ライフサイエンスコーパス: class switching

1 ifferentiation, B cell proliferation, and Ig class switching.

2 is attributed to inefficient immunoglobulin class switching.

3 pport affinity maturation and immunoglobulin class switching.

4 somal domains that contact this locus during class switching.

5 g faithful repair, mutagenic processing, and class switching.

6 ID accumulation and increased immunoglobulin class switching.

7 full-length HA and stem alters stem-antibody class switching.

8 and selective T-dependent impairment of IgG1 class switching.

9 duced cytidine deaminase (AID)-dependent IgH class switching.

10 e, we report that NFIL3 is important for IgE class switching.

11 ption in response to IL-4 and subsequent IgE class switching.

12 ein phosphatase 2A (PP2A) leads to decreased class switching.

13 ) locus, leading to defective immunoglobulin class switching.

14 y diversity through somatic hypermutation or class switching.

15 ay directly promote B cell activation and Ig class switching.

16 production of cytokines that direct antibody class switching.

17 V gene hypermutation and little heavy-chain class switching.

18 s as well as to become activated and undergo class switching.

19 bute to the choice between hypermutation and class switching.

20 ot affected by T cells, nor was autoantibody class switching.

21 yield severely diminished hypermutation and class switching.

22 ion and CD4 cell-mediated anti-AChR antibody class switching.

23 ase (AID), an enzyme associated with ongoing class switching.

24 otide excision repair does not contribute to class switching.

25 -/-) mice was partially due to a decrease in class switching.

26 C B cell proliferation, differentiation, and class switching.

27 cell responses, as determined by impaired Ig class switching.

28 ependent antibody responses and promotes IgA class switching.

29 ut is not required for early B-cell help and class switching.

30 acts from splenic B cells induced to undergo class switching.

31 iated with somatic rearrangement and isotype class switching.

32 ortant role in T cell differentiation and Ig class switching.

33 a GC-like phenotype or the rate of antibody class switching.

34 hat Bryo inhibition occurred at the level of class switching.

35 of B cell CD153 by T cell CD30 modulates Ig class switching.

36 ecific human CD8 T cells, and immunoglobulin class switching.

37 eir B cells could not undergo immunoglobulin class switching.

38 nd CD8 T cells, or to undergo immunoglobulin class switching.

39 t IgM-to-IgA or sequential IgM-to-IgG-to-IgA class switching.

40 otein P6, with impaired IgG1, IgG2a, and IgA class switching.

41 ligand and secreted cytokines that guide Ig class switching.

42 d with progressive B-cell maturation and IgE class-switching.

43 -kappaB activation for B cell immunoglobulin class-switching.

44 profound deficits in immunoglobulin isotype class switching, accompanied by impaired germinal centre

45 After stimulation with class-switching activators, such as LPS, Rb becomes hype

46 AID from Japanese puffer and zebra fish for class-switching activity in mouse B cells.

47 aminase, Apobec3 might directly influence Ab class switching and affinity maturation independently of

48 aining lymph nodes, suggesting that impaired class switching and affinity maturation may have led to

49 Class switching and affinity maturation were easily dete

50 Evidence for IgG-expressing B cells, class switching and antibody maturation in normal and ma

51 when mutated to alanine, leads to increased class switching and c-myc/IgH translocations without aff

52 IL-4 activation of B cells is essential for class switching and contributes to the induction of B ef

53 requirement for the mTORC1 complex in B cell class switching and demonstrated that rapamycin skewed t

54 etion prevented humoral immune responses and class switching and depleted existing and adoptively tra

55 -stimulate B cells to undergo proliferation, class switching and differentiation into antibody-secret

56 DCs, and examine its capacity to induce IgA class switching and differentiation of naive B cells in

57 of immune cell communication crucial for Ig class switching and enhanced Ag presentation.

58 he autoreactive transgenic B cells underwent class switching and epitope spreading.

59 ase (AID) in engineered cells allowed for Ig class switching and generated BCR variants with improved

60 F-kappaB pathway, it promoted immunoglobulin class switching and generation of pathogenic antibodies

61 Class switching and hypermutation are temporally and ana

62 cision repair pathway play a central role in class switching and hypermutation.

63 Given that isotype class switching and Ig gene somatic hypermutation share

64 pregulated class II expression, promoted IgE class switching and inhibited inflammatory cytokine prod

65 n deposition argued for local immunoglobulin class switching and ongoing production.

66 ells, significantly reduced CD40-mediated Ig class switching and plasma cell differentiation ex vivo.

67 hibition, together with the rescue of B cell class switching and plasma cell survival by enforced NF-

68 a neutrophil-regulated pathway that elicited class switching and plasmablast expansion via a combinat

69 4 derived from Tfh cells is required for IgE class switching and plasmablast formation.

70 By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS a

71 the cell cycle is critical to promote normal class switching and prevent genomic instability.

72 n, and in this study we mechanistically link class switching and proliferation via c-Myc.

73 T-dependent mechanisms orchestrate Ig alpha class switching and SIgA responses against commensal and

74 pact catalytic activity, but interferes with class switching and somatic hypermutation in vivo.

75 ted murine 3' enhancers, hs3B and/or hs4, in class switching and somatic hypermutation.

76 germinal center B-cell responses, including class switching and somatic hypermutation.

77 Anti-CD154 treatment blocked both class switching and somatic mutation and induced a varia

78 gene knockout or Rab7 activity inhibition in class switching and survival, respectively, whereas prol

79 e that MMR proteins are directly involved in class switching and that the role of Msh2 differs from t

80 ll-dependent Ab response, B cells undergo Ab class switching and V region hypermutation, with the lat

81 t COX-2, activity resulted in a defect in Ig class-switching and a lack of Borrelia-specific IgG prod

82 e increased expression of genes related with class-switching and memory B cell development, including

83 nt infections due to impaired immunoglobulin class-switching and somatic hypermutation.

84 lack of germinal centers (GCs), impaired Ig class switching, and affinity maturation.

85 IL-4 secretion, isotype class switching, and antigen recognition are intact in t

86 ion of key proteins required for DNA repair, class switching, and cell death.

87 les, proliferation, differentiation to AFCs, class switching, and entry into GCs and somatic hypermut

88 e protein and affects somatic hypermutation, class switching, and gene conversion in immunoglobulin g

89 nvolved in mRNA editing, immunoglobulin gene class switching, and immunoglobulin gene hypermutation.

90 that ICs on FDCs can promote AID production, class switching, and maturation of naive IgM(+) B cells,

91 reasing germline gamma 1 transcription, IgG1 class switching, and mature IgG1 transcription, while th

92 hibited more double-stranded DNA breaks, IGH class switching, and new IGHV-D-J mutations.

93 B-cell proliferation, immunoglobulin G (IgG) class switching, and plasmablast differentiation through

94 ils and mast cells, promoting immunoglobulin class switching, and preventing excessive activation.

95 B cells underwent normal class switching, and produced antigen-specific immunoglo

96 3 s.d.), four IGH locus variants influencing class switching, and ten new associations with the HLA r

97 sable for germinal center formation, isotype class switching, and Th2 and T follicular helper cell di

98 NFIL3-deficient mice show impaired IgE class switching, and this defect is B-cell intrinsic.

99 S, augmented anti-DNA Ab levels and promoted class switching, and this response was dependent on dono

100 y, respond to antigenic stimulation, undergo class switching, and use a normal repertoire of light ch

101 s high-affinity antibodies, promote antibody class switching, and yield B cell memory.

102 th plasma cell differentiation, Ig assembly, class-switching, and Ig production.

103 s impaired, with fewer memory cells, reduced class-switching, and lower frequency and complexity of s

104 munity, inflammasome activation and antibody class switching; and dysregulation of CH25H may contribu

105 tant costimulatory signal for immunoglobulin class switching, antibody affinity maturation, and primi

106 tivation, antigen presentation, T cell help, class switching, antibody production and cytokine produc

107 NP, local IgE level and key markers of local class switching are increased compared with AR and norma

108 IgG1 antibody production and immunoglobulin class switching are not affected.

109 tation, affinity maturation, and heavy chain class switching are overtly normal in A-myb-deficient mi

110 the cellular interactions necessary for IgA class switching are poorly defined.

111 munogenic in mice and induced immunoglobulin class switching as well as affinity maturation.

112 rogressive introduction of hypermutation and class-switching as animals age.

113 for antibody diversification with respect to class-switching as well as hypermutation and, in the con

114 An in vitro class-switching assay showed that MZ B cells were capabl

115 SceI DSB frequency, undergo I-SceI-dependent class switching at almost normal levels.

116 In activated, class-switching B cell cultures, it is associated with m

117 cing ligand cooperate with LMP1 to induce Ig class switching because their neutralization by appropri

118 ro failed to augment anti-DNA Abs or promote class switching beyond that induced by LPS alone.

119 Class switching, but not development, of IgM anti-self B

120 TBK1 negatively regulated IgA class switching by attenuating noncanonical signaling vi

121 importance in Th2 cytokine expression and Ab class switching by B cells.

122 Blimp-1 also inhibited immunoglobulin class switching by blocking expression of AID, Ku70, Ku8

123 ur data indicate that bacteria elicit IgA(2) class switching by linking lamina propria B cells with I

124 CD40 expression on B cells is essential for class switching by those B cells.

125 Although IgA class switching can occur at mucosal sites, high-affinit

126 ns from PMS2-deficient mice and propose that class switching can occur by microhomology-mediated end-

127 otential mechanism through which appropriate class-switching can be coupled to plasmablast proliferat

128 s of somatic hypermutation (SHM) and also Ig class switching, can have a potent mutator phenotype in

129 In vivo class-switching CLL B cells down-regulate switch circles

130 , B cell maturation, and immunoglobulin (Ig) class switching critical for adaptive immunity.

131 Notably, early IgE class switching did not require germinal center formatio

132 T- and B-cell development and immunoglobulin class switching did not reveal a defect in these pathway

133 uman basophils enhance B cell proliferation, class switching, differentiation into PC, maturation of

134 e implications for somatic hypermutation and class switching during affinity maturation and as B cell

135 region of IgM with that of IgG, IgA, or IgE, class switching enables Abs to acquire new effector func

136 ivation of GATA-3 but also by regulating IgE class-switching, epithelial cell permeability, and muscl

137 re a role for T-bet in the regulation of IgG class switching, especially to IgG2a.

138 Elevated chemokines and IgE class switching events were observed in IMT samples, con

139 These processes, including class switching, evolved with and appear inseparable fro

140 itors diminished both AID expression and IgG class switching, exogenous PGE(2) and butaprost, a selec

141 A non-canonical form of class switching from IgM to IgD occurs in the human uppe

142 Immunoglobulin class switching from IgM to IgG in response to peptides

143 in place of Sgamma1 undergo I-SceI-dependent class switching from IgM to IgG1 at 5-10% of normal leve

144 -SceI DSBs mediate recombinational IgH locus class switching from IgM to IgG1 without S regions or AI

145 Immunoglobulin class switching from immunoglobulin M (IgM) to IgG and I

146 associated with impaired immunoglobulin (Ig) class-switching from IgM to IgG and IgA, a defect that l

147 vaccination through their effect on the IgA class-switching function of LDCs.

148 erns and lineage characteristics of antibody class switching have remained uncharacterized in living

149 ferentiation and showed that TOR-KIs enhance class switching in a manner dependent on forkhead box, s

150 macologic inhibition of PKA prevents isotype class switching in a murine B-cell lymphoma cell line; c

151 Antibody class switching in activated B cells uses class switch r

152 for somatic hypermutation and immunoglobulin class switching in activated B cells.

153 ctive transducer of IFN-gamma-mediated IgG2a class switching in B cells and emphasize the importance

154 The suppression of IgA class switching in B cells by a macrophage-derived stero

155 -dependent and T cell-independent IgM-to-IgD class switching in B cells of the human upper respirator

156 ptides that block interleukin-4 mediated IgE class switching in B cells yielded 13 peptides that sele

157 nal epithelial cells (IECs) triggered IgA(2) class switching in B cells, including IgA(1)-expressing

158 formation of germinal centers and inhibited class switching in B cells, which yielded a unique reper

159 te as it is central to the initiation of IgE class switching in B cells.

160 ect activation-induced deaminase to initiate class switching in B cells.

161 frequency, but this treatment suppresses IgA class switching in B1 cells.

162 f autoantigen specificities and autoantibody class switching in BXD2 and control (C57BL/6) mice and h

163 IgG responses, suggesting defective isotype class switching in CD73-deficient mice.

164 HEJ is insufficient to impact immunoglobulin class switching in DEK knockout mice.

165 fferentiation and overrode IL-21-induced IgG class switching in favor of IgA.

166 hensively measured the landscape of antibody class switching in human adult twins using antibody repe

167 ther CD45 also plays a regulatory role in Ig class switching in human B cells, we examined the effect

168 salivary prostaglandin E2 triggers antibody class switching in mature B cells, increasing the levels

169 attenuated immunoglobulin G2 (IgG2) and IgA class switching in systemic and intestinal lymphoid foll

170 T cells are playing a role in regulating Ig class switching in the absence of CD4(+) T cells.

171 Furthermore, IgG1 class switching in the GCs was impaired.

172 he S(mu) tandem repeats are not required for class switching in the mouse immunoglobulin H-chain locu

173 use line that completely failed to induce Ig class switching in vitro and in vivo.

174 increase the fraction of B cells undergoing class switching in vitro.

175 ed T cell-dependent B cell Ab production and class switching in vivo after antigen challenge.

176 We further demonstrate that AhR suppresses class switching in vivo after influenza virus infection

177 an important role in antibody production and class switching in vivo.

178 enome that are mechanistically important for class switching in vivo.

179 -21-induced proliferation and immunoglobulin class-switching in B cells, cytokine production in T cel

180 B cells undergo maturation and class-switching in response to antigen exposure and T-ce

181 t IL-17 plays a role in Ab production and Ig class-switching in response to infection and that COX-1

182 of a Th2 influence on B cell immunoglobulin class-switching in the IL-10 Tg group.

183 globulinemia, nonspecific B cell activation, class switching, increased cell turnover, breakage of to

184 , nonspecific B cell activation, nonspecific class switching, increased cell turnover, breakage of to

185 arable somatic hypermutation frequencies and class-switching indicated affinity-matured antibodies in

186 double-strand breaks associated with isotype class switching induce Blimp-1 transiently, independentl

187 From humans to frogs, immunoglobulin class switching introduces different effector functions

188 Antibody class switching is a feature of the adaptive immune syst

189 Class switching is activation-induced cytidine deaminase

190 Isotype class switching is central to the humoral immune respons

191 Immunoglobulin (Ig) class switching is central to the maturation of the anti

192 Immunoglobulin class switching is crucial for the generation of antibod

193 ability of A2 mice to undergo immunoglobulin class switching is due to deficient CD4 helper T cell fu

194 Even though class switching is essential for mounting a protective r

195 atible with the idea that division-linked Ig class switching is in part due to CDK2-regulated AID nuc

196 Class switching is initiated by activation-induced cytid

197 Immunoglobulin (Ig) class switching is initiated by deamination of C-->U wit

198 During class switching, isotype-specific targeting occurs indep

199 city of PSD95(pdz3) quantitatively towards a class-switching ligand.

200 low affinity IgE is generated through direct class switching (mu-->epsilon) and is much less mutated.

201 affinity IgE is generated through sequential class switching (mu-->gamma-->epsilon) in which an inter

202 rlichial infection is to promote appropriate class switching, not lineage specification.

203 C B cell differentiation, proliferation, and class switching occur but are defective.

204 Because the DSBs that initiate class switching occur during the G(1) phase of the cell

205 Class switching occurs by a deletional recombination bet

206 Ab class switching occurs by an intrachromosomal recombinat

207 Antibody class switching occurs in mature B cells in response to

208 IgH class switching occurs rapidly after activation of matur

209 Class switching occurs through class switch DNA recombin

210 e class switch recombination, suggested that class switching occurs within the ectopic lymphoid tissu

211 Class switching of alloantibody to a high-affinity IgG r

212 a cytokine that promotes T-cell-independent class switching of B cells to IgA.

213 t of B cells into the lamina propria and IgA class switching of B cells.

214 creased proliferation, survival, and thereby class switching of ex vivo-activated B cells.

215 ar differentiation, GC B cell frequency, and class switching of GC B cells to IgG1.

216 C T cell frequency, GC B cell frequency, and class switching of GC B cells to IgG1.

217 to increased local clearance via PGDH or the class switching of lipid mediators from the prostaglandi

218 protein (CD40-muIg) binding, and rescued IgG class switching of naive B cells in vitro.

219 nograft recipients, anti-CD154mAb may reduce class-switching of anti-pig antibodies by binding both T

220 found significant expansion, retention, and class-switching of autoreactive B cells in GCs under con

221 h2 cells and are capable of inducing isotype class-switching of B-cells to produce IgE after allergen

222 nd peripherally by somatic hypermutation and class-switching of the rearranged genes.

223 esults suggest a mechanism for decreased IgG class switching or production.

224 dergone immunoglobulin (Ig) heavy chain gene class switching or somatic hypermutation.

225 -cell subsets to generate IgE(+) PCs and the class switching pathways involved.

226 ycle time of approximately 11 h, and that Ig class switching preferentially occurred in the late G1 o

227 d, suggesting that the later appearance of a class-switching reaction was dependent on the evolution

228 s and supports a controllable immunoglobulin class-switching reaction.

229 ugh upregulating differentiation-related and class switching-related genes, indicating a potential ro

230 Whether ECs initiate class switching remains unknown.

231 Ig class switching requires cell proliferation and is divis

232 PP IgA class switching requires innate lymphoid cells, which pr

233 Before Ig class switching, RNA transcription through the specific

234 lp in germinal center reactions that support class switching, somatic hypermutation, and the generati

235 induce B cell maturation and immunoglobulin class switching than cells from HIV progressors.IMPORTAN

236 and implicate an alternative pathway for IgE class switching that involves generation and joining of

237 ls, end-joining activity, and immunoglobulin class switching that rely on 53BP1.

238 production is thought to involve sequential class-switching that requires input from T cells.

239 the need for multiple stimuli to induce IgA class switching, the relative contribution of B cell sub

240 ardians' orchestrating frontline IgG and IgA class switching through a Toll-like receptor-inducible s

241 e they act to limit TfH responses and B cell class switching through antigen presentation.

242 ng B cells, and show that p53 inhibits IgG2a class switching through its antioxidant-regulating funct

243 IL-4 signaling promotes IgE class switching through STAT6 activation and the inducti

244 gesting a possible defect in T cell help and class switching to anti-AChR IgG(2) isotype.

245 To address this issue, we asked whether class switching to different Ig isotypes could occur in

246 Ig alpha constant region gene and to direct class switching to IgA antibodies.

247 New evidence suggests isotype class switching to IgA can occur in the absence of mIgM.

248 TNFSF13, a cytokine involved in plasma cell class switching to IgA.

249 Thus, LSF represses class switching to IgA.

250 n in response to interleukin 4 (IL-4), hence class switching to IgE and IgG1, is not fully understood

251 xamined the effects of CD45 triggering on Ig class switching to IgE and its relationship with CD45 JA

252 th cytokines synergistically promoted B-cell class switching to IgE and plasma cell differentiation.

253 B cells determines their capacity to undergo class switching to IgE ex vivo, with the GC-derived B ce

254 ed for the interleukin-4 (IL-4) induction of class switching to IgE in B cells lacking BCL-6.

255 incubated with IL-4 and anti-CD40 to induce class switching to IgE in vitro, mCD23 is upregulated, a

256 evealed that the Bryo-mediated inhibition of class switching to IgE occurred independently of the num

257 0 signaling, cell proliferation, and de novo class switching to IgE were analyzed by RT-PCR and FACS.

258 irst evidence of local receptor revision and class switching to IgE, and B-cell differentiation into

259 cell development, germinal center formation, class switching to IgE, and lung inflammation.

260 sation of CD4(+) T cell responses and B cell class switching to IgE.

261 ivated by cytokines that regulate Ig H chain class switching to IgE.

262 ter that controls immunoglobulin heavy chain class switching to IgE.

263 -driven activation of the Cepsilon locus and class switching to IgE.

264 f mucosal tissues of allergic disease favors class switching to IgE; and the exceptionally high affin

265 s with broader IGHV gene usage and extensive class switching to IgG and IgA subclasses with limited s

266 pendent mechanism of selective regulation of class switching to IgG and IgE and further suggest disti

267 rrelia-specific Ig isotypes, the kinetics of class switching to IgG, and the complexity of the Ags re

268 d defects in L. mexicana-specific Ig isotype class switching to IgG1 and IgG2a and reduced total IgE

269 patches and provide indirect help for B-cell class switching to IgG1 in both transnuclear and wild-ty

270 ng MOG to the transgenic T cells and undergo class switching to IgG1 in the presence of the transgeni

271 TII cells alone induce T helper 2-associated class switching to IgG1, but few AFC or GC B cells expre

272 antibody response with preferential isotype class switching to IgG1, IgG2a, IgG2b, and IgG3, as well

273 ve macrophage activation, and immunoglobulin class switching to IgG1, were enhanced in Batf3(-/-) mic

274 gM(+)IgD(+)CD27(+) B cells into PCs, induced class switching to IgG2, and was reproducible in cocultu

275 ives B cells to undergo preferential isotype class switching to IgG2a and IgG3 subtypes.

276 et protein has been shown to be required for class switching to IgG2a.

277 cular understanding of the regulation of IgG class switching to IL-4-independent isotypes, particular

278 nase TBK1 as a pivotal negative regulator of class switching to the immunoglobulin A (IgA) isotype.

279 germline transcripts and inhibited efficient class switching to the immunoglobulin G1 isotype.

280 increased B cell death, low impairs antibody class switching to the pro-inflammatory IgG2c antibody i

281 Secondary analyses of GBCA class, switching to an alternative GBCA, and allergy ski

282 Cytokines direct IgH class-switching to a particular isotype by initiation of

283 (H)2 responses in T cells and immunoglobulin class-switching to IgE in B cells.

284 We found that class-switching to IgG1 biased the fate choice made by B

285 The resulting class switching was amplified by thymic stromal lymphopo

286 Ig class switching was completely reconstituted by expressi

287 numbers with Stat3-deficient TFH cells, IgG1 class switching was greatly increased.

288 Class switching was indicated by a shift from IgM to IgG

289 ying targeted antibody transgenes capable of class switching was monitored in immunized mice.

290 nses were significantly reduced and aberrant class switching was observed.

291 Class switching was restored in ICOS-/- mice by CD40 sti

292 in the face of robust Th2 generation, B cell class-switching was entirely dependent upon expression o

293 atic hypermutation (SHM), and immunoglobulin class-switching was performed.

294 These negative regulatory effects on Ig class switching were concomitant with the ability of CD4

295 ases in both regions and reduced heavy chain class switching, whereas Msh3-deficient mice had normal

296 capable of Ag-specific Ab production and Ig class switching, which is corroborated by transfer exper

297 th lymphocyte development and immunoglobulin class switching, which rely on the generation and repair

298 SBs through the cell cycle may ensure proper class switching while preventing AID-induced genomic ins

299 undergoing cytokine-specific immunoglobulin class switching with evidence of somatic hypermutation.

300 ic hypermutation with affinity selection and class switching within GCs and EF, are major contributor