ライフサイエンスコーパス: clastogenic

1 DNA adducts are mutagenic and clastogenic.

2 In contrast, clastogenic activity of these G4 ligands is countered by

3 uding its ability to form free radicals, its clastogenic activity, and its estrogenic activity, contr

4 ated histone H2AX (-H2AX) as compared with a clastogenic agent, camptothecin, indicating that the qua

5 T positive micronuclei, indicating that both clastogenic and aneugenic effects were involved.

6 creased the frequency of micronuclei by both clastogenic and aneugenic events.

7 Clastogenic and cytotoxic activities of all agents were

8 cation of, with 95% accuracy, the aneugenic, clastogenic and negative compounds within the data set (

9 ive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topois

10 tumor suppression and cellular resistance to clastogenic cancer therapeutics.

11 elevated somSV frequencies induced by known clastogenic compounds in human primary cells.

12 FANCG disruption also resulted in increased clastogenic damage on irradiation, but only FANCG disrup

13 FANCC and FANCG disruption caused increased clastogenic damage, G2/M arrest, and decreased prolifera

14 ion of chronic oxidative stress resulting in clastogenic DNA damage.

15 the key intermediate in the synthesis of the clastogenic DNA precursor, most likely dITP.

16 e degree of cellular hypersensitivity to the clastogenic effect of diepoxybutane and severity of clin

17 ators and radiotherapy patients can induce a clastogenic effect on naive cells, showing indirect indu

18 show that Aag protects against the toxic and clastogenic effects of 1,3-bis(2-chloroethyl)-1-nitrosou

19 ycosylase become sensitive to the lethal and clastogenic effects of alkylating agents.

20 When the clastogenic effects of BCNU and temozolomide were examin

21 ficantly to protection against the toxic and clastogenic effects of several chemotherapeutic nitrogen

22 atopoietic progenitor cells to the toxic and clastogenic effects of the antitumor agents 1,3-bis(2-ch

23 ility, death-inducing and bystander effects, clastogenic factors and transgenerational effects.

24 cells (death-inducing and bystander effects, clastogenic factors) and perpetuate genomic instability

25 Altogether our results support that clastogenic G4 ligands act as DNA structure-driven TOP2

26 ajor effector of cytotoxicity induced by two clastogenic G4 ligands, pyridostatin and CX-5461, the la

27 nd while some studies suggest that it may be clastogenic, its carcinogenicity has not been demonstrat

28 ature, can form spatter mounds, ramparts and clastogenic lava flows.

29 halein has been shown to have estrogenic and clastogenic properties.

30 However, 7 was clastogenic when examined in vivo in rat micronucleus as