ライフサイエンスコーパス: circadian oscillation

1 of KaiC phosphorylation, which is central to circadian oscillation.

2 were small compared to the magnitude of the circadian oscillation.

3 encephalitis by using the cosinor model for circadian oscillation.

4 while excluding most effects associated with circadian oscillation.

5 it reduced amplitude and shortened period of circadian oscillation.

6 enotypes, such as blood pressure, subject to circadian oscillation.

7 is subset of roughly 7000 genes screened for circadian oscillation.

8 tenuated and failed to exhibit a significant circadian oscillation.

9 oteins and more modern proteins required for circadian oscillation.

10 ipid homeostasis under nutritional stress or circadian oscillation.

11 elasticity and temporal structure of the SCN circadian oscillation.

12 l activation by BMAL1/CLOCK and for in vitro circadian oscillation.

13 etabolic and physiological processes display circadian oscillations.

14 transcriptional networks and the creation of circadian oscillations.

15 s in generating as well as modulating robust circadian oscillations.

16 phosphorylation dramatically dampened PAI-1 circadian oscillations.

17 rresponds to one circuit topology that shows circadian oscillations.

18 and increase the robustness and accuracy of circadian oscillations.

19 of heat responsive genes exhibits diurnal or circadian oscillations.

20 e marrow (BM) and peripheral blood following circadian oscillations.

21 is, mPer RNAs exhibit prominent, synchronous circadian oscillations.

22 oupled systems synchronize leading to robust circadian oscillations.

23 nes, and ~6% of their transcriptome presents circadian oscillations.

24 ption-translation feedback loops to generate circadian oscillations.

25 es, suppressing them or giving rise to novel circadian oscillations.

26 influences the circadian clock and undergoes circadian oscillations.

27 trol introduces delays that are critical for circadian oscillations.

28 entify 789 (~17%) phosphorylation sites with circadian oscillations.

29 olecular species, may bear the potential for circadian oscillations.

30 rtion of mammalian gene expression undergoes circadian oscillations.

31 cal co-stabilization is essential for robust circadian oscillations.

32 ry of their protein products is the basis of circadian oscillation [1, 2].

33 d liver X receptor alpha as well as with the circadian oscillation activator DBP and the repressor E4

34 uc/p75(NTR-/-) liver explants showed reduced circadian oscillation amplitude compared with those of P

35 essential features: the ability to generate circadian oscillations, an output signal, and the abilit

36 or contributors to determining the period of circadian oscillation and enhancing robustness.

37 nogen activator inhibitor-1 activity shows a circadian oscillation and may account for the morning on

38 an receptor) nuclear receptors to potentiate circadian oscillation and protect against metabolic dysf

39 ment for keeping sustainable cell-autonomous circadian oscillation and reveals the extent of the impa

40 iological processes, from the cell cycle, to circadian oscillations and developmental processes.

41 Robust circadian oscillations and entrainment to light pulses w

42 aling a previously unrecognized link between circadian oscillations and intercellular heterogeneity.

43 plasma membrane aquaporin in rosettes, shows circadian oscillations and is correlated with K (ros) Tr

44 heral cellular activities by governing their circadian oscillations and pulmonary margination, which

45 express self-sustained, rather than damped, circadian oscillations and suggest the existence of orga

46 n SOV and seizures are primarily governed by circadian oscillations and the notion that hippocampal t

47 n trans) features, able to fine-tune its own circadian oscillation, and consequently, adjust the onse

48 ion, namely loss of plasmatic corticosterone circadian oscillation, and promotes reduction of GR hipp

49 Of these, five showed persistent, large circadian oscillations, and four had partial optic nerve

50 tic cells harbor an intact clock with robust circadian oscillations, and genetic knockout models reve

51 nous CHRONO occupancy around E-boxes shows a circadian oscillation antiphasic to BMAL1.

52 We observe that Rev-erbalpha circadian oscillations are disrupted with YAP/TAZ nuclea

53 Circadian oscillations are generated by the purified cya

54 Circadian oscillations are generated via transcriptional

55 Circadian oscillations are markedly altered when mice ar

56 Circadian oscillations are predicated on transcriptional

57 Circadian oscillations are regulated by interactions of

58 Autonomous circadian oscillations arise from transcriptional-transl

59 ), revealed internal phase patterning to the circadian oscillation at these extreme periods and diffe

60 pecific gene activity that is independent of circadian oscillations but differs between reproductive

61 In contrast, xPer1 mRNA exhibits circadian oscillations but is relatively insensitive to

62 cted that GABA would affect the amplitude of circadian oscillations but not synchrony among individua

63 receptor occupancy at the Cxcl5 locus shows circadian oscillations, but this is disrupted in mice wi

64 ite leaf diel datasets identified genes with circadian oscillation, CAM-related functions, and source

65 A circadian oscillation can be reconstituted in vitro from

66 holog of this gene have similar fast-running circadian oscillations compared with WT.

67 l a/b binding protein gene CAB, in which the circadian oscillations damp to low steady state mRNA abu

68 entified over 1,000 transcripts that exhibit circadian oscillations, demonstrating that the cell-auto

69 Protein synthesis rates demonstrate circadian oscillations dependent on BMAL1.

70 REGULATOR7 (PRR7), and PRR9, although later circadian oscillations develop in mutants defective in e

71 human cancers that these parameters exhibit circadian oscillations, driven by both the endogenous ci

72 ANCE STATEMENT We recorded the onset of PER2 circadian oscillations during embryonic development in t

73 Circadian oscillations emerge from transcriptional and p

74 While individual neurons produce circadian oscillations even when dispersed in culture, t

75 pheral tissues are capable of self-sustained circadian oscillations for >20 cycles in isolation.

76 nor) sequentially and is designed to measure circadian oscillations from infrequently sampled clinica

77 models of molecular processes essential for circadian oscillations have been developed, their comple

78 Circadian oscillations have been observed in animals, pl

79 ude that individual SCN neurons can generate circadian oscillations; however, there is no evidence fo

80 ncement of OxPhos decreased the amplitude of circadian oscillation in a subset of tumor cell lines.

81 these proteins can reconstitute a remarkable circadian oscillation in a test tube.

82 achiasmatic nuclei (SCN) exhibit a prominent circadian oscillation in cAMP response element (CRE)-med

83 It exhibits a circadian oscillation in constant conditions.

84 iA protein abundance undergoes little if any circadian oscillation in constant light.

85 Although circadian oscillation in dynamics of intracellular Ca2+

86 ASS1 acetylation by CLOCK exhibits circadian oscillation in human cells and mouse liver, po

87 The circadian oscillation in markers of mRNA translation was

88 2 and Cryptochrome1, whose expression show a circadian oscillation in peripheral tissues, inhibit the

89 ramatically underestimated the prevalence of circadian oscillation in plant gene expression.

90 enylyl cyclase and MAPK activities undergo a circadian oscillation in the hippocampus and that inhibi

91 /2 MAPK phosphorylation and cAMP underwent a circadian oscillation in the hippocampus that was parall

92 mage by nucleotide excision repair, exhibits circadian oscillation in the liver but not in testis.

93 erodimer is best known as a regulator of the circadian oscillation in the mammalian CLOCK system.

94 als, the transcription factor CLOCK controls circadian oscillation in the suprachiasmatic nucleus of

95 The chick retina and pineal gland exhibit circadian oscillations in biochemical and physiological

96 Normal, opposing circadian oscillations in calcineurin-dependent activiti

97 We found evidence of large circadian oscillations in calcineurin-dependent activiti

98 Circadian oscillations in cAMP and MAPK activity were ab

99 Circadian oscillations in cAMP and MAPK activity were ab

100 of PER2, rather than CRY1, are critical for circadian oscillations in cells and in the intact organi

101 Circadian oscillations in clock components are central t

102 vantage of clear phenotypic heterogeneity of circadian oscillations in clonal cell populations to inv

103 are sufficient to either entrain or restart circadian oscillations in cortical glia.

104 ported to be required for the maintenance of circadian oscillations in cultured cells.

105 represses Fgf21 expression and disrupts its circadian oscillations in cultured hepatocytes.

106 e show that loss of PER2 expression silences circadian oscillations in decidualizing human endometria

107 ndicate that the SCN regulates expression of circadian oscillations in different peripheral organs by

108 The potential connections between circadian oscillations in gene expression and circadian

109 This loop in turn drives circadian oscillations in gene expression that direct SC

110 elongatus PCC 7942 exhibits global biphasic circadian oscillations in gene expression under constant

111 ty, in addition to providing the impetus for circadian oscillations in general.

112 the bone marrow microenvironment, directing circadian oscillations in hematopoiesis and HSC migratio

113 show that transcription is not required for circadian oscillations in humans, and that non-transcrip

114 echocystis sp. PCC 6803 homologs, we observe circadian oscillations in KaiC3 phosphorylation in vitro

115 is modulated by but does not require normal circadian oscillations in locomotor activity.

116 Circadian oscillations in mammalian physiology and behav

117 tion of the metazoan transcriptome undergoes circadian oscillations in many cells and tissues.

118 ircadian oscillations in gene expression and circadian oscillations in metabolic activity are a major

119 y expressing viral oncogenes E6/E7) disrupts circadian oscillations in mouse embryonic fibroblasts, m

120 otein levels of GM129 exhibit high amplitude circadian oscillations in mouse liver, and Gm129 gene en

121 in roots (SHM4), and show that both exhibit circadian oscillations in mRNA abundance that are in pha

122 protein, the period protein PER, show robust circadian oscillations in mRNA and protein levels.

123 In other tissues, circadian oscillations in nucleosome occupancy influence

124 Interestingly, serum shock generated circadian oscillations in PAI-1 mRNA in NIH3T3 cells, su

125 In the fruitfly Drosophila, circadian oscillations in per expression occur in chemos

126 Circadian oscillations in period (per) mRNA and per prot

127 Circadian oscillations in peripheral tissues, such as th

128 Circadian oscillations in spontaneous action potential f

129 There is also evidence for independent circadian oscillations in synaptic strength and morpholo

130 There are circadian oscillations in the abundance of many chloropl

131 Plants have circadian oscillations in the concentration of cytosolic

132 We have tested the hypothesis that circadian oscillations in the concentration of cytosolic

133 and leading to tissue-specific, differential circadian oscillations in the expression of endothelial

134 o two components, 12 h apart, with antiphase circadian oscillations in the left and right SCN.

135 Low amplitude circadian oscillations in the molecular circadian clock

136 method investigated to suggest that loss of circadian oscillations in the peripheral oscillator was

137 onal regulation (PTR) circuit that generates circadian oscillations in the phosphorylation state of t

138 Recently, circadian oscillations in the redox state of peroxiredox

139 However, the methods used to detect circadian oscillations in these datasets are not able to

140 molecular level, the core clock genes induce circadian oscillations in thousands of genes in a tissue

141 sferase activity is in fact not required for circadian oscillations in vitro in a range of tissues, n

142 eria (KaiA, KaiB, and KaiC) can reconstitute circadian oscillations in vitro.

143 has been shown to play a fundamental role in circadian oscillations, influencing how groups of cells

144 on factor known to be essential for cellular circadian oscillation is also slowed.

145 l epithelial cells, and the amplitude of the circadian oscillation is controlled by the microbiota th

146 The peak-to-trough circadian oscillation is paralleled by the sequential ac

147 ght also impacts another key property of the circadian oscillation, its amplitude.

148 y for high-amplitude (approximately 10-fold) circadian oscillation lie upstream of -317 and are remov

149 onfer a low-amplitude (approximately 2-fold) circadian oscillation lies within 317 base pairs of the

150 The model simulated circadian oscillations, light entrainment, and a phase-r

151 ll Alzheimer's disease risk genes, displayed circadian oscillations, many of which were altered by pa

152 mammalian circadian system has revealed that circadian oscillations may be a fundamental property of

153 Circadian oscillation of body temperature is a basic, ev

154 Our study therefore demonstrates a circadian oscillation of CIPN and its underlying transcr

155 cillation, since loss of p75(NTR) alters the circadian oscillation of clock genes in the SCN, liver,

156 In the liver, SIRT1 coordinates the circadian oscillation of clock-controlled genes, includi

157 Synchronously, in the bladder, circadian oscillation of crucial molecules occurs to red

158 udy shows for the first time region-specific circadian oscillation of dCREB2/NF-kappaB activity in th

159 All promoters seem to exhibit circadian oscillation of expression, but the phasing of

160 e Lhcb gene in plants, we tested whether the circadian oscillation of free calcium is responsible for

161 -protein-coupled receptor (GPCR), to augment circadian oscillation of glucocorticoid levels in a para

162 reover, deletion of p75(NTR) also alters the circadian oscillation of glucose and lipid homeostasis g

163 ominent and likely contributes to the robust circadian oscillation of many transcripts, including tho

164 Circadian oscillation of mouse SCN organotypic slice cul

165 hese results suggest that CLIF regulates the circadian oscillation of PAI-1 gene expression in endoth

166 embryonic brain were not detected, a robust circadian oscillation of PER immunoreactivity is present

167 Immunohistochemical staining revealed a circadian oscillation of phospho-MAPK in the vicinity of

168 component of the circadian network, controls circadian oscillation of several clock genes, including

169 egulated in a cyclic manner in virtue of the circadian oscillation of the coenzyme NAD(+).

170 ng and quantitative MS analyses suggest that circadian oscillation of the FRQ phosphorylation profile

171 The circadian oscillation of the repair capacity is caused a

172 r capacity is caused at least in part by the circadian oscillation of the xeroderma pigmentosum A DNA

173 A key unanswered question is whether the circadian oscillation of this signaling pathway is intri

174 Furthermore, we find that the circadian oscillation of XPA is achieved both by regulat

175 of zCry1a and zPer2 genes and the subsequent circadian oscillation of zPer1.

176 gnalling, in addition to its role in driving circadian oscillations of [Ca(2+) ] in the cytosol and c

177 We suggest that the circadian oscillations of [Ca(2+)](cyt) and CAB2 promote

178 Both red and blue light regulate circadian oscillations of [Ca(2+)](cyt).

179 e the temporal development of light/dark and circadian oscillations of AANAT activity in cultured ret

180 e shell converts the VIP rhythmic signals to circadian oscillations of arginine vasopressin (AVP), wh

181 Circadian oscillations of bioluminescent PER2 and Bmal1

182 's transcriptional feedback loops and drives circadian oscillations of Ca2+ release.

183 tablished a mathematical model that predicts circadian oscillations of cell cycle components and circ

184 n dispersed culture can generate independent circadian oscillations of clock gene expression and neur

185 Circadian oscillations of clock gene products are though

186 of peripheral intracellular clocks revealed circadian oscillations of clock genes and their targets

187 At the molecular level, circadian oscillations of gene expression are regulated

188 We apply this method to analyze circadian oscillations of gene expression in individual

189 Circadian oscillations of gene expression regulate daily

190 omponent of the clock pathway that regulates circadian oscillations of gene expression.

191 ucial factor in this issue is the endogenous circadian oscillations of genes during sampling.

192 Recently, circadian oscillations of hormone secretion, clock gene

193 loops determine the period and amplitude of circadian oscillations of individual cells.

194 escence imaging to visualize GCaMP3-reported circadian oscillations of intracellular calcium [Ca2+]i

195 hiasmatic nucleus (SCN) but exhibited normal circadian oscillations of mPer1 and mCry1 messenger RNA

196 n the phase and 2- to 4-fold in amplitude of circadian oscillations of Per2, Cry1, and Bmal1 between

197 lock maintains energy constancy by producing circadian oscillations of rate-limiting enzymes involved

198 The remarkably stable circadian oscillations of single cyanobacteria enable a

199 Robust circadian oscillations of the proteins PERIOD (PER) and

200 lock elements is required to maintain strong circadian oscillations of these clock-controlled outputs

201 nonlinearity is essential to simulate robust circadian oscillations of transcription in our model and

202 ative feedback strength necessary for stable circadian oscillations over a range of component concent

203 Surprisingly, however, circadian oscillations persist in the livers of mice dev

204 Circadian oscillations persisted when the positive feedb

205 Its cell-autonomous circadian oscillations pivot around a well characterised

206 n paclitaxel-treated rats exhibited a robust circadian oscillation, reaching the nadir during the day

207 er, the molecular mechanisms regulating this circadian oscillation remain unknown.

208 In mice, this pathway undergoes a circadian oscillation required for memory persistence th

209 , includes enzymes whose transcripts exhibit circadian oscillations, such as ornithine decarboxylase

210 nsferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core cl

211 ns in CAT3 mRNA abundance and reveals strong circadian oscillations that persist for multiple cycles

212 Unexpectedly, we unveiled normal circadian oscillations that reflect the allelic state of

213 Both models displayed circadian oscillations that were robust to parameter var

214 st that, despite its lack of self-sustaining circadian oscillation, the proto-circadian system may ha

215 to hemostasis and vascular integrity undergo circadian oscillation, the role of the molecular clock i

216 L influences the period and the amplitude of circadian oscillations through changing model parameters

217 topologies of a simple biochemical model of circadian oscillations to ask two questions: Do differen

218 nal and cytosolic rhythms, thereby promoting circadian oscillations to integral properties of cellula

219 nts and innate immune cells tunes epithelial circadian oscillations via Nfil3, modulating lipid uptak

220 quantify the pervasiveness and plasticity of circadian oscillations, we conduct the first large-scale

221 Circadian oscillations were only obtained if time delays

222 These circadian oscillations were preceded by a rapid and tran

223 PER2::luc bioluminescence demonstrated that circadian oscillations were significantly lower in ampli

224 were found to be essential for simulation of circadian oscillations with this model.

225 ette expansion and leaf movement exhibited a circadian oscillation, with superimposed transients afte

226 results in selective neuronal loss of robust circadian oscillations, with a resulting behavioural phe

227 in expression, leading to the phase shift of circadian oscillations, with similar effects for Per1 In