ライフサイエンスコーパス: ciliated cell

1 t eventually differentiate into post-mitotic ciliated cells .

2 terfowl viruses (which preferentially infect ciliated cells).

3 localisation of mRNA and proteins in motile ciliated cells.

4 er drove early progenitor differentiation to ciliated cells.

5 ed with the expression of ttll3 and ttll6 in ciliated cells.

6 with generation of differentiated Clara and ciliated cells.

7 ith the normal AP asymmetric distribution of ciliated cells.

8 14ECs) function as progenitors for Clara and ciliated cells.

9 to DNA damage when compared with neighboring ciliated cells.

10 y receptors Sstr5 and Htr7, respectively, in ciliated cells.

11 ressed basolaterally in differentiated nasal ciliated cells.

12 ifferentially in mucus-secreting cells or in ciliated cells.

13 consist of mucus-secreting goblet cells and ciliated cells.

14 ns protein DYF1 that was highly expressed in ciliated cells.

15 cluding superficial epidermal cells and deep ciliated cells.

16 ed lumens lined with differentiated club and ciliated cells.

17 an virus, which infected proportionally more ciliated cells.

18 d that the promoter drives expression in all ciliated cells.

19 avian influenza viruses exclusively infected ciliated cells.

20 into the outer epithelial cell layer to form ciliated cells.

21 ytoskeleton originating from basal bodies of ciliated cells.

22 denatonium included increased [Ca(2+)](i) in ciliated cells.

23 otubule-based transport, such as neurons and ciliated cells.

24 LR development are specifically required in ciliated cells.

25 ably caused by a defect at the basal body of ciliated cells.

26 signated rootletin, found in the rootlets of ciliated cells.

27 e dynamics and planar cell polarity in multi-ciliated cells.

28 erated exposing their contents, but never to ciliated cells.

29 ct from both actively infected and bystander ciliated cells.

30 d metaplasia, which included the presence of ciliated cells.

31 d step to regulate the spacing of the mature ciliated cells.

32 e generation of the spacing pattern of these ciliated cells.

33 n of left-right asymmetry and development of ciliated cells.

34 r trafficking of molecules in unciliated and ciliated cells.

35 of B. pertussis to asialo-GM2 and to rabbit ciliated cells.

36 cate CDHR3 is critical to HRV-C infection of ciliated cells.

37 Epithelial in both groups were dominated by ciliated cells.

38 ing in goblet cell hyperplasia and decreased ciliated cells.

39 helial markers relating to goblet, club, and ciliated cells.

40 on of genes involved in differentiation into ciliated cells.

41 and suppresses gene transcripts specific to ciliated cells.

42 oxygen species (ROS) than epithelia with few ciliated cells.

43 ression of SLC26A9 in the apical membrane of ciliated cells.

44 nd creates persistent trafficking defects in ciliated cells.

45 ultiple basal bodies, and mature into single ciliated cells.

46 o samples of live human bronchial epithelial ciliated cells.

47 h was previously thought to contain only non-ciliated cells.

48 d ciliary length and a reduced percentage of ciliated cells.

49 ing of ciliogenesis, and the accumulation of ciliated cells.

50 nal differentiation program and convert into ciliated cells.

51 d produce differentiated secretory cells and ciliated cells.

52 he other expresses c-myb and directly yields ciliated cells.

53 docking during the differentiation of airway ciliated cells.

54 ted view of planar polarization of the brain ciliated cells.

55 al body of primary cilia in human and murine ciliated cells.

56 e show that two PCP signals are operating in ciliated cells.

57 reas its ligand EGF is induced by smoking in ciliated cells.

58 process causes an increase in the number of ciliated cells.

59 t proteins B and C, without affecting airway ciliated cells.

60 t cell metaplasia, and the loss of Clara and ciliated cells.

61 ury, PNECs can contribute to Clara cells and ciliated cells.

62 ntrosome/basal body in non-ciliated, but not ciliated, cells.

63 sed in basal, intermediate, club, mucus, and ciliated cells; 3) ACE2 is upregulated in the SAE by smo

64 e adenosine to signal in a paracrine faction ciliated cell A(2b) receptors to activate ion/water secr

65 tion in both zebrafish embryos and mammalian ciliated cells, a defect phenocopied by the silencing of

66 2 localizes to the basal body and axoneme of ciliated cells, a pattern reminiscent of that of the BBS

67 tron microscopy demonstrates the presence of ciliated cells, a proximal cell type, in the most periph

68 almost exclusively expressed in a subset of ciliated cells, a strong indicator of cilia-related func

69 eER adult mice, we have followed the fate of ciliated cells after epithelial injury by naphthalene or

70 hildren exhibit a decrease in proportions of ciliated cells, among the primary targets of SARS-CoV-2,

71 emical staining demonstrated decreases in in ciliated cells and altered morphology.

72 By contrast, Il-6 null mice regenerate fewer ciliated cells and an increased number of secretory cell

73 rootletin fibers connect the basal bodies in ciliated cells and are present both at the ends of and i

74 e airway epithelial cell types, Clara cells, ciliated cells and basal cells, and activated UCHL1, a m

75 RVs, RSV-B, and HCoV-OC43 infected ciliated cells and caused no major cell death, whereas H

76 summarize current knowledge regarding airway ciliated cells and cilia, how they function to maintain

77 tion of proximal epithelial cells, including ciliated cells and Clara cells, appears to be unaffected

78 microscopy, we demonstrate viral tropism to ciliated cells and club cells of the bronchiolar epithel

79 Importantly, the combination of no ciliated cells and excess mucous cells can account for t

80 by human airway epithelium secretory but not ciliated cells and leads to increase of apical surface l

81 erentiating deep layer cell types, including ciliated cells and neurons.

82 on in both cultures was restricted to apical ciliated cells and occasional nonciliated cells but not

83 signaling to PI3K that prevents apoptosis of ciliated cells and on IL-13 signaling that promotes tran

84 basal cell fate by driving the generation of ciliated cells and preventing the production of Clara-li

85 oid morphogenesis and the differentiation of ciliated cells and reduces the expression of both notch

86 e human influenza viruses primarily infected ciliated cells and replicated efficiently, whereas a hig

87 dentified intense viral egress from infected ciliated cells and severe cytopathogenesis, culminating

88 green fluorescent protein (GFP) to cilia of ciliated cells and targets GFP to lipid rafts if the cel

89 in the microtubule organization of mammalian ciliated cells and that anosmia might be a useful determ

90 ment, apoptosis of terminally differentiated ciliated cells and their replacement by basal progenitor

91 hat develop into surface mucus secretory and ciliated cells and then contrasts these to the unique sp

92 Spike protein primer TMPRSS2 was highest in ciliated cells and type I alveolar epithelial cells (AT1

93 We identified bronchial ciliated cells and type II alveolar cells as a major loc

94 infectious virus, a more pronounced loss of ciliated cells, and a reduced thickness of the epithelia

95 e that WT CFTR is predominantly expressed in ciliated cells, and deltaF508 CFTR pathogenesis in nativ

96 HbB and eNOS were colocalized in ciliated cells, and heme affected oxidation of the NOS p

97 KIAA0556 is expressed almost exclusively in ciliated cells, and the worm and human KIAA0556 proteins

98 lara and goblet cell populations but not the ciliated cells, and this infection pattern corresponds t

99 n of asymmetry-called Kupffer's vesicle (KV)-ciliated cells are asymmetrically positioned along the a

100 d further weight to recent observations that ciliated cells are capable of transdifferentiating to ot

101 uggest that ACh-induced [Ca2+]i decreases in ciliated cells are caused by stimulated Ca2+ uptake into

102 In the mutant, ciliated cells are devoid of rootlets.

103 In zebrafish, these ciliated cells are found in Kupffer's vesicle (KV) and a

104 n the nasal epithelium of E2f4-/- mice where ciliated cells are replaced by columnar secretory cells

105 In Drosophila, the only ciliated cells are sensory neurons and sperm.

106 These findings identify transitional pre-ciliated cells as a cancer-prone cell state and point to

107 adenylated viral transcripts and highlighted ciliated cells as a major target at the onset of infecti

108 ial cells, airway club cells and respiratory ciliated cells as potential reservoirs of the SARS-CoV-2

109 rectional non-cell-autonomous cues to orient ciliated cells as they differentiate, thus playing a cri

110 O) receptor cells and may represent the same ciliated cells as those found in the non-sensory part of

111 e human airway epithelium is the presence of ciliated cells bearing motile cilia, specialized cell su

112 it remained unclear how the distribution of ciliated cells becomes asymmetric during KV development.

113 a consists of two to three irregular rows of ciliated cells but arise from 1q and 2q daughters, simil

114 The majority of the staining was in ciliated cells but was also observed in basal cells and

115 rn that appeared to originate primarily with ciliated cells, but lateral spread from the base of the

116 the swine respiratory tract at the level of ciliated cells by attaching specifically to the cilium m

117 Infection of ciliated cells by rgPIV3 was sensitive to a neuraminidas

118 the apical surface and spread to neighboring ciliated cells by the motion of the cilial beat.

119 ear and unambiguous evidence to suggest that ciliated cells can become goblet cells using immunoelect

120 tate virus spread via the extruded apoptotic ciliated cells carrying RSV.

121 e higher in WD-PBECs, coincident with higher ciliated cell contents, cell sloughing, and slightly com

122 oV GFP also replicated to a lesser extent in ciliated cell cultures derived from hamster or rhesus mo

123 cells, mucus-secreting goblet cells, motile ciliated cells, cystic fibrosis transmembrane conductanc

124 This glycopeptide reproduces the specific ciliated cell damage observed in the respiratory tract d

125 norrhoeae contribute to the inflammation and ciliated cell death associated with gonorrhea and pelvic

126 induce inflammatory cytokine production and ciliated cell death in human fallopian tubes.

127 nd dLGN and found that the overall number of ciliated cells declined during development.

128 , structural and functional abnormalities of ciliated cells, decreased number of secretoglobin (SCGB1

129 .7 luminosity/epithelial area) and decreased ciliated cells (Delta - 0.07 +/- 0.03 Foxj1(+) cells/epi

130 isomy 21 cells eventually ciliate, but these ciliated cells demonstrate persistent trafficking defect

131 V is asymmetric along the AP axis, with more ciliated cells densely packed into the anterior region.

132 on after naphthalene-mediated Clara-like and ciliated cell depletion.

133 ion for LRD protein in both ciliated and non-ciliated cells, despite its sequence classification as a

134 tment, while it's expression correlated with ciliated cell development and decreased along with incre

135 ective ablation of CTNNB1 from the oviductal ciliated cells did not affect embryo transport, possibly

136 epithelial cell fate by inhibiting Clara and ciliated cell differentiation and activating Uchl1, a ma

137 tream of aPKC and is sufficient to stimulate ciliated cell differentiation and inhibit superficial ep

138 airway epithelial cell fate, Fgf10 prevents ciliated cell differentiation and promotes basal cell di

139 ckout of CDHR3 in human AECs did not prevent ciliated cell differentiation but was associated with a

140 we found that the O(2) level in air directs ciliated cell differentiation by increasing mitochondria

141 ction studies demonstrate that aPKC inhibits ciliated cell differentiation in Xenopus ectoderm and pr

142 A time course analysis during ciliated cell differentiation of RTE cells in culture de

143 DNAH7 was induced during ciliated cell differentiation, and immunohistochemistry

144 further our understanding of the process of ciliated cell differentiation.

145 tracheal epithelium, SOX21 inhibits basal to ciliated cell differentiation.

146 ation of SOX2+ progenitor cells to basal and ciliated cells during mouse lung development.

147 coronavirus 2 (SARS-CoV-2) primarily targets ciliated cells during the initial infection of the upper

148 MMP-9, TIMP-1, and TIMP-2 were localized in ciliated cells, endothelial cells, pneumocytes, macropha

149 Compared to other airway cell types, ciliated cells express high levels of mitochondrial unco

150 e links between infection, inflammation, and ciliated cell extrusion remain unresolved.

151 mponents associated with either secretory or ciliated cell fate commitment.

152 ch acts when commitment to a ciliated or non-ciliated cell fate occurs in proximal progenitors, silen

153 l cell fate at the expense of a proximal and ciliated cell fate, whereas WNT signaling promoted a pro

154 (Aqp5 and Sftpc), Clara cells (Scgb1a1) and ciliated cells (Foxj1) in E18.5 lungs.

155 However, isolated ciliated cells from both polyps and turbinates maintaine

156 ssfully identified new senescence markers in ciliated cells from human idiopathic pulmonary fibrosis

157 that govern the scattering of flagellated or ciliated cells from solid surfaces.

158 that E2f4-deficiency leads to an absence of ciliated cells from the entire airway epithelium and the

159 The loss of ciliated cells from the epithelium is thought to be both

160 Whereas ciliated cells have been described in developing heart,

161 Specialized groups of ciliated cells have been implicated in LR patterning in

162 ockade (using s-IL-13Ralpha2-Fc) exacerbates ciliated cell hyperplasia but still inhibits goblet cell

163 Here we show that long-term ciliated cell hyperplasia coincides with mucous (goblet)

164 reduction of KIF11 expression, the number of ciliated cells in asynchronously growing populations was

165 Interestingly, shorter ciliated cells in both regions were identified as neuron

166 tact intracellular virions were found within ciliated cells in compartments with a single membrane be

167 on, factors that regulate the development of ciliated cells in culture regulated the expression of ax

168 22G variants infected a higher proportion of ciliated cells in cultures of human airway epithelium th

169 Thus, motile ciliated cells in general might use a similar cellular c

170 Efficient SARS-CoV infection of ciliated cells in HAE provides a useful in vitro model o

171 ry syncytial virus (RSV) selectively targets ciliated cells in human bronchial epithelium and can cau

172 ngth and with a reduction of the fraction of ciliated cells in Npc1-deficient mouse brains and the hu

173 m concentration ([Ca2+]i) of rabbit tracheal ciliated cells in response to 8-bromo-cGMP (Br-cGMP) wer

174 onic development and contribute to Clara and ciliated cells in the adult lung.

175 n increase in mucous cells and a decrease in ciliated cells in the airway.

176 or different functions: basal, secretory and ciliated cells in the conducting airways and type II and

177 al mechanisms that polarize cilia, using the ciliated cells in the developing Xenopus larval skin as

178 syncytial virus (RSV) naturally infects the ciliated cells in the human airway epithelium.

179 Scattered ciliated cells in this transition zone resembled neither

180 n protein is enriched in cytosolic puncta in ciliated cells in zebrafish embryos.

181 protein is enriched in the apical domain of ciliated cells, in close proximity to the apical actin c

182 ncentration ([Ca(2+)](i)) of rabbit tracheal ciliated cells, in response to ATP, were simultaneously

183 rate luminal cells, including differentiated ciliated cells, in the absence of stroma.

184 In ciliated cells, including bovine and Xenopus laevis rod

185 shape changes that mediate tight packing of ciliated cells into the anterior pole.

186 calation becomes limiting and the spacing of ciliated cells is maintained.

187 We propose that the differentiation of the ciliated cells is not only regulated by Notch-mediated l

188 monas reinhardtii, and other flagellated and ciliated cells, is a highly specific process that involv

189 addition to using this homology to attach to ciliated cells, it activates human neonatal regulatory B

190 s required for TZ assembly in all Drosophila ciliated cells, it also regulates basal-body growth and

191 In contrast, pre-ciliated cells (Krt5+, Prom1+, Trp73+) remain cancer-pro

192 lub cells, but not terminally differentiated ciliated cells, led to increased proliferation, goblet c

193 multiciliogenesis by blocking commitment to ciliated cell lineages through inhibition of HES6, leadi

194 ubsequently differentiate into secretory and ciliated cell lineages.

195 primary cilium and to the plasma membrane in ciliated cell-lines and primary cells.

196 We also show that wild-type ciliated cells located at a mutant clone border reorient

197 cell death, whereas H3N2 and EV-D68 induced ciliated cell loss and tissue integrity disruption.

198 The beating of cilia on multi-ciliated cells (MCCs) is essential for normal developmen

199 and lineage differentiation (ss-tubulin IV+ ciliated cells, MUC5AC+ goblet cells, p63 + basal cells)

200 on by smoke and alcohol was only observed in ciliated cells, not basal bronchial epithelium.

201 increased mucous cell numbers and decreased ciliated cell numbers.

202 FOXJ1 is expressed in ciliated cells of the airways, testis, oviduct, central

203 icates a strong pattern of expression by the ciliated cells of the efferent ducts and strong staining

204 a 1-kb FOXJ1 promoter to drive CreER in the ciliated cells of the embryonic and adult lung.

205 response leads to the death and sloughing of ciliated cells of the Fallopian tube.

206 ion and motility specifically in a subset of ciliated cells of the mouse COA (posterior notochord, PN

207 optotic death of photoreceptors, the primary ciliated cells of the retina.

208 optotic death of photoreceptors, the primary ciliated cells of the retina.

209 et tissues: Serotonergic cells innervate the ciliated cells of the velum, numerous muscle systems, po

210 Retinas and ciliated cells of these zebrafish morphants were analyze

211 n shown both to increase the beating rate of ciliated cells of Tritonia and to accelerate heart contr

212 CE We have previously shown that RSV infects ciliated cells on the apical side of the lung airway.

213 y cells and the other contributing to either ciliated cells or one of the stromal cell types.

214 To produce directed flow, ciliated cells orient along a common planar axis in a di

215 tube, gastrocoel roof plate, epidermal multi-ciliated cells, otic vesicles, and kidneys.

216 ti-IL-33 also re-established the presence of ciliated cells over mucus-producing cells and decreased

217 pathogenesis, culminating in the shedding of ciliated cells packed with virions, providing a large vi

218 ce that loss-of-gene function exclusively in ciliated cells perturbs vertebrate LR patterning.

219 e grown to goblet or normally differentiated ciliated cell phenotype at air-liquid interface in the p

220 ption factor 4, a factor associated with the ciliated cell phenotype.

221 We conclude that ciliated cells play a prominent role in repair of distal

222 data derived from tissues possessing motile ciliated cell populations.

223 rtion of alpha-2,6-linked sialic acid, while ciliated cells possess both sialic acid linkages.

224 t CEP290 localizes to the transition zone in ciliated cells, precisely to the region of Y-linkers bet

225 f ectoderm are selected out by Notch to form ciliated cell precursors (CCPs) that then radially inter

226 Because nascent ciliated-cell precursors prevent neighboring cells from

227 Ciliated-cell precursors then intercalate into the outer

228 et of cells are chosen to differentiate into ciliated-cell precursors.

229 Ciliated cells produce ATP that powers cilia beating by

230 Gas8 knockdown in ciliated cells reduces Smo signaling activity and ciliar

231 undant functions of different RFX factors in ciliated cells remains lacking.

232 the proximal region of cilia in dividing and ciliated cells, respectively.

233 nt modulation of Jag1 and Jag2 expression in ciliated cells results in the inhibition of Notch signal

234 Ectopic coexpression of PCARE and WASF3 in ciliated cells results in the remarkable expansion of th

235 sitting atop the PCF is pushed along by the ciliated cell's beating cilia, the PCF and its virus con

236 These findings indicate that ciliated cells sacrifice mitochondrial efficiency in exc

237 let cell, and mast cell scores and decreased ciliated cell scores.

238 Ciliated cells showed multiple immune responses and were

239 , viral antigen is detected predominantly in ciliated cells, similar to wild-type virus.

240 re derived from mice expressing GFP from the ciliated-cell specific FOXJ1 promoter (FOXJ1:GFP).

241 Importantly, ciliated cell-specific cAMP production (estimated by FRE

242 tein kinase (PKA) subunits expressed under a ciliated cell-specific promoter) in response to increase

243 y human airway cultures establish NEK10 as a ciliated-cell-specific kinase whose activity regulates t

244 re significant strain-related differences in ciliated cell squamation, initiation and duration of pro

245 beta-Tubulin IV, a marker of ciliated cells, stained the atypical columnar cells prod

246 rplasia is shown to stem from a novel mucous ciliated cell state, as well as goblet cell hyperplasia.

247 Sox17 expression was restricted primarily to ciliated cells, suggesting its potential role in airway

248 ike epithelium with basal cells and immature ciliated cells surrounded by smooth muscle and myofibrob

249 embryos contains a population of specialized ciliated cells that are distributed in an evenly spaced

250 +) probes show in cultured airway epithelial ciliated cells that ATP can trigger periodic oscillation

251 urprisingly, we also found a region of multi-ciliated cells that line the posterior dorsal pole of th

252 It has been proposed that ciliated cells that produce a leftward fluid flow mediat

253 only assembled in terminally differentiating ciliated cells through the acentriolar pathway to trigge

254 ls demonstrate that Lrdr1 functions in these ciliated cells to control LR patterning.

255 nds on secretory cells (club and goblet) and ciliated cells to produce and transport mucus.

256 ucted an RNAi-based screen in Drosophila non-ciliated cells to test for cilium-independent loss-of-fu

257 E2, and IL-13 signatures and negatively with ciliated cell transcriptional signatures.

258 ncreased tuft cell transcripts and decreased ciliated cell transcripts along with an IL-13 activation

259 sis and confocal microscopy we conclude that ciliated cells transiently change their morphology in re

260 ypes, including a previously uncharacterized ciliated cell type, during four major phases of endometr

261 -specific gene expression, especially in the ciliated cell type.

262 eceptors and to the transition zone in other ciliated cell types and that cilia are present in these

263 necessary to differentiate ciliated from non-ciliated cell types during early animal evolution.

264 ar structures of axonemes vary across motile-ciliated cell types in the body.

265 regulators of ciliome genes also in sensory ciliated cell types suggesting that this regulatory logi

266 theoretical framework to conduct a census of ciliated cell types, create structural maps, and resolve

267 lene-mediated depletion of the secretory and ciliated cell types, the two basal cell pools coordinate

268 In most ciliated cell types, tubulin is modified by glycylation,

269 hology and no spread of the virus beyond the ciliated cell types.

270 rt of a highly conserved complex in multiple ciliated cell types.

271 ss of club cells, with a concomitant gain in ciliated cells, under homeostatic conditions without inc

272 amphioxus frontal eye is composed of simple ciliated cells, unlike vertebrate rods and cones, which

273 an ADGB-dependent increase in the number of ciliated cells upon overexpression of the full-length pr

274 In addition to infection of ciliated cells via the apical membrane, RSV was shed exc

275 The proportion of ciliated cells was lower in the CF group than in the nor

276 orescence staining showed that the number of ciliated cells was significantly decreased by the flavor

277 Focusing on genes expressed in ciliated cells, we have identified new candidate cilioge

278 In ciliated cells, we observe localization of recombinant C

279 , in a model of ectopic expression of LAT in ciliated cells, we show that GMAP210 tethering activity

280 make up 75% or more of infected cells, only ciliated cells were associated with increased virus prod

281 ecrease in Clara cells and a 25% decrease in ciliated cells were completely compensated for by an inc

282 Infection was highly cytolytic, as infected ciliated cells were necrotic and shed over time onto the

283 Ciliated cells were negative for EGFR and MUC5AC both in

284 to cluster the cell subtypes, and FOXJ1(+) -ciliated cells were sub-classified into multiciliated an

285 Apical ciliated cells were the target for both viruses, but RSV

286 GAS2L2 is abundant at the apical surface of ciliated cells, where it localizes with basal bodies, ba

287 (alpha2,6-linked) receptors predominated on ciliated cells, whereas avian-like (alpha2,3-linked) rec

288 ylases ccp2, ccp5, and ccp6 are expressed in ciliated cells, whereas ccp1 expression is restricted to

289 tered epithelial cell phenotypes and loss of ciliated cells which associate with worsened asthma seve

290 fficked exclusively to the apical surface of ciliated cells, which also was the site of release of pr

291 strong tropism preference for secretory and ciliated cells, which consistently make up 75% or more o

292 gesting that non-exocytotic ATP release from ciliated cells, which dominate our cultures, mediated hy

293 tivation response to RSV infection in infant ciliated cells, which was exploited to facilitate virus

294 vy chains correlated with the development of ciliated cells, while cytoplasmic dynein heavy chain exp

295 ed to identify the location and cell type of ciliated cells with the use of antibodies specific for c

296 and showed airways populated essentially by ciliated cells, with an increase in neuroendocrine cells

297 study to show that HPIV1 selectively infects ciliated cells within the HAE and that progeny virus is

298 protein localized to the apical membrane of ciliated cells within the superficial epithelium and gla

299 rock2b knockdown altered the AP placement of ciliated cells without affecting cilia number or length.

300 nstrate a direct conversion of club cells to ciliated cells without proliferation, meeting a conserva