be fully desc

202 We show that cilia in TTC26-mutated patient cells display variable le

203 cells, a classic model for studying primary cilia in vitro, with a genetic dissection of the protein

204 Cytoplasmic cilia, a specialized type of cilia in which the axoneme resides within the cytoplasm

205 gene essential for the formation of primary cilia, in a mouse model of SCLC induced by conditional d

206 odihexosylganglioside accumulates in Bbs2-/- cilia, indicating impairment of glycosphingolipid (GSL)

207 embly pathway, controlling the final step of cilia initiation.

208 Simulations of a minimal model of cilia interacting hydrodynamically show the same trends

209 Approximately 184 genes in the cilia interactome are targeted by 548 currently approved

210 Taken together, the cilia interactome presented here provides novel insights

211 The cilia interactome revealed interconnections between cili

212 The resulting cilia "interactome" consists of 165 ciliary proteins, 1,

213 ling, pointing to a key role in cytoskeleton-cilia interdependency.

214 ructural features of both primary and motile cilia is harbored.

215 f G protein-coupled receptors (GPCRs) out of cilia is mediated by the BBSome.

216 pkd2 mutant cilia lack mastigonemes, and mutant cells swim with redu

217 roteins originate from the cell body because cilia lack protein synthesis machinery.

218 xpression while also ensuring normal primary cilia length and renal epithelial morphogenesis, and sug

219 Cilia length in NP and AF during IVDD were significantly

220 e observed a significant increase in primary cilia length in vitro in the context of either of the tw

221 the autophagy-mediated regulation of motile cilia length via kinesin Kif19a, a regulator of cilia le

222 with a concomitant increase in photoreceptor cilia length.

223 ia length via kinesin Kif19a, a regulator of cilia length.

224 ion of spatial cAMP signaling in controlling cilia length.

225 d EPLIN interact with known ciliogenesis and cilia-length regulators and as such represent novel play

226 and impairs channel opening without altering cilia localization and channel assembly.

227 -induced process is dependent on the primary cilia located on the apical side of epithelial cells.

228 type II collagen-positive cells resulted in cilia loss in GP and EP, and disrupted IVD structure wit

229 ystin-2 channel dysregulation in the primary cilia may contribute to cystogenesis.

230 c-like scoliosis to irregularities in motile cilia-mediated cerebrospinal fluid flow [7-9].

231 spinal curvatures in the absence of obvious cilia motility defects.

232 However, because loss of cilia motility in human primary ciliary dyskinesia patie

233 her, these findings demonstrate that primary cilia not only orchestrate beta-cell-intrinsic activity

234 However, cilia numbers increased by 63% in AF during repair.

235 e, we demonstrate that among the many motile cilia of a multiciliated cell, a hybrid cilium with stru

236 protein robustly localizes within the motile cilia of airway epithelial cells, which likely represent

237 oplasmic reticulum (ER) membrane and primary cilia of all cell and tissue types.

238 otransduction channel complex in the sensory cilia of Caenorhabditis elegans mechanoreceptor neurons.

239 inally, ubiquitinated proteins accumulate in cilia of mammalian photoreceptors and Chlamydomonas cell

240 ng that the fungus induced paralysis via the cilia of nematode sensory neurons.

241 Primary cilia on crown cells are required to interpret the direc

242 We identified primary cilia on endothelial cells as the underlying cause of th

243 Using cilia-GFP mice, we found presence of cilia on growth plate (GP), cartilage endplate (EP) annu

244 The loss of primary cilia on melanocytes is a useful biomarker for the disti

245 Synchronized beating of cilia on multiciliated cells (MCCs) generates a directio

246 Cilia on pit cells are posteriorly tilted, rotate clockw

247 the unidirectional array of basal bodies of cilia on the MCCs.

248 apart during extension, thousands of lobate cilia on the underlapping feathers lock probabilisticall

249 cur in other small compartments like primary cilia or dendritic spines.

250 Primary cilia, organelles protruding from the surface of eukaryo

251 cy to the actively beating cilia can entrain cilia oscillations.

252 entrainment strongly depend on the number of cilia per cell.

253 Consistent with this, cilia play an important role in brain development, parti

254 Our data suggest that primary cilia play an integral role in maintaining the function

255 Primary cilia play critical roles in development and disease.

256 Motile cilia power cell locomotion and drive extracellular flui

257 In the airways, hundreds of motile cilia present on the surface of a multiciliated epitheli

258 Thus, the requirement for primary cilia presents a conundrum: how are proliferative signal

259 transition zone, ciliary membrane and motile cilia proteins.

260 anscription factor STAT3, a component of the cilia proteome that is involved in crosstalk between imm

261 We conclude that endothelial cell primary cilia regulate islet vascularization and vascular barrie

262 Here, we show that LUZP1 is a cilia regulator.

263 so suggest that defects in the biogenesis of cilia-related EVs may contribute to human ciliopathies.

264 No detectable cilia-related phenotypes were observed in double heteroz

265 kidney disease, but the function of PKD2 in cilia remains unclear.

266 a consequence, we observed the presence of a cilia remnant that promoted the asymmetric inheritance o

267 Construction and function of virtually all cilia require the universally conserved process of intra

268 t EYS protein localization to the connecting cilia requires interaction with the matriglycan and that

269 The coordinated bending of cilia requires mechanoregulation by the radial spoke (RS

270 s remained stable over time, suggesting that cilia retention is a critical feature for optimal neuron

271 Cilia serve as cellular antennae that translate sensory

272 t diminish Siah2-activity leading to primary cilia shortening and attenuation of the mitogenic respon

273 nection between adenylate cyclase 6 (AC6), a cilia signaling mediator, and the autophagy-mediated reg

274 To explore how STAT3 intersects with cilia signaling, renal inflammation, and cyst growth, we

275 epithelia results in abnormally long primary cilia similar to that observed in Notch-signaling-defici

276 ia and their co-depletion results in reduced cilia size, impaired planer polarity and impaired cilia

277 ensory organs of Caenorhabditis elegans in a cilia specific manner.

278 ressed in the primary cilium, and disrupting cilia structure significantly slows ADPKD progression fo

279 e been described, while those distinguishing cilia subtypes are poorly defined.

280 s on the role of basal foot across different cilia systems.

281 most animals is mediated by neurons bearing cilia that are accessible to the environment.

282 photoreceptor cells are specialized sensory cilia that contain hundreds of opsin-loaded stacked memb

283 pushed along by the ciliated cell's beating cilia, the PCF and its virus content are also pushed alo

284 he distal end of the centriole templates the cilia, the proximal end associates with the nucleus.

285 , lipidated cargoes are transported into the cilia through the coordinated actions of cargo carrier p

286 e Ttbk2 conditional mutant mice quickly lose cilia throughout the brain.

287 Recently, Kif19a, a kinesin residing at the cilia tip, was identified to be essential for ciliary le

288 Cells use motile cilia to generate force in the extracellular space.

289 ing a basal foot-an appendage linking motile cilia together to ensure coordinated beating.

290 rough an indirect mechanism in which primary cilia trigger macrophage recruitment to the kidney, whic

291 lved in the structure or function of primary cilia, ubiquitous antenna-like organelles essential for

292 Cells with few cilia (up to five) can be entrained at flows comparable

293 determine whether ARL13B is required within cilia, we knocked in a cilia-excluded variant of ARL13B

294 ble, high-stress cellular structures such as cilia, we sought to determine if these modifications alt

295 a, and Smo is derepressed and accumulates in cilia where it activates signaling.

296 PC-1 and PC-2 enrich on primary cilia, where they are thought to form a heteromeric ion

297 ena basal bodies (BBs) nucleate and position cilia, whereby BB-associated striated fibers (SFs) promo

298 ction of ARMC9 or TOGARAM1 resulted in short cilia with decreased axonemal acetylation and polyglutam

299 three causes Smo to aberrantly accumulate in cilia without pathway activation.

300 7 and the BBSome, cause Smo to accumulate in cilia without pathway activation.