ライフサイエンスコーパス: citrate synthase

1 , MP1 does not process the precursor form of citrate synthase.

2 l-CoA dehydrogenase activity or its ratio to citrate synthase.

3 e target proteins, alcohol dehydrogenase and citrate synthase.

4 ses the aggregation of thermally inactivated citrate synthase.

5 etic patients, although it modestly elevated citrate synthase.

6 oxidative branch of the Krebs cycle, IDH and citrate synthase.

7 otide binding domain 1, insulin B chain, and citrate synthase.

8 the ability of PA700 to promote refolding of citrate synthase.

9 Similar results were also obtained with citrate synthase.

10 application of this method to porcine heart citrate synthase.

11 dues to individual steps in the mechanism of citrate synthase.

12 but not cytosolic malate dehydrogenase with citrate synthase.

13 T2, a gene encoding a peroxisomal isoform of citrate synthase.

14 ed in the screen, pyruvate dehydrogenase and citrate synthase.

15 mechanistic features distinct from those of citrate synthase.

16 ndrial reactive oxygen species and bacterial citrate synthase.

17 to evaluate thermally induced aggregation of citrate synthase.

18 n also suppresses the thermal aggregation of citrate synthase.

19 tipode of the citrate synthesized by the (S)-citrate synthase].

20 Hindlimb muscle oxidative (citrate synthase, 21%; beta-HAD, 32%) and glycolytic (PF

21 eobacter species, expression and function of citrate synthase, a key enzyme in the TCA cycle that is

22 red the activities of the following enzymes: citrate synthase, a marker of oxidative metabolism; beta

23 event the aggregation of thermally denatured citrate synthase, a measure of passive chaperoning activ

24 A. aceti citrate synthase (AaCS), a hexameric type II citrate syn

25 the previously unexplained role of A. aceti citrate synthase (AarA) in acetic acid resistance at a l

26 Here we showed that citrate synthase, aconitase, isocitrate dehydrogenase, f

27 h were consistent with the expression of ATP-citrate synthase (ACS) and isocitrate dehydrogenase (IDH

28 companying the fall in CK flux, total CK and citrate synthase activities and the absolute activities

29 chondrial density and cytochrome oxidase and citrate synthase activities relative to M-ERRalphaWT.

30 Creatine kinase and citrate synthase activities were measured as markers of

31 Although complex-IV and citrate synthase activities were similar in VOE platelet

32 ransporter, citrate transporter protein, and citrate synthase activities.

33 ter normalization for a moderate decrease in citrate synthase activity (P<0.05).

34 ion was normalized to muscle wet weight, and citrate synthase activity (standard measure of mitochond

35 Myocilin protected citrate synthase activity against thermal inactivation f

36 Remarkably, re-acidification restores citrate synthase activity and ATP content in an insulin

37 layed reduced mitochondrial content (reduced citrate synthase activity and cytochrome c protein) and

38 the eoPE group and an increase of P/O ratio, citrate synthase activity and decrease of Ca(2+)-induced

39 Mitochondrial content was normalized to citrate synthase activity and mitochondrial function was

40 Mitochondrial mass was analysed by citrate synthase activity and mitochondrial protein cont

41 al dysfunction, which is revealed by reduced citrate synthase activity and mtDNA copy number.

42 dative function was impaired, with decreased citrate synthase activity and spare respiratory capacity

43 mice showed a approximately 25% increase in citrate synthase activity but no further increase with t

44 Citrate synthase activity decreased in autotrophic and a

45 Citrate lyase activity was higher than ATP citrate synthase activity in autotrophic cultures.

46 d muscle PGC-1a expression and mitochondrial citrate synthase activity in chronically exercised mice.

47 a, together with the significant increase in citrate synthase activity in heart, but not in soleus an

48 d glucose tolerance, liver NAD(+) levels and citrate synthase activity in offspring.

49 muscle HK-II activity correlated with muscle citrate synthase activity in the normal subjects (r = 0.

50 Similarly, skeletal muscle citrate synthase activity increased by 13% in the exerci

51 aintained levels of cytochrome C oxidase and citrate synthase activity levels.

52 as induced in the absence of any increase in citrate synthase activity or in subunit IV of the cytoch

53 an uncoupler and expressed as a function of citrate synthase activity per total amount of protein.

54 Citrate synthase activity was decreased significantly on

55 Citrate synthase activity was lower (P < 0.0001) and cyt

56 Also, citrate synthase activity was reduced in type 2 diabetic

57 These results suggested that citrate synthase activity was the source of the increase

58 eta2, insulin receptor, glycogen content and citrate synthase activity were similar among groups.

59 hat, in the wild-type strain, high levels of citrate synthase activity were the source of a toxic met

60 lowest for patients in the middle tertile of citrate synthase activity when normalized to either musc

61 otide (NADH) oxidase activity (normalized to citrate synthase activity) in lymphocytic mitochondria f

62 content (cytochrome c, COXIV-subunit I, and citrate synthase activity) significantly increased (P <

63 ss, mitochondrial DNA depletion, and reduced citrate synthase activity, an index of mitochondrial mas

64 m and alterations in their respiratory rate, citrate synthase activity, and AMP/ATP ratio, while tryp

65 Mitochondrial oxygen consumption rate, citrate synthase activity, and ATP content are all reduc

66 Total mtDNA content, citrate synthase activity, and cytochrome c oxidase acti

67 nstrated by increases in oxygen consumption, citrate synthase activity, and induction of key metaboli

68 opy number (mtDNA), OXPHOS gene transcripts, citrate synthase activity, and maximal mitochondrial ATP

69 ed adult neurogenesis, greater mitochondrial citrate synthase activity, and modulation of the adult h

70 me c content, cytochrome c oxidase activity, citrate synthase activity, and oxygen consumption, param

71 s exercise training improved cardiac output, citrate synthase activity, and peak tissue diffusing cap

72 analyzed for CK total activity, CK isoforms, citrate synthase activity, and total creatine.

73 Disruption of citrate synthase activity, however, suppressed the effec

74 Citrate synthase activity, mitochondrial DNA (mtDNA) abu

75 Measurements of renal cardiolipin levels, citrate synthase activity, rotenone-sensitive NADH oxida

76 drial superoxide dismutase (SOD2), and lower citrate synthase activity, the first step in the tricarb

77 s, and mitochondrial densities, assessed via citrate synthase activity, were consistent between group

78 ining, mitochondrial DNA quantification, and citrate synthase activity.

79 ing, DNA quantification, and measurements of citrate synthase activity.

80 rmalized to creatine kinase activity, as was citrate synthase activity.

81 nate-resistant strain contained 12-fold less citrate synthase activity.

82 acid cycle deficiency without affecting the citrate synthase activity.

83 l muscle this was paralleled by a decline in citrate synthase activity.

84 n rat heart extracts, after normalization to citrate synthase activity.

85 e dismutase 2, concomitant with increases in citrate synthase activity.

86 (per million fibroblasts), of protein, or of citrate synthase activity.

87 There was also no increase in citrate synthase activity.

88 to alphaB-crystallin, MTB HSP16.3 suppressed citrate synthase aggregation and in the presence of 3.5

89 xtended apo conformation in the context of a citrate synthase aggregation assay.

90 Insulin and citrate synthase aggregation assays showed 38 and 30% im

91 e highly conserved Glu-240, fails to prevent citrate synthase aggregation at 43 degrees C.

92 y luciferase as well as in the prevention of citrate synthase aggregation.

93 lasses of secondary structure such as alpha (citrate synthase), alpha + beta (lysozyme), beta (concav

94 hrome c, delta-aminolevulinate synthase, and citrate synthase also occurred before an increase in PGC

95 Citrate synthase and aconitase activities in cells grown

96 n artificial chaperone-assisted refolding of citrate synthase and artificial chaperone-assisted refol

97 n levels of complexes I, II, and IV, whereas citrate synthase and ATP synthase were unaffected.

98 taneous and glucose-induced second wind; and citrate synthase and beta-hydroxyacyl coenzyme A dehydro

99 ygen uptake (14%), cardiac output (15%), and citrate synthase and beta-hydroxyacyl coenzyme A dehydro

100 Functional assays of mitochondrial citrate synthase and complex IV, key rate-limiting steps

101 microm PQQ for 24-48 h resulted in increased citrate synthase and cytochrome c oxidase activity, Mito

102 lary density were analyzed by stereology and citrate synthase and cytochrome c oxidase by biochemical

103 illary density were three times greater, and citrate synthase and cytochrome c oxidase were only appr

104 ), activity of muscle mitochondrial enzymes (citrate synthase and cytochrome c oxidase, 45-76%) and m

105 ecreased mitochondrial ATP production and/or citrate synthase and cytochrome oxidase activities in th

106 Mitochondrial citrate synthase and cytochrome oxidase activity decreas

107 moxia or hypoxia increased the activities of citrate synthase and cytochrome oxidase.

108 and mitochondrial malate dehydrogenase, and citrate synthase and cytosolic malate dehydrogenase.

109 yethylene glycol or with a co-precipitate of citrate synthase and cytosolic malate dehydrogenase.

110 rogenase occurred but no interaction between citrate synthase and cytosolic malate dehydrogenase.

111 We report the utilization of an alternative citrate synthase and describe a dynamic branching of the

112 itofusin 2]), and oxidative phosphorylation (citrate synthase and electron transport chain complexes)

113 ompanied by a three- to fourfold increase in citrate synthase and fatty acid synthase activity.

114 ors, in the CIT1 gene encoding the TCA cycle citrate synthase and in other genes of oxidative metabol

115 o fibrillization or aggregation of alphaSyn, citrate synthase and insulin.

116 : FKBP65 inhibits the thermal aggregation of citrate synthase and is active in the denatured rhodanes

117 he citZ gene, which encodes the cell's major citrate synthase and is subject to carbon catabolite rep

118 two classical chaperone substrate proteins, citrate synthase and luciferase.

119 It protected citrate synthase and malate dehydrogenase from thermal a

120 on model of porcine mitochondrial enzymes of citrate synthase and malate dehydrogenase was used, show

121 nd inactivation of the heat-labile proteins, citrate synthase and malate dehydrogenase.

122 The interactions between pig heart citrate synthase and mitochondrial malate dehydrogenase

123 mpetitors for oxaloacetate when precipitated citrate synthase and mitochondrial malate dehydrogenase

124 is method showed that an interaction between citrate synthase and mitochondrial malate dehydrogenase

125 ed using polyethylene glycol precipitates of citrate synthase and mitochondrial malate dehydrogenase,

126 was able to protect the heat-labile enzymes citrate synthase and Nde1 from thermal aggregation and i

127 ough it could prevent thermal aggregation of citrate synthase and Nde1, was unable to refold and rest

128 A fusion protein of porcine citrate synthase and porcine cytosolic malate dehydrogen

129 olding intermediates of chemically denatured citrate synthase and prevents their aggregation in vitro

130 bundance of the mitochondrial matrix-located citrate synthase and pyruvate dehydrogenase complex E1al

131 aining, we measured markers of mitochondria (citrate synthase and succinate dehydrogenase) and glucos

132 ncrease (p < 0.05) in the activities of both citrate synthase and superoxide dismutase in the digastr

133 that citrate is produced by a putative (Re)-citrate synthase and then enters the oxidative (forward)

134 complex inhibited the thermal aggregation of citrate synthase and was active in the denatured rhodane

135 that a fusion protein of yeast mitochondrial citrate synthase and yeast mitochondrial malate dehydrog

136 osition of the SbnG active site to TCA cycle citrate synthases and site-directed mutagenesis suggests

137 to CO(2), enzymatic activities (beta-HAD and citrate synthase), and the expression levels of cytochro

138 of oxaloacetate from malate dehydrogenase to citrate synthase), and use of alternative cofactors (e.g

139 between mitochondrial malate dehydrogenase, citrate synthase, and aconitase were identified.

140 olism, such as pyruvate dehydrogenase (PDH), citrate synthase, and acyl-CoA dehydrogenases.

141 gregation of reduced insulin, heat-denatured citrate synthase, and alcohol dehydrogenase.

142 sc66 suppressed aggregation of rhodanese and citrate synthase, and ATP caused effects consistent with

143 tured model substrate proteins rhodanese and citrate synthase, and calorimetric and surface plasmon r

144 activated receptor-gamma coactivator 1alpha, citrate synthase, and cytochrome c oxidase I.

145 cular chaperone activity by protecting DrdI, citrate synthase, and GAPDH from thermal inactivation.

146 , TRAP1 (TNF receptor-associated protein 1), citrate synthase, and GDH (glutamate dehydrogenase 1), a

147 nstrate our method on lactate dehydrogenase, citrate synthase, and lactoferrin.

148 model substrate proteins, such as rhodanese, citrate synthase, and luciferase.

149 ferent model substrates, firefly luciferase, citrate synthase, and malate dehydrogenase (MDH) provide

150 < 0.02), OXPHOS gene transcripts (P < 0.01), citrate synthase, and MAPR (P < 0.03) were higher in Ind

151 escue of mitochondrial malate dehydrogenase, citrate synthase, and Rubisco, are related to the large

152 ase-1, mitochondrial transcription factor 1, citrate synthase, and uncoupling protein-3, although KPF

153 ies formation and energy metabolism, such as citrate synthase ( approximately 19 and approximately 5%

154 roximately 25%) and the mitochondrial enzyme citrate synthase ( approximately 20%).

155 Mitochondrial malate dehydrogenase and citrate synthase are sequential enzymes in the Krebs tri

156 The energetics of citrate synthase are surprisingly tightly coupled.

157 dehydrogenase complex, NAD-malic enzyme, and citrate synthase, are similarly low in mitochondria from

158 erone activity of HuAtp12p was studied using citrate synthase as a model substrate.

159 ity with alcohol dehydrogenase, insulin, and citrate synthase as substrates compared to the other alp

160 ) to cytological position 5F3 and identified citrate synthase as the affected gene.

161 ngle-chain monellin (SCM) at 80 degreesC and citrate synthase at 40 degreesC.

162 the activity of L-lactate dehydrogenase and citrate synthase at least in part by disruption of prote

163 Inactivation of citrate synthase, but not down-stream enzymes suppressed

164 haB-crystallin with alcohol dehydrogenase or citrate synthase by applying thermal stress.

165 se reaction and anaplerotic pathways) and Re-citrate synthase (Ccar_06155) was a key enzyme in its tr

166 encoding the tricarboxylic acid cycle enzyme citrate synthase Cit1p, an "assembly mutation," i.e. a m

167 A deletion in the peroxisomal citrate synthase CIT2 in Deltayfh1 cells decreased the r

168 c selection unearthed the Krebs cycle enzyme citrate synthase (CitA) as a checkpoint regulator contro

169 tabolite repression of the Bacillus subtilis citrate synthase (citZ) and aconitase (citB) genes, prev

170 or, represses the transcription of genes for citrate synthase (citZ) and aconitase (citB) in response

171 The citrate synthase (citZ) gene was found to be part of a c

172 yme activity in cell extracts, and the major citrate synthase (citZ) transcript was present at higher

173 cle, aconitase (citB) and to a lesser extent citrate synthase (citZ).

174 ow spinning speed 13C NMR spectra of the CMX-citrate synthase complex were obtained under a variety o

175 biochemical analysis revealed a reduction in citrate synthase-corrected complex I and complex II/III

176 Citrate synthase-corrected complex II-III activity was m

177 oxaloacetate in the malate dehydrogenase and citrate synthase-coupled systems was tested using polyet

178 reen in Drosophila cells using mitochondrial Citrate synthase (CS) activity as the primary readout.

179 levels of mitochondrial proteins as well as citrate synthase (CS) activity.

180 as much as 39% and 28% when measured by the citrate synthase (CS) aggregation assay.

181 Citrate synthase (CS) and beta-HAD mRNA were rapidly inc

182 conducted on an artificial fusion protein of citrate synthase (CS) and malate dehydrogenase (MDH) to

183 A citrate synthase (CS) deletion mutant of Agrobacterium t

184 wt alphaB crystallin in protecting unfolded citrate synthase (CS) from aggregation.

185 y, actively participates in the refolding of citrate synthase (CS) in vitro.

186 Citrate synthase (CS) performs two half-reactions: the m

187 raldehyde 3-phosphate dehydrogenase (GAPDH), citrate synthase (CS), and total p38 content.

188 The activities of the metabolic enzymes citrate synthase (CS), malate dehydrogenase, and strombi

189 ey mutations in the gltA gene, which encodes citrate synthase (CS), occurred both before and after Es

190 RNAi screening revealed that suppression of citrate synthase (CS), the first TCA cycle enzyme, preve

191 ein in mitochondrial extracts, identified as citrate synthase (CS).

192 Mitochondrial content (estimated by citrate synthase [CS] activity, cardiolipin content, and

193 Protein and citrate synthase data were grouped into tertiles and 5-y

194 ntrast, PGC-1a expression did not change and citrate synthase decreased by approximately 30% in SKM-D

195 eticulin) as well as a mitochondrial enzyme (citrate synthase) did not interact with COX genes.

196 nteresting situations in aspartyl proteases, citrate synthase, EF hands, haemoglobins, lipocalins, gl

197 -catalyzed phosphorylation and inhibition of citrate synthase, elevated acetyl-CoA levels, and hypera

198 However, concomitant loss of IDH and of citrate synthase eliminates these effects, suggesting th

199 mitochondrial protein synthesis, and COX and citrate synthase enzyme activities were increased by ins

200 le (vastus lateralis) mitochondrial content (citrate synthase enzyme activity).

201 vitro experiments performed with homogeneous citrate synthase enzyme indicated that this enzyme was c

202 nted the muscle tricarboxylic acid cycle and citrate synthase facilitating energy expenditure.

203 um insulin concentrations (-53%) and hepatic citrate synthase flux (-38%), respectively.

204 in assessing rates of hepatic mitochondrial citrate synthase flux (V CS) and pyruvate carboxylase fl

205 ruvate dehydrogenase (VPDH) flux relative to citrate synthase flux (VCS) in healthy lean, elderly sub

206 rs yielded a noninvasive estimate of hepatic citrate synthase flux of 74 +/- 12 micromol/kg/min for 2

207 culate the anaplerotic flux (0.90 +/- 0.07 x citrate synthase flux) and [2-13C]acetyl-CoA fractional

208 Geobacter sulfurreducens did not require citrate synthase for growth with hydrogen as the electro

209 hilum (TpCS), are compared with those of the citrate synthase from a mesophile, pig heart (PCS).

210 The kinetics and mechanism of the citrate synthase from a moderate thermophile, Thermoplas

211 xtending the number of crystal structures of citrate synthase from different organisms to a total of

212 The crystal structure of citrate synthase from the thermophilic Archaeon Sulfolob

213 termediates in the reaction catalyzed by the citrate synthase from Thermoplasma acidophilum is accomp

214 A comparison of their atomic structures with citrate synthases from mesophilic and psychrophilic orga

215 Citrate synthases from Thermoplasma acidophilum (optimal

216 nction and oxygen consumption but increasing citrate synthase function.

217 partially bypassed by deletion of the major citrate synthase gene (citZ), by raising the pH of the m

218 al DNA intergenic spacer regions (ISR) and a citrate synthase gene (gltA) fragment and by amplified f

219 ition, there were striking increases in both citrate synthase gene expression and enzymatic activity

220 Expression of the citrate synthase gene, gltA, was repressed by a transcri

221 hylogenetic analysis of the 16S rRNA and the citrate synthase genes showed that the novel Bartonella

222 comparison of DNA sequences of three genes (citrate synthase gltA, 60-kDa heat shock protein gene gr

223 isolate, including partial sequencing of the citrate synthase (gltA) and 16S rRNA genes indicated tha

224 A 337-bp fragment of the citrate synthase (gltA) gene amplified by polymerase cha

225 PCR and DNA sequence analyses of the citrate synthase (gltA) gene and the 16S-23S intergenic

226 d resistance to propionate was mapped to the citrate synthase (gltA) gene.

227 isolate, including partial sequencing of the citrate synthase (gltA), groEL, and 16S rRNA genes, indi

228 thylcitrate (2-MC) by the Krebs cycle enzyme citrate synthase (GltA).

229 icity is likely due to the fact that as a si-citrate synthase, GltA may produce multiple isomers of 2

230 Its ability to protect citrate synthase, glyceraldehyde-3-phosphate dehydrogena

231 that strain 195 may contain an undocumented citrate synthase (>95% Re-type stereospecific), i.e., a

232 rboxymethyldethia coenzyme A (CMX), bound to citrate synthase have been investigated using solid stat

233 6 A crystal structure of one such complex, a citrate synthase homodimer.

234 ACLY forms a homotetramer with a rigid citrate synthase homology (CSH) module, flanked by four

235 ht a novel and unique role of the C-terminal citrate synthase homology domain in ACLY function and ca

236 role of the uncharacterized ACLY C-terminal citrate synthase homology domain in the mechanism of ace

237 nner, with nearly full protection of 1.5 muM citrate synthase in the presence of 650 nM myocilin.

238 acetyl-CoA and oxaloacetate, substrates for citrate synthase in the TCA cycle, to produce oxalic aci

239 ta(H) crystallin, alcohol dehydrogenase, and citrate synthase in vitro.

240 d in higher OXPHOSCI+CII (pmol oxygen/s x mg/citrate synthase) in the cortex (6.00 +/- 0.28 vs 3.88 +

241 ctures generated on the basis of that of pig citrate synthase indicate very high structural and elect

242 evisiae encode mitochondrial and peroxisomal citrate synthases involved in the Krebs tricarboxylic ac

243 The activity of citrate synthase is determined in every experiment as a

244 citrate synthase (AaCS), a hexameric type II citrate synthase, is required for acetic acid resistance

245 which encodes a glyoxylate cycle isoform of citrate synthase, is responsive to the functional state

246 ic acid cycle enzymes: malate dehydrogenase, citrate synthase, isocitrate dehydrogenase, and succinyl

247 erent unfolded protein substrates, including citrate synthase, lactate dehydrogenase, malate dehydrog

248 c acid esters to a single linkage block in a citrate synthase-like gene.

249 denylate kinase, aspartate aminotransferase, citrate synthase, liver alcohol dehydrogenase, and the c

250 egulation of TCA cycle components, including citrate synthase, malate dehydrogenase, and aconitase, r

251 In the second case, that of a citrate synthase-malate dehydrogenase fusion protein, a

252 Substrate channeling of oxaloacetate with citrate synthase-mitochondrial malate dehydrogenase prec

253 The symbiotic defect of a citrate synthase mutant could thus be due to disruption

254 ic network is disrupted; and (c) P. furiosus citrate synthase mutants in which the C-terminal arms th

255 diminished again in malate dehydrogenase and citrate synthase mutants.

256 vs middle tertile; HR = 2.93; P = 0.008) and citrate synthase normalized to protein concentration (lo

257 dispensable for CtrA control, and functional citrate synthase paralogs cannot replace CitA in promoti

258 , in contrast to (Si)-citrate synthase, (Re)-citrate synthase produces a different isomer of 2-fluoro

259 Genetic knockdown of citrate synthase promotes increased nuclear acetyl-CoA l

260 ll mutant also exhibited increased levels of citrate synthase protein and enzyme activity in cell ext

261 sed mitochondrial transcription factor-A and citrate synthase protein levels; and augmented mtDNA cop

262 as homologous to both archaeal and bacterial citrate synthases; PrpD showed homology to yeast and Bac

263 Moreover, in contrast to (Si)-citrate synthase, (Re)-citrate synthase produces a diffe

264 nsition/intermediate states in the multistep citrate synthase reaction.

265 Citrate synthase reactivation experiments in the presenc

266 directed mutations in the gene that encodes citrate synthase reversed the bright luminescence of aco

267 This bacterium also possesses a second citrate synthase, SbnG, that is necessary for supplying

268 thod based on inner membrane permeability to citrate synthase substrates, TG induced MPT in a concent

269 in expression of Cit2, the cytosolic form of citrate synthase that functions in the glyoxylate pathwa

270 5% Re-type stereospecific), i.e., a novel Re-citrate synthase that is apparently different from the o

271 anced low-temperature activity for A. pernix citrate synthase that is synthesized during leucine to m

272 vered between aspartate aminotransferase and citrate synthase that only come to light in the context

273 ediately adjacent to CIT1, which encodes the citrate synthase that performs a key regulated step in t

274 For luciferase and citrate synthase, the efficiency of substrate protection

275 Citrate synthase, the first and rate-limiting enzyme of

276 Corroborated by data referring to citrate synthase, these results confirm the transitory (

277 but not ATP citrate synthase, work opposite citrate synthase to control the direction of carbon flow

278 However, the ratio of citrate synthase to cytochrome c oxidase was higher in t

279 significantly reduced thermal aggregation of citrate synthase to levels 36% to 44% of control levels.

280 analysis of site-directed mutants of the two citrate synthases to investigate the contribution of the

281 action performed by Thermoplasma acidophilum citrate synthase (TpCS) with the natural thioester subst

282 Citrate synthase Vmax and citrate levels were lowered 45

283 lowered level of G-6-P and 50% reductions in citrate synthase Vmax and the citrate content.

284 As predicted, citrate synthase Vmax was lowered and PFK Vmax was incre

285 drial markers transcription factor A (TFAM), citrate synthase, voltage-dependent anion channel (VDAC)

286 aperone substrates and decreased to 66% when citrate synthase was the chaperone substrate.

287 rt to the in vivo data, which suggested that citrate synthase was the source of a toxic metabolite.

288 and chaperone test substrates (rhodanese or citrate synthase) was inhibited by CK2 phosphorylation.

289 asmic reticulum calcium ATPase isoform 2 and citrate synthase, was evident in GW7647-treated hearts.

290 gene, encoding Sinorhizobium meliloti 104A14 citrate synthase, was isolated by complementing an Esche

291 showed that only L-lactate dehydrogenase and citrate synthase were inhibited but only by two specific

292 f both ICDH, found to be NAD+ dependent, and citrate synthase were measured in cell extracts of wild-

293 activities of respiratory chain enzymes and citrate synthase were measured in cortical mitochondria

294 were swapped; (b) mutants of the P. furiosus citrate synthase where the inter-subunit ionic network i

295 ignificant cell death, whereas mitochondrial citrate synthase, which is oxidative stress insensitive,

296 The production of acetyl-CoA was coupled to citrate synthase, which produced citrate and coenzyme A.

297 ppears to be essentially the same as that of citrate synthase, with the electrophile activated for nu

298 AMP-forming acetate:CoA ligase, but not ATP citrate synthase, work opposite citrate synthase to cont

299 (Y(TR) 92 +/- 4% versus O(TR) 140 +/- 25%); citrate synthase (Y(TR) 37 +/- 8% versus O(TR) 97 +/- 33

300 SbnG is structurally distinct from TCA cycle citrate synthases yet similar to metal-dependent class I