ライフサイエンスコーパス: class

1 dissipative ones and tune their universality class.

2 studied but biologically important substance class.

3 ly designed representatives of this compound class.

4 still too complex to examine beyond compound classes.

5 re one of the fastest growing pharmaceutical classes.

6 R) mechanisms have evolved to most herbicide classes.

7 ably identified six discrete functional cell classes.

8 gorithm aimed at the discovery of novel RiPP classes.

9 increases with substantial variation across classes.

10 Class 1 mutations (8 of 27) inhibit while class 2 mutati

11 Class 1 presented during long-term follow-up with a low

12 follow-up with a low graft failure rate: 5% class 1, vs 30% class 2, vs 50% class 3 (P = .009).

13 /logPGE(2) was between values calculated for classes 1 and 3, similarly to disease control and severi

14 Class 1 mutations (8 of 27) inhibit while class 2 mutations (5 of 27) enhance PFC neurogenesis.

15 a low graft failure rate: 5% class 1, vs 30% class 2, vs 50% class 3 (P = .009).

16 WAGO-class 22G-RNAs are also broadly required for transposon

17 ure rate: 5% class 1, vs 30% class 2, vs 50% class 3 (P = .009).

18 The MAbs' reactivities to a panel of class 5 adhesins in enzyme-linked immunosorbent assays (

19 g two conserved arginines, are shared by the class 5 adhesins.

20 The new classification includes 2 classes, 6 types and 33 subtypes, compared with 5 types

21 repress the transcription of genes encoding class A ARFs.

22 against a panel of clinically relevant BLs: class A CTX-M-15 and KPC-2, subclass B1 NDM-1 and VIM-2

23 This study provides class A evidence that systematic drug level monitoring o

24 distinct dependence on PIP(2) compared with class A GPCRs.

25 Notably, class A PBPs could process this nascent peptidoglycan fr

26 olymerize glycan strands and crosslink them: class A penicillin-binding proteins (aPBPs) and complexe

27 on of the auxiliary role of the bifunctional class A penicillin-binding proteins (aPBPs) as well as t

28 Class A serine beta-lactamases (SBLs) are key antibiotic

29 oducibility using slides containing multiple classes, a single class, or no parasites.

30 GPR52 is a class-A orphan G-protein-coupled receptor that is highly

31 ingle heartbeat and classifies them into two classes: a heartbeat and not a heartbeat.

32 rt of NERD patients with the means of latent class analysis (LCA).

33 and in diabetes groups, defined by a latent class analysis of diabetes duration, complexity, and int

34 formed nonsupervised clustering using latent class analysis to identify subgroups of patients on the

35 tions for subgroups based on NYHA functional class and race.

36 predominantly of the immunoglobulin G (IgG) class and targeted the S2 subunit.

37 ent in New York Heart Association functional class and were 20% to 40% less likely to experience wors

38 s, thus identifying at least 7 distinct gRNA classes and 50 different PAM sequence requirements.

39 across multiple (more than ten) nucleophile classes and can accommodate a diverse array of radical p

40 hey can bind to Galpha subunits of different classes and either stimulate or inhibit nucleotide excha

41 of authentic standards belonging to 12 lipid classes and helps to assign 133/58 lipid features in pos

42 the genomic properties of structural variant classes and short tandem repeats that are associated wit

43 an algorithm for the quantification of sRNA classes and the detection of novel expressed non-coding

44 However, this family is divided into three classes and, though the regulated transporter activity o

45 71 orthogonal tRNAs, covering 16 isoacceptor classes, and 23 functional orthogonal tRNA-cognate aaRS

46 erous viral genes spanning all three kinetic classes, and suppress productive infection.

47 aled that chlorination status and metabolite class are strong predictors of the in vitro cardiovascul

48 While most classes are characterized by responses to specific subse

49 GTPases directly have resulted in them being classed as "undruggable".

50 s in each analysed disorder to specific cell classes as well as the CNV-region genes they express.

51 XGBDA classification afforded 100% correct class assignment for all tested regions using the EEM of

52 Gs from 40,258 patients with four arrhythmia classes: atrial fibrillation, general supraventricular t

53 The class B G protein-coupled receptor (GPCR) calcitonin rec

54 Class B G protein-coupled receptors (GPCRs) are importan

55 This work advances our understanding of class B GPCR activation and Gs coupling.

56 uctures, these provide coverage of the major class B GPCR subfamilies.

57 PCRs) are a thirty-three-member subfamily of Class B GPCRs that control a wide array of physiological

58 sations (3.42 [1.28-9.12]), pretreatment CPT class B or C (62.5 [3.08-1246.42]) and MELD scores (1.37

59 42]) and MELD scores (1.37 [1.03-1.82]), CPT class B or C at SVR (10.71 [1.32-87.01]), CD4 cell count

60 s (aPBPs) and complexes of SEDS proteins and class B PBPs (bPBPs).

61 g of the events that drive the activation of class B receptors.

62 f eHNP-A1-CD15-LDE225 via scavenger receptor class B type 1 (SR-B1) and CD15 on brain SHH MB cells in

63 n with decreased Bacteroidia- and Clostridia-class bacteria, whereas after treatment, responders' mic

64 The RBGs are grouped into three major classes based on molecular and morphological characteris

65 tures of RE-MOFs are presented, divided into classes based on the composition of the RE-metal node be

66 loenzyme name, ligand identifier, functional class, bioinorganic class, metal ion and metal-containin

67 their footprints on Env are similar to VRC01-class bNAbs.

68 E is the least abundant circulating antibody class but is constitutively present in healthy tissues b

69 he dura prevented activation of all neuronal classes but not the initiation or maintenance of the sei

70 2, subclass B1 NDM-1 and VIM-2 MBLs, and the class C P. aeruginosa AmpC.

71 ntigenicity with retained affinity for VRC01-class, CD4bs-directed bNAbs and dampened affinity for no

72 One class classifier is a powerful and devoted for non-targe

73 with class modeling is determining which one-class classifier to use followed by the challenge of opt

74 Here we report a new cell class ('cue cell') encoding visual cues that could be us

75 By contrast, there are no structures of class D GPCRs, which are found exclusively in fungi wher

76 hed hydrolysis products, the reaction of the class D nucleophilic serine beta-lactamases (SBLs) with

77 Phylotypes within the class Dehalococcoidia associated with organohalide dechl

78 s of mechanosensory neurons with marked cell-class dependence.

79 Rates of categorization were class dependent with best performance for alcohols and a

80 ble, differing in their format, the antibody class detected, the targeted antigen, and the acceptable

81 The class-E group demonstrated improved survival and a high

82 information, but that selectivity for sound classes emerges first in the frontal cortex.

83 parameterized to match the five topological classes encompassing all amyloid fibril structures so fa

84 uce an error of up to 6-fold and recommend a class-equivalent approach instead.

85 Of approximately 4000 generic drugs and drug classes evaluated, the method detected 19 distinct drug

86 Children with ABL-class fusion B-cell acute lymphocytic leukaemia have poo

87 Students and classes gained points and rewards for engaging in any ac

88 Several general classes have been explored including heterobimetallic co

89 depends on major histocompatibility complex class I (MHC I) molecules loaded with peptides.

90 tide-loaded major histocompatibility complex class I (pMHCI) tetramer technology.

91 Class I adenylate-forming enzymes share a conserved stru

92 th beta-2-microglobulin (beta2M) and affects class I Ag presentation through sequestration of beta2M

93 sponses to responses restricted by other HLA class I alleles longitudinally after control of peak vir

94 ion through interaction with the proteins of class I and class II major histocompatibility complex (M

95 cells (DCs), as well as up-regulation of MHC class I and down-regulation of checkpoint regulator PD-L

96 PI therapy, which significantly reduced both class I and II HLA antibodies and increased the likeliho

97 peptides predicted to bind a broad range of class I and II HLA molecules were selected for in vitro

98 infection increased expression of CD54, MHC Class I and II molecules in endothelial but not epitheli

99 d (calculated panel reactive antibody [cPRA] class I and/or II >99%, complement-dependent cytotoxicit

100 sive in silico analysis of viral peptide-MHC class I binding affinity across 145 HLA-A, -B, and -C ge

101 cells mismatched at major histocompatibility class I can enhance tolerance to subsequent skin allogra

102 l, we observed that individuals carrying HLA class I genotypes characterized by greater tapasin indep

103 Class I KNOX genes are major contributors to this proces

104 pesvirus-7 (HHV-7) U21 glycoprotein binds to class I major histocompatibility complex (MHC) molecules

105 The class I pathway requires MSH4 and MSH5 (MutSgamma) to ma

106 tep toward comprehensive modeling of the MHC class I pathway.

107 esent an important first step in repurposing class I PI3K inhibitors to modulate CMA in vivo.

108 Here, we report that inhibition of class I PI3K or PDPK1 activates CMA.

109 though the regulated transporter activity of class I proteins is becoming better understood, class II

110 A phylogenetic analysis of class I RNRs suggests that activity regulation is not an

111 These models predicted endogenous HLA class I-associated ligands with 1.5-fold improvement in

112 presentation on the cell surface through MHC class I.

113 e is linked to human leukocyte antigen (HLA) class I/II variants and their individual capacity to pre

114 , which contributes toward inhibition of MHC class I:beta2M:peptide complex formation.

115 CHED1, CYCLOIDEA, PCF15 (TCP15), and related class-I TCP transcription factors in stamen filament elo

116 xt of major histocompatibility complex (MHC) class Ia and class II molecules and provide anti-microbi

117 Ag presentation via the nonclassical MHC class Ib molecule HLA-E, with nearly complete identity b

118 HLA class II alleles encode MHC proteins on antigen-presenti

119 lexes through incorporation of mixed-valence class II and class II-III bis(dioxolene) bridging ligand

120 ) T cells unconventionally restricted by MHC class II and the nonclassical MHC-E molecule in RM.

121 tivariate Cox proportional hazard model, HLA class II antibodies before transplantation were associat

122 as the residual ~15% are consistent with the class II CO pathway.

123 ls present overlapping sets of Chlamydia-MHC class II epitopes to link inductive and effector phases

124 ltiple islet autoantibodies, irrespective of class II HLA DR-DQ genotype.

125 interaction with the proteins of class I and class II major histocompatibility complex (MHC) pathways

126 istocompatibility complex (MHC) class Ia and class II molecules and provide anti-microbial and anti-t

127 ithin proinsulin, which are presented by HLA class II molecules associated with T1D risk.

128 lective deletion of major histocompatibility class II molecules in cDC1 also prevented early CD4(+) T

129 Class II patients were also less likely to be discharged

130 However, the underlying mechanism for the class II phenotype is not known.

131 incorporation of mixed-valence class II and class II-III bis(dioxolene) bridging ligands with suffic

132 Here, we focus on the class-II Hsp40, human DNAJB6b, a highly efficient inhibi

133 m the canonical MEF2 corepressor function of class IIa HDACs.

134 Here, we report that class IIa histone deacetylases (HDAC4 and HDAC5) are req

135 Class IIa histone deacetylases (HDACs) repress cardiomyo

136 This study provides Class IIb evidence for beneficial effects of STN-DBS on

137 for patients with New York Heart Association Class III heart failure (HF) and a prior HF hospitalizat

138 nited States with New York Heart Association class III HF and a prior HFH within 12 months evaluated

139 racterized by 65% New York Heart Association Class III or IV, nearly all on a loop diuretic, and 70%

140 ss I proteins is becoming better understood, class III protein functions continue to be obscure.

141 abling New York Heart Association functional classes III/IV (5.2%/year); 67% have survived, including

142 y features and control false discoveries for class-imbalance learning.

143 eature selection method for high-dimensional class-imbalanced data, which is simple and can be an alt

144 ernative for performing feature selection in class-imbalanced data.

145 feature selection applied it to complicated class-imbalanced data.

146 f a metallic Fermi sea, and its universality class in the local magnetic response is unaffected by th

147 tidylethanolamine are two major phospholipid classes in eukaryotes.

148 mous diversity of small noncoding RNA (sRNA) classes in mammalian cells.

149 wetlands are by far the dominant land cover classes in riparian zones of the Lower Savannah River Ba

150 A, HSA, GOx, beta-galactosidase) and monomer classes including acrylates, methacrylates, styrenics an

151 The serine-glycine dipeptide lipid classes, including lipid 430 and lipid 654, are produced

152 present decRiPPter (Data-driven Exploratory Class-independent RiPP TrackER), a RiPP genome mining al

153 in vivo PK properties, to identify first-in-class inhibitors that demonstrate LDH inhibition in vivo

154 and to follow homologous series or compound classes, instead of individual components, as a function

155 , the OLE (ornate, large, extremophilic) RNA class is among the largest and most structurally complex

156 ed in the human genome and describe how each class is assigned a standardised nomenclature.

157 specific subsets of the stimuli, the largest class is not reliably responsive to any of the stimuli a

158 ggests that the distinction between the gene classes is due to multiple components rather than any si

159 Thus, the combination of these therapeutic classes is of intense research interest.

160 , using mixtures of compounds from different classes is widely accepted as optimal resistance managem

161 Here, ~39 kDa class IV chitinase (HrCHI4) was purified from seabucktho

162 al reference data are available and predicts classes lacking tandem mass spectrometry training data.

163 that one distinction between these two gene classes lies in the mechanisms that balance mRNA synthes

164 Bempedoic acid is a first-in-class lipid-lowering drug recommended by guidelines for

165 overed that during ligule development, the E class MADS-box TF GRCD5 activates GhCYC3 expression.

166 thematical underpinnings that performs multi-class marker selection in an informed manner.

167 In particular, cross-resistance to unrelated classes may occur by co-selection of resistant strains,

168 t of molecular switching systems and storage-class memories.

169 d identifier, functional class, bioinorganic class, metal ion and metal-containing cofactor, which wi

170 Problematic with class modeling is determining which one-class classifier

171 racts were observed on the level of compound classes, molecular formulae and specific molecules.

172 nts in apolipoprotein E (APOE), forkhead box class O3a, clusterin, and phosphatidylinositol binding c

173 This emerging class of 'post-functionalizable' hybrid-POMs constitute

174 rs (SPAs) has been the introduction of a new class of actuators called fabric soft pneumatic actuator

175 gamma as regulator of a functionally related class of AF-miRNAs.

176 The name ViscY is proposed to refer to the class of all NMR spectroscopy experiments that rely on v

177 d that copper dependent inhibitors (CDIs), a class of antibiotics that are only active in the presenc

178 gulatory architecture underlies this special class of behavior, and review literature that suggests a

179 In this study, a new class of bifunctional inhibitors of bacterial ureases, i

180 Polyketide natural products are an important class of biologically active compounds.

181 for quantum-assisted measurements on a large class of biologically relevant molecules.

182 s in robust blocking of viral infection by a class of broadly neutralizing antibodies (bnAbs) against

183 In order to achieve these results, a class of Bronsted basic guanidinylated peptides, which c

184 xemplified the preparation of an undescribed class of carbocyclic nucleoside analogues and provided a

185 In this work, the class of compounds termed cycloparaphenylenes (CPPs)-sha

186 This is the first report of a promising class of compounds that not only targets the DNA damage

187 on of electrophilic ring cleavage products-a class of compounds that poses potential health risks at

188 yet frustratingly complicated and difficult class of compounds to analyze, manipulate, and use.

189 structure-activity relationships within this class of compounds.

190 PVHIs represent a new class of cruzain inhibitors that could progress to viabl

191 nt organic frameworks (COFs) are an emerging class of crystalline porous polymers with tailor-made st

192 A specific class of deep learning-based methods allows for the pred

193 nd oncologic disorders, giving rise to a new class of drugs, JAK inhibitors (or Jakinibs).

194 calculations for engineering analogs of this class of fluorophores are offered.

195 vity profiling in cancer, we developed a new class of in situ probes that can be applied to fresh-fro

196 Thus, NPY neurons are a novel class of inhibitory neurons that use GABA and NPY signal

197 ystems-was selected as a conceptually simple class of intrinsically porous nanocarbons to serve as a

198 Here we describe a second class of local excitatory inputs to granule cells that a

199 Thiopeptides are a broad class of macrocyclic, heavily modified peptide natural p

200 Textiles are their own class of materials due to the specific structural develo

201 a new class of polyurethanes (PUs) and a new class of materials featuring an unprecedented backbone s

202 emiconducting polymers represent an exciting class of materials for bioelectronic devices, they are s

203 Our findings open up this class of materials for voltage-controlled functionality.

204 A theoretically proposed class of mechanisms, termed "distal pinning," achieves r

205 buted to our understanding of this important class of microalgae in the context of evolution, cell bi

206 ctrocyclization of dithienylethenes, a major class of molecular switches.

207 enocarcinoma, was observed, pointing to this class of molecules as a valuable template for boosting t

208 in the essential oils, a broadly distributed class of natural flavours.

209 Here, we review each major class of ncRNA that is currently annotated in the human

210 Circular RNAs (circRNAs), a class of non-coding RNAs generated from non-canonical ba

211 l soluble-globular proteins, we identified a class of nonconserved positions for which various substi

212 Another class of nonpeptidergic neurons innervated mucosal crypt

213 ere, we show that liver X receptors (LXRs)-a class of nuclear receptors and transcription factors wit

214 can nevertheless play an important role in a class of optical nonlinearities driven by both the elect

215 f two-dimensional perovskites as an exciting class of optoelectronic materials.

216 phospholipid bilayers represents a distinct class of phase transformation that occurs in structurall

217 Strigolactones are an important class of plant signalling molecule with both external rh

218 ting materials respectively constitute a new class of polyurethanes (PUs) and a new class of material

219 Covalent organic frameworks are an emerging class of porous crystalline organic materials that can b

220 This observation considerably broadens the class of possible interactions that result in peripheral

221 Neuroligins (NLGNs) are a class of postsynaptic cell adhesion molecules that inter

222 describe the discovery and optimization of a class of potent, orally bioavailable inhibitors of gluco

223 ifs for target engagement, have emerged as a class of potentially powerful therapeutics for neurodege

224 n tertiary structure mimetics as an emerging class of PPI modulators.

225 r the production and diversification of this class of promising anti-microbial therapeutics in hetero

226 ly deregulated in disease and targeting this class of proteins is a major focus of interest.

227 NME1 is a metastasis suppressor, a class of proteins which inhibits metastatic spread of ca

228 1A (5-HT(1A)) receptors, may represent a new class of psychotropic agent for the treatment of psychos

229 sight into the physical interactions of this class of RAS variants with its regulatory and effector p

230 nic and nuclear dynamics of this fundamental class of reactions.

231 n is a structural signature for a ubiquitous class of receptors in the plant kingdom.

232 implementing GRNs allows for a more general class of response functions but makes analysis more diff

233 NATION1, is a typical representative of this class of RNAs.

234 A rarer class of S-box riboswitches is predicted to regulate tra

235 Compound 5 represents a new class of selective ligands with antileishmanial activity

236 ssable electrochemical sensors (LAESs) are a class of sensors that use light to activate an electroch

237 Later in evolution, another class of Ser codons, UCX, were derived from alanine codo

238 Our model combines the class of Stochastic Block Models for community formation

239 the arylation of one spiro-bicyclic amine, a class of substrates that has not been studied in the con

240 of unactivated 1,2-disubstituted alkenes, a class of substrates that has not readily undergone coppe

241 lead for further optimization of this novel class of survivin inhibitors.

242 Furans merit consideration as a new class of therapeutic agents for controlling cancer metas

243 Trifluoromethyl sulfoxides are a new class of trifluoromethylthiolating reagent.

244 e mechanical metamaterials, leading to a new class of tunable metamaterial over a wide range of opera

245 In this study, we engineered a class of type III hammerhead ribozymes to develop RNA sw

246 Here we study sulfuramidimidoyl fluorides, a class of weak electrophiles that undergo sulfur(VI) fluo

247 We previously developed several classes of 2-aminoquinoline-based nNOS inhibitors, but t

248 avel a unique ligand rearrangement for these classes of anionic mesoionic carbene-based ligands.

249 New structural classes of antibiotics are rare, structurally novel broa

250 Surprisingly, three different classes of binding-induced changes were identified.

251 increased in distinct patterns in different classes of breast cancer tumor samples.

252 Nerve endings arising from two classes of colorectal-projecting DRG neuron were identif

253 Finally, we identified classes of DMS-defined variants with significantly diffe

254 tent with the published mechanisms for three classes of drugs with different mechanisms of action.

255 In order to evaluate the different classes of experiment for studies of IDRs or IDPs in bot

256 These two classes of genes responded differently to XRN1 deletion

257 cerebellar) nucleus, we identify five major classes of glutamatergic projection neurons distinguishe

258 ion of charge distribution between different classes of GPL under MALDI-MSI conditions.

259 strate that both the straight and bent CDRH3 classes of HCV bNAb can be elicited in a single individu

260 Two new classes of heteroarene-fused [1,2,4]thiadiazole and [1,2

261 Moreover, we describe two mechanistic classes of independently arising mutations in AAAD paral

262 Different classes of introns are excised by the U2-type or the U12

263 to generate models for predicting different classes of kinase inhibitors including types I, I(1)/(2)

264 Here, we show that the three major classes of LCCBs activate STIM/ORAI-mediated Ca(2+) entr

265 This data indicates that distinct classes of neurons individualize remodeling of their mye

266 cancer cells are one of the fastest growing classes of oncology therapeutics, with eight ADCs and tw

267 AFFF-associated PFSAs and identifies several classes of potentially bioaccumulative novel PFASs that

268 We identify two major classes of PVT neurons-termed type I and type II-that di

269 into stem cells capable of regenerating all classes of retinal neurons and restoring visual function

270 for the detection and quantification of six classes of significant pharmaceutical compounds, includi

271 ped to inhibit enzyme activity; however, new classes of small molecules that endow new functions to e

272 9 transcript features that tag multiple rare classes of SNX19 transcripts, whereas they only weakly a

273 case in mixtures of 5-, 8-, and 13-different classes of steroids in exposure concentrations of 10-10,

274 However, several major classes of therapeutically relevant proteins have unknow

275 mplexes preferentially assemble on different classes of transcripts.

276 le cells and endothelial cells-the two major classes of vascular cells.

277 hip between LVEF, New York Heart Association class on presentation, and the end points of mortality a

278 slides containing multiple classes, a single class, or no parasites.

279 ipids (notably GM(3) gangliosides) and lipid classes previously associated with cardiometabolic disea

280 and HILIC retention time for 22 and 23 lipid classes, respectively, were trained using the large expe

281 assumes different conformations in the five classes, revealing how contacts to the small subunit are

282 et snacks was observed for households in the classes SSB (18.5%, 95% CI 18.1%-19.0%) and Diet (18.8%,

283 the functionalization of important compound classes, such as ligand derivatives and polyaromatics, a

284 e fidelity functions of 53BP1 coevolved with class switch recombination (CSR) in the immune system.

285 ir functionality, somatic mutational status, class switch recombination, and oncogenic Ig translocati

286 ll intrinsic functions to moderately enhance class-switch DNA recombination (CSR), while decreasing a

287 teraction fields (MIFs), a global descriptor class that typically has the highest dimensionality.

288 s of TMDs, effectors group into two distinct classes that both require a member of the Eag family of

289 The study highlights protein families and classes that have received more attention and those that

290 anogenesis is an ancestral metabolism of the class Thermoplasmata.

291 east one but no more than two antiretroviral classes to add either fostemsavir (at a dose of 600 mg t

292 t to the triazoles, the frontline antifungal class used in medicine and agriculture to control A. fum

293 benzo[d]oxazole (ezutromid, 1) is a first-in-class utrophin modulator that has been evaluated in a ph

294 Furthermore, with CLASSED we developed a context-specific model of beta-ad

295 ular function and New York Heart Association class were assessed at baseline (after randomization) an

296 specificity, intersubclass specificity, and class-wide cross-reactivity, suggesting that some conser

297 Low-level class-wide resistance, which often goes undetected in th

298 onated ions of the species of the same lipid class with two additional CH(2) and three double bonds (

299 to study interactions of different compound classes with nanocellulose materials in food, pharmaceut

300 ing of New York Heart Association functional class, with statistically significant effects that were