ライフサイエンスコーパス: circadian clock

1 l, and these responses depended on an intact circadian clock.

2 at circuit is conveyed to the brain's master circadian clock.

3 blue light regulation of development or the circadian clock.

4 lengthening and amplitude enhancement of the circadian clock.

5 enes and pathways that provide inputs to the circadian clock.

6 f negative limb gene proteins that reset the circadian clock.

7 o specifically mediate its modulation of the circadian clock.

8 ically modulates the pace of the Arabidopsis circadian clock.

9 and YTHDF3), which regulates the pace of the circadian clock.

10 vitamin A pathway operates downstream of the circadian clock.

11 A key player in this adaptation is the circadian clock.

12 mulate with a daily rhythm controlled by the circadian clock.

13 rmomorphogenesis, and input of phyB into the circadian clock.

14 sphorylates eIF2alpha in the suprachiasmatic circadian clock.

15 onents of the NRON complex also regulate the circadian clock.

16 sport is strongly regulated by light and the circadian clock.

17 a link between CR, lipid metabolism, and the circadian clock.

18 inputs, but is independent of the molecular circadian clock.

19 tes end-of-day light conditions to the plant circadian clock.

20 s, such as flowering time, dormancy, and the circadian clock.

21 n diverse biological pathways, including the circadian clock.

22 cal role for ISR in regulating the mammalian circadian clock.

23 P-dependent gene regulation in the mammalian circadian clock.

24 k to various diseases affected by a derailed circadian clock.

25 ion between light signaling pathways and the circadian clock.

26 splicing might act as a thermometer for the circadian clock.

27 n endogenous timekeeping system known as the circadian clock.

28 two important components of the Arabidopsis circadian clock.

29 ny physiological processes requires a robust circadian clock.

30 mechanisms underlying COR regulation of host circadian clock.

31 ciated with dysfunctions of the NAc cellular circadian clock.

32 region critical for coordinating peripheral circadian clocks.

33 suprachiasmatic nucleus, controls peripheral circadian clocks.

34 alling hub and a core component of the plant circadian clock(2,3).

35 3% of the transcriptome was regulated by the circadian clock, a smaller proportion than reported in m

36 ntial differences and demonstrating that the circadian clock affects posttranscriptional regulation.

37 Circadian clocks allow organisms to predict environmenta

38 beta-Bmal1 (OV) mice display enhanced islet circadian clock amplitude and augmented in vivo and in v

39 ological pathways that are controlled by the circadian clock, an important regulator of organismal fi

40 e state in cyanobacteria is regulated by the circadian clock and can adapt to seasonal changes of day

41 However, with the exception of the circadian clock and cell cycle, only a few such genes ar

42 Dissociation between the output of the circadian clock and external environmental cues is a maj

43 l regulation that can regulate the mammalian circadian clock and gene expression at large.

44 ransferase activity of SPY in modulating the circadian clock and implicate that O-glycosylation might

45 m of metabolic gene expression driven by the circadian clock and its metabolic consequences is explor

46 on and cis-elements pointed to a role of the circadian clock and light in coordinating the acclimator

47 critically involved in the regulation of the circadian clock and may represent a link to various dise

48 gene expression in PD patients, including a circadian clock and mitotic network that was altered sim

49 harmacologically accessible link between the circadian clock and neuroinflammation.

50 d widespread disruption in genes of the core circadian clock and output pathways regulating cell meta

51 The circadian clock and physical activity are both required

52 Thus, our data support crosstalk between the circadian clock and plant innate immunity and imply an i

53 2) gene is a core molecular component of the circadian clock and plays an important role in the gener

54 eptor REVERBalpha is a core component of the circadian clock and proposed to be a dominant regulator

55 er of hepatic functions are regulated by the circadian clock and recent evidence suggests that clock

56 ls, cryptochromes are core components of the circadian clock and repressors of the glucocorticoid rec

57 otential reciprocal relationship between the circadian clock and skin inflammation.

58 cation across kingdoms, is influenced by the circadian clock and the light-dark (diel) cycle in an op

59 lants, the effects of O-glycosylation on the circadian clock and the underlying mechanisms remain lar

60 d provide a mechanistic link between the NAc circadian clock and vulnerability to depression.

61 an unrecognized molecular connection between circadian clocks and cell cycle regulation and highlight

62 stemic metabolic circuit to regulate central circadian clocks and energy intake.

63 An intimate link exists between circadian clocks and metabolism with nearly every metabo

64 tural light-dark conditions is a function of circadian clocks and photic input pathways, but a mechan

65 d in the control of development, metabolism, circadian clock; and 80% of them were associated with sk

66 related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apopto

67 ver, it is unclear whether autophagy and the circadian clock are coordinated by common control mechan

68 ations in light sensitivity in the mammalian circadian clock are interrelated.

69 Some of the genes controlled by the circadian clock are oncogenes or tumor suppressors.

70 Mammalian circadian clocks are driven by transcription/translation

71 Studies show that beta-cell circadian clocks are important regulators of GSIS and gl

72 Whether pathogens modulate host circadian clock as a potential strategy to suppress host

73 Circadian clock assays revealed that ELF3 and GI are ess

74 egulators LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED1 (CCA1) in Arabidopsis (Arabi

75 ulation of their respective regulatory genes CIRCADIAN CLOCK-ASSOCIATED1 (CCA1) and FLOWERING LOCUS C

76 CIRCADIAN CLOCK-ASSOCIATED1 (CCA1), a well-known central

77 psis UCH3 acts to maintain the period of the circadian clock at high temperatures redundantly with UC

78 present a succinct description of the plant circadian clock, briefly reviewing a number of recent st

79 us mammalian 12-h clock independent from the circadian clock, but its function and mechanism of regul

80 y for entrainment of the Madeira cockroach's circadian clock, but the cellular nature of its entrainm

81 physiological steady states, is regulated by circadian clocks, but whether or how endogenous redox si

82 rse agonists advanced the phase of the mouse circadian clock by 1.3-1.5 h when given at subjective du

83 estriction (CR) delays aging and affects the circadian clocks by reprogramming circadian rhythms in g

84 ediate the feedback modulation of peripheral circadian clocks by SFA-induced inflammatory signaling.

85 Disruptions of the circadian clock can predispose or exacerbate substance a

86 Disruptions of the circadian clock can result in metabolic diseases, mood d

87 Disabling the circadian clock causes abnormal collagen fibrils and col

88 ickness is a fatal disease that disrupts the circadian clock, causes disordered temperature regulatio

89 s review, we explore the connections between circadian clock, chromatin remodeling, lncRNAs, and CRFH

90 odulatory signaling peptide produced only by circadian clock circuit neurons.

91 Circadian clock circuitry intersects with a plethora of

92 We recently demonstrated that the circadian clock component CRY2 is an essential cofactor

93 on and high nighttime expression of the core circadian clock component CRYPTOCHROME (CRY) in the NAc.

94 This study highlights a role for the circadian clock component REV-ERBalpha in regulating fla

95 The highly conserved core circadian clock component TIMING OF CAB EXPRESSION1 (TOC

96 te that Rev-erbalpha, a nuclear receptor and circadian clock component, is a mediator of microglial a

97 and viral replication, supporting a role for circadian clock components in regulating HIV-1 replicati

98 We show instead that loss of specific circadian clock components Period (Per) and Timeless (Ti

99 RESPONSE REGULATOR 5 (PRR5), one of the core circadian clock components, as a new SPY-interacting pro

100 Light-entrained circadian clocks confer rhythmic dynamics of cellular an

101 Circadian clock confers temporal control in metabolism,

102 ubiquitylating enzymes are a core element of circadian clocks, conserved from plants to animals.

103 The mammalian circadian clock consists of a transcription-translation

104 Circadian clocks constitute the evolutionary molecular m

105 It appears that the circadian clock contributes to the control of transpirat

106 Circadian clocks control the function of our immune syst

107 The circadian clock controls many molecular activities, impa

108 e night, confirming that the canonical plant circadian clock controls the PD transport light response

109 We identify that the circadian clock controls the timing and extent of glypho

110 1) The circadian clock controls transcription of 2000 genes in

111 hanism by which hypothermia synchronises the circadian clock: cooling induces nuclear accumulation of

112 The circadian clock coordinates a variety of immune response

113 Circadian clock coordinates numerous plant growth and de

114 The circadian clock coordinates regulation of gene expressio

115 arental strains indicates a possible role of circadian clock core components.

116 dic control of flowering, entrainment of the circadian clock, cotyledon opening and expansion, anthoc

117 Temperature, light, and circadian clock cues are integrated to impinge on the le

118 one receptor-associated protein 3) regulates circadian clock-dependent AS by binding to exons at codi

119 HC class II-IL-10-epithelial barrier axis by circadian clock disarrangement, alterations in feeding t

120 Compared to control mice, circadian clock disruption significantly exacerbated pos

121 al relationship by which dysfunctions in the circadian clock drive AD pathology and AD pathology driv

122 These results suggest a role for the circadian clock, driven by BMAL1, as a negative regulato

123 The mammalian circadian clock encodes time via rhythmic action potenti

124 We also tested the effects of circadian clock-enhancing small-molecule nobiletin on GS

125 est that the PLC21C-mediated contribution to circadian clock entrainment operates on a drastically sl

126 stem is able to contribute its full share to circadian clock entrainment, both with regard to behavio

127 ke behavior (helplessness), we found altered circadian clock function and high nighttime expression o

128 ter approach, we sought to determine whether circadian clock function in human adipocytes from subcut

129 We then focus on emerging data tying circadian clock function to immunologic activities withi

130 utilizing the self-assembling properties of circadian clock gene 2 hydrophobin chimera and homogenei

131 In addition, we genetically targeted the key circadian clock gene Bmal1 (also known as Arntl) in a li

132 The circadian clock gene Bmal1 is required to control the ti

133 t heterozygous coding variations in the core circadian clock gene cryptochrome 1 in 15 unrelated mult

134 human hearts display a circadian pattern of circadian clock gene expression but phase-shifted relati

135 Comparable studies of circadian clock gene expression in samples recovered fro

136 brain-dead donors show marked differences in circadian clock gene expression patterns, suggesting fun

137 del in three disparate applications, namely, circadian clock gene expression, corticoptropin levels i

138 Compared with rodent hearts, the human circadian clock gene transcripts showed a similar tempor

139 The 5 known circadian clock gene transcripts showed a strong circadi

140 Silencing expression of the core circadian clock gene, LHY/CCA1, allows light to strongly

141 Circadian clocks generate rhythms in cellular functions,

142 The expression of 5 known circadian clock genes and 19 additional ion channel gene

143 k relationship between diurnal regulation of circadian clock genes and histone modifications in Arabi

144 Expression profiles of circadian clock genes are abnormal in well-differentiate

145 Circadian clock genes can control the expression of key

146 nses, we probed wild-type and mutants of the circadian clock genes CCA1, LHY, PRR7, and PRR9 followin

147 e hypotheses about the physiological role of circadian clock genes in the circannual timer.

148 Circadian clock genes promote diurnal regulation of SDG2

149 euronal activity regulates the expression of circadian clock genes within brain endothelial cells, wh

150 of specific genes, which are referred to as 'circadian clock genes'.

151 nscriptional repressor of multiple predicted circadian clock genes, including GmCCA1a, which directly

152 Multiple whole-genome approaches suggest two circadian clock genes, period (per) and pigment-dispersi

153 rhythmicity, amplitude, period, and phase of circadian clock genes.

154 tions in two key elements of the Arabidopsis circadian clock, GIGANTEA (GI) and ZEITLUPE (ZTL), which

155 e, we review the physiological links between circadian clocks, glucose metabolism and insulin sensiti

156 amined the effects of beta-Bmal1 (OV) on the circadian clock, GSIS, islet transcriptome, and glucose

157 r expectations, long-term disturbance of the circadian clock had only modest effects on metabolic par

158 Disturbance of the circadian clock has been associated with increased risk

159 hin the suprachiasmatic nucleus (SCN) master circadian clock have the ability of encoding afferent in

160 Endogenous circadian clocks have evolved to anticipate 24 hr rhythm

161 provide organisms with a fitness advantage, circadian clocks have to react appropriately to changes

162 al role of O-GlcNAc in regulating the animal circadian clock, here we report that nuclear-localized S

163 We recently highlighted a role for the circadian clock in a mouse model of pulmonary inflammati

164 Thus, the local circadian clock in AECs is vital in lung health by coord

165 he question about whether enhancement of the circadian clock in beta-cells will confer protection aga

166 cts of Myc mutation or overproduction on the circadian clock in comparison to their effects on cell c

167 s, indicating the existence of an endogenous circadian clock in diatoms.

168 In this Review, we discuss aspects of the circadian clock in Drosophila melanogaster and mammals,

169 The circadian clock in eukaryotes controls transcriptional a

170 f recent reports that have characterized the circadian clock in ILC3s.

171 sophisticated, tissue-dependent role of the circadian clock in maintaining fitness in the face of lo

172 w-dimensional macroscopic model for the core circadian clock in mammals.

173 The circadian clock in plants temporally coordinates biologi

174 cent studies establish a crucial role of the circadian clock in regulating plant defense against path

175 cise has been proposed as a time cue for the circadian clock in rodents and humans.

176 acterium Synechococcus elongatus possesses a circadian clock in the form of a group of proteins whose

177 cation of an essential role of the molecular circadian clock in the regulation of competent insulin-p

178 ic input to the retina entraining the master circadian clock in the suprachiasmatic nuclei (SCN) and

179 t difference in the sensitivity of the major circadian clock in the suprachiasmatic nucleus to a low

180 raction between the hypoxic response and the circadian clock in vivo.

181 Circadian clocks in fungi and animals are driven by a fu

182 genes and molecular mechanisms underpinning circadian clocks in multicellular organisms are well und

183 d insulin-like growth factor 1 (IGF-1) reset circadian clocks in vivo and in vitro by induction of PE

184 ained by periodic environmental changes, the circadian clock incorporates external information to coo

185 dent kinase 5 (CDK5) regulates the mammalian circadian clock involving phosphorylation of PER2.

186 The circadian clock is a critical regulator of immune functi

187 The circadian clock is a global regulatory mechanism that co

188 The circadian clock is a master regulator of mammalian physi

189 The circadian clock is a timekeeper but also helps adapt phy

190 The circadian clock is an endogenous time-keeping system tha

191 The circadian clock is an endogenous, time-tracking system t

192 The circadian clock is an intrinsic oscillator that imparts

193 The mammalian cell-autonomous circadian clock is built around a self-sustaining transc

194 The suprachiasmatic nucleus (SCN) circadian clock is critical for optimising daily cycles

195 The mammalian circadian clock is deeply rooted in rhythmic regulation

196 The molecular circadian clock is driven by interlocked transcriptional

197 The circadian clock is encoded by a negative transcriptional

198 The circadian clock is important for cellular and organ func

199 her, these findings indicate that the muscle circadian clock is important for longevity and that circ

200 The circadian clock is known to regulate plant innate immuni

201 Given that phase coherence between circadian clocks is considered favorable, we propose tha

202 ation of the 12-hour clock, but not the core circadian clock, is associated with the onset and progre

203 The circadian clock itself has the potential for use as a ta

204 Circadian clocks keep time via ~ 24 h transcriptional fe

205 so generated CRISPR-mediated neuron-specific circadian clock knockouts.

206 Accumulating evidence indicate that the circadian clock machinery governs diverse biological pro

207 In conclusion, our study has identified a circadian clock mechanism of protein homeostasis wherein

208 en proposed to be a zeitgeber for the muscle circadian clock mechanism.

209 ional regulation plays a central role in the circadian clock mechanism.

210 Circadian clock mechanisms have been extensively investi

211 a tissue-dependent manner led to intertissue circadian clock misalignment.

212 d the all-in-one adenoviral CRISPR-Cas9 in a circadian clock model cell line U2OS, and demonstrated t

213 illations in protein expression levels for a circadian clock model, we illustrate the adaptability of

214 The circadian clock modulates immune responses in plants and

215 components of the negative limbs of the core circadian clock, most notably REV-ERBalpha.

216 rrelates with circadian period in Neurospora circadian clock mutants.

217 -based enrichment studies identifies altered circadian clock networks, and phytohormone and stress re

218 interactions between the light-signaling and circadian-clock networks, focusing on the role of light

219 nd temperature and gates sensory inputs into circadian clock neuron networks.

220 As in mammals, Drosophila circadian clock neurons display rhythms of activity with

221 Because circadian clock neurons in insects receive light input t

222 om distinct sets of upstream sleep-promoting circadian clock neurons, and arousal neurons.

223 We conclude that the Arabidopsis circadian clock not only controls transcription of genes

224 a key gene involved in the mammalian central circadian clock, observed via a luciferase reporter cons

225 pathways to the accessory medulla (AME), the circadian clock of the Madeira cockroach.

226 gain further insight into the effect of the circadian clock on this important oncogene/oncoprotein a

227 Circadian clocks operative in pancreatic islets particip

228 Circadian clocks orchestrate daily rhythms in organismal

229 The circadian clock orchestrates biological processes so tha

230 atory module between chromatin modifiers and circadian clock oscillators orchestrates diurnal gene ex

231 PA-producing enzymes had opposite effects on circadian clock outputs.

232 two opposing enzyme types are necessary for circadian clock pacing.

233 set of genes involved in light signaling and circadian clock pathways to promote photomorphogenesis.

234 Whether such variations are dependent on the circadian clock per se or are secondary to circadian dif

235 hanism by which the negative elements of the circadian clock (PER-TIM) regulate the positive elements

236 deed, in the spen3-1 and hub1-4 mutants, the circadian clock period was shortened as observed by luci

237 exercise, are sufficient to shift the muscle circadian clock phase, likely through changes in core cl

238 The fungal circadian clock photoreceptor Vivid (VVD) contains a pho

239 Hence, circadian clock-pituitary epigenetic pathway interaction

240 Circadian clocks play important roles in regulating cell

241 d by aphids, suggesting that the Arabidopsis circadian clock plays a defensive role.

242 ions during the night-time when the internal circadian clock promotes sleep, in many cases resulting

243 HLH proteins also regulate circadian clocks, protect against hypoxic stress, promot

244 ollectively, these findings suggest that the circadian clock protects from IR-induced toxicity and po

245 ins beta-casein, and apomyoglobin as well as circadian clock protein KaiB isolated from Escherichia c

246 he stabilizing action of the light-sensitive circadian clock protein TIMELESS (TIM).

247 Circadian clock proteins are endogenous timing mechanism

248 Thus, orthologous hypoxia, heat-shock, and circadian clock proteins were found to cluster according

249 There are also circadian clock-regulated lncRNAs with an emerging funct

250 The mammalian circadian clock regulates a wide variety of physiologica

251 The circadian clock regulates immune responses to microbes a

252 The circadian clock regulates many aspects of immunity.

253 The circadian clock regulates plant tissue hydraulics to syn

254 The circadian clock regulates the cell cycle such that the t

255 Here, we show that the plant circadian clock regulates the effectiveness of glyphosat

256 The circadian clock regulates various aspects of brain healt

257 Here, we show circadian clock regulation of endoplasmic reticulum-to-p

258 OCK-ASSOCIATED1 (CCA1), a well-known central circadian clock regulator, coordinates plant responses t

259 reported to alter the hepatic expression of circadian clock regulators, however the impact on clock-

260 Exploration of circadian clock-related genes, associated with the envir

261 The mammalian circadian clock relies on the transcription factor CLOCK

262 ates electrophysiological depolarization and circadian clock resetting in response to blue or ultravi

263 n-image-forming photoreceptors contribute to circadian clock resetting.

264 feeding, which affects the phase of the skin circadian clock, reverses the diurnal rhythm of IMQ-indu

265 In mammals, endogenous circadian clocks sense and respond to daily feeding and

266 stems-level control mechanisms involving the circadian clock set rates of nighttime starch mobilizati

267 Molecular disruption of the circadian clock severely interferes with light-evoked at

268 lutionarily conserved role in modulating the circadian clock system, via O-GlcNAcylation in mammals,

269 ential roles in finely modulating eukaryotic circadian clock systems.

270 ction to circadian rhythms and the molecular circadian clock that underpins them.

271 hown the effects of individual miRNAs on the circadian clock, the global functional miRNA-mRNA intera

272 cesses are influenced by organisms' internal circadian clocks, the pace of which is linked to the sol

273 re factors that control period length of the circadian clock through removal of their bound ubiquitin

274 ls to compute light schedules that shift the circadian clock to a new time zone as quickly as possibl

275 at are more aggressive, possibly linking the circadian clock to cellular differentiation.

276 hour clock exists in addition to the 24-hour circadian clock to coordinate metabolic and stress rhyth

277 olecular pathways linking clock genes or the circadian clock to insect photoperiodic responses remain

278 y understood mechanisms to synchronize their circadian clock to light.

279 llow us to predict the phase response of the circadian clock to these interventions and time them app

280 the biophysical mechanisms linking molecular circadian clocks to cardiac arrhythmogenesis are not ful

281 Mammals rely on a network of circadian clocks to control daily systemic metabolism an

282 rcadian activity and synchronizes peripheral circadian clocks to daily environmental cycles, thereby

283 Honey bees are highly dependent on circadian clocks to regulate critical behaviors, such as

284 eg, neurohumoral factors) and intrinsic (eg, circadian clocks) to cells.

285 These changes in the levels of circadian clock transcription factors lead to changes in

286 ence indicates that metabolic control by the circadian clock underpins specific hallmarks of cancer m

287 These data argue that the circadian clock uses circuit-specific and molecularly di

288 We investigated the role of the circadian clock using mice bearing targeted deletion of

289 ns link thermosensory PNs in the lACA to the circadian clock via the accessory medulla.

290 ary-thyroid axis is under the control of the circadian clock via the suprachiasmatic nucleus pacemake

291 At the turn of the century, the circadian clock was determined to be regulated by a tran

292 ripts that encode negative regulators of the circadian clock, which are released into the cytoplasm u

293 plications from chlamydia infection and host circadian clock, which may lead to a better understandin

294 previously underappreciated function of the circadian clock, which not only prepares organisms for n

295 ammalian tissues have functional, autonomous circadian clocks, which free-run with non-24 h periods a

296 repair activity itself is controlled by the circadian clock with a single phase at which the repair

297 ction as a cellular conduit to integrate the circadian clock with lipid metabolism.

298 y a prominent cue for the synchronization of circadian clocks with the environment.

299 mous response branch, whereby light entrains circadian clocks without any commitment of other Bmal1-d

300 w how the molecular workings of the cellular circadian clock work as building blocks of those propert