ライフサイエンスコーパス: circulating level of

1 Circulating levels of 111 biomarkers were analyzed for a

2 Circulating levels of 1449 metabolites were measured usi

3 Higher circulating levels of 22:1 and 24:1, with apparently div

4 Circulating level of 25(OH)D was associated with higher

5 t of Cyp2r1 and Cyp27a1 maintained a similar circulating level of 25-hydroxyvitamin D3 and 1alpha,25-

6 We evaluated the relationship between the circulating levels of 25(OH)D and acute cellular rejecti

7 tic liability to type 2 diabetes, parity, or circulating levels of 25-hydroxyvitamin D and sex hormon

8 Vitamin D deficiency (circulating levels of 25[OH]D </=20 ng/mL, defined using

9 oxygen-sensing pathways, are associated with circulating levels of 4 fatty acids in the de novo lipog

10 We found differences in circulating levels of 43 proteins involved in the acute-

11 We determined the circulating levels of 7 selected candidate miRNAs in 14

12 of Strongyloides infection, we measured the circulating levels of a large panel of pro- and anti-inf

13 Circulating levels of a soluble type I IFNR are elevated

14 ainst hAAT (AAT-ASO) and found reductions in circulating levels of AAT and both soluble and aggregate

15 on studies and the peripheral measurement of circulating levels of acute phase proteins have focused

16 We studied circulating levels of acyl and desacyl ghrelin in rats a

17 m of this study is to evaluate the local and circulating levels of adipocytokines (resistin, adiponec

18 ty or gestational diabetes mellitus have low circulating levels of adiponectin (ADN) and frequently d

19 ers of adipose tissue macrophages, increased circulating levels of adiponectin and preserved glucose

20 oma risk may be partly attributed to reduced circulating levels of adiponectin in obese individuals.

21 Circulating levels of adiponectin, an adipocyte-secreted

22 Obese pregnant women have decreased circulating levels of adiponectin, which is associated w

23 such as 19 might also be useful to increase circulating levels of adult stem cells, thereby exerting

24 In individuals with MS, the circulating levels of AHR agonists were decreased.

25 ase dUTP nick-end labeling (TUNEL) staining, circulating levels of alanine aminotransferase and lacta

26 p.Glu167Lys was also associated with higher circulating levels of alanine transaminase, a marker of

27 es from our laboratory showing that elevated circulating levels of AngII during hypertension result i

28 ercise arm (N = 117), or control (N = 87) on circulating levels of angiogenic biomarkers.

29 han levels in noncarriers (P<1x10(-20)), and circulating levels of APOC3 in carriers were 46% lower t

30 Circulating levels of arginine vasopressin (AVP) are ele

31 viable target for therapies aiming to reduce circulating levels of atherogenic apoB lipoproteins.

32 al FGF1 expression was associated with lower circulating levels of atrial and brain natriuretic pepti

33 issues were collected over time to assay for circulating levels of bacterial 16S DNA, IgE, mast cell

34 the BA sequestrant colestipol, which lowered circulating levels of BAs, prevented exacerbated spontan

35 al to energy expenditure; however, increased circulating levels of BCAA are linked to obesity and dia

36 s evaluating the relation between dietary or circulating level of beta-carotene and risk of total mor

37 ATX with disorders associated with increased circulating levels of bile salts.

38 A biomarker risk score (BRS) based on the circulating levels of biomarkers C-reactive protein, fib

39 Circulating levels of BNP may increase meaningfully earl

40 Circulating levels of bone-derived fibroblast growth fac

41 These mutations lead to reduced circulating levels of both BMP9 and BMP10.

42 release of miRNAs into the bloodstream: the circulating levels of both cardiac- and non-cardiac-spec

43 production of IL-1beta and IL-18 and higher circulating levels of both cytokines.

44 Circulating levels of both seasonal and pandemic influen

45 e vervet monkeys for 4 weeks continuously to circulating levels of BPA that were in the range measure

46 PA from multiple sources and has significant circulating levels of BPA.

47 , reduced ejection fraction, and an elevated circulating level of brain natriuretic peptide or N-term

48 ts reminiscent of IR accompanied by elevated circulating levels of branched-chain amino acids (BCAAs)

49 p between lifetime ovulatory years (LOY) and circulating levels of C-reactive protein (CRP), counter

50 For serum inflammatory biomarker analysis, circulating levels of C-reactive protein (CRP), IL6, IL1

51 Genetically elevated circulating levels of C-reactive protein (CRP), interleu

52 g an apparent fold increase of >10(6) in the circulating levels of C24 bile acids and C27 bile alcoho

53 ylglycerol classes in plasma correlated with circulating levels of CA19-9, albumin and bilirubin.

54 alcitriol (1,25-dihydroxyvitamin D) and high circulating levels of calcidiol (25-hydroxyvitamin D) ea

55 ofibrate treatment was associated with lower circulating levels of CCL11-a proinflammatory and athero

56 al inflammation is associated with increased circulating levels of CGRP in chronic migraineurs.

57 hepatocytes reduced by approximately 50% the circulating levels of cleaved ANGPTL3, while the lack of

58 We found no difference in the circulating levels of Clusterin in late-stage prion dise

59 We hypothesized that circulating levels of complement factor B (FB), an impor

60 iemann-Pick C1-like 1 protein decreased when circulating levels of CORT increased.

61 ization increased anxiety-like behaviors and circulating levels of corticosterone, a stress hormone,

62 we also evaluated survival by prediagnostic circulating levels of cotinine, a metabolite of nicotine

63 i-IFN-gamma antibody significantly decreased circulating levels of CXCL9, CXCL10, and downstream proi

64 palmitoylethanolamide content and normalized circulating levels of cytokines and immunoglobulin E.

65 The elevated circulating levels of cytokines associated with a variet

66 Here, we investigated whether circulating levels of Dickkopf-1 (DKK-1), a specific inh

67 Circulating levels of docosahexaenoic acid (DHA) were al

68 Circulating levels of E-selectin and ICAM-1 and increase

69 and the only effect seen was a reduction in circulating levels of EDN.

70 may in part or wholly explain the increased circulating levels of endocannabinoids reported after co

71 Circulating levels of endotoxin in plasma from patients

72 r/day) for 4-30 days progressively decreased circulating levels of EPCs positive for both Flk-1 and S

73 ents suggest that iron deficiency and higher circulating levels of erythropoietin (EPO) stimulate the

74 Circulating levels of exosomes are associated with the o

75 p between myocardial expression of miR-1 and circulating levels of FABP3 was found both in vitro and

76 enzyme, and limited studies suggest that the circulating level of FAP correlates with the degree of t

77 We also demonstrated that circulating levels of FGF2 were associated with non-mela

78 Decreased hepatic and circulating levels of FGF21 in fasted SIRT1 LKO mice wer

79 es not support a causal relationship between circulating levels of fibrinogen and coronary artery dis

80 notypes available in FHS (Alzheimer disease, circulating levels of fibrinogen, high-density lipoprote

81 Most importantly, dysregulation of circulating levels of fibrinogen, protein C activity, an

82 Circulating levels of fibroblast growth factor (FGF)21 i

83 ctivation also raised hepatic expression and circulating levels of fibroblast growth factor 21 (FGF21

84 dipocyte-specific Atg5 KO mice had increased circulating levels of fibroblast growth factor 21 and ad

85 Circulating levels of fibroblast growth factor 21, a nov

86 Circulating levels of fibroblast growth factor 23 (FGF23

87 Circulating levels of fibroblast growth factor-21 (FGF21

88 (+/+)-STZ mice, which encompass increased 1) circulating levels of free fatty acid, ketone bodies, an

89 ing in both HFD-FBX groups and decreased the circulating levels of free fatty acids and triglycerides

90 As expected from the enhanced fat oxidation, circulating levels of free fatty acids were reduced in t

91 HIV-infected patients had increased circulating levels of functional CD8(+)CD28(-)CD127(lo)C

92 SR-AI-deficient mice, which exhibit reduced circulating levels of FX in vivo and loss of FX-macropha

93 These data suggest that circulating levels of gamma'-Fg modulate the susceptibil

94 sue expression of GDF15 mRNA correlates with circulating levels of GDF-15 and whether elevations in c

95 We validated our previous finding that circulating levels of GDF11/8 decline with age in mice,

96 of clinical transplantation data linked low circulating levels of GDF15 to an increased incidence of

97 In summary, metformin elevates circulating levels of GDF15, which is necessary to obtai

98 the Vasculature in Uppsala Seniors (PIVUS), circulating levels of ghrelin and leptin were measured a

99 glucose-lowering properties, and an elevated circulating level of GLP-1 is a known characteristic of

100 Given a normally basal circulating level of GLP-1, knowledge of mechanisms regu

101 story of nicotine consumption show increased circulating levels of glucagon and insulin, and diabetes

102 ndent of changes in pancreatic hormones, and circulating levels of glucose and free fatty acids.

103 Circulating levels of glycine have previously been assoc

104 ts with this condition show highly increased circulating levels of GM-CSF, which is also locally expr

105 These effects occurred without increases in circulating levels of growth hormone and insulin-like gr

106 olymorphisms in 7 novel loci associated with circulating levels of >/=1 of these fatty acids.

107 appeared to modify the relationship between circulating levels of HDM-IgE and HR: a significant posi

108 sponse was associated with a 34% decrease in circulating levels of hepcidin within 24 hours of vitami

109 homozygosity, likely through an increase of circulating levels of hepcidin.

110 Circulating levels of high-mobility group box 1 (HMGB1)

111 A high circulating level of homocysteine (Hcy), also known as h

112 n was measured (Illumina 450K BeadChip), and circulating levels of hs-CRP and IL-18 were assessed in

113 The epileptic rats showed circulating levels of Hsp60 higher than controls.

114 We also determined the circulating levels of Hsp60 in epileptic animals and TLE

115 Circulating levels of ICAM-1 may also be associated with

116 Circulating levels of IGF-I, IGF-II, IGFBP-3, PAPP-A, an

117 were stable after additional adjustments for circulating levels of IL (interleukin)-6 and high-sensit

118 ce and beta-cell dysfunction, whereas higher circulating levels of IL-1 receptor antagonist (IL-1RA),

119 ndotoxaemia which can contribute to elevated circulating levels of IL-10 and down-regulation of MHC c

120 Circulating levels of IL-10 and TNFalpha were significan

121 hese protective SNPs translated into reduced circulating levels of IL-1beta, IL-1alpha, IL-6, granulo

122 onhuman primates) by colonic spray increased circulating levels of IL-1R antagonist (IL-1Ra).

123 healthy donors and SLE patients have similar circulating levels of IL-2, whereas SLE patients exhibit

124 nthesitis and dactylitis was not due to high circulating levels of IL-23, as transgenic animals and c

125 Higher circulating levels of immune activation markers among tr

126 Targeted metabolomics confirmed increased circulating levels of individual fatty acids in the plas

127 ase response in adipocytes, leading to lower circulating levels of inflammatory cytokines.

128 iolipin composition in mitochondria; reduced circulating levels of inflammatory cytokines; and elicit

129 markers correlated with liver expression and circulating levels of inflammatory mediators such as CXC

130 tor expression in CSCs, together with a high circulating level of insulin-like growth factor-1, repre

131 ature, enhanced insulin sensitivity, and low circulating levels of insulin and insulin-like growth fa

132 In mammals, circulating levels of insulin and nutrients, which fluct

133 Low circulating levels of insulin-like growth factor binding

134 ronic health factors significantly influence circulating levels of insulin-like growth factor-1 and i

135 Moreover, it abolished circulating levels of interleukin (IL)-1beta and IL-18 i

136 relationship between glycated hemoglobin and circulating levels of interleukin (IL)-6, IL-8, and C-X-

137 Also measured were circulating levels of interleukin-6 (IL-6), an inflammat

138 We assessed the association between baseline circulating levels of isoleucine, leucine, valine, tyros

139 JH in queens was suggested by the fact that circulating levels of JH were ca. 2 orders of magnitude

140 Circulating levels of large extracellular vesicles (lEVs

141 controls, patients with cirrhosis had higher circulating levels of LBP and IL-10, an expansion of per

142 iants of PCSK9 that were associated with low circulating levels of LDL cholesterol (LDL-C) and a redu

143 DOL) as a regulator of LDLR abundance and of circulating levels of LDL-cholesterol in humans.

144 PCSK9-based therapeutic approaches to reduce circulating levels of LDL-cholesterol.

145 urthermore, the treatment did not affect the circulating levels of leptin and adiponectin in any grou

146 oot planing (SRP) on clinical parameters and circulating levels of leptin and adiponectin in patients

147 Circulating levels of leptin are elevated in systemic lu

148 both obesity and periodontitis affected the circulating levels of leptin in favor of proinflammation

149 HFD induced increased body weight gain, circulating levels of leptin, cholesterol, HDL and LDL i

150 t are thought to be due to persistently high circulating levels of LH from the pituitary.

151 Whether circulating levels of lipasin in humans are altered in a

152 Simvastatin therapy did not affect circulating levels of lipid mediators, suggesting that p

153 dy confocal microscopy was used to determine circulating levels of lipopolysaccharide (LPS) in contro

154 cal solutions enabling the quantification of circulating levels of liposoluble micronutrients such as

155 Low circulating levels of long chain omega-3 polyunsaturated

156 Here we showed that circulating levels of LPS are significantly elevated in

157 lts, AH patients had significantly increased circulating levels of macrophage activation (sCD163 and

158 ients with colorectal cancer (CRC) have high circulating levels of macrophage inhibitory cytokine-1 (

159 Remarkably, circulating levels of macrophage migration inhibitory fa

160 ss in the vasculature as evidenced by higher circulating levels of malondialdehyde compared with WT c

161 ale and male mice associated with changes in circulating levels of many glycoproteins.

162 omics revealed that nephrocytes regulate the circulating levels of many secreted proteins, the most n

163 Conclusions: Higher circulating levels of MCP-1 are associated with increase

164 Objective: To determine whether circulating levels of MCP-1 are associated with risk of

165 Nrf2 did not affect circulating levels of MDSC in tumor-bearing mice because

166 Increasing circulating levels of Metrnl stimulates energy expenditu

167 In addition, circulating levels of miR-134, -10a, -195, -133b were si

168 Low circulating levels of miR-150 are associated with LV rem

169 In addition, circulating levels of miR-22 in 154 patients with systol

170 Increased circulating levels of miR-30e-3p predict the development

171 Circulating levels of miRNA-122 were independent predict

172 levels were highest in HIV/HBV patients, and circulating levels of miRNA-34a correlated positively wi

173 We analyzed the circulating levels of miRNAs in HIV patients with regard

174 Circulating levels of miRNAs were measured by sequencing

175 Circulating levels of mitochondrial DNA at ICU admission

176 GDM may modulate both local and circulating levels of MMP-8 especially when associated w

177 as multiple myeloma, that feature increased circulating levels of monoclonal immunoglobulin fragment

178 tivity, loss of grip strength, and increased circulating levels of muscle damage marker LDH.

179 nd that AMI is accompanied by an increase in circulating levels of myo-miRs, with miR-1, 208, and 499

180 Circulating levels of myonectin were tightly regulated b

181 ed with reduced and increased expression and circulating levels of myonectin, respectively, suggestiv

182 this double blind crossover study, shifts in circulating levels of n-3 and n-6 PUFA-derived bioactive

183 Circulating levels of n-3 PUFAs provide an objective mea

184 coordinated, mostly transient, reduction of circulating levels of nine immune signalling molecules.

185 s that could have significantly affected the circulating levels of NPs or lipid profile) or low-quali

186 HF) and atrial fibrillation (AF) have higher circulating levels of NT-proBNP (N-terminal pro-B-type n

187 nts predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and

188 ey roles of the ManR and ASGR in controlling circulating levels of numerous glycoproteins critical fo

189 rove these behaviors in wild-type mice, when circulating levels of OCN decline as they do with age.

190 We investigated whether circulating levels of osteoprotegerin are related to fea

191 Fluctuations in circulating levels of ovarian hormones have been shown t

192 ever, so far, few studies reported increased circulating levels of oxidative stress markers in patien

193 In epidemiologic studies, circulating levels of palmitic acid (16:0) are associate

194 rprisingly, there was no correlation between circulating levels of PD-L1 and Galectin-9 and their int

195 In fact, circulating levels of PD-L1 and Galectin-9 were predicti

196 Although the circulating level of peptide hormone urotensin II (UII)

197 We have recently found higher circulating levels of pituitary adenylate cyclase-activa

198 3-OHB infusion increased circulating levels of plasma 3-OHB from 0.4+/-0.3 to 3.3

199 The circulating levels of plasma PK activity were measured i

200 Circulating levels of PMPs (either CD31+/42b+ or CD31+/4

201 jection fraction is associated with elevated circulating levels of pro-inflammatory cytokines opened

202 adaptive immune systems, their impact on the circulating levels of pro-inflammatory cytokines, and th

203 These changes were accompanied by suppressed circulating levels of proangiogenic growth factors (EGF

204 olipid transfer protein (PLTP) increases the circulating levels of proatherogenic lipoproteins, accel

205 Transgenic mice that produce high circulating levels of progastrin (hGAS) have increased p

206 ed individuals exhibited significantly lower circulating levels of proinflammatory cytokines (gamma i

207 T decreased microglial activation, decreased circulating levels of proinflammatory cytokines, and pre

208 istance, altered hormone signaling, and high circulating levels of proinflammatory mediators.

209 ted hepatic LDLR expression, and reduced the circulating levels of proprotein convertase subtilisin/k

210 epsis, including melioidosis, have decreased circulating levels of protein C.

211 The circulating levels of proteins associated with the top-r

212 ive cART during infancy significantly limits circulating levels of proviral and replication-competent

213 um is a metabolic disorder caused by reduced circulating levels of pyrophosphate, a potent mineraliza

214 Renal function and circulating levels of renin-angiotensin-aldosterone syst

215 Periodontitis mainly influenced the circulating levels of resistin and adiponectin, whereas

216 t of cells, and its deletion in mice reduces circulating levels of S1P, alters immune cell traffickin

217 , however, resulted in contrasting effect in circulating levels of S1P.

218 Our data suggest that circulating levels of sCD40L and sCD40R are associated w

219 es in gene expression and partially restored circulating levels of secondary BAs.

220 High circulating levels of sENG contribute to the pathogenesi

221 This study investigated whether circulating levels of serum C-reactive protein (CRP) and

222 CRS is associated with elevated circulating levels of several cytokines including interl

223 Intriguingly, circulating levels of several miRNAs are lower in patien

224 Circulating levels of sex hormones, cortisol, and insuli

225 at shows pronounced seasonal fluctuations in circulating levels of sex-steroid hormones, which are kn

226 genome-wide association study suggested that circulating levels of shed human transferrin receptor 1

227 In particular, these studies suggest that circulating levels of short vascular endothelial growth

228 AN, which will treat patients stratified for circulating levels of short VEGF-A isoforms with bevaciz

229 Circulating levels of SLPI, monocyte cluster of differen

230 ts with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary sTyro3 and s

231 Circulating levels of SN and other biomarkers were asses

232 Plasma exchange reduced circulating levels of soluble B7 in patients with ALF an

233 Circulating levels of soluble forms of urokinase-type pl

234 Higher circulating levels of sPLA2-IIA mass or sPLA2 enzyme act

235 Mertk(CR) mice also have increased circulating levels of SPMs and less lung injury after I/

236 Serial changes in circulating levels of sub-clonal private mutations corre

237 r periodontitis is associated with increased circulating levels of systemic inflammation and endothel

238 Flow cytometry was used to analyze circulating levels of T and B cells and bone marrow (BM)

239 ker of insulin secretion and sensitivity and circulating levels of testosterone in humans, but the en

240 Serum samples were quantified for circulating levels of Tetranectin and a panel of circula

241 Circulating levels of TGFBIp were measured in patients a

242 Circulating levels of TGFBIp were significantly elevated

243 which are vulnerable to the effects of high circulating levels of THC, and 2) associated either with

244 nt resulted in a significant decrease of the circulating level of the predominant thyroid hormone fre

245 sistance in osteoblasts led to a decrease in circulating levels of the active form of osteocalcin, th

246 renal phosphate wasting, inappropriately low circulating levels of the active form of vitamin D, and

247 impaired insulin sensitivity correlated with circulating levels of the adipokine resistin in a lipoly

248 RAGE(-/-) mice is associated with increased circulating levels of the anti-inflammatory cytokine int

249 In response to calorie deficiency the circulating levels of the appetite-promoting hormone, ac

250 Circulating levels of the biomarkers surfactant protein

251 Higher circulating levels of the branched-chain amino acids (BC

252 e-3-carbonitrile 61 significantly raised the circulating levels of the branched-chain amino acids leu

253 Circulating levels of the chitinase-like protein YKL-40

254 ockade of cell proliferation also normalized circulating levels of the cytokines leptin and interleuk

255 oduced a significant increase in hepatic and circulating levels of the endocannabinoid anandamide, wh

256 ve biomimetic approach, we have investigated circulating levels of the gut metabolites betaine, choli

257 Recently, we reported downregulated circulating levels of the microRNAs miR-19b, miR-29a, an

258 de novo lipogenesis, alongside increases in circulating levels of the most abundant free fatty acids

259 Here we report that circulating levels of the muscle-enriched miR486 is lowe

260 ciated with APOL1 is probably not related to circulating levels of the mutant protein.

261 y-risk" rs9939609 A allele have dysregulated circulating levels of the orexigenic hormone acyl-ghreli

262 bject recognition and location but only when circulating levels of the ovarian steroids, estradiol an

263 led clinical trials-that metformin increases circulating levels of the peptide hormone growth/differe

264 negatively correlated with clinical pain and circulating levels of the proinflammatory citokine inter

265 Lipid- and protein-rich nutrition attenuated circulating levels of the proinflammatory cytokines tumo

266 e, fat pad weight, and tissue expression and circulating levels of the secreted glycoprotein, lipocal

267 he aim of the present study was to determine circulating levels of the soluble forms of RAGE in perio

268 insufficiently high in the case of cortisol) circulating levels of the target-organ hormones.

269 Longitudinal changes in circulating levels of the top metabolite, were examined

270 ed adeno-associated viral vectors to elevate circulating levels of the tumorkines IL6 and/or activin

271 Previously, we observed that circulating levels of these 2 DAMPs are increased in hyp

272 Circulating levels of these biomarkers have a heritable

273 onal cells, indicating that the elevation of circulating levels of these microRNAs after cardiac arre

274 Circulating levels of these molecules, however, have har

275 ver, we found a negative correlation between circulating levels of these three lncRNAs and body mass

276 Finally, we tested the circulating levels of these three lncRNAs in 8 obese hum

277 Our results suggest that circulating levels of these TTR-binding compounds in Inu

278 therapeutic action of GLP-1 and suggest that circulating levels of this hormone directly stimulate in

279 hich may mobilize methylmercury and increase circulating levels of this neurotoxin.

280 We found a significant decrease in circulating levels of three lncRNAs (lncRNA-p5549, lncRN

281 or environmental phthalate exposure to alter circulating levels of thyroid hormones in pregnant women

282 In addition, circulating levels of thyroid hormones thyroxine (T4) an

283 lamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH)

284 onic anterior pituitary that resulted in low circulating levels of thyroxine and IGF-1.

285 ested that these chemical agents may disrupt circulating levels of total 25(OH)D in adults.

286 proteins in neoplastic lesions and increased circulating levels of total free fatty acids.

287 way in hepatocytes that contributes to basal circulating levels of tPA and to fibrinolysis after vasc

288 clinical intervention studies indicate that circulating levels of triglycerides and cholesterol tran

289 yperglycemia, hypercholesterolemia, and high circulating levels of triglycerides.

290 Breast tumors exposed to high circulating levels of TSLP were arrested at an early ade

291 ed obesity resulted in an 80-95% decrease in circulating levels of TTR and RBP4.

292 Here, high circulating levels of tumor necrosis factor (TNF)-alpha

293 ent infection is characterized by diminished circulating levels of type 1 (interferon gamma, interleu

294 in osteoblasts in mice resulted in decreased circulating levels of undercarboxylated OCN, impaired gl

295 ects associated with CKD arise from elevated circulating levels of urea that increase islet protein O

296 r insufficiency in PAD occurs despite higher circulating levels of vascular endothelial growth factor

297 As increased circulating levels of VEGFs and Angs have been observed

298 tive androstane receptor, profoundly reduced circulating levels of vemurafenib in humanized mice.

299 sed lower serum FGF23 levels, despite normal circulating levels of vitamin D metabolites.

300 Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overa