ライフサイエンスコーパス: class switch recombination

1 G1 Abs, demonstrating a functional effect on class switch recombination.

2 deletion of intervening DNA sequences during class switch recombination.

3 ution and impedes B cell differentiation and class switch recombination.

4 tation but defective affinity maturation and class switch recombination.

5 homologous end-joining during immunoglobulin class switch recombination.

6 ects VDJ recombination with minor effects on class switch recombination.

7 plex human B cell phenotypes during antibody class switch recombination.

8 )J recombination, somatic hypermutation, and class switch recombination.

9 ate somatic hypermutation and immunoglobulin class switch recombination.

10 ate of IgG1 transcription, without affecting class switch recombination.

11 ht into the molecular mechanisms involved in class switch recombination.

12 anslocate configured the earliest version of class switch recombination.

13 D-dependent antibody gene diversification by class switch recombination.

14 egulate transcriptional responses needed for class switch recombination.

15 cular events such as V(D)J recombination and class switch recombination.

16 on and joining as measured by immunoglobulin class switch recombination.

17 e AID scaffold compromised hypermutation and class switch recombination.

18 are diversified by somatic hypermutation and class switch recombination.

19 but not alternative end-joining, during IgH class switch recombination.

20 ines in mediating B-cell differentiation and class switch recombination.

21 s endonuclease activity is essential for IgA-class switch recombination.

22 erate double-strand DNA breaks for efficient class switch recombination.

23 , Id3-depleted B cells displayed a defect in class switch recombination.

24 ting Ab production, affinity maturation, and class switch recombination.

25 s recruitment to switch (S) regions leads to class-switch recombination.

26 y diversification: somatic hypermutation and class-switch recombination.

27 delayed-type hypersensitivity responses, and class-switch recombination.

28 and Toll receptor stimuli and undergo normal class-switch recombination.

29 ription 3 phosphorylation and immunoglobulin class-switch recombination.

30 were detectable in plasma, demonstrating IgG class-switch recombination.

31 ver, TET2-deficient B cells showed defective class-switch recombination.

32 tion of B lymphocytes and T cell-independent class-switch recombination.

33 nitiating antibody somatic hypermutation and class-switch recombination.

34 cription-dependent somatic hypermutation and class-switch recombination.

35 ), or enzymes responsible for immunoglobulin class-switch recombination.

36 h regions, suggesting that they occur during class-switch recombination.

37 e (AID) to undergo somatic hypermutation and class-switch recombination.

38 terminal maturation, and immunoglobulin (Ig) class-switch recombination.

39 somatic hypermutation, gene conversion, and class-switch recombination.

40 d DNA lesions in cells attempting to undergo class-switch recombination.

41 n in vivo, resulted in proliferation but not class-switch recombination.

42 d apoptosis during somatic hypermutation and class-switch recombination.

43 to become Ab-producing cells and to undergo class-switch recombination.

44 over extended regions during immunoglobulin class-switch recombination.

45 in switch (S) regions during immunoglobulin class switch recombination, a physiological, deletion/re

46 , or initiation of somatic hypermutation and class switch recombination (activation-induced cytidine

47 rmal primary humoral responses, encompassing class switch recombination, affinity maturation, and ger

48 of cytokines, including IL-21, and inhibited class switch recombination and B cell activation.

49 l center (GC) reaction where B cells undergo class switch recombination and clonal selection to gener

50 ster (3' regulatory region) are required for class switch recombination and for high levels of IgH ex

51 ismatch repair activity and displayed normal class switch recombination and meiosis.

52 GC reaction in primary B cells by impairing class switch recombination and memory B and plasma cell

53 ription factor IRF4 regulates immunoglobulin class switch recombination and plasma cell differentiati

54 1 production, whereas in B cells it controls class switch recombination and plasma cell differentiati

55 Our rigorous analysis included ex vivo class switch recombination and plasmablast differentiati

56 This has important implications for class switch recombination and somatic hypermutation and

57 Both class switch recombination and somatic hypermutation are

58 in gene products crucial for immunoglobulin class switch recombination and somatic hypermutation imp

59 tidine deaminase (AID) is a key regulator of class switch recombination and somatic hypermutation of

60 ase (AID) is a mutator enzyme that initiates class switch recombination and somatic hypermutation of

61 ) is a genome-mutating enzyme that initiates class switch recombination and somatic hypermutation of

62 lack the ability to undergo normal levels of class switch recombination and somatic hypermutation, tw

63 hat targets immunoglobulin genes to initiate class switch recombination and somatic hypermutation.

64 uced cytidine deaminase (AID), the enzyme of class switch recombination and somatic hypermutation; th

65 of B cells involves the sequential events of class switch recombination and somatic hypermutations ch

66 ts or (ii) deletion of enhancer elements for class switch recombination and transcription, or (iii) a

67 dergone the affinity-maturation processes of class switch recombination and, possibly, somatic hyperm

68 Class-switch recombination and antibody affinity maturat

69 maturation, but have also been implicated in class-switch recombination and B cell lymphoma survival.

70 ous end-joining (NHEJ) during immunoglobulin class-switch recombination and consequently impairs immu

71 Because BAFF promotes B cell class-switch recombination and humoral autoimmunity, we

72 together with previously reported defects in class-switch recombination and memory immune response, u

73 s B-cell differentiation leading to antibody class-switch recombination and secretion.

74 idine deaminase (AID), which is required for class-switch recombination and somatic hypermutation, ar

75 AID(+) GC B cells then undergo class-switch recombination and somatic hypermutation.

76 bility, confirming that these AHAs underwent class-switch recombination and somatic hypermutation.

77 negatively regulatory function regarding Ab class switch recombination, and blockade of PI3K can str

78 e in B cell development, allelic regulation, class switch recombination, and chromosomal looping.

79 ir functionality, somatic mutational status, class switch recombination, and oncogenic Ig translocati

80 o B cells to facilitate affinity maturation, class switch recombination, and plasma cell differentiat

81 ate the involvement of local IgE production, class switch recombination, and receptor revision in NP.

82 nase (AID), initiates somatic hypermutation, class-switch recombination, and gene conversion of Ig ge

83 inase (AID) initiates somatic hypermutation, class-switch recombination, and gene conversion of immun

84 Upregulation of IgE by sCD23 occurs after class-switch recombination, and its effects are isotype-

85 ls, IRF4 controls germinal center formation, class-switch recombination, and the generation of plasma

86 ating NHEJ at dysfunctional telomeres and in class switch recombination are not identical.

87 ing transcription, alternative splicing, and class switch recombination are required to facilitate de

88 ich accumulates in the nucleus and increases class switch recombination as well as chromosomal transl

89 al and plays an important role in regulating class switch recombination as well as in the selection o

90 pair, V(D)J recombination and immunoglobulin class switch recombination, as well as innate immune and

91 nzymatic function of host UNG in an in vitro class switch recombination assay.

92 me is required for somatic hypermutation and class switch recombination at the immunoglobulin locus.

93 ficiency in immunoglobulin hypermutation and class switch recombination, both AID-dependent mechanism

94 osphatidylcholine prevents proliferation and class switch recombination but leads to unfolded protein

95 In addition, class switch recombination, but not somatic hypermutatio

96 ells and revealed that the inhibition of IgE class switch recombination by IL-21 was attenuated by CD

97 region and Aicda locus, E-proteins regulated class switch recombination by inducing both Igh germline

98 tant role in repairing DSBs generated during class switch recombination by promoting the classical NH

99 Loss of PTIP inhibited class switch recombination by suppressing transcription

100 deaminase (AID) that abolish immunoglobulin class-switch recombination, causing an accumulation of I

101 Classical class-switch recombination (cCSR) substitutes the Cmu ge

102 inability of CCTalpha-/- B-cells to undergo class switch recombination correlated with a proliferati

103 rt that RNF8 deficiency results in defective class switch recombination (CSR) and accumulation of unr

104 ls, including DSBs generated during antibody class switch recombination (CSR) and DSBs generated by i

105 are severely compromised for 53BP1-dependent class switch recombination (CSR) and fusion of dysfuncti

106 hat PTIP accumulation at DSBs contributes to class switch recombination (CSR) and genome stability in

107 eaminase that initiates Ig heavy chain (IgH) class switch recombination (CSR) and Ig somatic hypermut

108 tiates immunoglobulin (Ig) heavy-chain (IgH) class switch recombination (CSR) and Ig variable region

109 We find that both class switch recombination (CSR) and R-loop formation de

110 n-induced cytidine deaminase (AID) initiates class switch recombination (CSR) and somatic hypermutati

111 ase (AID) catalyzes two of these mechanisms: class switch recombination (CSR) and somatic hypermutati

112 re B cells diversify their antibody genes by class switch recombination (CSR) and somatic hypermutati

113 immunoglobulin locus of B lymphocytes during class switch recombination (CSR) and somatic hypermutati

114 ed deaminase (AID) is an enzyme required for class switch recombination (CSR) and somatic hypermutati

115 Activation-induced deaminase (AID) catalyses class switch recombination (CSR) and somatic hypermutati

116 Ig class switch recombination (CSR) and somatic hypermutati

117 Both class switch recombination (CSR) and somatic hypermutati

118 o immunoglobulin (Ig) loci promotes antibody class switch recombination (CSR) and somatic hypermutati

119 uced cytidine deaminase (AID) initiates both class switch recombination (CSR) and somatic hypermutati

120 mphocytes use two DNA alteration mechanisms, class switch recombination (CSR) and somatic hypermutati

121 ing (V(D)J) recombination and immunoglobulin class switch recombination (CSR) are key processes in ad

122 tion through somatic hypermutation (SHM) and class switch recombination (CSR) are similarly initiated

123 d the mechanisms underlying abnormalities in class switch recombination (CSR) associated with the hum

124 D) initiates somatic hypermutation (SHM) and class switch recombination (CSR) by deaminating cytidine

125 n this study, we show that Ab production and class switch recombination (CSR) depend on autocrine C3a

126 Class switch recombination (CSR) diversifies antibodies

127 Class switch recombination (CSR) diversifies antibodies

128 hypermutation (SHM) and immunoglobulin (Ig) class switch recombination (CSR) enable B cells to produ

129 ismatch repair (MMR) protein is critical for class switch recombination (CSR) events that occur in mi

130 In mature B cells, class switch recombination (CSR) generates different ant

131 Class switch recombination (CSR) generates isotype-switc

132 Class switch recombination (CSR) has the potential to ge

133 in joining DSBs during Ig heavy chain (IgH) class switch recombination (CSR) in activated B lymphocy

134 recombination in developing lymphocytes and class switch recombination (CSR) in antigen-stimulated B

135 on-induced deaminase (AID) triggers antibody class switch recombination (CSR) in B cells by initiatin

136 ernative-end-joining (Alt-EJ) pathway during class switch recombination (CSR) in B cells, and HMCES d

137 Class switch recombination (CSR) in B lymphocytes is ini

138 Antibody class switch recombination (CSR) in B lymphocytes joins

139 Antibody class switch recombination (CSR) in B lymphocytes replac

140 During IgH class switch recombination (CSR) in B lymphocytes, switc

141 e fidelity functions of 53BP1 coevolved with class switch recombination (CSR) in the immune system.

142 Class switch recombination (CSR) involves a DNA rearrang

143 dies through somatic hypermutation (SHM) and class switch recombination (CSR) is a critical component

144 In B lymphocytes, Ig class switch recombination (CSR) is induced by activatio

145 Immunoglobulin (Ig) class switch recombination (CSR) is initiated by activat

146 In B cells, Ig class switch recombination (CSR) is initiated by activat

147 Immunoglobulin (Ig) class switch recombination (CSR) is initiated by the tra

148 Immunoglobulin (Ig) class switch recombination (CSR) is initiated by the tra

149 Class switch recombination (CSR) is instigated by activa

150 Ig class switch recombination (CSR) is regulated through lo

151 Ig class switch recombination (CSR) occurs in activated mat

152 ant region in the IgH locus, indicating that class switch recombination (CSR) occurs in the absence o

153 IgH class switch recombination (CSR) occurs through the deli

154 to initiate somatic hypermutation (SHM) and class switch recombination (CSR) of antibody genes.

155 hRNA screen to identify factors required for class switch recombination (CSR) of antibody loci.

156 ine, and the somatic hypermutation (SHM) and class switch recombination (CSR) pipeline.

157 Class switch recombination (CSR) plays an important role

158 Immunoglobulin heavy chain class switch recombination (CSR) requires targeted forma

159 We hypothesize that MMSET also regulates class switch recombination (CSR) through its effect on 5

160 Naive B cells undergo class switch recombination (CSR) to generate antibodies

161 gE(+) cells in vivo and the low frequency of class switch recombination (CSR) to IgE ex vivo.

162 Immunoglobulin class switch recombination (CSR) to IgE is a tightly reg

163 ity maturation and DNA breakage for antibody class switch recombination (CSR) via transcription-depen

164 Here, we studied immunoglobulin (Ig) class switch recombination (CSR), a physiological proces

165 B cell function with age is decreased in class switch recombination (CSR), activation-induced cyt

166 d mice and humans, including decreases in Ig class switch recombination (CSR), activation-induced cyt

167 transcriptional program, immunoglobulin (Ig) class switch recombination (CSR), and plasma cell develo

168 ) in the IgH gene (Igh) to stimulate isotype class switch recombination (CSR), and widespread breaks

169 uch as those occurring during immunoglobulin class switch recombination (CSR), are repaired by non-ho

170 globulin switch (S) regions is essential for class switch recombination (CSR), but no molecular funct

171 eaminase (AID) initiates immunoglobulin (Ig) class switch recombination (CSR), somatic hypermutation

172 n to DNA double-strand break (DSB) repair in class switch recombination (CSR), we ablated Rev3, the c

173 ions has been implicated in regulation of Ig class switch recombination (CSR).

174 serves as a novel DNA repair regulator of Ig class switch recombination (CSR).

175 duced cytidine deaminase (AID)-dependent IgH class switch recombination (CSR).

176 cytes hypersecrete IgM and do not undergo Ig class switch recombination (CSR).

177 ature B cells in the germinal center through class switch recombination (CSR).

178 ld-type 53BP1 with respect to immunoglobulin class switch recombination (CSR).

179 al cellular processes such as immunoglobulin class switch recombination (CSR).

180 ediates in Ig gene rearrangements: V(D)J and class switch recombination (CSR).

181 on, indicating a reduced capacity to undergo class switch recombination (CSR).

182 y to produce somatic hypermutation (SHM) and class switch recombination (CSR).

183 rmutation or DNA double-strand breaks during class switch recombination (CSR).

184 into switch (S) regions, leading to antibody class switch recombination (CSR).

185 (non-coding) transcription (GT) and promote class switch recombination (CSR).

186 Germline transcription precedes class switch recombination (CSR).

187 diversity) joining [V(D)J] recombination and class switch recombination (CSR).

188 , initiating somatic hypermutation (SHM) and class switch recombination (CSR).

189 deaminase (AID, also known as AICDA) during class switch recombination (CSR).

190 d plays a central function in the process of class switch recombination (CSR).

191 ate antibody somatic hypermutation (SHM) and class switch recombination (CSR).

192 atory intermediates for Ig heavy chain (Igh) class switch recombination (CSR).

193 lls undergo Immunoglobulin Heavy Chain (IgH) class switch recombination (CSR).

194 hat needs isotype-switched Abs generated via class switch recombination (CSR); however, stimulating t

195 Class-switch recombination (CSR) alters the Ig isotype t

196 Activated B cells undergo immunoglobulin class-switch recombination (CSR) and differentiate into

197 ntigens and cytokines, mouse B cells undergo class-switch recombination (CSR) and differentiate into

198 eviously unappreciated role for Flt3 in IgG1 class-switch recombination (CSR) and production.

199 tidine deaminase (AID), the enzyme-mediating class-switch recombination (CSR) and somatic hypermutati

200 ed cytidine deaminase (AID) is essential for class-switch recombination (CSR) and somatic hypermutati

201 6, must process the deoxyuridine to initiate class-switch recombination (CSR) and somatic hypermutati

202 an immune response and is essential for both class-switch recombination (CSR) and somatic hypermutati

203 AID mediates class-switch recombination (CSR) and somatic hypermutati

204 CD103(+) and CD24(+)CD11b(+) DCs induced IgA class-switch recombination (CSR) by activating B cells t

205 y initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during transcription of

206 Class-switch recombination (CSR) ensures that these Abs

207 n require Ig somatic hypermutation (SHM) and class-switch recombination (CSR) for high-affinity respo

208 nduced cytidine deaminase (AID) initiates Ab class-switch recombination (CSR) in activated B cells re

209 that trigger immunoglobulin G (IgG) and IgA class-switch recombination (CSR) in B cells by engaging

210 e same, BXD2-p19(-/-) mice exhibited a lower class-switch recombination (CSR) in the GC B cells, lead

211 Somatic hypermutation (SHM) and class-switch recombination (CSR) increase the affinity a

212 Class-switch recombination (CSR) is a DNA recombination

213 idine deaminase (AID) to efficiently mediate class-switch recombination (CSR) is dependent on its pho

214 Ig class-switch recombination (CSR) is directed by the long

215 M(+) mouse B cells and hybridomas, we induce class-switch recombination (CSR) of the IgH chain to the

216 enes through somatic hypermutation (SHM) and class-switch recombination (CSR) processes.

217 Immunoglobulin heavy chain (IgH) class-switch recombination (CSR) replaces initially expr

218 Ig heavy chain (IgH) class-switch recombination (CSR) replaces the IgH C mu c

219 Immunoglobulin class-switch recombination (CSR) requires activation-ind

220 ls activated to undergo Ig heavy-chain (IgH) class-switch recombination (CSR) to be reprogrammed into

221 mologous end-joining (NHEJ) factors, Ab gene class-switch recombination (CSR) uses an alternative end

222 atory functions that control IgH expression, class-switch recombination (CSR), and somatic hypermutat

223 Following class-switch recombination (CSR), antigen-activated B ce

224 lity to perform somatic hypermutation (SHM), class-switch recombination (CSR), or both.

225 During immunoglobulin class-switch recombination (CSR), the cytidine deaminase

226 e Igh locus plays a major role in regulating class-switch recombination (CSR), the process by which a

227 insights into the process of immunoglobulin class-switch recombination (CSR).

228 ctivation-induced deaminase during IgH (Igh) class-switch recombination (CSR).

229 the mechanism by which BATF controls in vivo class-switch recombination (CSR).

230 IgH switch (S) region DNA breaks (DSBs) for class-switch recombination (CSR).

231 t for V(D)J recombination and immunoglobulin class-switch recombination (CSR); however, little is kno

232 inal maturation and Ig isotype class switch (class switch recombination [CSR]).

233 ncy patients into subgroups and identified a class-switch recombination defect caused by an UNG mutat

234 Immunoglobulin class-switch recombination defects (CSR-D) are rare prim

235 genes that undergo somatic hypermutation and class switch recombination during B cell activation in r

236 Thus, we find that the dramatic induction of class-switch recombination during Ag-driven differentiat

237 ell differentiation and guide B cell isotype class-switch recombination during host defense against P

238 region super-enhancer and leads to decreased class switch recombination efficiency.

239 We find that AhR negatively regulates class-switch recombination ex vivo by altering activatio

240 s required for humoral memory, and underwent class-switch recombination following Ag encounter.

241 The dramatic reduction in class switch recombination for all H chain genes and the

242 joining recombination in vivo but not during class switch recombination, for which PAXX appeared to b

243 and joining recombination and immunoglobulin class switch recombination, here, using Cre/lox-specific

244 Ig class-switch recombination (Ig-CSR) deficiencies are rar

245 e functionality of AID by evaluating in vivo class switch recombination in 52 MCL cases; and sought f

246 Consistent with this, we show that class switch recombination in Aplf(-/-) B cells is biase

247 PTIP protein in transcription regulation and class switch recombination in B cells, a process that de

248 d break repair protein that is essential for class switch recombination in B lymphocytes and for sens

249 S phases of the cell cycle, interferes with class switch recombination in B lymphocytes, and leads t

250 ese allowed direct simultaneous detection of class switch recombination in both immunoglobulin-heavy

251 protein ATM has long been known to influence class switch recombination in ex vivo-cultured B cells.

252 omatic hypermutation and immunoglobulin (Ig) class switch recombination in germinal center (GC) B cel

253 c stability in mouse fibroblasts, and in IgH class switch recombination in mature B cells.

254 ated in NP, and there was evidence for local class switch recombination in NP.

255 It directly demonstrated asynchrony of the class switch recombination in the two alleles in structu

256 ro but also trigger antibody production with class switch recombination in vivo.

257 n history, somatic hypermutation status, and class-switch recombination in 17 children with Down synd

258 receptor participates in the control of IgE class-switch recombination in B cells.

259 e authors show that IgE can be generated via class-switch recombination in IgG1 memory B cells withou

260 ic gene expression, antigen presentation and class-switch recombination in plasmablasts.

261 ase (AID) involved in somatic hypermutations/class switch recombination, in primary human B cells.

262 underwent efficient V(D)J recombination and class switch recombination, indicating that phosphorylat

263 xpression, germ-line transcription preceding class switch recombination, interactions between targete

264 Ab class switch recombination involves a recombination betw

265 cells class switch in vitro, suggesting that class switch recombination is directed toward specific i

266 Immunoglobulin class switch recombination is governed by long-range int

267 dine deaminase (AID) expression, and blocked class switch recombination, leading to markedly decrease

268 ctivities in cells undergoing immunoglobulin class switch recombination leads to a compound defect in

269 Germinal center somatic hypermutation and class switch recombination machineries were activated, a

270 sured the expression of two miRs crucial for class switch recombination, miR-155 and miR-16, in human

271 l not fully understood where in the body IgE class switch recombination of food allergen-specific B c

272 vents that lead to somatic hypermutation and class switch recombination of immunoglobulin genes.

273 se (AID) initiates somatic hypermutation and class switch recombination of the immunoglobulin genes.

274 Class-switch recombination of Ab isotype is mediated by

275 Somatic hypermutation and class-switch recombination of the immunoglobulin (Ig) ge

276 n genes encoded proteins contributing to IgE class switch recombination or B-cell receptor signaling.

277 was previously found to be unable to support class switch recombination or to promote radial chromoso

278 in various physiological processes, such as class-switch recombination or crossing-over during meios

279 ot show any obvious defects in Ab secretion, class switch recombination, or somatic hypermutation.

280 liferation, IgE, IgG1, IgG4, IgA production, class switch recombination, plasma cell differentiation

281 ty of the double-strand break repairs in the class-switch recombination process in vivo.

282 immunoglobulin M (IgM) BCR despite an active class-switch recombination process, and by the introduct

283 4 as a regulator of PARP1-dependent NHEJ and class-switch recombination, providing a molecular basis

284 in the normal G+C-rich context of mammalian class switch recombination regions, R-loops are obligato

285 ne segment usage, CDR3 length distributions, class switch recombination, somatic hypermutation levels

286 hich B lymphocytes undergo clonal expansion, class switch recombination, somatic hypermutation, and a

287 induced cytidine deaminase gene required for class switch recombination/somatic hypermutation inducti

288 ular DNA intermediates, a hallmark of active class switch recombination, suggested that class switchi

289 Beyond class switch recombination, the IgH 3'RR is a central el

290 In B cells, STAT6 is required for class switch recombination to IgE and for germinal cente

291 itch circle transcripts reveal ongoing local class switch recombination to IgE.

292 remodeling (global somatic hypermutation and class switch recombination to major isotypes) in activat

293 Class switch recombination to several isotypes was also

294 , which in part impacts the overall level of class switch recombination to targeted C(H) regions.

295 in various basic nuclear processes, such as class-switch recombination, transcription termination an

296 and joining recombination and immunoglobulin class switch recombination, two events requiring nonhomo

297 genes associated with B cell activation and class switch recombination was measured by qRT-PCR.

298 Class switch recombination was partly lost due to a fail

299 s attenuated by CD40 signaling, whereas IgG1 class switch recombination was potentiated by IL-21 in t

300 event, supporting somatic hypermutation and class-switch recombination within the salivary follicles