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1 synthesizing rhizoferrin from putrescine and citrate.
2 hours after a 100 mg oral dose of sildenafil citrate.
3 lts for the pulmonary delivery of sildenafil citrate.
4 r sustained pulmonary delivery of sildenafil citrate.
5 density lipoprotein (VLDL), amino acids, and citrate.
6 ake and sperm production through gut-derived citrate.
7 organic chelators, such as nicotianamine and citrate.
8 r anaplerosis and reductive carboxylation to citrate.
9 imilar to the already known inhibitor sodium citrate.
10 HepG2 cells and decreases cellular levels of citrate.
11 tch between E. coli physiology and growth on citrate.
13 rbonate (4.0g.L(-1)), chloride (5.0g.L(-1)), citrate (6.5g.L(-1)), hydroxide (4.0g.L(-1)), hypochlori
14 of sunflower pectin with 0.74% (w/v) sodium citrate (72 degrees C, 194 min) and different procedures
15 ing following treatment with oral sildenafil citrate, a phosphodiesterase type 5 (PDE5) inhibitor and
19 rlactatemia (>/= 4 mmol/L), the frequency of citrate accumulation was 0.77%, 2.70%, and 6.33%, respec
22 ificantly more patients randomized to ferric citrate achieved the primary end point (61 [52.1%] versu
23 carrier family 13 member 5, which transports citrate across cell membranes, halts liver cancer cell g
26 ats, chlorthalidone is superior to potassium citrate alone or combined with chlorthalidone in reducin
29 endogenous type I IFN controls the cellular citrate/alpha-ketoglutarate ratio and inhibits expressio
30 biomarkers [e.g., omega-3 (n-3) fatty acids, citrate, alpha1-acid glycoprotein, HDL, and MUFA] in the
31 tients, lower levels of urinary excretion of citrate, an endogenous inhibitor of calcium crystal form
32 ilability in the rhizosphere (as a result of citrate and acid phosphatase exudation) compared with ma
33 ve a 20-fold increase in signal-to-noise for citrate and an 8-fold increase for isocitrate as compare
34 with its mechanistically related metabolites citrate and aspartate, are widely reported as reduced in
35 on of citC and citS operons was dependent on citrate and CitAB, whose transcription was autorepressed
36 lytic mutant of ACLY in the presence of ATP, citrate and CoA substrates reveals a phospho-citryl-CoA
37 nd catalyses the ATP-dependent conversion of citrate and coenzyme A (CoA) to oxaloacetate and acetyl-
38 e transport of the metabolites succinate and citrate and hence are of paramount physiological importa
42 ies identified included: iron complexes with citrate and malate: Fe(III)(Cit)(3)(Mal), Fe(III)(Cit)(2
43 eceptor MCP2201, which governs chemotaxis to citrate and other organic compounds in Comamonas testost
46 at pilot-scale by the extraction with sodium citrate and purification with membrane separation, eco-f
47 (4207) operon was induced in the presence of citrate and tartrate, perhaps by the activity of a diver
48 two surface chemistries that include anionic citrate and the cationic polyelectrolyte poly(allylamine
49 ) mice (previously shown to have low urinary citrate and to develop calcium oxalate stones) had a 40%
50 ide a fast and simple method to detect zinc, citrate, and aspartate levels as a biomarker signature f
52 metabolite pools such as malate, fumarate or citrate, and flux calculations suggest the involvement o
53 the Krebs cycle intermediates succinate and citrate, and the Krebs cycle-derived metabolite itaconat
54 binding affinity of citrinin with diammonium citrate, and urea derived CD over Congo red in presence
56 we present several examples of binding of a citrate anion to the active sites of E. coli L-asparagin
58 s were randomized to receive either regional citrate anticoagulation (n = 300), which consisted of a
59 rrent guidelines suggest the use of regional citrate anticoagulation (which involves the addition of
60 Risk of citrate accumulation during regional citrate anticoagulation in a well-selected cohort of pat
61 fety and efficiency of heparin-free regional citrate anticoagulation of the dialysis circuit using a
63 layer facing draw solution) using trisodium citrate as draw solute, most likely due to the unique sw
64 nc, in the form of ZnCl(3)(-), together with citrate, aspartate, and N-acetylaspartate on human prost
67 ention of citrate-coated gold nanoparticles (citrate-Au-NPs) were studied in partially saturated soil
68 he assay is based on inducing aggregation of citrate AuNPs decorated with a specific nucleic acid pro
70 y to characterize Fe plaque using dithionite-citrate-bicarbonate (DCB) extraction and elemental analy
74 membrane-embedded CitA construct slows down citrate-binding kinetics by at least a factor of 60, con
76 urthermore, bioinformatics data, showing key citrate-binding motifs conserved across a broad range of
77 teric, mostly hydrophobic cavity next to the citrate-binding site, and requires extensive conformatio
81 conclusion, black tea polyphenols and sodium citrate can be used as additives to inhibit TMAO-demethy
84 h potassium chloride (as control), potassium citrate, chlorthalidone (with potassium chloride to equa
87 e previously reported that aerobic growth on citrate (Cit(+)) evolved in an Escherichia coli populati
88 in size distributions have been observed for citrate- (cit) and polyvinylpyrrolidone- (PVP) capped si
89 its absorption in the small intestine, both citrate cleavage in hepatocytes and microorganism-derive
90 phosphate, and arsenate-on the retention of citrate-coated gold nanoparticles (citrate-Au-NPs) were
92 ity were observed with silver nanoparticles (citrate-coated) with an initial hydrodynamic diameter (D
93 To test whether chlorthalidone and potassium citrate combined would reduce calcium phosphate stone fo
94 ement therapy, anticoagulation with regional citrate, compared with systemic heparin anticoagulation,
96 of the dialysis circuit using a calcium-free citrate-containing dialysate, with calcium reinjected ac
97 3 m(2) 2:1 to receive a fixed dose of ferric citrate coordination complex (two tablets per meal, 210
99 pitalization, suggest that fixed-dose ferric citrate coordination complex has an excellent safety pro
100 The beneficial effects of fixed-dose ferric citrate coordination complex on biochemical parameters,
103 Of the 133 patients randomized to ferric citrate coordination complex, 31 (23%) initiated dialysi
104 etabolism), malic acid and oxoglutaric acid (citrate cycle), carnitine (fatty acid metabolism), and p
105 g starch and sucrose metabolism, glycolysis, citrate cycle, amino acids synthesis, and plant hormones
107 LIM), was matched in the cytosol by a lag in citrate cycling, as shown with a FRET reporter targeted
111 analyses showed that PFKFB3 is required for citrate-dependent H3K27 acetylation at enhancer sites of
112 nusual lipodepsipeptides containing a unique citrate-derived fatty acid and a rare dehydro-beta-alani
114 gnostic solutions, we recently established a citrate-derived synthesis platform for the development o
115 nal group chemistry dictated the kinetics of citrate desorption, while the guest ligand concentration
121 at root structure plays an important role in citrate-enhanced uptake (additional phosphate uptake due
131 the malate-aspartate shuttle, mitochondrial citrate export and complex I supply the substrates neede
133 e malate-aspartate shuttle and mitochondrial citrate export are required to maintain synthesis of asp
138 study, we explored regulatory mechanisms of citrate fermentation genes by global regulators ArcA and
139 can also directly regulate the expression of citrate fermentation genes in E. coli under anaerobic co
141 ctly regulated but also indirectly modulated citrate fermentation genes via controling CitA-CitB syst
142 ArcA indirectly controled the expression of citrate fermentation genes via regulating CitA-CitB syst
143 olerae can utilize citrate in vivo using the citrate fermentation pathway and that V. cholerae likely
149 ith the systemic heparin group, the regional citrate group had significantly fewer bleeding complicat
151 ached statistical significance in the ferric citrate group, including the mean relative change in hem
152 ven chlorthalidone with or without potassium citrate had higher bone mineral density and better mecha
153 sts.Twenty patients received the taurolidine-citrate-heparin lock and 21 received the heparin lock, w
157 overprescribing of omeprazole and maropitant citrate in hospitalised dogs, highlighting a need for in
159 r suggests that the role of surface-adsorbed citrate in nanomaterial fate and transport must be bette
161 eriments showed that V. cholerae can utilize citrate in vivo using the citrate fermentation pathway a
163 lidone increased urine citrate and potassium citrate increased it even more; the combination did not
169 ld) and Krebs cycle intermediates, including citrate, isocitrate, succinate, and malate (1.4-3.9-fold
172 bolism, including increased cytoplasmic (iso)citrate levels, reduced glycolytic flux, and functional
175 inherited variants in the genes encoding ATP citrate lyase (ACLY) and HMGCR to create instruments tha
176 cs and metabolite profiling, we identify ATP-citrate lyase (ACLY) as a distinctly mTORC2-sensitive AK
178 methylglutaryl-CoA reductase (HMGCR) and ATP-citrate lyase (ACLY) in a TGF-beta receptor/PI3K/protein
184 Both forms of RuBisCO, together with ATP citrate lyase genes in the rTCA cycle, increase with dis
185 re bempedoic acid, an adenosine triphosphate-citrate lyase inhibitor that reduces cholesterol synthes
186 ate instruments that mimic the effect of ATP citrate lyase inhibitors and HMGCR inhibitors (statins),
187 enetic variants that mimic the effect of ATP citrate lyase inhibitors and statins appeared to lower p
192 Neither lifelong genetic inhibition of ATP citrate lyase nor lifelong genetic inhibition of HMGCR w
193 boxylase (ACCalpha), and increased FASN, ATP citrate lyase(ACLY), and malic enzyme (ME) protein expre
194 completed for bempedoic acid (targeting ATP-citrate lyase) and inclisiran (an interference RNA-based
195 ate transporter Slc25A1, and the nuclear ATP-citrate lyase, in association with intracellular accumul
196 own that bempedoic acid, an inhibitor of ATP citrate lyase, reduces levels of low-density lipoprotein
197 MyD88 and TRIF resulted in activation of ATP-citrate lyase, which in turn facilitated the induction o
198 yltransferase 1A and adenosine tri-phosphate citrate lyase, which, together, impart macrophages with
199 fat diet (HFD) results in suppression of ATP citrate-lyase levels in tissues such as adipose and live
201 MED score was associated with higher urinary citrate, magnesium, oxalate, phosphate, uric acid, volum
205 d trait refinement and adaptation to the new citrate niche, while also suggesting a recalcitrant mism
206 itions of the rigor-like conformation with a citrate of crystallization at the nucleotide binding sit
210 igate the relationship between succinate and citrate/oxalate levels, we assessed blood and urine leve
211 d isocitrate (p = 1.2 x 10(-3)), but reduced citrate (p = 5.0 x 10(-4)), were found to be associated
212 d analytical method for the determination of citrate, phosphate and sulfite in seafood by capillary z
213 influenced strongly vitamin C degradation in citrate-phosphate buffer but not in the apple puree seru
215 ith chlorthalidone, and rats given potassium citrate plus chlorthalidone had some stones but fewer th
218 ative genomics and transcriptome analysis of citrate-producing strains-namely, A. niger H915-1 (citra
220 ne and central carbon metabolism and reduces citrate production, leading to a decrease in the steady-
221 After brief tissue preparation, the glucose/citrate ratio can be recorded on a tissue sample in 1 mi
225 ity could collectively exude high amounts of citrate, resulting in a delayed spike in citrate-enhance
226 leukocyte scintigraphy (LS), and Gallium-67 citrate scintigraphy for the diagnosis of CIED infection
228 ycolytic metabolism to sustain physiological citrate secretion, whereas prostate adenocarcinoma consu
230 a testis-midgut interaction via cytokine and citrate signaling that regulates intestinal metabolism,
232 oagulation (which involves the addition of a citrate solution to the blood before the filter of the e
236 h were consistent with the expression of ATP-citrate synthase (ACS) and isocitrate dehydrogenase (IDH
237 se reaction and anaplerotic pathways) and Re-citrate synthase (Ccar_06155) was a key enzyme in its tr
238 c selection unearthed the Krebs cycle enzyme citrate synthase (CitA) as a checkpoint regulator contro
239 The activities of the metabolic enzymes citrate synthase (CS), malate dehydrogenase, and strombi
240 companying the fall in CK flux, total CK and citrate synthase activities and the absolute activities
245 eta2, insulin receptor, glycogen content and citrate synthase activity were similar among groups.
246 m and alterations in their respiratory rate, citrate synthase activity, and AMP/ATP ratio, while tryp
248 ed adult neurogenesis, greater mitochondrial citrate synthase activity, and modulation of the adult h
250 ecreased mitochondrial ATP production and/or citrate synthase and cytochrome oxidase activities in th
252 itofusin 2]), and oxidative phosphorylation (citrate synthase and electron transport chain complexes)
256 in assessing rates of hepatic mitochondrial citrate synthase flux (V CS) and pyruvate carboxylase fl
257 ition, there were striking increases in both citrate synthase gene expression and enzymatic activity
259 ht a novel and unique role of the C-terminal citrate synthase homology domain in ACLY function and ca
260 role of the uncharacterized ACLY C-terminal citrate synthase homology domain in the mechanism of ace
261 dispensable for CtrA control, and functional citrate synthase paralogs cannot replace CitA in promoti
263 d in higher OXPHOSCI+CII (pmol oxygen/s x mg/citrate synthase) in the cortex (6.00 +/- 0.28 vs 3.88 +
265 -catalyzed phosphorylation and inhibition of citrate synthase, elevated acetyl-CoA levels, and hypera
270 compared with frequently used Ca sources (Ca citrate tetrahydrate (CCT), tri-Ca phosphate (triCP) and
271 a substantial net uptake of both glucose and citrate that delivered exogenous energy and provided app
272 ation of alpha-ketoglutarate, aconitate, and citrate that is associated with reversal of the tricarbo
274 e-producing strains-namely, A. niger H915-1 (citrate titer: 157 g L(-1)), A1 (117 g L(-1)), and L2 (7
275 TP-citrate lyase (ACL), an enzyme converting citrate to acetyl-CoA, is highly induced in the kidney o
276 itrate lyase (ACLY) enzyme cleaves cytosolic citrate to generate acetyl-CoA, and is upregulated after
277 on, whereas prostate adenocarcinoma consumes citrate to power oxidative phosphorylation and fuel lipo
278 er the genomic mutations nor the addition of citrate to the medium overcomes ethanol toxicity or temp
279 : for Gu-0 membranes almost no phosphate and citrate transport could be detected, while the Gu-100 me
280 0 at pH 7, showing an enhanced phosphate and citrate transport for Gu-100 in comparison to Gu-0.
282 hibits the expression of the plasma membrane citrate transporter NaCT in HepG2 cells and decreases ce
285 :C increased expression of the mitochondrial citrate transporter Slc25A1, and the nuclear ATP-citrate
286 NaCT (SLC13A5; mINDY), a sodium-coupled citrate transporter, is the mammalian ortholog of Drosop
287 mily 13 member 5 (SLC13A5), a sodium-coupled citrate transporter, plays a key role in importing citra
292 both ArcA and Fnr can indirectly control the citrate utilization via CitA-CitB system, while Fnr can
296 g alpha-KG, succinate, fumarate, malate, and citrate were observed in TGF-beta1-differentiated myofib
297 lement thorium and counterions phosphate and citrate were separated effectively from the REEs in the
298 d metabolites (e.g., lactate, glutamine, and citrate) were mapped to pathways of glycolysis and the T
299 herefore, the decrease in cellular levels of citrate would stimulate glycolysis and inhibit gluconeog
300 cotianamine: Cu(II)(NA); zinc complexes with citrate: Zn(II)(Cit)(2) and nicotianamine Zn(II)(NA) and