ライフサイエンスコーパス: ciliary

1 The loss of Anks6 causes ciliary abnormalities, ductal plate remodeling defects a

2 ed-1 (Ptch1) localizes to cilia and prevents ciliary accumulation and activation of smoothened (Smo).

3 We further determine whether ciliary ACE2 expression in the upper airway is influence

4 nfection through enhancing the expression of ciliary ACE2 receptor.

5 reases in the expression of genes related to ciliary activity in vivo and alters multiple immune-rela

6 ed with greater epithelial damage with lower ciliary activity, cilium loss, less tight junction expre

7 ia to become active and maintain and enhance ciliary adhesion and signaling [8-14].

8 rs in a characteristic hierarchy of bending, ciliary alteration, contractions, and detachment, which

9 material 1 in the mouse leads to progressive ciliary, anatomical, psychomotor, and cognitive abnormal

10 stnatal brain, with progressive degenerative ciliary and behavioral phenotypes; and they support a co

11 arises naturally as alternating sub-cellular ciliary and contractile activities rearrange the cell's

12 Axonemal dynein ATPases direct ciliary and flagellar beating via adenosine triphosphate

13 We propose that CFAP45 supports mammalian ciliary and flagellar beating via an adenine nucleotide

14 unction of the BBSome, a complex integral in ciliary and intracellular trafficking, in ribbon synapti

15 358A) cells displayed short cilia and lacked ciliary ARL3 and INPP5E.

16 Multi-ciliary arrays promote fluid flow and cellular motility

17 ctions and cortical interactions to organize ciliary arrays.

18 Kinesin-2 enables ciliary assembly and maintenance as an anterograde intra

19 nd our understanding of the role of PACRG in ciliary assembly and motility, we used a combination of

20 consistent with it playing a role in motile ciliary assembly or activity.

21 The ciliary axoneme has a 9 + 2 microtubule structure consis

22 ponents toward the ciliary base; second, the ciliary axoneme shortens and motors slow down; and third

23 S, we determined the structure of the intact ciliary axoneme with up to resolution of 12 angstrom.

24 bidirectional protein trafficking along the ciliary axoneme.

25 expressed in ciliated tissues, localizes to ciliary axonemes and basal bodies, and is required for c

26 these are specifically expressed in the main ciliary band of the mollusc Tritia (also known as Ilyana

27 shared by many spiralians is the presence of ciliary bands used for locomotion and feeding.

28 ar ciliated structures, most consistently in ciliary bands.

29 here we characterize the organization of the ciliary basal foot, an appendage of basal bodies whose m

30 ciliary proteins are transported between the ciliary base and tip.

31 by the translocation of the BBSome into the ciliary base mediated by BBS1.

32 mutant cells, mutant PC2 accumulates at the ciliary base, forming a ring pattern consistent with dis

33 sary and sufficient for its targeting to the ciliary base.

34 ap3 (tm1a/tm1a) , MCCs lacked CAMSAP3 at the ciliary base.

35 he conserved core TZ protein, Cep290, to the ciliary base.

36 ds, redistributing IFT components toward the ciliary base; second, the ciliary axoneme shortens and m

37 ized approaches for systematically assessing ciliary beat dynamics and for drug testing would improve

38 No change in ciliary beat frequency (CBF) or airway surface liquid (A

39 igration, and specialised responses, such as ciliary beat frequency (CBF).

40 atter via an increase in LRRC26 expression), ciliary beat frequency and airway surface liquid volume

41 eltaF508/DeltaF508 and DeltaF508/-) based on ciliary beat frequency and coordination.

42 of the cilium, could perceive forces during ciliary beating and transfer these signals to locally re

43 g either microRNA in 22q11DS mice normalizes ciliary beating and ventricular size.

44 autosomal recessive inheritance) that impair ciliary beating cause a variety of motile ciliopathies,

45 ong been noticed that zebrafish defective in ciliary beating develop abnormal body curvatures.

46 ntify the most efficient drugs for restoring ciliary beating for each individual donor.

47 -DDM) can be used to characterize collective ciliary beating in a non-biased automated manner.

48 ral and third ventricles and deceleration of ciliary beating on ependymal cells lining the ventricula

49 ture is well-suited for mechanoregulation of ciliary beating through physical collisions with the CP.

50 cellular processes such as cell division or ciliary beating while performing their function.

51 cellular position is biased and dependent on ciliary beating.

52 ay essential roles in generating coordinated ciliary beating.

53 sitioning them perpendicular to the plane of ciliary beating.

54 These quantitative features of ciliary behavior illuminate the biophysics of cilia moti

55 onclude that FAM149B1 is required for normal ciliary biology and that its deficiency results in a ran

56 gment epithelium and photoreceptors, and the ciliary body and choroid plexus, the sources of aqueous

57 in the vascular uvea of the human eye (iris, ciliary body and choroid).

58 les that originate from the vasculature-rich ciliary body and extend along the surface of the lens ca

59 in the lens immune response and suggest the ciliary body as a source of immune cells to the avascula

60 aled a partially cystic mass adjacent to the ciliary body between the 5 and 9 o'clock meridians as we

61 The ciliary body epithelial and neuroepithelial tumors (aden

62 neovascular glaucoma, and dose to 20% of the ciliary body had the largest impact on ocular hypertensi

63 the use of targeted chemotherapy to treat a ciliary body medulloepithelioma with aqueous and vitreou

64 A 17-month-old boy with a diagnosis of ciliary body medulloepithelioma with concomitant seeding

65 me complete regression of a non-infiltrating ciliary body medulloepithelioma with seeding achieved wi

66 age points including the aortic root and the ciliary body of the eye and that systemic overexpression

67 The volume of the ciliary body receiving 26 Gy was the only variable assoc

68 e., optic disc, macula, retina, globe, lens, ciliary body) correlated with clinical outcome.

69 quadrants of the angle: anteriorly directed ciliary body, absent ciliary sulcus, iris angulation, fl

70 and site (retina, C69.2; choroid, C69.3; and ciliary body, C69.4) from 1975 through 2011 using the Su

71 from all sites of the uveal tract (choroid, ciliary body, iris).

72 tive organisms or fibrosis encapsulating the ciliary body, leading to hypotony.

73 nonpigmented and pigmented epithelia of the ciliary body, lens epithelium, and a subset of retinal n

74 of allergic or idiosyncratic reaction of the ciliary body.

75 se 1 like 1 (PKD1L1), a gene associated with ciliary calcium signaling and embryonic laterality deter

76 negatively regulated by constitutively high ciliary cAMP maintained by the Galpha(s)-coupled GPCR, G

77 x, the BBSome, which mediates trafficking of ciliary cargoes.

78 tigrella crozieri, and found it expressed in ciliary cells of eyes in the larva, and in extraocular c

79 microvillar cells with rhabdomeric opsin and ciliary cells with ciliary opsin, each type having speci

80 All melanocytic tumors (iris melanoma, ciliary-choroidal melanoma, and melanocytoma) and retina

81 mes from the distal appendages (DAPs) to the ciliary compartment (CC), moving slowly in the DAPs, rel

82 c and monogenic mouse models highlighted the ciliary compartment as a common dysregulated target, wit

83 within the cytoplasm rather than within the ciliary compartment, are proposed to allow for the effic

84 ood but are thought to involve resorption of ciliary components into the cell body.

85 g, as well as for the assembly of additional ciliary components that play essential roles in generati

86 lowing a rescue of both cilia morphology and ciliary composition.

87 reassessment of the relationship between the ciliary cytoskeleton and microtubule-based transport in

88 can be reversed by targeting the underlying ciliary defect via reduction of GSL metabolism.

89 An association between ciliary defects and obesity has been suggested, but the

90 yos and mammalian cell culture, arguing that ciliary defects are at least partially involved in the p

91 channel dysfunction of cystic fibrosis, and ciliary defects of primary ciliary dyskinesia.

92 d photoreceptor outer segment morphology and ciliary defects.

93 ss indicate that two processes contribute to ciliary disassembly in response to cessation of anterogr

94 res of the major mechanoregulators that bind ciliary doublet microtubules in Chlamydomonas reinhardti

95 The absence of Prom1 impairs ciliary dynamics and abolishes the growth stimulation ef

96 Thm2-null MEF show normal ciliary dynamics and Hedgehog signaling, but additional

97 sor tooth epithelia as a model, we show that ciliary dynamics in stem cells require the proper functi

98 Ciliary dysfunction causes severe diseases, termed cilio

99 insights into CSF flow dynamics and role of ciliary dysfunction in hydrocephalus pathogenesis.

100 thies, a group of genetic diseases linked to ciliary dysfunction, and gene therapy is an attractive t

101 specified set of 2,016 genes associated with ciliary dysgenesis and/or dysfunction or cholestasis wer

102 In contrast, adult-onset ciliary dysgenesis in POMC neurons causes no significant

103 Primary ciliary dyskinesia (PCD) is a genetically heterogeneous

104 Primary ciliary dyskinesia (PCD) originates from dysfunction of

105 otypes, some of which are typical of primary ciliary dyskinesia (PCD), a condition caused by motile c

106 nce, for example in cystic fibrosis, primary ciliary dyskinesia (PCD), and select immunodeficiencies(

107 atients with ciliopathies, including primary ciliary dyskinesia and Bardet-Biedl syndrome, also suffe

108 phic mutations of human DNAAF2 can result in ciliary dyskinesia and identify Dnaaf2 as an essential c

109 ause loss of cilia motility in human primary ciliary dyskinesia patients is not fully associated with

110 ired, the disorder is referred to as primary ciliary dyskinesia, the most common motile ciliopathy.

111 tic fibrosis, and ciliary defects of primary ciliary dyskinesia.

112 e is no evidence-based treatment for primary ciliary dyskinesia; therapies aim at relieving symptoms

113 sence of PAM in mammalian cilia suggest that ciliary ectosome-mediated peptidergic signaling dates to

114 rtases, amidated products, and receptors) in ciliary ectosomes from the green alga Chlamydomonas.

115 iffusion-binding-transport model showed that ciliary enrichment of a rhodopsin kinase probe occurs vi

116 eletion of residues 261-275 of IFT54 reduced ciliary entry and anterograde traffic of IFT dynein with

117 ther with Thm2, regulates cilia disassembly, ciliary entry of membrane-associated protein, Hedgehog s

118 defect for IFT and BBS proteins, and reduced ciliary entry of membrane-associated proteins.

119 Ciliary entry per se of SAG1 is independent of anterogra

120 This suggests a two-step model of ciliary entry; PC2 first traffics to the cilium base bef

121 c analysis and open-flap biopsy specimens of ciliary epithelial and iris epithelial neoplasms, melano

122 to the variable cytokeratin staining in the ciliary epithelial neoplasms and the variable Lin28A sta

123 Mechanisms driving ciliary EV biogenesis are almost entirely unknown.

124 nted ciliary proteins for recognition by the ciliary exit machinery.

125 a common dysregulated target, with enhanced ciliary expression and length changes in the digenic mod

126 B connections and cortical interactions in a ciliary force-dependent mechanism.

127 se disrupts either SF steady-state length or ciliary force-induced SF elongation.

128 sed expression of many genes associated with ciliary function and assembly.

129 expression of downstream genes that modulate ciliary function and inflammatory response to influence

130 enriched in coexpression network modules for ciliary function and inflammatory response.

131 The role of adenylyl cyclases in ciliary function has been of interest because the produc

132 ve the way to the molecular understanding of ciliary function in health and disease.

133 rgetable signaling axis that controls motile ciliary function in humans and has potential implication

134 s been consistently shown to cause defective ciliary function in several model organisms.

135 How input from the cell body affects IFT and ciliary function is not well understood.

136 s for PKD1L1 in laterality determination and ciliary function suggest that PKD1L1 is a biologically p

137 h plays a critical role in regulating proper ciliary function.

138 ction and viability, potentially through its ciliary function.

139 Here, we show that the ciliary G-protein Rab28, associated with human autosomal

140 The blockade of ipsilateral ciliary ganglion parasympathetic fibers by mepivacaine m

141 ly regulates the functional component of the ciliary gate and suggest a correlation between defective

142 al degenerations associated with compromised ciliary gates.

143 We show that a mutation in the ciliary gene Inpp5e leads to a transient increase in dir

144 In vitro silencing of ciliary genes in endothelial cells disrupts VEGF-A/VEGFR

145 pathies, the mechanism by which mutations in ciliary genes lead to bile duct developmental abnormalit

146 results provide a valuable list of candidate ciliary genes.

147 Chemogenetic activation of ciliary GPCR signaling and cilia-specific optogenetic mo

148 Here we find that, upon activation, ciliary GPCRs become tagged with ubiquitin chains compri

149 R GPR161 demonstrates that ubiquitination of ciliary GPCRs is required for their regulated exit from

150 re required for the signal-dependent exit of ciliary GPCRs, but the functional interplay between beta

151 ould potentially serve as one of the crucial ciliary growth checkpoints and could be channeled to dev

152 Cell-cell communication via ciliary GTPase signaling directs mitotic spindle orienta

153 Our findings demonstrate that ciliary IFT80 is important for the maintenance of IVD ce

154 have been co-opted for independent roles in ciliary import.

155 assembly, and increased impairment of INPP5E ciliary import.

156 Key features were conjunctival ciliary injection and mutton fat keratic precipitation i

157 g mechanisms, and uncouples its binding with ciliary kinesin Kif19a.

158 c inhibition of V2R with tolvaptan increases ciliary length and mechanosensory function.

159 lates the motile ciliary proteome to promote ciliary length and mucociliary transport but which is di

160 ilia tip, was identified to be essential for ciliary length control through its microtubule depolymer

161 utation Y819F/Y828F) significantly decreases ciliary length in Madin-Darby canine kidney cells.

162 length, although the effect of tolvaptan on ciliary length is dampened.

163 of V2R, however, does not have any effect on ciliary length, although the effect of tolvaptan on cili

164 (AF), and nucleus pulposus (NP) with varying ciliary length.

165 factor-like protein 13B, a key regulator of ciliary length.

166 sly observed enhancing effect of WT PROM1 on ciliary length.

167 se data provide a mechanism to control Smo's ciliary level during Hedgehog signaling by regulating th

168 tif disrupt binding with PP1alpha and impair ciliary localization of PC1.

169 We discover that TULP3-dependent ciliary localization of the omega-3 fatty acid receptor

170 icult to uncouple cystoprotein function from ciliary localization.

171 gether, these results suggest that mammalian ciliary loss involves a tunable decision between decilia

172 of WDR92 expression in planaria resulted in ciliary loss, reduced beat frequency and dyskinetic moti

173 Moreover, in the ventral ciliary margin zone (CMZ), which contains progenitors th

174 with a progenitor population residing in the ciliary marginal zone (CMZ) at the retinal peripheral ma

175 The ciliary marginal zone (CMZ) of the zebrafish retina cont

176 tants also possessed a reduced proliferative ciliary marginal zone, and decreased and disorganized Mu

177 gametes rapidly becomes enriched in the peri-ciliary membrane and enters the cilia to become active a

178 lagellar transport, BBSome, transition zone, ciliary membrane and motile cilia proteins.

179 o regulate the actin-driven expansion of the ciliary membrane at the initiation of new outer segment

180 that the organization of cholesterol in the ciliary membrane can be modified by extracellular ligand

181 3), which controls sequential recruitment of ciliary membrane components, histone deacetylase, and tr

182 mble into the BBSome, a key regulator of the ciliary membrane proteome.

183 naling pathway that links nuclear enzymes to ciliary membrane receptors via TULP3, describes a dynami

184 ge is required to recruit the complex to the ciliary membrane.

185 sible for initiating disc formation from the ciliary membrane.

186 ity to generate cAMP upon trafficking to the ciliary membrane.

187 geting of lipidated Rab28 to periciliary and ciliary membranes is highly dependent on the BBSome and

188 Pase (ARL6/BBS3) that recruits the BBSome to ciliary membranes.

189 ion and yeast 2-hybrid screens to identify a ciliary module whose dysfunction underlies JBTS.

190 ed severe nasal airway blockage and abnormal ciliary morphologies in nasal MCCs.

191 Despite their importance for ciliary motility across eukaryotes, the molecular functi

192 rd1 mechanism contributes to deceleration of ciliary motility and age-dependent ventricular enlargeme

193 Ciliary motility depends on both the precise spatial org

194 Ciliary motility is driven by axonemal dyneins that are

195 symptoms and reducing the effects of reduced ciliary motility.

196 d SPEF2 have a PCD phenotype with defects in ciliary motility.

197 st the repeated mechanical stress induced by ciliary motility.

198 erves as a central hub for the regulation of ciliary motility.

199 n all lead to defects in dynein assembly and ciliary motility.

200 concept uses the (remaining) strength of the ciliary muscle, whereas another is triggered by the pupi

201 om neighboring tissues, predominantly in the ciliary muscle/scleral spur, which together correspond t

202 Ciliary neurotrophic factor (CNTF) has been tested in cl

203 e family, including oncostatin (OSM), IL-11, ciliary neurotrophic factor (CNTF), and leukemia inhibit

204 phic factor, fibroblast growth factor-2, and ciliary neurotrophic factor (CNTF), and the implantation

205 E3 inhibits OPC proliferation by stimulating ciliary neurotrophic factor (CNTF)-mediated signaling th

206 cardiotrophin-like cytokine factor 1 (CLCF1)-ciliary neurotrophic factor receptor (CNTFR) signaling a

207 Rat models of brain metastasis and ciliary neurotrophic factor were used to induce astrocyt

208 ransport but which is dispensable for normal ciliary number, radial structure, and beat frequency.

209 ith rhabdomeric opsin and ciliary cells with ciliary opsin, each type having specialized molecular co

210 rst organism known to have both xenopsin and ciliary opsin, showing that these opsins are not necessa

211 mics of the probes, including presynapse and ciliary OS enrichment, depending on lipid moiety and pro

212 recycling as it perpetually leaks out of the ciliary OS.

213 Therefore, Tulp3 controls distinct ciliary pathways that positively or negatively regulate

214 Data underlining the importance of ciliary PC2 localisation in preventing PKD are limited b

215 hat EXOC5 mRNA almost completely rescues the ciliary phenotypes in exoc5-mutant zebrafish, unlike the

216 We examined the ciliary phenotypes of mutant MEF.

217 ssential for Shh signal transduction and the ciliary phosphatidylinositol phosphatase Inpp5e is linke

218 downstream effector, Inpp5e, and deregulates ciliary-PI3K/AKT signaling.

219 Ns and EHDs are dynamically localized to the ciliary pocket membrane (CPM) and transported away from

220 Using both reconstituted and ciliary polycystin channels, we further show that a solu

221 orly understood how fluid flow activates the ciliary polycystin complex.

222 s that this mechanism evolved from an innate ciliary process of releasing small extracellular vesicle

223 onths of age and anterior PFV with elongated ciliary processes.

224 m, in the transition zone, where it controls ciliary protein composition and signalling.

225 hat targeted exon skipping is able to rescue ciliary protein composition defects, provides functional

226 novel insights into the relationship between ciliary protein dysfunction and neuropsychiatric disorde

227 e emerging roles for RanGTP/importin beta in ciliary protein targeting, we further investigated the e

228 ANKS6 is a ciliary protein that localizes to the proximal compartme

229 system that segregates RanGTP regulation of ciliary protein trafficking from its nuclear roles.

230 thought to act as a gatekeeper that controls ciliary protein trafficking.

231 Tubby-related proteins regulate ciliary protein transport; however, their roles in remod

232 Novel PPIs were predicted for each ciliary protein using a computational method we develope

233 iodigital syndrome 1 (Ofd1), which encodes a ciliary protein, in Wnt1-Cre; Ofdfl/Y mice led to a comp

234 les of intraflagellar transport (IFT), where ciliary proteins are transported between the ciliary bas

235 that Ub chains mark GPCRs and other unwanted ciliary proteins for recognition by the ciliary exit mac

236 a deeper systems-level understanding of how ciliary proteins function together may provide new mecha

237 The inactivation of the ciliary proteins polycystin 1 or polycystin 2 leads to a

238 alize and quantify the real-time response of ciliary proteins to dendritic ablation.

239 wever, the mechanisms by which PC1 and other ciliary proteins traffic to the primary cilium remain po

240 that mutations in genes coding for multiple ciliary proteins underlie polycystic kidney disease, a d

241 Known PPIs of ciliary proteins were assembled from online databases.

242 esulting cilia "interactome" consists of 165 ciliary proteins, 1,011 known PPIs, and 765 novel PPIs.

243 nteractome revealed interconnections between ciliary proteins, and their relation to several pathways

244 c kinase whose activity regulates the motile ciliary proteome to promote ciliary length and mucocilia

245 ary targeting sequence (CTS) that resides in ciliary receptors is considered to function in the proce

246 d disorders manifested by mislocalization of ciliary receptors.SIGNIFICANCE STATEMENT Retinal ciliopa

247 g signaling decreases Smo ubiquitination and ciliary removal, resulting in its accumulation.

248 Aberrant serum-induced ciliary resorption and cold-induced depolymerization in

249 ryonic fibroblasts (MEF), we investigate the ciliary roles of two mammalian orthologues of Chlamydomo

250 s) promote BB anchorage and orientation into ciliary rows.

251 that trigger cilia formation, extension and ciliary signal transduction are still not fully understo

252 These data suggest that ciliary signaling acts to modulate axonal connectivity a

253 in vivo in zebrafish to specifically analyze ciliary signaling and function.

254 that promoted the asymmetric inheritance of ciliary signaling components and supported cilium reasse

255 Analyzing ciliary signaling has been challenging due to the lack o

256 tbk2 knockout, indicating that disruption of ciliary signaling is a key driver of these phenotypes.

257 adhesion receptors SAG1 and SAD1 activate a ciliary signaling pathway [7].

258 Execution of a ciliary signaling pathway, however, can critically depen

259 s (PI3K, AKT, and AC3) commonly regulated by ciliary signaling receptors induce rapid changes in axon

260 ging due to the lack of tools to investigate ciliary signaling.

261 strate how defects in the balanced output of ciliary signalling events are coupled to developmental d

262 og (HH) pathway, for example, is a bona fide ciliary signalling system that regulates cell fate and s

263 sease, such as dysregulated mTOR and primary ciliary signalling, have roles in metabolic regulation a

264 r this new JBTS-associated protein module in ciliary stability.

265 s, and returns to the cell surface at a peri-ciliary staging area for entry into cilia.

266 ology of Bbs2-/- mice by directly preserving ciliary structure and function towards a normal phenotyp

267 tudies have identified mutations that affect ciliary structure and nucleation in PCD(4), but the regu

268 ese effects are secondary to preservation of ciliary structure and signaling, and stimulation of cell

269 Loss of Inpp5e also affects ciliary structure coinciding with reduced Gli3 repressor

270 Tube-shunt implantation through the ciliary sulcus in pseudophakic eyes appears relatively s

271 evice outside the eye was implanted into the ciliary sulcus with or without trans-scleral suture fixa

272 le: anteriorly directed ciliary body, absent ciliary sulcus, iris angulation, flat iris plane, and ir

273 to our 3D results on the Smoothened-measured ciliary surface.

274 The mechanism underlying the ciliary targeting of PRPH2 and the etiology of cone dyst

275 The present study reveals a novel ciliary targeting pathway, in which the newly synthesize

276 A ciliary targeting sequence (CTS) that resides in ciliary

277 in phosphatase 1alpha interacts with a novel ciliary targeting sequence of polycystin-1 and regulates

278 of protein function observed after fusion to ciliary targeting sequences.

279 s results in the remarkable expansion of the ciliary tip.

280 with accumulation of IFT complexes near the ciliary tip.

281 We show that conditional knockout of the key ciliary trafficking gene Ift88 in adult mice results in

282 ng proteins, WDR44, in negatively regulating ciliary trafficking in concert with Akt.

283 otential function of SMO in regulating basal ciliary trafficking of GLI2 when the pathway is off.

284 e that dictates nuclear transport, regulates ciliary trafficking of KAP3, a key component for functio

285 at the tubby family protein Tulp3 determines ciliary trafficking of polycystins in kidney collecting

286 Arl/ARF GTPases regulate ciliary trafficking, but their tissue-specific functions

287 m to activate distinct sets of target genes (ciliary transcription factor genes versus basal body amp

288 CEP290 proteins localize to the ciliary transition zone and are thought to act as a gate

289 ion of glycolysis in mammalian cells induces ciliary translocation of Smo-a key step in pathway activ

290 After tagging individual ciliary transmembrane proteins, specifically Smoothened,

291 3B pathomechanisms can impair kinesin-driven ciliary transport in the photoreceptor.

292 It has been previously suggested that ciliary transport is analogous to nuclear transport mech

293 The mechanism underlying the ciliary transport of PRPH2 is unclear.

294 t be detected in cilia, even when retrograde ciliary transport was blocked.

295 Ciliary tumor and seeding totally regressed after a tota

296 rved in the structural maps, supporting that ciliary vesicles budding may serve as ectosomes for cell

297 he role of mechanoregulation in defining the ciliary waveform.

298 ese results demonstrate that lens-associated ciliary zonules are directly involved in the lens immune

299 icrofibril-associated protein-1 (MAGP1)-rich ciliary zonules that originate from the vasculature-rich

300 ury involving the lens-associated MAGP1-rich ciliary zonules.