ライフサイエンスコーパス: cilium

1 ansmembrane proteins that translocate to the cilium.

2 e-depolymerizing factor KIF2A to disassemble cilium.

3 the microtubule-based organelle, the primary cilium.

4 to permit cAMP elevation selectively in the cilium.

5 activity controls the delivery of LAT to the cilium.

6 ne tubules along with proteins that exit the cilium.

7 or to visualize Ca(2+) fluxes in the primary cilium.

8 tically sorts newly synthesized PRPH2 to the cilium.

9 from the motion of the cell body and of the cilium.

10 HH targeting these cells through the primary cilium.

11 aired in fibroblasts depleted of the primary cilium.

12 he neonatal and adult heart harbor a primary cilium.

13 amics of signaling pathways localized to the cilium.

14 ellular sensory organelle called the primary cilium.

15 Hh signaling is triggered at the primary cilium.

16 ional regulation and function of the primary cilium.

17 ting mechanisms localized at the base of the cilium.

18 ghts the complexity of pathways taken to the cilium.

19 D, and the cAMP biosensor mlCNBD-FRET to the cilium.

20 tion by inhibiting ectosome release from the cilium.

21 of AURKA is required to maintain the primary cilium.

22 e it acts to regulate protein content of the cilium.

23 d IFT-A and IFT-B, that carry cargo into the cilium.

24 dynamics of trafficking into and out of the cilium.

25 errantly localized away from the base of the cilium.

26 tivation and its localization to the primary cilium.

27 embly and bidirectional transport within the cilium.

28 ograde intraflagellar (IFT) transport of the cilium.

29 for proteins destined for the centrosome and cilium.

30 or of cargo protein targeting to the primary cilium.

31 on of the basal body (BB) that templates the cilium.

32 clinically diverse disorders of the primary cilium.

33 gh calcium-permeable ion channels within the cilium.

34 but not leave small compartments such as the cilium.

35 outer segment of photoreceptors, a modified cilium.

36 , and efficiently recruits it to the primary cilium.

37 otors slow down; and third, motors leave the cilium.

38 well as small GTPases Arl13b and Arl3 in the cilium.

39 defective Arl13b localization to the primary cilium.

40 istinct cellular compartments, including the cilium.

41 ssociated signal transduction modules in the cilium.

42 ession by impairing SMO translocation to the cilium.

43 ) regulate cilia gating and make the primary cilium a distinct functional entity.

44 e show that NRP1 localization to the primary cilium, a key platform for HH signal transduction, does

45 ility of the cell to disassemble the primary cilium, a microtubule-based cellular organelle, to the d

46 d us to analyze the formation of the primary cilium, a non-motile organelle that is specialized for S

47 The primary cilium, a sensory appendage that is present in most mamm

48 The primary cilium, a sensory organelle, regulates cell proliferatio

49 We found that the primary cilium, a signaling structure that arises from the mothe

50 tify the nanoscale morphology of the primary cilium, a tiny tubular cellular structure (~2-6 mum long

51 emonstrate that C2orf71/PCARE (photoreceptor cilium actin regulator) can interact with the Arp2/3 com

52 e report for the first time that the primary cilium acts as a crucial sensor for electrical field sti

53 in ciliary genes that build and maintain the cilium also cause renal cystic disease through unknown p

54 Although the primary cilium also participates in each of these pathways, its

55 which encode proteins active at the primary cilium, an antenna-like organelle that acts as the cell'

56 Polycystins localize to the primary cilium, an organelle essential for cell signaling, inclu

57 n organelle membranes, including the primary cilium-an antennae-like structure on the luminal side of

58 y as a mechanism contributing to the primary cilium and BB formation defects seen after KIF14 depleti

59 ption factors, signal transduction proteins, cilium and BBSome components, and lipid binding proteins

60 ated that ectosomes can be released from the cilium and can mediate the intercellular communication [

61 The neuronal primary cilium and centriolar satellites have functions in neuro

62 ure of protein confinement at the connecting cilium and consequent accumulation of inner segment memb

63 we examined the role of USP9X in the primary cilium and found that endogenous USP9X localizes along t

64 h signaling by binding to Hh and Ptc1 at the cilium and increasing the interaction of the receptor an

65 this phenotype is independent of the primary cilium and instead can be attributed to alterations in i

66 in 107 (TMEM107) is localized in the primary cilium and is enriched at the transition zone where it a

67 hat ARMC9 localizes to the basal body of the cilium and is upregulated during ciliogenesis.

68 ell fate, polarity, tissue organization, and cilium and lumen formation.

69 is essential for the function of the primary cilium and maintenance of phosphoinositide balance in no

70 exes initially accumulate at the base of the cilium and periodically enter the cilium, suggesting an

71 d that MAPKBP1 is not present at the primary cilium and that fibroblasts from affected individuals di

72 mitotic spindle, the function of the primary cilium and the DNA damage response.

73 Being homologous organelles, the primary cilium and the OS share common building blocks and molec

74 are the structural properties of the primary cilium and the OS, and propose a hypothesis that the OS

75 rafficking of cargo destined for the sensory cilium and this balance requires molecular specializatio

76 ify cells in adult heart harboring a primary cilium and to determine whether primary cilia play a rol

77 ies, disorders of the cholangiocytes primary cilium and various degrees of bile duct paucity and dysp

78 tability at sites of neuronal sensory input (cilium) and neuronal output (synapse).

79 ion led to retarded cilium disassembly, long cilium, and delayed cell cycle progression leading to de

80 Polycystins are expressed in the primary cilium, and disrupting cilia structure significantly slo

81 appearance, increased length of the primary cilium, and dysregulated SHH signaling.

82 es, SHH signaling is mediated by the primary cilium, and genetic defects affecting either SHH pathway

83 ontrolling a cellular organelle, the primary cilium, and its associated Hh signaling pathway and also

84 PKA was recently detected within the cilium, and PKA activity specifically in cilia regulates

85 with PDGF-AA, c-Cbl becomes enriched in the cilium, and the receptor is subsequently ubiquitinated a

86 seases resulting from defects of the primary cilium, and these patients often have cleft lip and pala

87 membrane protein composition of the primary cilium are central to development and homeostasis, but w

88 The nine axonemal MtCs in a cilium are found to differ significantly in length indic

89 ck inhibition of PDGFRalpha signaling at the cilium are unknown.

90 Here, we identify the primary cilium as a critical determinant controlling tumor pathw

91 into BCC treatment and identify the primary cilium as an important lineage gatekeeper, preventing HH

92 um, the immunological synapse is a surrogate cilium as it utilizes the same machinery as ciliogenesis

93 cells were capable of signaling through the cilium, as determined by gene expression analysis after

94 f rescuing wild-type (WT) motor function for cilium assembly and Hedgehog signaling in Kif3a/Kif3b do

95 ces in how kinesin-2 motors were adapted for cilium assembly and IFT function across species.

96 standing of how kinesin-2 motors function in cilium assembly and IFT.

97 IF3B/KAP is the sole and essential motor for cilium assembly and maintenance in mammalian cells.

98 IF3A/KIF3B function is required not just for cilium assembly but also for cilium maintenance, as inhi

99 ulin kinase 2 (TTBK2) is a key player in the cilium assembly pathway, controlling the final step of c

100 or PCM1 and a group of satellite proteins in cilium assembly.

101 n of satellite proteins and perturbs primary cilium assembly.

102 3 through poly-ubiquitylation and suppresses cilium assembly.

103 in" and "inside-out" signaling that restrain cilium assembly.

104 tor EHD1 as a novel regulator of the primary cilium-associated trafficking of Smoothened and Hedgehog

105 tein Dishevelled and to position the primary cilium at the abneural edge of the apical surface.

106 Thus, we have identified a primary cilium-autophagy-Nrf2 (PAN) control axis coupled to cell

107 of ciliary entry; PC2 first traffics to the cilium base before TOP domain dependent entry.

108 ation and interaction with components of the cilium base, promoting ciliopathy and premature neurogen

109 some compartment in proximity to the primary cilium base.

110 (posterior mesenchyme) and Shh-independent, cilium-based (anterior mesenchyme) Hedgehog pathway func

111 G protein-coupled receptors (GPCRs) controls cilium-based signaling pathways.

112 The life cycle of a primary cilium begins in quiescence and ends prior to mitosis.

113 ciliary structures thought to be crucial for cilium biogenesis and function by acting as a ciliary ga

114 The pathways controlling cilium biogenesis in different cell types have not been

115 expanded our understanding of centriole and cilium biology, revealing exciting avenues for future ex

116 served that GPC6 is localized outside of the cilium but moves into the cilium upon the addition of Hh

117 , rod and cone photoreceptors have a sensory cilium, but develop and function abnormally and then rap

118 cell migration independently of the primary cilium, but how IFT proteins integrate with the cell mig

119 IFT slowdown and IFT components leaving the cilium, but not in activation of retrograde IFT.

120 n4 is not required to extend a single motile cilium by cells involved in left-right patterning.

121 accessibility in the membrane of the primary cilium by inactivating the transporter-like protein Patc

122 in protein concentrated in the light-sensing cilium (called the outer segment) of the vertebrate phot

123 The structure of a cilium can be classified into three subdomains: the intr

124 As genetic variants affecting the primary cilium can cause ciliopathies in which RD may be either

125 N3 activity from the lumen of the connecting cilium (CC) destabilized the photoreceptor axoneme and r

126 e clinical consequences of defective primary cilium (ciliopathies) are characterized by marked phenot

127 hird component" of the vertebrate centrosome/cilium complex, which profoundly changes the way we thin

128 ary localization at the distal region of the cilium, consistent with the role of Arl13b in modulating

129 The primary cilium constitutes a subcellular compartment that orches

130 ceptors consist of a highly modified primary cilium containing phototransduction machinery necessary

131 ineage commitmentin vivoand that the primary cilium contributes to this process.

132 As the primary cilium coordinates several signaling pathways essential

133 traffic Hedgehog pathway proteins within the cilium correctly.

134 mastigoneme arrays, on opposing sides of the cilium, could perceive forces during ciliary beating and

135 Finally, primary cilium-dependent lipophagy and mitochondrial biogenesis

136 ral membrane proteins and a leaky connecting cilium diffusion barrier.

137 se A (AURKA) is necessary for proper primary cilium disassembly before mitosis.

138 veals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly, disruption of which contributes to m

139 WDR62 ablation led to retarded cilium disassembly, long cilium, and delayed cell cycle

140 sis in a feed-forward fashion by restraining cilium disassembly.

141 (ECM) turnover and biogenesis of the primary cilium during mouse embryogenesis.

142 signaling pathways localized to the primary cilium during the differentiation process.

143 ous deletion of PI3K-C2alpha in mice induced cilium elongation defects in kidney tubules and predispo

144 cilium formation and the dynamics of primary cilium elongation, and disrupts the localization of the

145 iogenesis and explains how the intracellular cilium emerges from the cell.

146 Furthermore, we show that the hybrid cilium emerges independently of other motile cilia and f

147 Similarly, VxPx inhibited primary cilium enrichment of a chimera of rhodopsin and somatost

148 or transmembrane molecules form the primary cilium, few secreted molecules are known to contribute t

149 e photoreceptor is a highly modified primary cilium filled with disc-shaped membranes that provide a

150 vertebrate photoreceptor cell is a modified cilium filled with hundreds of flattened 'disc' membrane

151 i is a single-celled eukaryote with a single cilium/flagellum.

152 Hh signal transduction requires the primary cilium for several steps in the pathway [1-5].

153 ) effectors and in developmentally regulated cilium formation [13, 14], contain multiple longin domai

154 led by different Ran mutants, is crucial for cilium formation and maintenance.

155 further investigated the effect of RanGTP in cilium formation and maintenance.

156 Rab23 has been linked to cilium formation and membrane trafficking at mature cili

157 ts absence hampers the efficiency of primary cilium formation and the dynamics of primary cilium elon

158 Given that KAP3 is essential for cilium formation and there are the emerging roles for Ra

159 Cilium formation arrested after docking of the ciliary v

160 ion of septin2, which is critical for normal cilium formation during early embryonic development.

161 ubset of Rab GTPases have been implicated in cilium formation in cultured mammalian cells [1-6].

162 basal body and proximal region of cilia, and cilium formation was compromised by depletion of either

163 ription factor Atoh1/MATH1 regulates primary cilium formation, enabling SHH signaling.

164 intracellular basal body (BB) that templates cilium formation, the extracellular axoneme that generat

165 subdistal appendages (sDAPs) during primary cilium formation.

166 at the center of the apical surface, enables cilium formation.

167 AMP and strategies to isolate signals in the cilium from the cell body and neighboring cells.

168 aspects that extend beyond hearing, such as cilium function, neuronal signal computation, and sensor

169 os lacking Tgifs were a number with links to cilium function.

170 lved in cell cycle, DNA damage response, and cilium function.

171 Thus, the role of cilium-generated signaling in cystogenesis is unclear.

172 urvature (rad/mum) was also conserved as the cilium grew.

173 Cilium growth is a highly regulated process that is assu

174 er centriole, leading to Rab8 activation and cilium growth.

175 We demonstrate that the photoreceptor cilium has an innate ability to release massive amounts

176 The beauty of the eukaryotic cilium has been appreciated since electron microscopy fi

177 The primary cilium has been found to be associated with a number of

178 select membrane proteins at the base of the cilium, illuminating BBSome roles at a critical host-pat

179 of the mechanosensing organelle, the primary cilium in a progenitor population, significantly decreas

180 ntified from polynomial curves fitted to the cilium in each image frame.

181 we have uncovered a function of the primary cilium in maintaining homeostasis of the CE by balancing

182 The cilium in mammalian cells protrudes out of the plasma me

183 Despite not entering the cilium in mutant cells, mutant PC2 accumulates at the ci

184 ond G1 into S phase, and the presence of the cilium in SMB55 cells determines the periods of Hh pathw

185 localises to the proximal end of the primary cilium, in the transition zone, where it controls ciliar

186 anelles-the midbody, the centrosome, and the cilium-in the same cellular process.

187 Failure to reabsorb the primary cilium induces cellular senescence.

188 In quiescent cells, the primary cilium insulates itself from contiguous dynamic membrane

189 transduction components within and along the cilium into the series of stacked, highly organized disk

190 The primary cilium is a cellular sensor that detects light, chemical

191 The primary cilium is a central signaling hub in cell proliferation

192 The primary cilium is a conserved organelle increasingly viewed as a

193 We propose that the cilium is a critical sensor acting as a responsive cAMP

194 The non-motile primary cilium is a critical sensory organelle on the cell surfa

195 The primary cilium is a highly conserved organelle housing specializ

196 The primary cilium is a membrane protrusion that is crucial for vert

197 The primary cilium is a paradigmatic organelle for studying compartm

198 The primary cilium is a singular cellular structure that extends fro

199 Primary cilium is a solitary organelle that emanates from the su

200 The primary cilium is a solitary organelle that responds to mechanic

201 irst time, that the formation of the primary cilium is altered in NPC1 disease.

202 The primary cilium is an organelle essential for cell signaling path

203 The primary cilium is an outward projecting antenna-like organelle w

204 of CEP290 is disrupted after the connecting cilium is assembled, we show that this domain is essenti

205 The hybrid cilium is conserved in mammalian multiciliated cells, or

206 The distal end of the eukaryotic flagellum/cilium is important for axonemal growth and signaling an

207 results suggest that PC2 localisation to the cilium is necessary to prevent PKD.

208 The primary cilium is nucleated by the mother centriole-derived basa

209 A primary cilium is present on most eukaryotic cells and represent

210 The primary cilium is the sensory organelle that is responsible for

211 The primary cilium is the site where a subset of the cell's membrane

212 that the exocyst, acting through the primary cilium, is necessary for renal ciliogenesis, cystogenesi

213 In those proliferating cells that do make a cilium, it is a transient organelle, being assembled in

214 arkers and displays microvilli and a primary cilium; its lumenal space is rich in Ca(2+) Time-lapse i

215 terations in the receptor composition of the cilium itself, and our understanding of the mechanisms t

216 t depleting KIF11 resulted in an increase in cilium length and an attenuation in the kinetics of cili

217 olangiocytes UDCA-HDAC6i #1 restored primary cilium length and exhibited potent antiproliferative act

218 F2A expression partially rescued deficits in cilium length and NPC proliferation.

219 associated with a shortening of the primary cilium length and with a reduction of the fraction of ci

220 The effects of cilium length on the dynamics of cilia motion were inves

221 es like Toxoplasma gondii have a specialized cilium-like structure called the conoid that organizes t

222 To investigate cilium loss in mammalian cells, we used live-cell imagin

223 The predominant mode of cilium loss was rapid deciliation, in which the membrane

224 ithelial damage with lower ciliary activity, cilium loss, less tight junction expression (ZO-1), and

225 beta-Catenin deregulation directly disrupts cilium maintenance and signaling via Tulp3, essential fo

226 e, and disrupts Notch1 signaling and primary cilium maintenance necessary for radial progenitor funct

227 ast, inhibition of dynein-2 has no effect on cilium maintenance within the same time frame.

228 ed not just for cilium assembly but also for cilium maintenance, as inhibition of i3A/i3B blocks IFT

229 products localize in and around the primary cilium, making JS a canonical ciliopathy.

230 that pharmaceutical targeting of the primary cilium may have therapeutic benefits in the treatment of

231 ulloblastoma cell line, SMB55, that requires cilium-mediated Hh pathway activity for proliferation [1

232 argeting of ciliary components necessary for cilium morphogenesis and signaling is largely unknown.

233 tool included genes/proteins associated with cilium morphogenesis, signal transduction proteins (part

234 ing regulation of centrosome number, primary cilium morphology, nuclear membrane morphology, chromoso

235 of axoneme-specific components essential for cilium motility.

236 in powers of the amplitude of the individual cilium movement.

237 The primary cilium must be disassembled to free its centriole to for

238 of doublet microtubules (DMTs), meaning the cilium must convert between different microtubule geomet

239 gene products (NPHP) function at the primary cilium, NPH is classified as a ciliopathy.

240 g Tgifs resulted in a partial restoration of cilium numbers and in the transcriptional response to ac

241 domains within the light-sensing rod sensory cilium of mouse retinas and reveal previously unknown su

242 in the retinal ganglion cells and connecting cilium of photoreceptor cells.

243 Our results suggest that the primary cilium or an associated structure influences the domain

244 hat signal transduction requires the primary cilium (PC) where major pathway components are dynamical

245 The primary cilium permits compartmentalization of specific signalin

246 he formation of the photoreceptor connecting cilium, pre-mRNA splicing and epigenetic modifiers.

247 y, periodic beating did not emerge until the cilium reached a critical length between 2 and 4 mum.

248 f ciliary signaling components and supported cilium reassembly after cell division.

249 at its loss of function could indeed disrupt cilium-regulated processes.

250 Signaling from the primary cilium regulates kidney tubule development and cyst form

251 ther ciliary proteins traffic to the primary cilium remain poorly understood.

252 How disks are formed within the cilium remains an area of active investigation.

253 ility and signaling functions of the primary cilium require a unique protein and lipid composition th

254 The cilium's capacity to sense and transduce extracellular s

255 Primary cilium size, architecture, and assembly-disassembly dyna

256 (OS) is a unique modification of the primary cilium, specialized for light perception.

257 d, dynamic, and can be recapitulated without cilium-specific proteins or lipids.

258 We examined primary cilium structure and composition in fibroblast cells der

259 uately methylate septin2, a key regulator of cilium structure and function.

260 that are associated with defects in primary cilium structure and function.

261 Apicomplexan parasites use a specialized cilium structure called the apical complex to organize t

262 We highlight the importance of the primary cilium structure in mechanosensing and lineage specifica

263 Hedgehog signaling requires the primary cilium such that maintenance of this compartment is esse

264 ase of the cilium and periodically enter the cilium, suggesting an as-yet-unidentified mechanism that

265 from a unicellular ancestor, with an apical cilium surrounded by a microvillar collar, that structur

266 ssociated with the anatomy and physiology of cilium; terms associated with docking.

267 e t7ubules from the developing intracellular cilium that attach to the plasma membrane, creating an e

268 e t7ubules from the developing intracellular cilium that attach to the plasma membrane, creating an e

269 ne tubules from the developing intracellular cilium that attach to the plasma membrane, creating an e

270 d-like undulating swimmer, and an artificial cilium that could mimic the complex beating patterns of

271 ion zone (TZ) is a domain at the base of the cilium that is involved in maintaining ciliary compartme

272 oscopy, we find that the cytoskeleton in the cilium, the axoneme, also exhibits abnormal morphology i

273 While immune cells lack a cilium, the immunological synapse is a surrogate cilium

274 in abundantly expressed in the light-sensing cilium, the outer segment, of the vertebrate photorecept

275 egulates actin disassembly in the connecting cilium, thus facilitating rhodopsin transport to photore

276 or localization of Hedgehog effectors at the cilium tip.

277 conserved non-motile kinesin Kif7 defines a "cilium-tip compartment" by localizing to the distal ends

278 the highest-resolution images of the motile cilium to date and reveal how BBs template axonemes.

279 tebrate CK1gamma is localized at the primary cilium to promote Smo phosphorylation and Sonic hedgehog

280 r segment structure evolved from the primary cilium to provide photoreceptor cells with vast membrane

281 important for IFT regulation that allows the cilium to rapidly adapt to changes in the outside enviro

282 indicating that Inpp5e functions within the cilium to regulate the pathway.

283 Further, primary cilium transience may have implications for other Hh-med

284 f basal bodies crucial for components of the cilium (transition zone) to emanate, and absence of phot

285 cterize morphological changes of the primary cilium under different treatments and uses stimulated em

286 Many cells only build a primary cilium upon cell cycle exit, in G0.

287 zed outside of the cilium but moves into the cilium upon the addition of Hh.

288 on, in which the membrane and axoneme of the cilium was shed from the cell.

289 nknown function, localizes to the connecting cilium where it is thought to regulate cargo trafficking

290 GR localises to the photoreceptor connecting cilium where its function remains unknown.

291 's localization to the basal body of primary cilium, where CEP170 recruits microtubule-depolymerizing

292 s to the proximal compartment of the primary cilium, where it regulates signaling.

293 ce by preventing reabsorption of the primary cilium, which inhibits centrosome and mitotic spindle fo

294 of transduction over the full length of the cilium, which suggests an additional ATP source.

295 tering the centrosome, and beckoning forth a cilium-who would have guessed this is how polarized epit

296 rimary or motile cilia and discover a hybrid cilium with a unique assembly that regulates polarity in

297 tile cilia of a multiciliated cell, a hybrid cilium with structural features of both primary and moti

298 the three-dimensional structure of a primary cilium with unprecedented clarity.

299 athies are clinical disorders of the primary cilium with widely recognized phenotypic and genetic het

300 ne bound and diffused through the connecting cilium without lipid binding chaperone protein interacti