ライフサイエンスコーパス: citric acid cycle

1 diauxic shift (including glycolysis and the citric acid cycle).

2 opomer analysis of liver gluconeogenesis and citric acid cycle.

3 thways: glycolysis, gluconeogenesis, and the citric acid cycle.

4 or example, 7 of the 10 intermediates in the citric acid cycle.

5 control the direction of carbon flow in the citric acid cycle.

6 or NAD biosynthesis or to acetyl-CoA for the citric acid cycle.

7 f the tricarboxylic acid branch of the Krebs citric acid cycle.

8 a-ketoglutarate, another intermediate in the citric acid cycle.

9 mer of cis-aconitate and an inhibitor of the citric acid cycle.

10 labeled because of isotopic exchanges in the citric acid cycle.

11 actate and other precursors derived from the citric acid cycle.

12 that contain all 11 members of the reductive citric acid cycle.

13 which can supply alpha-ketoglutarate to the citric acid cycle.

14 intermediary metabolism in autotrophs is the citric acid cycle.

15 imulated growth, we suspected a block in the citric acid cycle.

16 d PDH activity and maintain flux through the citric acid cycle.

17 e transfer between two of the enzymes of the citric acid cycle.

18 ondria as they lack DNA, cytochromes and the citric acid cycle.

19 substrate between two of the enzymes of the citric acid cycle.

20 sed on abiotically replicating the reductive citric acid cycle.

21 d flux of glucose through glycolysis and the citric acid cycle.

22 glycolysis and through intermediates of the citric acid cycle.

23 a substantial fraction to anaplerosis of the citric acid cycle.

24 yl-CoA, and 2-ketoglutaric acid entering the citric acid cycle.

25 cludes the ability to oxidize acetate in the citric acid cycle.

26 relative abundance of metabolites within the citric acid cycle.

27 provide a ready feedstock for entry into the citric acid cycle.

28 ccurred after glucose had passed through the citric acid cycle.

29 ic pathway for providing constituents of the citric acid cycle.

30 tivity and to be perturbed by defects in the citric acid cycle.

31 of ATP, phosphate, and intermediates of the citric acid cycle.

32 bles "anaplerotic" influx of carbon into the citric acid cycle.

33 moiety of heptanoate into anaplerosis of the citric acid cycle.

34 of isocitrate to alpha-ketoglutarate in the citric acid cycle.

35 of two distinct pathways after it enters the citric acid cycle.

36 OGDHc), a rate-limiting enzyme in the Krebs (citric acid) cycle.

37 ncluding glycolysis, sucrose metabolism, the citric acid cycle, 2,3-butanedione and 3-penten-2-one bi

38 In addition to being the major citric acid cycle aconitase in Escherichia coli the acon

39 not only glycolysis but also, independently, citric acid cycle activity in beta-cells.

40 vers appeared more inclined toward continual citric acid cycle activity postsucrose, whereas low-sens

41 adenine dinucleotide metabolism and altered citric acid cycle activity, but not with disease-specifi

42 dition to its role as an intermediary of the citric acid cycle, acts as an alarmin, initiating and pr

43 enosine triphosphate production via improved citric acid cycle, altered accumulation of calcium local

44 Pathways such as glycolysis/gluconeogenesis, citric acid cycle, amino acid metabolism, and fatty acid

45 proliferation, especially in the context of citric acid cycle anaplerosis.

46 e bifunctional proteins that function in the citric acid cycle and act as posttranscriptional regulat

47 ines, and pyruvate, a core metabolite in the citric acid cycle and amino acid biosynthesis.

48 unctional in 12 processes: photorespiration, citric acid cycle and associated reactions, lipid metabo

49 an increase in matrix Ca(2+) stimulates the citric acid cycle and ATP synthase.

50 iation in key metabolic pathways such as the citric acid cycle and branched chain amino acid degradat

51 xes, resulting in diminished capacity of the citric acid cycle and disruption of energy metabolism.

52 wo different ways: for detoxification in the citric acid cycle and for a possibly novel biosynthetic

53 orm of Trypanosoma brucei lacks a functional citric acid cycle and is dependent solely on glycolysis

54 ellular metabolism linking glycolysis to the citric acid cycle and lipogenesis.

55 ccinate dehydrogenase (SDH) functions in the citric acid cycle and loss of function predisposes to th

56 ntly used to provide carbon flux through the citric acid cycle and maintain adequate amounts of the a

57 ically block key steps of glycolysis and the citric acid cycle and monitor the effect on RpoS degrada

58 (13)C MFA studies have identified increased citric acid cycle and pentose phosphate pathway fluxes a

59 sphate form as a cofactor for enzymes in the citric acid cycle and pentose-phosphate pathways.

60 We apply the method to the Citric Acid Cycle and the Glycolysis pathways of differe

61 increases SMC glucose metabolism through the citric acid cycle and the pentose phosphate pathway by 2

62 The root of this tree combines the reductive citric acid cycle and the Wood-Ljungdahl pathway into a

63 ylase (Calvin cycle), citrate lyase (reverse citric acid cycle), and malyl coenzyme A lyase (3-hydrox

64 owever, glycerol may also be oxidized in the citric acid cycle, and glycogen synthesis from glycerol

65 metabolism, primary bile acid biosynthesis, citric acid cycle, and lipid metabolism.

66 ycolysis, gluconeogenesis, lipid metabolism, citric acid cycle, and neurodevelopment.

67 ular, the balance between glycolysis and the citric acid cycle appears as a determinant/indicator of

68 The intermediates of the citric acid cycle are present at micromolar concentratio

69 flux through lactate dehydrogenase, and the citric acid cycle (as inferred by flux through pyruvate

70 Although analysis of the citric acid cycle by NMR is simpler (and more intuitive)

71 succinyl analogs ties its metabolism to the citric acid cycle by reduction of the fumarate pool.

72 actate dehydrogenase fluxes while activating citric acid cycle (CAC) flux and glutamine uptake.

73 6pc2 led to ~60% increases in glycolytic and citric acid cycle (CAC) fluxes at both 5 and 11 mM gluco

74 ate (alphaKG), which subsequently enters the citric acid cycle (CAC) for oxidation.

75 The citric acid cycle (CAC) is linked to acetic acid resista

76 Yet some tumours harbour mutations in the citric acid cycle (CAC) or electron transport chain (ETC

77 ly diminished availability of glycolytic and citric acid cycle (CAC) pathways metabolites, altered ex

78 A high rate of cardiac work increases citric acid cycle (CAC) turnover and flux through pyruva

79 systems of reactions like glycolysis and the citric acid cycle can also be considered at specified co

80 that glutamate formed from the amination of citric acid cycle-derived alpha-ketoglutarate is a messe

81 at glycogen production from the level of the citric acid cycle did not occur and that the glycerol co

82 e enzyme catalyzing the only reaction of the citric acid cycle directly producing energy; succinyl-Co

83 ntrols the transition from glycolysis to the citric acid cycle, effectively reduces Treg and Breg ele

84 ical model of the mitochondria including the citric acid cycle, electron transport chain and ROS prod

85 le of mitochondrial processes, including the citric acid cycle, electron transport, and oxidative pho

86 f NO. exposure inactivated the NO.-sensitive citric acid cycle enzyme aconitase, and inactivation was

87 untranslated region of the transcript of the citric acid cycle enzyme mitochondrial aconitase from fo

88 In addition, the nearly ubiquitous citric acid cycle enzyme, aconitase, plays a role in tra

89 r work thus reveals a novel subunit of a key citric acid-cycle enzyme and shows how this large comple

90 ts suggest that the novel cross-talk between citric acid cycle enzymes and electron transfer chain co

91 lase (KDM) KDM6A, BRCA1-associated BAP1, and citric acid cycle enzymes IDH1/2, SDHA/B, and FH.

92 In contrast, several citric-acid cycle enzymes, the peptide transporter CstA,

93 nning several important pathways such as the citric acid cycle, fatty acid metabolism, and amino acid

94 lls, including the electron transport chain, citric acid cycle, fatty acid oxidation, amino acid synt

95 ose and glycerol that had passed through the citric acid cycle first increased in fasted animals from

96 For the group infused with both tracers, citric acid cycle flux estimates from the analysis of gl

97 ed PPARalpha(-/-) mice suggested compromised citric acid cycle flux, enhanced urea cycle activity, an

98 rated analysis of hepatic glucose output and citric acid cycle fluxes from plasma glucose isotopomers

99 asurements of hepatic glucose production and citric acid cycle fluxes from the NMR analysis of a sing

100 Citric acid cycle fluxes, pyruvate cycling, anaplerosis,

101 boxylation pathway travels in reverse of the citric acid cycle from alpha-ketoglutarate to citrate.

102 d reaction chemistry with the portion of the citric acid cycle from oxaloacetate to alpha-ketoglutara

103 ansporter gene in the order Lactobacillales, citric acid cycle genes in Burkholderiales or molybdenum

104 azolidinedione treatment, beta-oxidation and citric acid cycle genes were upregulated.

105 processes, including muscle contraction, the citric acid cycle, glycogen metabolism, release of neuro

106 alpha-ketoglutaric acid (all members of the citric acid cycle) have not been identified in extraterr

107 Relative to the citric acid cycle, HF feeding increased metabolic flux t

108 tance factor (AarC) with a role in a variant citric acid cycle in Acetobacter aceti.

109 ough BCAT/BCKDC and further oxidized via the citric acid cycle in F98 glioma.

110 protein export, proteasome, ferroptosis, and citric acid cycle in high PMI group.

111 se (fumarase), a vulnerable component of the citric acid cycle in Mycobacterium tuberculosis (Mtb), i

112 utants, these results suggest a role for the citric acid cycle in the infection and colonization stag

113 The citric acid cycle in the microaerophilic pathogen Campyl

114 lic archaeon Pyrobaculum islandicum uses the citric acid cycle in the oxidative and reductive directi

115 hetases catalyze the reverse reaction in the citric acid cycle in which the ADP-forming enzyme augmen

116 roduce several (nonenzymatic) members of the citric acid cycle including oxaloacetic acid.

117 e phosphate pathway (PPP), metabolism in the citric acid cycle, incomplete equilibration by triose ph

118 e cells but forms spontaneously from the key citric acid cycle intermediate cis-aconitate, we suggest

119 esized as an antimicrobial compound from the citric acid cycle intermediate cis-aconitic acid.

120 se tissue, suggesting that signaling by this citric acid cycle intermediate may regulate energy homeo

121 esis of 12 amino acids, of ornithine, and of citric acid cycle intermediate products.

122 By highlighting three receptor families-(a) citric acid cycle intermediate receptors, (b) purinergic

123 Creatine and the citric acid cycle intermediate succinate followed a simi

124 We show that selective accumulation of the citric acid cycle intermediate succinate is a universal

125 Among these, the citric acid cycle intermediate succinate stands out owin

126 ptor (GPCR), functions as a receptor for the citric acid cycle intermediate succinate.

127 n was obtained from the labeling patterns of citric acid cycle intermediates and related compounds.

128 The method was optimized for amino acids and citric acid cycle intermediates and was shown to have hi

129 verall, our data show that gluconeogenic and citric acid cycle intermediates cannot be considered as

130 The higher levels of citric acid cycle intermediates found in the mitochondri

131 ter (NaDC1) is involved in the absorption of citric acid cycle intermediates from the lumen of the re

132 +)/dicarboxylate cotransporter NaDC1 absorbs citric acid cycle intermediates from the lumen of the sm

133 Oscillations in citric acid cycle intermediates have never been previous

134 oxyacetone phosphate); and (iii) labeling of citric acid cycle intermediates in tissue versus effluen

135 Other citric acid cycle intermediates measured either did not

136 In addition to citric acid cycle intermediates such as alpha-ketoglutar

137 boxylate cotransporter transports Na(+) with citric acid cycle intermediates such as succinate and ci

138 1 (NaDC1) is a low-affinity transporter for citric acid cycle intermediates such as succinate and ci

139 pendent mechanism for transporting Krebs and citric acid cycle intermediates through the epithelium o

140 e pathway involves synthesis of PEP from the citric acid cycle intermediates via PEP carboxykinase, w

141 Citric acid cycle intermediates were lower in salt-treat

142 erosis, the net synthesis in mitochondria of citric acid cycle intermediates, and cataplerosis, their

143 oxidative phosphorylation (OxPhos), reducing citric acid cycle intermediates, and suppressing complex

144 Anaplerosis, the synthesis of citric acid cycle intermediates, by pancreatic beta cell

145 of gluconeogenic carbon leaves the liver as citric acid cycle intermediates, mostly alpha-ketoglutar

146 Sodium-coupled transport of citric acid cycle intermediates, such as succinate and c

147 ism for feedback inhibition of glycolysis by citric acid cycle intermediates.

148 six enzymes that convert protocatechuate to citric acid cycle intermediates.

149 ty acid profile, cardiolipin remodeling, and citric acid cycle intermediates.

150 The mitochondrial citric acid cycle is a central hub of cellular metabolis

151 tain group of chemoautotrophs, the reductive citric acid cycle is an engine of synthesis, taking in C

152 The citric acid cycle is central to the regulation of energy

153 Specifically, we will focus on how the citric acid cycle is involved in cardioprotection.

154 omplex (PDC) must be down-regulated when the citric acid cycle is provided sufficient acetyl-CoA.

155 at mitochondrial aconitase, an enzyme in the citric acid cycle, is a specific target during aging of

156 1-(11)C-Labeled acetate, a substrate for the citric acid cycle, is superior.

157 direct homologue of 3-isopropylmalate in the citric acid cycle, isocitrate, is also a very poor subst

158 different tissues, including changes in the citric acid cycle (jejunum), beta-alanine metabolism (sk

159 oxygen, but it also plays a key role in the citric acid cycle, ketone metabolism, and heme synthesis

160 of metabolites of liver gluconeogenesis and citric acid cycle labeled from NaH(13)CO(3) or dimethyl

161 mitochondrial aconitase and function of the citric acid cycle may be regulated by iron levels in cel

162 we report that glutamine-dependent oxidative citric acid cycle metabolism is required to generate fum

163 tween arginine, tryptophan, glucose, and the citric acid cycle metabolism, protein and histone post-t

164 , and [U-13C]propionate, a tracer of hepatic citric acid cycle metabolism.

165 The lesion can be prevented or reversed by citric acid cycle metabolites that anaerobically generat

166 abolomics also revealed a global decrease in citric acid cycle metabolites, affecting NADH-generating

167 und widespread downregulation of glycolysis, citric acid cycle, mitochondrial genes, and alterations

168 to enhance aerobic glycolysis coupled to the citric acid cycle, mitochondrial respiration and ATP gen

169 Combined with the results of other citric acid cycle mutants, these results suggest a role

170 The essential role of sulfur in the citric acid cycle, non-ribosomal peptide synthesis and p

171 anism for the order Corynebacteriales, whose citric acid cycle occupies a central position in energy

172 ecule metabolic cycles such as the reductive citric acid cycle on mineral surfaces make unreasonable

173 s demonstrated by chemical inhibitors of the citric acid cycle or mitochondrial respiration.

174 t evidence for metabolism of glycerol in the citric acid cycle or the PPP but not an influence of eit

175 to support the hypothesis that the reductive citric acid cycle originated as a self-organized cycle c

176 s the main catalyst for this reaction in the citric acid cycle outside the retina, and that the retin

177 ation of all the processes involved, such as citric acid cycle, oxidative phosphorylation and ATP-pro

178 alysis pointed to a major involvement of the citric acid cycle (P < .001) and some amino acids (lysin

179 of several metabolic pathways, including the citric acid cycle, polyamine, and fatty acid metabolism.

180 trate ( alpha = 0.11, P = 7.2.10(-7)), a key citric acid cycle reaction.

181 regulation of in vivo glucose-producing and citric acid cycle-related fluxes during an acute bout of

182 involving lipolysis, beta-oxidation, and the citric acid cycle, required for the production of energe

183 function in the electron transport chain and citric acid cycle, respectively.

184 at contribute to glutamine transport and the citric acid cycle, respectively.

185 hway and 2-oxoglutarate dehydrogenase of the citric acid cycle, respectively.

186 ations in enzymes that catalyse steps in the citric acid cycle result in human diseases with various

187 that altered redox status down-regulates the citric-acid cycle, sparing fatty acids for triglyceride

188 ory effect on aconitase, a key enzyme of the citric acid cycle, suggesting that these methyltransfera

189 Cytokine stimulation generates citric acid cycle (TCA) intermediates from both glucose

190 o investigate transcriptional changes in the citric acid cycle, the glyoxylate pathway, [Formula: see

191 Ni deficiency also disrupted the citric acid cycle, the second stage of respiration, wher

192 ted that one third of glutamine entering the citric acid cycle travels to citrate via reductive carbo

193 glycerol, or substrates passing through the citric acid cycle via glyceroneogenesis.

194 letion of the catalytic intermediates of the citric acid cycle via leakage through cell membranes (ca

195 A derivatives involved in anaplerosis of the citric acid cycle via precursors of propionyl-CoA, i.e.,

196 he glycerol contribution to oxidation in the citric acid cycle was negligible in the presence of alte

197 In general, genes involved in the citric acid cycle were not differentially expressed; how

198 ast, genes related to beta-oxidation and the citric acid cycle were relatively overexpressed in adipo

199 The glutaminolysis pathway follows the citric acid cycle, whereas the reductive carboxylation p

200 s encodes aconitase, the enzyme of the Krebs citric acid cycle, which is responsible for the intercon

201 aerobic conditions, they participate in the citric acid cycle, while in anaerobic bacteria, they are

202 of alpha-ketoacid analogues of the reductive citric acid cycle without the need for metals or enzyme

203 there is robust oxidation of glucose in the citric acid cycle, yet glucose contributes less than 50%