ライフサイエンスコーパス: classical complement pathway

1 2GPI antibodies occurs primarily through the classical complement pathway.

2 ffinities for C1, the first component of the classical complement pathway.

3 ible transplantation and do not activate the classical complement pathway.

4 multiple amyloid regulation pathways and the classical complement pathway.

5 rarely with IgM indicating activation of the classical complement pathway.

6 h immune complex dependent activation of the classical complement pathway.

7 iphery by the activation and fixation of the classical complement pathway.

8 ts C1r and C1s of the first component of the classical complement pathway.

9 n through C1q fixation and activation of the classical complement pathway.

10 ace that recruit natural IgM to initiate the classical complement pathway.

11 so can bind C1q and act as inhibitors of the classical complement pathway.

12 lity of FX to protect Ad5 from attack by the classical complement pathway.

13 lization was mediated by natural IgM and the classical complement pathway.

14 ollate injection, suggesting a defect in the classical complement pathway.

15 or killing was mediated by activation of the classical complement pathway.

16 s to apoptotic cells, thereby activating the classical complement pathway.

17 ling of the lptA mutant occurred through the classical complement pathway.

18 s, which triggered activation of C1q and the classical complement pathway.

19 f C5 but not of downstream components of the classical complement pathway.

20 lement factor 1q (C1q) and activation of the classical complement pathway.

21 h FcgammaRI and FcgammaRII and activates the classical complement pathway.

22 great extent on its ability to activate the classical complement pathway.

23 mplement components C1q, C1r, and C1s of the classical complement pathway.

24 dothelium of the graft and activation of the classical complement pathway.

25 to GBS was associated with activation of the classical complement pathway.

26 that sialylation may indirectly regulate the classical complement pathway.

27 min) mediated through the antibody-dependent classical complement pathway.

28 in diseases accompanied by the activation of classical complement pathway.

29 ins, indicating a role for components of the classical complement pathway.

30 G2 donors showed significant reduction in classical complement pathway activation and decreased le

31 nt-mediated growth restriction by inhibiting classical complement pathway activation and impacted E.

32 Classical complement pathway activation did not promote

33 This protein blocked classical complement pathway activation in a comparable

34 gG3-triggered CML and to force a switch from classical complement pathway activation to C1q-dependent

35 via its most N-terminal SCR, which leads to classical complement pathway activation.

36 totoxic IgM anti-mouse antibodies and strong classical complement pathway activity with minimal alter

37 teps of complement and effectively depressed classical complement pathway activity, alternative compl

38 C1q is the target recognition protein of the classical complement pathway and a major connecting link

39 ion strongly inhibits both activation of the classical complement pathway and Ab-dependent cellular p

40 imannan immunoglobulin G (IgG) activates the classical complement pathway and accelerates initiation

41 s open a connection between the inflammatory classical complement pathway and connective tissue homeo

42 plement C1q protein, thereby attenuating the classical complement pathway and facilitating pneumococc

43 DRE females showed dysregulation of the classical complement pathway and lower TNFalpha and inte

44 C1q is the initiator of the classical complement pathway and opsonizes apoptotic cel

45 was protective in mice lacking a functional classical complement pathway and show that alternative c

46 C1q is the initiator of the classical complement pathway and, as such, is essential

47 and C1s, proteases required to activate the classical complement pathway, and C3 showed a significan

48 h C1q, leading to a strong activation of the classical complement pathway, and results in consumption

49 for exploring CRP-mediated activation of the classical complement pathway, and that the characteristi

50 s rapid and is mediated by components of the classical complement pathway; and that gC mainly protect

51 addition to AMR-triggered activation of the classical complement pathway, antibody-dependent cellula

52 vation but have fully active alternative and classical complement pathways, are protected from cardia

53 nonoverlapping epitopes, which activates the classical complement pathway as well as inhibits fH bind

54 The classical complement pathway associated proteins were ac

55 We hypothesized that activation of the classical complement pathway at the endothelial cell sur

56 that elicits serum antibodies that activate classical complement pathway bacteriolysis and also inhi

57 expressed in eukaryotic cells activated the classical complement pathway but not the alternative or

58 Modified forms of LDL activate the classical complement pathway, but no lectin pathway acti

59 nnii cells, indicating the activation of the classical complement pathway by NAbs.

60 The first step in the activation of the classical complement pathway, by immune complexes, invol

61 Deficiency of an early component of the classical complement pathway, C1q, C1r/C1s, C4, or C2, r

62 directly with the initiating protease of the classical complement pathway, C1r.

63 The results indicated that activation of the classical complement pathway (CCP) was a primary mechani

64 in and C1q, the recognition component of the classical complement pathway (CCP), which results in the

65 ndicated that genetic variation within early classical complement pathway components (C1q, C1r, and C

66 es have found non-immunological roles of the classical complement pathway (CP) in brain development a

67 L. longipalpis) as a potent inhibitor of the classical complement pathway (CP), its precise mechanism

68 cheal model of type 8 infection in mice with classical complement pathway deficiency.

69 cantly more resistant to antibody-dependent, classical complement pathway-directed bacteriolysis than

70 etic deficiencies of early components of the classical complement pathway (e.g., C1q, C4, and C2) are

71 ulted in normal functional properties of the classical complement pathway followed by reduced severit

72 at the characteristic of CRP to activate the classical complement pathway has no role in protecting m

73 es usually promote serum killing through the classical complement pathway; however, "cloaking antibod

74 V009 proved sufficient for inhibition of the classical complement pathway in all patients, as measure

75 ave been previously reported to activate the classical complement pathway in an antibody-independent

76 Thus, to investigate the role of the classical complement pathway in contusion-induced SCI, m

77 Inactivation of the classical complement pathway in normal human serum with

78 de the first direct genetic evidence for the classical complement pathway in the induction of EAMG in

79 cteria can activate both the alternative and classical complement pathways in the absence of specific

80 CMV-infected fibroblasts activated via the classical complement pathway independent of specific ant

81 time of human platelet-poor plasma or in the classical complement pathway, indicating that it is a sp

82 In addition, PepO binds the classical complement pathway inhibitor C4BP, thereby reg

83 Several gonococcal strains bind the classical complement pathway inhibitor, C4b-binding prot

84 tly, mice that lack a major component of the classical complement pathway initiation complex (C1q) bu

85 The first step of activation of the classical complement pathway involves the binding of the

86 The classical complement pathway is activated by antibody-an

87 The classical complement pathway is activated by antigen-bou

88 ntibodies (DSA) to bind C1q and activate the classical complement pathway is an efficient predictor o

89 The classical complement pathway is initiated by IgG molecul

90 The classical complement pathway is triggered when antigen-b

91 C1q, a key component of the classical complement pathway, is a major player in the r

92 C1q, the first component of the classical complement pathway, is also a pattern recognit

93 s to the donor endothelium that activate the classical complement pathway, it was hypothesized that p

94 bular head region of C1q and to initiate the classical complement pathway, leading to activation of C

95 We tested ex vivo the activation of the classical complement pathway on ICL CD4+ T cells.RESULTS

96 q-dependent C4b deposition on live bacteria (classical complement pathway), only those antibodies tha

97 opulation of the alternative rather than the classical complement pathway, previously not appreciated

98 itopes, engage C1q, activate C4, and mediate classical complement pathway SBA.

99 ), a meningococcal vaccine antigen, activate classical complement pathway serum bactericidal activity

100 ed to inhibit IgM-mediated activation of the classical complement pathway, since survival of the tspB

101 ase, primarily with the C1s inhibitor of the classical complement pathway sutimlimab, as well as with

102 nd ongoing activation of the alternative and classical complement pathways, the latter associated wit

103 nd altered self components, and triggers the classical complement pathway through activation of its a

104 um against N. gonorrhoeae is mediated by the classical complement pathway through an antibody-depende

105 cognize microbial pathogens and activate the classical complement pathway through C1q (refs 3 and 4).

106 lternative complement pathway as well as the classical complement pathway; trigger the formation of c

107 ermatomyositis result from activation of the classical complement pathway triggered by direct binding

108 We found that activation of the classical complement pathway up to C5 was sufficient to

109 Specific inhibition of the classical complement pathway using TNT003 or C1q-deplete

110 ese data indicate that ethanol activates the classical complement pathway via C1q binding to apoptoti

111 r, these data suggest that initiation of the classical complement pathway via C1q is detrimental to r

112 le levels, suggesting that activation of the classical complement pathway was not required for innate

113 Since IgM is a potent activator of the classical complement pathway, we examined IgM binding to

114 binding site of SpA and 2) proceeded via the classical complement pathway, we tested a panel of monoc

115 Immune complexes with activation of the classical complement pathway were found on the endotheli

116 Activation of the classical complement pathway with deposition of C3 is pa