ライフサイエンスコーパス: ciliary neurotrophic factor

1 noic acids, vitamin D, thyroid hormones, and ciliary neurotrophic factor.

2 genesis factor-1 (AF-1) and AF-2, along with ciliary neurotrophic factor.

3 the highest homology to cardiotrophin-1 and ciliary neurotrophic factor.

4 th its proposed function as a target-derived ciliary neurotrophic factor.

5 gainst brain-derived nerve growth factor and ciliary neurotrophic factor.

6 c factor, platelet-derived growth factor and ciliary neurotrophic factor.

7 fibroblast growth factor-2 (FGF2) but not by ciliary neurotrophic factor.

8 e glutamate receptor agonist, treatment with ciliary neurotrophic factor afforded marked protection a

9 Ciliary neurotrophic factor, along with other neuropoiet

10 The ciliary neurotrophic factor alpha-receptor (CNTFRalpha)

11 ions showed that the increased production of ciliary neurotrophic factor and brain-derived neurotroph

12 neration of astrocytes in collaboration with ciliary neurotrophic factor and growth factors.

13 Ciliary neurotrophic factor and leukemia inhibitory fact

14 rs of the same cytokine subfamily, including ciliary neurotrophic factor and leukemia inhibitory fact

15 Treatment of SN56 cells with the cytokines ciliary neurotrophic factor and leukemia inhibitory fact

16 uggest that astrocytes themselves respond to ciliary neurotrophic factor and that ciliary neurotrophi

17 Messenger RNA for both ciliary neurotrophic factor and the alpha-component of t

18 In contrast, ciliary neurotrophic factor and thyroid hormone T3 act i

19 Brain-derived neurotrophic factor, ciliary neurotrophic factor, and 8-(4-chlorophenylthio)-

20 (LIF), granulocyte colonystimulating factor, ciliary neurotrophic factor, and cardiotrophin-1), many

21 regulated by platelet-derived growth factor, ciliary neurotrophic factor, and glial growth factor 2 (

22 IL-10, IL-4, ciliary neurotrophic factor, and IL-2, cytokines not kno

23 of this group of cytokines, oncostatin M and ciliary neurotrophic factor, and the LIF receptor beta a

24 ted by a neutralizing anti-LIF, but not anti-ciliary neurotrophic factor, antiserum.

25 hree other drugs, bupropion, topiramate, and ciliary neurotrophic factor, are undergoing clinical tri

26 The related cytokines Il-6, ciliary neurotrophic factor, as well as epidermal growth

27 actor, brain derived neurotrophic factor, or ciliary neurotrophic factor at the lesion site also show

28 e examined the effects of a modified form of ciliary neurotrophic factor [Axokine, which is hereafter

29 otrophin-3 (NT-3), neurotrophin-4/5 (NT4/5), ciliary neurotrophic factor, basic fibroblast growth fac

30 ctodomains bound to their respective ligands ciliary neurotrophic factor, cardiotrophin-like cytokine

31 Ciliary neurotrophic factor (CNTF) activates cells via t

32 Ciliary neurotrophic factor (CNTF) acts as a potent neur

33 Ciliary neurotrophic factor (CNTF) acts as a potent neur

34 Ciliary neurotrophic factor (CNTF) acts instructively to

35 Ciliary neurotrophic factor (CNTF) administration mainta

36 Exogenous ciliary neurotrophic factor (CNTF) administration promot

37 riptional activity via the 5th intron of the ciliary neurotrophic factor (CNTF) alpha receptor gene (

38 lls provides a feed-forward loop, increasing ciliary neurotrophic factor (CNTF) and basic fibroblast

39 ed to determine the mRNA expression of bFGF, ciliary neurotrophic factor (CNTF) and brain-derived neu

40 Here, we examined ciliary neurotrophic factor (CNTF) and fibroblast growth

41 factor (FGF2) and in situ hybridization for ciliary neurotrophic factor (CNTF) and glial growth fact

42 Ciliary neurotrophic factor (CNTF) and interleukin-6 (IL

43 Ciliary neurotrophic factor (CNTF) and leptin decrease f

44 n of retinal glia, and subsequent release of ciliary neurotrophic factor (CNTF) and leukaemia inhibit

45 Ciliary neurotrophic factor (CNTF) and leukemia inhibito

46 Neuropoietic cytokines, including ciliary neurotrophic factor (CNTF) and leukemia inhibito

47 etermine the intracellular pathways by which ciliary neurotrophic factor (CNTF) and leukemia inhibito

48 trophic factors, but the mechanisms by which ciliary neurotrophic factor (CNTF) and other neurotrophi

49 rtex coexpress surface receptor proteins for ciliary neurotrophic factor (CNTF) and platelet-derived

50 ic factor (BDNF), nerve growth factor (NGF), ciliary neurotrophic factor (CNTF) and their respective

51 The cytokine ciliary neurotrophic factor (CNTF) and transforming grow

52 he CDFs leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) bind to a LIFR.gp130

53 Neuropoletic cytokines such as ciliary neurotrophic factor (CNTF) can activate multiple

54 te that leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) cause sympathetic neu

55 normal adult canine retina and suggest that ciliary neurotrophic factor (CNTF) could have a direct p

56 was to evaluate the therapeutic efficacy of ciliary neurotrophic factor (CNTF) delivered through enc

57 proof of concept phase 2 study, we evaluated ciliary neurotrophic factor (CNTF) delivered via an intr

58 Ciliary neurotrophic factor (CNTF) exhibits multiple bio

59 A likely trigger of such sprouting is ciliary neurotrophic factor (CNTF) expressed in local sp

60 cellular pathways by which neurotrophins and ciliary neurotrophic factor (CNTF) function to regulate

61 Basic fibroblast growth factor (bFGF) and ciliary neurotrophic factor (CNTF) gene expression were

62 Ciliary neurotrophic factor (CNTF) has been found to inc

63 Ciliary neurotrophic factor (CNTF) has been implicated i

64 Ciliary neurotrophic factor (CNTF) has been implicated i

65 Ciliary neurotrophic factor (CNTF) has been shown to be

66 Ciliary neurotrophic factor (CNTF) has been shown to pro

67 Ciliary neurotrophic factor (CNTF) has been tested in cl

68 Ciliary neurotrophic factor (CNTF) has potent survival-p

69 c protein and neurotrophic factors including ciliary neurotrophic factor (CNTF) in astrocytes in a do

70 filtrating DCs, which were a major source of ciliary neurotrophic factor (CNTF) in the cornea.

71 r changes induced by sustained expression of ciliary neurotrophic factor (CNTF) in the rds mutant mou

72 Similar to leptin, the cytokine ciliary neurotrophic factor (CNTF) induces hypophagia an

73 Ciliary neurotrophic factor (CNTF) induces weight loss i

74 ome of these changes are mimicked by chronic ciliary neurotrophic factor (CNTF) infusions into the sa

75 dogenous GFAP gene was examined by injecting ciliary neurotrophic factor (CNTF) into the eye.

76 ugh lentiviral gene transfer of the cytokine ciliary neurotrophic factor (CNTF) into the rat striatum

77 Ciliary neurotrophic factor (CNTF) is a cytokine that ha

78 Ciliary neurotrophic factor (CNTF) is a leading therapeu

79 Ciliary neurotrophic factor (CNTF) is a neuropoietic cyt

80 Ciliary neurotrophic factor (CNTF) is a neurotrophic fac

81 Ciliary neurotrophic factor (CNTF) is a potent neural cy

82 Ciliary neurotrophic factor (CNTF) is a promyelinating t

83 Ciliary neurotrophic factor (CNTF) is a trophic factor f

84 Ciliary neurotrophic factor (CNTF) is important for the

85 Ciliary neurotrophic factor (CNTF) is pleiotrophic for c

86 Ciliary neurotrophic factor (CNTF) is primarily known fo

87 Here we report that the sprouting induced by ciliary neurotrophic factor (CNTF) is qualitatively diff

88 Ciliary neurotrophic factor (CNTF) is undergoing testing

89 Ciliary neurotrophic factor (CNTF) maintains survival of

90 ctor (BDNF), and a 24-h delayed induction of ciliary neurotrophic factor (CNTF) mRNA.

91 of basic fibroblast growth factor (bFGF) and ciliary neurotrophic factor (CNTF) on axotomy-induced ce

92 fferentiation into GFAP+ cells is induced by ciliary neurotrophic factor (CNTF) or by leukemia inhibi

93 The neuropoietic cytokine ciliary neurotrophic factor (CNTF) potently induces tran

94 Ciliary neurotrophic factor (CNTF) potently reduces appe

95 Exogenous ciliary neurotrophic factor (CNTF) promotes motor neuron

96 Ciliary neurotrophic factor (CNTF) promotes photorecepto

97 We previously demonstrated that ciliary neurotrophic factor (CNTF) promotes process outg

98 Ciliary neurotrophic factor (CNTF) promotes the survival

99 inson's disease and animals reduces, whereas ciliary neurotrophic factor (CNTF) promotes, neurogenesi

100 Ciliary neurotrophic factor (CNTF) protects pancreatic i

101 Ciliary neurotrophic factor (CNTF) protein and bioactivi

102 and recruited to the gp130 component of the ciliary neurotrophic factor (CNTF) receptor complex upon

103 MiR-383-5p directly targets ciliary neurotrophic factor (CNTF) receptor components,

104 Indirect data suggest that endogenous ciliary neurotrophic factor (CNTF) receptor signaling ma

105 prenatal to early postnatal treatment with a ciliary neurotrophic factor (CNTF) small-molecule peptid

106 Ciliary neurotrophic factor (CNTF) specifically induced

107 Ciliary neurotrophic factor (CNTF) sustains the viabilit

108 brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) to developing neuromu

109 Furthermore, GDNF synergizes with ciliary neurotrophic factor (CNTF) to enhance TRKA recep

110 In this Phase I safety trial, human ciliary neurotrophic factor (CNTF) was delivered by cell

111 Ciliary Neurotrophic Factor (CNTF) was first characteriz

112 Ciliary neurotrophic factor (CNTF) was found to have a r

113 Consistently, a transient upregulation of ciliary neurotrophic factor (CNTF) was observed within t

114 Ciliary neurotrophic factor (CNTF) was the most effectiv

115 his study was conducted to determine whether ciliary neurotrophic factor (CNTF), a combination of BDN

116 Ciliary neurotrophic factor (CNTF), a cytokine closely r

117 mulation of wild-type neural stem cells with ciliary neurotrophic factor (CNTF), a differentiation-in

118 Expression of apolipoprotein E (apoE) and ciliary neurotrophic factor (CNTF), a pleiotropic neuron

119 a (LIFbeta) heterodimeric receptors, such as ciliary neurotrophic factor (CNTF), activated signal tra

120 bitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF), all involve the sign

121 l effects of hepatocyte growth factor (HGF), ciliary neurotrophic factor (CNTF), and Artemin through

122 inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1

123 lex consisting of gp130, LIF-R, the cytokine Ciliary Neurotrophic Factor (CNTF), and its alpha recept

124 e family, including oncostatin (OSM), IL-11, ciliary neurotrophic factor (CNTF), and leukemia inhibit

125 phic factor, fibroblast growth factor-2, and ciliary neurotrophic factor (CNTF), and the implantation

126 ne receptor (DRD3), apolipoprotein E (APOE), ciliary neurotrophic factor (CNTF), and the mu opioid re

127 licated gp130 receptor ligands, particularly ciliary neurotrophic factor (CNTF), as potential anti-ob

128 ctor (BDNF), neurotrophin-3, neurotrophin-4, ciliary neurotrophic factor (CNTF), Axokine (a mutein of

129 PCR demonstrated the presence of message for ciliary neurotrophic factor (CNTF), brain-derived neurot

130 (BDNF) and an unrelated neurotrophic factor, ciliary neurotrophic factor (CNTF), but not by NGF [7] [

131 t their response to the anorectic actions of ciliary neurotrophic factor (CNTF), corticotropin releas

132 udies using transgenic mice that overexpress ciliary neurotrophic factor (CNTF), direct injection of

133 ng brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), fibroblast growth fa

134 or brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), glial cell-derived n

135 in (OPN)/insulin-like growth factor 1 (IGF1)/ciliary neurotrophic factor (CNTF), induces regrowth of

136 Inhibitory Factor (LIF), Oncostatin M (OSM), Ciliary Neurotrophic Factor (CNTF), Interleukin-11 (IL-1

137 ardiotrophin-1 (CT-1), a cytokine related to ciliary neurotrophic factor (CNTF), is expressed at high

138 of brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), or basic fibroblast

139 cytokines: leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), or cardiotrophin-1 (

140 ssessed in normal and rcd1 dogs treated with ciliary neurotrophic factor (CNTF), to examine the effec

141 erived O-2A/OPCs to thyroid hormone (TH) and ciliary neurotrophic factor (CNTF), well-characterized i

142 Ciliary neurotrophic factor (CNTF), which acts parallel

143 astrocytes mediates endogenous production of ciliary neurotrophic factor (CNTF), which prevents the a

144 Ciliary neurotrophic factor (CNTF)-dependent induction o

145 Cytokines of the ciliary neurotrophic factor (CNTF)-leukemia inhibitory f

146 A mechanism by which members of the ciliary neurotrophic factor (CNTF)-leukemia inhibitory f

147 impact of exaggerated polyol pathway flux on ciliary neurotrophic factor (CNTF)-like bioactivity and

148 E3 inhibits OPC proliferation by stimulating ciliary neurotrophic factor (CNTF)-mediated signaling th

149 mitter acetylcholine (ACh) is upregulated by ciliary neurotrophic factor (CNTF).

150 leukemia inhibitory factor (LIF) or LIF and ciliary neurotrophic factor (CNTF).

151 s: basic fibroblast growth factor (bFGF) and ciliary neurotrophic factor (CNTF).

152 e-derived neurotrophic factor (GDNF) and the ciliary neurotrophic factor (CNTF).

153 ue with respect to the neurotrophic molecule ciliary neurotrophic factor (CNTF).

154 uction of hypothalamic cell proliferation by ciliary neurotrophic factor (CNTF).

155 the signalling mediated by the neurotrophin ciliary neurotrophic factor (CNTF).

156 differentiate into astrocytes in response to ciliary neurotrophic factor (CNTF).

157 ated cell technology (ECT) devices releasing ciliary neurotrophic factor (CNTF).

158 as well as a therapeutically useful protein [ciliary neurotrophic factor (CNTF)].

159 [Axokine, which is hereafter referred to as ciliary neurotrophic factor (CNTF)Ax15], which uses a le

160 ture media with the differentiating cytokine ciliary neurotrophic factor (CNTF; n = 9) or 2) allowed

161 ematopoietins (IL-6, oncostatin M [OSM], and ciliary neurotrophic factor [CNTF]), we found that while

162 iven the effects of a related family member (ciliary neurotrophic factor, CNTF) on neuronal cell surv

163 ion of the alpha subunit of the receptor for ciliary neurotrophic factor (CNTFR alpha), which is esse

164 tor, nerve growth factor, neurotrophin-3, or ciliary neurotrophic factor could protect striatal outpu

165 In untreated rats, ciliary neurotrophic factor cRNA labeling density was hi

166 s on removal of mitogens and the addition of ciliary neurotrophic factor (days >90).

167 ntiated from these cells by stimulation with ciliary neurotrophic factor express phosphorylated tau s

168 These results demonstrate that astroglial ciliary neurotrophic factor expression is increased in f

169 nitis pigmentosa study 3 (CNTF3; n = 65) and ciliary neurotrophic factor for early-stage retinitis pi

170 Ciliary neurotrophic factor for late-stage retinitis pig

171 c factors brain-derived neurotrophic factor, ciliary neurotrophic factor, forskolin, or insulin.

172 Brain-derived neurotrophic factor, ciliary neurotrophic factor, glial-derived neurotrophic

173 Ciliary neurotrophic factor has also been shown to have

174 based expression vector containing the human ciliary neurotrophic factor (hCNTF) was transfected into

175 t that astrocytes are a source of endogenous ciliary neurotrophic factor in the central nervous syste

176 Ciliary neurotrophic factor increases the expression of

177 esence of basic fibroblast growth factor and ciliary neurotrophic factor induces the generation of A2

178 Intravitreal injection of ciliary neurotrophic factor inhibited photoreceptor inju

179 ember of a family of cytokines that includes ciliary neurotrophic factor, interleukin-6, interleukin-

180 Ciliary neurotrophic factor is a cytokine that has effec

181 Long-term intraocular delivery of ciliary neurotrophic factor is achieved by the encapsula

182 for some myeloma cells include IL-6, IL-11, ciliary neurotrophic factor, leukemia inhibitory factor,

183 The gp130 family cytokines ciliary neurotrophic factor, leukemia inhibitory factor,

184 ce and inhibit neurotrophic factors, such as ciliary neurotrophic factor, leukemia inhibitory factor,

185 pond to ciliary neurotrophic factor and that ciliary neurotrophic factor may also be important in gli

186 Intraocular injection of ciliary neurotrophic factor mimics the effect of injury

187 contains sequences thought to confer direct ciliary neurotrophic factor modulation of glial fibrilla

188 ed in the present study to determine whether ciliary neurotrophic factor mRNA expression is increased

189 at, in both control and experimental tissue, ciliary neurotrophic factor mRNA was colocalized with gl

190 owth factor, basic fibroblast growth factor, ciliary neurotrophic factor, N-acetyl cysteine, vitamin

191 ), brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor, nerve growth factor, basic

192 h brain-derived neurotrophic factor, but not ciliary neurotrophic factor, neurotrophin-4, or glial ce

193 bited elaborate processes immunoreactive for ciliary neurotrophic factor, neurotrophin-4/5, nerve gro

194 his study, we demonstrate in vivo effects of ciliary neurotrophic factor on astrocytes in both the in

195 taining and was attenuated by application of ciliary neurotrophic factor or insulin-like growth facto

196 ts suggest that TS acts in synergy with host ciliary neurotrophic factor or leukemia inhibitory facto

197 fferences were observed in the expression of ciliary neurotrophic factor or nerve growth factor.

198 TF3, there was no change in acuity in either ciliary neurotrophic factor- or sham-treated eyes at 1 y

199 Evidence that ciliary neurotrophic factor promotes axonal sprouting an

200 ites/cell) affinity receptors for [125I]-rat ciliary neurotrophic factor (rCNTF) on astrocytes.

201 cardiotrophin-like cytokine factor 1 (CLCF1)-ciliary neurotrophic factor receptor (CNTFR) signaling a

202 d that the receptor for CLF-1/CLC signaling, ciliary neurotrophic factor receptor (CNTFR), was expres

203 CE ciliary neurotrophic factor receptor (CNTFRalpha) and CN

204 the 5th intron of the alpha component of the ciliary neurotrophic factor receptor (CNTFRalpha) gene f

205 Ciliary neurotrophic factor receptor alpha (CNTFR alpha)

206 Ciliary neurotrophic factor receptor alpha (CNTFRalpha)

207 Expression of CNTF and its receptors, ciliary neurotrophic factor receptor alpha (CNTFRalpha)

208 Ciliary neurotrophic factor receptor alpha subunit (CNTF

209 rophic factor and the alpha-component of the ciliary neurotrophic factor receptor is demonstrated in

210 t neurons express the alpha-component of the ciliary neurotrophic factor receptor, the results of the

211 the p40 subunit of interleukin-12 and to the ciliary neurotrophic factor receptor, whose expression i

212 was used to antagonize signaling through the ciliary neurotrophic factor receptor-alpha (CNTFRalpha).

213 t from its known role as a co-ligand for the ciliary neurotrophic factor receptor.

214 Over the short term, ciliary neurotrophic factor released continuously from a

215 estigations indicated that recombinant human ciliary neurotrophic factor (rhCNTF) may have potential

216 tically engineered recombinant human variant ciliary neurotrophic factor (rhvCNTF) that signals throu

217 ve previously purified and cloned a secreted ciliary neurotrophic factor that was called growth-promo

218 dministration of epidermal growth factor and ciliary neurotrophic factor to adult mice with chronic h

219 Our studies revealed that neither CT-1 nor ciliary neurotrophic factor treatment affected adipocyte

220 In both studies, ciliary neurotrophic factor treatment resulted in a dose

221 Interleukin-6 and ciliary neurotrophic factor, two cytokines related struc

222 ein 130 receptor cytokines interleukin-6 and ciliary neurotrophic factor via membrane-bound signaling

223 ia cell line-derived neurotrophic factor, or ciliary neurotrophic factor, was increased at the lesion

224 Rat models of brain metastasis and ciliary neurotrophic factor were used to induce astrocyt

225 cortical progenitor cells were treated with ciliary neurotrophic factor, which induces precocious gl