ライフサイエンスコーパス: classical

1 Moreover, since the classical 12/23 rule for the V(D)J recombination fails t

2 The classical 2-oxoglutaric dehydrogenase complex can exist

3 C-MS) were significantly heritable under the classical ACE twin model (h(2) = 0.28-0.59), which inclu

4 llar-based device with longevity analyses of classical aging mutants (daf-2, age-1, eat-2, and daf-16

5 fidelity as a cost function, providing both classical and efficient quantum implementations.

6 he air/liquid water interface is studied via classical and first-principles molecular dynamics simula

7 Using advanced imaging methods and quasi-classical and fully quantum theory, we found that a sync

8 rmation of the C3 proconvertase and inhibits classical and lectin pathway activation upstream of C3 a

9 Activation of the classical and lectin pathway of complement may contribut

10 n vitro complement C3 deposition through the classical and lectin pathways in human serum and in mous

11 a novel ultrahigh-affinity inhibitor of the classical and lectin pathways of the complement cascade

12 mys, we examined the chromosome evolution by classical and molecular cytogenetics of both parental sp

13 The classical and most prevalent polyubiquitin chains are th

14 (PPARgamma) and retinoid X receptor (RXR) by classical and nonclassical THs as another molecular acti

15 ectrophoretic systems, microfluidic systems (classical and nonclassical), custom-built polymerase cha

16 Here, we demonstrate that classical and novel protein kinase C (PKC) isoforms dist

17 rk, and find a surprising richness in both a classical and quantum context.

18 Here we employ multiscale modeling within classical and quantum dynamics frameworks to investigate

19 h as ab initio energies) for applications in classical and quantum dynamics including reaction dynami

20 Efficient interconversion of both classical and quantum information between microwave and

21 d tunable polaritonic spintronic devices for classical and quantum information-processing application

22 The development of classical and quantum information-processing technology

23 for realizing mechanical oscillators in both classical and quantum regimes.

24 Immobilized human ApoE activated both the classical and the alternative complement pathways.

25 that expression of Interleukin-10 (IL-10), a classical anti-inflammatory cytokine, extends lifespan i

26 In a classical approach, several parameters obtained through

27 l explanations substantially outperforms the classical approach.

28 ies have focused on utilizing a Frequentist (classical) approach for obtaining single-point estimates

29 ey usually achieve superior performance over classical approaches, especially, when bigger training d

30 Instead of the classical ATM-Chk2 DDR, Mtb gains survival advantage thr

31 ts have been studied in-depth, especially in classical bacteriophages that infect Escherichia coli or

32 A classical battery converts chemical energy into a persis

33 In contrast, classical behavioral predictors of reading abilities and

34 for introduction across 18 countries for the classical biological control of weeds.

35 sion of CD163 and functionally distinct from classical bone marrow-derived macrophages.

36 l encephalitis cases in humans caused by the classical Borna disease virus (BoDV-1) has been increasi

37 s of the TAD hierarchy were more enriched in classical boundary marks and more conserved across cell

38 -binding region in C2A domain is longer than classical C2 domains and a novel Ca(2+) binding site in

39 and function of epithelial sheets depends on classical cadherin-containing adherens junctions, which

40 Classical cadherins are well-known adhesion molecules re

41 Classical capacitance studies have revealed that the fir

42 hemical reactivity and distinguish them from classical carbonyl compounds.

43 ectron-precise M=B triple bonds analogous to classical carbyne systems.

44 ike trains require the concerted action of a classical CaV-like channel and a potassium channel, BK (

45 glycan moieties and found that reactivity to classical CCD epitopes (core beta-1,2-xylose, alpha-1,3-

46 Its mode of action is distinct from classical CDAs.

47 th up to 5-fold higher expression level than classical cell-free systems.

48 Intermediate and non-classical cells are known to exhibit varying levels of p

49 ), lower than the threshold concentration in classical cellular sensors).

50 By analogy with the classical central venous pressure rules to assess a flui

51 nd in a mouse pneumonia model.Methods: Total classical (CH50) and alternative complement (AH50) funct

52 carbon-hydrogen (C-H) bond activation using classical chemical methods (i.e. high temperature, rare

53 in other vertebrates, and, unlike polymorpic classical class I, we anticipate that it may bind to a c

54 This classical clinical picture can be preceded by diabetes m

55 ia cluster analysis on model explanations to classical cluster analysis on the original data.

56 While classical clustering algorithms have popularly been used

57 expression profiling revealed that RNLs and "classical" CNLs trigger similar transcriptome changes, s

58 science, promising unconditional security to classical communication and providing the building block

59 We address the quantum-classical comparison of phase measurements in optomechan

60 We also detected in vivo classical complement activation on CD4+ T cells in 14% o

61 Despite extensive examples that implicate classical complement proteins and their receptors in CNS

62 cular way in which quantum computing extends classical computing means that one cannot expect arbitra

63 This work stresses the need to revisit classical concepts concerning viral and tumour immunity,

64 Trace eyeblink classical conditioning was used to assess the impact of

65 Rather than the classical core-shrinking mechanism often used to rationa

66 ntribution, we investigate the bipartite non-classical correlations (NCCs) of a system formed by two

67 actions, complement is activated through the classical (CP), the alternative (AP), and the lectin pat

68 Mechanistic studies suggested a classical cross-coupling catalytic cycle.

69 In addition to classical cross-couplings involving preformed or preacti

70 Classical culture-based methods (CCBM) suggest that colo

71 Cells identified as classical DC subsets, cDC1s and cDC2s, and lacking Fcgr1

72 ighly reactive bonding groups, as is done in classical DCC, is often not feasible or desirable, as it

73 Type 1 classical DCs (cDC1), which depend on the transcription

74 Classical DCs include type 1 and type 2 subsets, which c

75 has become increasingly evidenced that this classical definition has left substantial gray areas in

76 sm, such as photorespiration, and reveal how classical definitions of metabolic pathways have overlap

77 of independently controlling all of light's classical degrees of freedom simultaneously.

78 PS; progenitors, monocytes, macrophages, and classical dendritic cells) are controlled by signals fro

79 spectrum of clinical symptoms, ranging from classical dengue fever to severe dengue hemorrhagic feve

80 ar syncytia were found to have deviated from classical developmental patterns.

81 agnostic accuracy than the one observed with classical diagnostic markers.

82 Classical diffractive optics are 2D diffractive optical

83 Very few abnormalities were detected by classical diffusion MRI metrics, such as fractional anis

84 chromatin localization patterns, often lack classical DNA-binding domains, presenting challenges in

85 While classical DOF measurements empirically correlate with bl

86 The classical drug development pipeline necessitates studies

87 The limitations of classical drugs have spurred the development of covalent

88 dispersion-corrected DFT calculations, quasi-classical dynamics calculations, and experiments to stud

89 al crises have led to the understanding that classical econometric models are limited in comprehendin

90 show that end-to-end learning is on par with classical encodings for embeddings of the same dimension

91 reted from living cells independently of the classical endoplasmic reticulum-Golgi exocytic route.

92 relation with the Hannay angle obtained from classical equations of motion.

93 ing is a fundamental quantum process with no classical equivalent, which can compete with Coulomb int

94 nd NIR-II luminophores, which complement the classical established complexes of expensive precious me

95 on Thr and Tyr residues and phosphorylates a classical eukaryotic protein kinase substrate in vitro T

96 ution in a reactive environment and identify classical evaporation-condensation as the mechanism gove

97 As a classical example, we demonstrate the influence of isome

98 roscopy of basket cells (BCs), we found that classical excitatory postsynaptic currents (EPSCs) are f

99 state, with low clonal expansion, unlike the classical exhausted state observed in primary HCC.

100 oshinskii-Moriya (DM) interactions adhere to classical expectations.

101 induced responses to IgG IC independently of classical FcgammaR, but optimal responses required FcRn

102 ned stimulus (US)-related information during classical fear conditioning, thereby having an indispens

103 ystem, these feedforward pathways define the classical feedforward receptive field (ffRF), the area i

104 reading frame, a feature uncharacteristic of classical flaviviruses.

105 dy shows that 54.5% of index cases display a classical FSHD phenotype with typical facial and scapula

106 t, whereas a few relatives (10.0%) display a classical FSHD phenotype.

107 experimentally reveal that the predicted non-classical function of CBX7 is biologically significant f

108 ng comparative genome structure analysis and classical genetic mapping approaches feasible.

109 Taking a classical genetics approach coupled with genome-wide ana

110 rs to lack resident neurogenic precursors or classical glia marked by sox10, plp1a, gfap or s100 Rath

111 ion rate misclassified patients according to classical glomerular filtration rate categories in appro

112 However, classical Golgi staining studies did not find interneuro

113 and reached at least nominal significance in classical GWAS.

114 with significantly different risk levels for classical hamartoma-related features (odds ratio [OR] ra

115 Several of the 11 classical HDAC enzymes are necessary for optimal Treg fu

116 Here, we use the classical Helfrich-Canham model for the RBC membrane to

117 n hematopoiesis, these tools reconstruct the classical hematopoietic hierarchy and detect couplings b

118 e key heterocyclic aglycon 7, (i) a six-step classical heterocyclization starting from 5-chloro-1-met

119 For example, classical Hodgkin lymphoma is characterized by an inflam

120 hort of patients with relapsed or refractory classical Hodgkin lymphoma was a post-hoc decision.

121 Unlike the malignant cells in classical Hodgkin lymphoma, the disease-defining lymphoc

122 nanoparticles offer a much richer basis than classical homogeneous and heterogeneous catalysts for tu

123 the likelihood of future PD not captured by classical HRV metrics.

124 tric stimulation rodent model which displays classical HS damage similar to that found in patients wi

125 Complimentary to classical hydroboration and boron-Wittig reactions, a ne

126 Herein, we highlight that non-classical hydrogen bonding (NCHB), likely resulting from

127 ers of this transcription, distinct from the classical hypoxia-inducible factor pathway.

128 globulin (swIg(+)) MBC populations; however, classical IgM MBCs waned rapidly, whereas swIg(+) and at

129 y B cell (MBC) response was mediated by both classical immunoglobulin M (IgM) (IgM(+)CD27(+)) and swi

130 In the classical incubation of drug craving rat model, drug see

131 Astrocytes perform classical innate immune functions, which contradict the

132 xpanding the role of this pathway beyond its classical interpretation in 'clock and wavefront' models

133 ical and collisional environment of the cold classical Kuiper Belt and therefore informs the accretio

134 orizons spacecraft's encounter with the cold classical Kuiper Belt object (486958) Arrokoth (provisio

135 Complement activation products covering the classical/lectin (C4d), alternative (C3bBbP) and common

136 id 4-mercaptopyridine ligand presents a more classical lifted octahedral coordination of the metallop

137 The (limiting) null distribution of the classical likelihood-ratio statistic is often intractabl

138 uantum metrology, can be translated into the classical linear optical framework.

139 ified more significant associations than the classical LMM.

140 n of low-dimensional random projections and "classical" low-dimensional hexagonal grid cell responses

141 leukocyte analysis indicated monocytosis and classical M1 phenotypic shifts.

142 We study the two-sender classical MAC, the simplest and best-understood network,

143 for single amino acids, as compared to more classical manually-curated encoding strategies, has not

144 R-375 expression, whereas ATOH1 knockdown in classical MCC cell lines reduced miR-375 expression.

145 on effects using a computationally efficient classical mean field method.

146 ten fundamental equations, including that of classical mechanics, fluid physics, statistical physics,

147 Beyond classical metabolic functions in energy storage and ener

148 tion that is competitive with the best known classical method, the Number Field Sieve.

149 rievers vs. 6 (22.2%) of those treated with "classical methods").

150 (29.2% vs. 15 (55.6%) in those treated with "classical methods", p=0.024).

151 We fine-mapped the classical MHC (chr6: 29.6-33.1 Mb), imputing 216 human l

152 phism (11 alleles), as was expected of a non-classical MHC gene.

153 Confocal microscopy and molecular and classical microbiology were used to investigate microasp

154 erstanding of MS pathogenesis, away from the classical model in which T cells were the sole central a

155 Our results support and further define the classical model of apical membrane traffic at the tip of

156 leatherwood and also call into question the classical model of lignification, which purports that li

157 The classical model of tip growth, which predicts bulk secre

158 ling researchers to extend beyond the set of classical model organisms to include novel species from

159 rom organelles to the nucleus in a lineal or classical model.

160 These values cannot be explained with classical models for optical outcoupling.

161 correlations stronger than those allowed by classical models.

162 ormational changes pose unique challenges to classical molecular dynamics simulations, as well as som

163 Since the utility of classical molecular genetics beyond model species is lim

164 nclassical patrolling monocytes but preserve classical monocyte and macrophage numbers and functions.

165 Furthermore, the classical monocyte subset of DNMT3A mutation carriers sh

166 ecific cellular subsets: pro-inflammatory or classical monocytes (Ly6c(Hi)) and pro-reparative or non

167 nocytes (Ly6c(Hi)) and pro-reparative or non-classical monocytes (Ly6c(Lo)).

168 Data revealed a decrease of classical monocytes accompanied by an increase of both C

169 esized that inherent differences in Ly6c(Hi) classical monocytes and Ly6c(Lo) non-classical monocytes

170 y6c(Hi) classical monocytes and Ly6c(Lo) non-classical monocytes determine susceptibility to perinata

171 In steady state, classical monocytes give rise to vasculature-resident ce

172 Pharmacologic inhibition of Ly6c(Lo) non-classical monocytes in this setting restored susceptibil

173 TLR2 expression on CD14 + + classical monocytes isolated in an acute phase from DENV

174 Glomerular endothelium and non-classical monocytes overexpressed a distinct chemokine a

175 but subsequent recruitment and retention of classical monocytes was associated with glomerular damag

176 RRV-mediated liver injury when Ly6c(Lo) non-classical monocytes were expanded.

177 During NTN, non-classical monocytes were recruited first, but subsequent

178 peripheral blood revealed reductions of non-classical monocytes, and subsets of NK and T lymphocytes

179 L-18 along with more robust induction of non-classical monocytes.

180 Contrary to the classical monomeric model, indirect evidence suggests th

181 Classical Monte Carlo simulations based on exchange inte

182 Studies in classical mouse model systems have provided evidence tha

183 otential to eliminate bottlenecks known from classical MS approaches, such as speed, reproducibility,

184 ted to be more appropriate and flexible than classical multivariate linear methods.

185 sclera, which sets these muscles apart from classical muscle-to-bone type of insertions.

186 Traits associated with classical mutants were consistent with reported phenotyp

187 llows ER-escaped glycoproteins to bypass the classical N-glycosylation trimming pathway involving ER

188 e MAS, as applied here, included besides its classical NADH oxidation reaction the generation of cyto

189 Ac (slan) antigen identifies a subset of non-classical (NC) monocytes in the bloodstream, namely the

190 ying network communication in the brain with classical neuroscience methods and demonstrate possible

191 In addition to classical neurotransmitters, neuropeptides are emerging

192 In addition to classical neurotransmitters, neuropeptides have emerged

193 ral recognition of small molecules using the classical ninhydrin agent is introduced.

194 After subtracting classical noise, our measurements show that the quantum

195 mer and a catalytic subunit (DNA-PKcs), is a classical non-homologous end-joining (cNHEJ) factor(1).

196 the large catalytic subunit (DNA-PKcs), is a classical nonhomologous end-joining (cNHEJ) factor.

197 ajor pathways, homology-dependent repair and classical nonhomologous end-joining.

198 sfer (HAT) chemistry is at play, rather than classical Norrish hydrogen atom abstraction as initially

199 ion of atomic-scale imaging, simulations and classical nucleation theory calculations, we investigate

200 By quantitative analyses based on classical nucleation theory, alpha' was obtained to be 3

201 When stimuli were presented in the classical oddball paradigm at jittered ISI (0.8-1.2 s),

202 pattern, leading to decreased expression of 'classical' oestrogen-regulated genes and was accompanied

203 Classical OFT predicts that dietary preferences do not c

204 We observe classical one-step pathways and nonclassical two-step pa

205 improved for quantum computers to outperform classical ones in useful tasks.

206 ly - and make suggestions for overcoming the classical opposition between the cultural versus cogniti

207 xciton diffusion length associated with most classical organic semiconductors used in organic photovo

208 en-bond exchange can occur (either through a classical over-the-barrier process or through quantum-me

209 th century in Sardinia (Italy) by the use of classical paleoparasitological techniques coupled with n

210 by a week, resulted in profound reduction of classical pathway activity lasting for at least 7 weeks.

211 dose-dependently reduces free C2 levels and classical pathway activity.

212 l domain of C3b has an important function in classical pathway C5 convertase activity.

213 thway for pERK operates in parallel with the classical pathway for pERK, whereas PKCdelta phosphoryla

214 e of vesicles into astrocytes follows a more classical pathway involving dynamin, clathrin, sorting e

215 ydroxylase, the rate-limiting enzyme for the classical pathway of bile salt synthesis.

216 In addition to the classical pathway of secretion, some transmembrane prote

217 athway-mediated C3 cleavage, hC3Nb3 inhibits classical pathway-driven hemolysis, suggesting that the

218 ingly, although the nanobody does not affect classical pathway-mediated C3 cleavage, hC3Nb3 inhibits

219 Furthermore, hC4Nb8 inhibits the classical pathway-mediated immune complex delivery to fo

220 nanobody prevents C3 deposition through the classical pathway.

221 hough excessive activation of the lectin and classical pathways contributes to multiple autoimmune an

222 We also identify a subset of non-classical PDAC samples that exhibit the HNF1A/KDM6A-defi

223 This is in contrast to the classical perception of EMT as leading to a binary choic

224 wo orders of magnitude more elastic than the classical plasma membrane suggesting a physical explanat

225 xplore higher-order topological states in 3D classical platforms.

226 he field that are not always associated with classical polymer networks, such as the advent of crysta

227 rein, we report a modified procedure for the classical Pomeranz-Fritsch protocol, which expands the s

228 two orders of magnitude higher than those of classical porous solids.

229 onless measure of heat transport-follows the classical power law of [Formula: see text] up to [Formul

230 We applied rPCA methods and classical principal component analysis (cPCA) on an RNA-

231 ur findings show that Neurog2 functions as a classical proneural gene to regulate the temporal progre

232 Its proposed function is inhibiting the classical protein nuclear import pathway mediated by imp

233 These dual updates echo and contextualize classical psychological models of learning, in particula

234 Classical psychometric theory, mostly focused on individ

235 ce in experimental research that complements classical psychometrics.

236 complex I in combination with hybrid quantum/classical (QM/MM) free energy calculations to explore ho

237 ld advanced intercross with a combination of classical QTL mapping of red colouration as a quantitati

238 [1 + 2] cycloaddition is a classical reaction between the electrophilic phosphinide

239 pon the interaction between signals from the classical receptive field (CRF) and the extra-classical

240 lassical receptive field (CRF) and the extra-classical receptive field (eCRF) in primary visual corte

241 muli that are rapidly changing outside their classical receptive fields.

242 Classical reinforcement learning (CRL) has been widely a

243 been shown to counteract the effects of the classical renin-angiotensin system.

244 RGC differentiation from stem cells utilized classical RGC signaling pathways mimicking retinal devel

245 rrent perception of the supremacy of current classical risk predictors for myocardial infarction, inc

246 substitution patterns that do not conform to classical S(E)Ar regioselectivity rules can be readily a

247 efore based on similar electronic factors to classical S(N) Ar chemistry, which implies the destabili

248 uld need to be superpolynomially faster than classical SAT solvers.

249 n have been found to consistently outperform classical scoring functions.

250 oped to facilitate the discovery of such non-classical secreted proteins; however, the existing metho

251 Among all the secreted proteins, 'non-classical' secreted proteins are difficult to identify a

252 um circuit as a joint dynamic system both in classical sensorimotor contexts and reward-related, cogn

253 loid LKB1 deficient mice had AMs with a 'non-classical' (SiglecFlowCD11bpos) phenotype.

254 We identified classical signatures of stress response in M. inflexa, i

255 rger system sizes than what is achievable by classical simulation.

256 ity to 3D segment wild-type cells as well as classical size and shape mutants.

257 lular cysteine protease belonging to the non-classical small optic lobe (SOL) family of calpains, an

258 processing conditions, analogous to those of classical soapmaking.

259 Specifically, we study various classical spin systems and identify the jamming point of

260 aper, compositional data analysis (CoDa) and classical statistical analyses, to demonstrate (1) how a

261 udying biomedical data may hinder the use of classical statistical methods.

262 ing pai-related interactions are embodied in classical statistical potentials.

263 These factors do not serve classical structural roles, but rather regulate matrix p

264 It outlines multiple examples of classical structure sensitivity on nanoparticle-based ma

265 Classical studies have suggested a role for Ca(2+) and p

266 Classical studies suggest that growth hormone (GH) secre

267 turbulence dynamics of the interface in the classical sub- and supercritical regimes.

268 matter volume (GMV) involving the cortex and classical subcortical foci, 2) a preponderance of region

269 She displayed classical symptoms commencing with fever, followed by pe

270 pepper fields in Alabama that displayed the classical symptoms of bacterial spot disease caused by X

271 and is thought to greatly contribute to the classical symptoms of decreased processing speed and mem

272 mechanisms have shown that they diverge from classical synaptic plasticity mechanisms that process an

273 cal states with complex wavenumbers in other classical systems, further study of topological states i

274 Classical T4 phage engineering and several newly propose

275 However, unlike classical targeted therapies, it is currently solely bas

276 ould catalyze its chemical transformation, a classical task for transition metals.

277 wever, high performers present an absence of classical task-induced activations and, instead, stronge

278 tem evaluations of two patients revealed the classical TDP-43 pathology of FTD/ALS, as well as huntin

279 The classical teardrop shape of the joint PDF between Q and

280 The integration of classical theories through a contemporary lens of consis

281 hen the separation falls below 10-20 nm, the classical theory deteriorates progressively due to its n

282 The classical theory of respiration is that the siphon and D

283 and electron populations in analogous to the classical theta-pinches in laboratory plasmas.

284 eriments, electronic-structure theory, quasi-classical trajectory studies, and astrochemical modeling

285 Classical transection studies suggest that, in addition

286 genes in their native chromosomal locations, classical transgenesis is still the preferred experiment

287 ides boundaries to understand the quantum-to-classical transition in optomechanics.

288 Classical transmission to humans occurs via drinking wat

289 the regime of strong dipole moments where a classical treatment is possible.

290 rowth inhibitory potency superior to that of classical two- or three-drug combinations.

291 embles more the human situation, compared to classical two-dimensional endothelial cell cultures.

292 e during the unfolding transition suggests a classical two-state unfolding behavior.

293 generate similar results as compared to the classical two-step method (i.e. lipid extraction and FA

294 , to the outer membrane via a variant of the classical type I secretion system.

295 Classical veno-occlusive disease/sinusoidal obstruction

296 The classical view is that these representations take the fo

297 lar circuit function that extends beyond the classical view of error-driven supervised learning, as w

298 Recent studies indicate that the classical visual cycle works together with light-depende

299 1 females), we document, in the context of a classical visual SL task, divergent rhythmic EEG activit

300 c alterations in chRCC tumors, including the classical Warburg effect, the downregulation of gluconeo