ライフサイエンスコーパス: clathrin heavy chain

1 eolin-1 (CAV-1) and dynamin-2 (DNM2) but not clathrin heavy chain.

2 that also bind to the terminal domain of the clathrin heavy chain.

3 n of epsin 1 with the terminal domain of the clathrin heavy chain.

4 ubunit with the amino-terminal domain of the clathrin heavy chain.

5 55 kDa N-terminal fragment from the 190 kDa clathrin heavy chain.

6 as a domain with resemblance to a region of clathrin heavy chain.

7 odes the last 654 amino acid residues of the clathrin heavy chain.

8 ferrin receptors (TfRs) and negative for the clathrin heavy chain.

9 ricarboxylate transport protein and a bovine clathrin heavy chain.

10 length CvpA interacted with AP2 subunits and clathrin heavy chain.

11 the regulatory clathrin light chain bound to clathrin heavy chain.

12 nal region of OCRL, but not of INPP5B, binds clathrin heavy chain.

13 with a small interfering RNA specific to the clathrin heavy chain.

14 essory proteins, most of which interact with clathrin heavy chain.

15 dle directly by the amino-terminal domain of clathrin heavy chain.

16 g human cancers that involve gene fusions of clathrin heavy chain.

17 reduced in a chicken B cell line depleted of clathrin heavy chain.

18 ) in ARH and to the N-terminal domain of the clathrin heavy chain.

19 in combination with a temperature-sensitive clathrin heavy chain.

20 nd altered the intracellular distribution of clathrin heavy chains.

21 protein zeta/delta, annexin A1/A3/A4/A5/A6, clathrin heavy chain 1, glyceraldehyde-3-phosphate dehyd

22 per, we report that RNAi depletion of CHC17 (clathrin heavy chain 17) clathrin, but not the CHC22 cla

23 Clathrin heavy chain 22 (CHC22) is an isoform of the wel

24 s an isoform of the well-characterized CHC17 clathrin heavy chain, a coat component of vesicles that

25 The clathrin heavy chain accesses the same contact surface o

26 The C-terminal part of CALM binds clathrin heavy chain, although the full-length protein e

27 ntaining alpha-solenoids related to those of clathrin heavy chain and COPI subunits.

28 AP-2 interacts with the clathrin heavy chain and cytoplasmic domains of receptor

29 Among them, we identified clathrin heavy chain and dynamin 1 as potential candidat

30 The knock-downs of clathrin heavy chain and dynamin produced maximal inhibi

31 We found that LdRab5b interacts with clathrin heavy chain and hemoglobin receptor.

32 e the binding site to residues 89-100 of the clathrin heavy chain and indicate that residues 1-100 ca

33 studies have shown that ACK1 interacts with clathrin heavy chain and is involved in clathrin-coated

34 ion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecul

35 ification of protein such as PfSortilin, the clathrin heavy chain and PfDyn1 as potential interactors

36 T40 to inactivate the endogenous alleles for clathrin heavy chain and replace them with human clathri

37 preference for light chains associated with clathrin heavy chain and show that Hip1R stimulation of

38 nvolves amino acid residues 1315-1557 of the clathrin heavy chain and the carboxy, but not the amino-

39 contrast, other endocytic proteins, such as clathrin heavy chain and the large GTPase dynamin-1, bin

40 athrin-coated vesicles at the TGN (the Chc1p clathrin heavy chain and the Vps1p dynamin homolog) and

41 ight chains to alter the conformation of the clathrin heavy chain and thereby regulates assembly.

42 n assembles into triskelia composed of three clathrin heavy chains and associated clathrin light chai

43 Vesicular structures containing both clathrin heavy chains and PtdIns(4,5)P2 are revealed imm

44 CD63, clathrin heavy chain, and beta-adaptin mRNAs, all of whi

45 However, LdRab5a failed to interact with the clathrin heavy chain, and interaction with hemoglobin re

46 Three clathrin heavy chains associated with clathrin light cha

47 receptor causes rapid phosphorylation of the clathrin heavy chain at tyrosine 1477, which lies in a d

48 2 and promotes binding of beta-arrestin 2 to clathrin heavy chain/beta-adaptin, thereby accelerating

49 clathrin light chain-binding domain nor the clathrin heavy chain-binding motif were needed for virus

50 Further more, A1AT associated with clathrin heavy chains, but not with caveolin-1 in the pl

51 We trace most of the 1,675-residue clathrin heavy chain by fitting known crystal structures

52 Reduced expression of the clathrin heavy chain by HCV prevents ENT1 recycling to t

53 cDNA selection protocol, we isolated a novel clathrin heavy chain cDNA (CLTD) from the VCFS/DGS minim

54 w that clathrin adaptor interaction sites on clathrin heavy chain (CHC) are repurposed during mitosis

55 naling involves inducible phosphorylation of clathrin heavy chain (CHC) in both CD4+ and CD8+ human T

56 The clathrin heavy chain (CHC) is the major structural prote

57 individualization complex in a male-sterile clathrin heavy chain (Chc) mutant is observed to be redu

58 Like partial loss-of-function Clathrin heavy chain (Chc) mutants, aux mutant males are

59 edistributed the adaptor protein AP2 and the clathrin heavy chain (CHC) to surface membranes.

60 Clathrin heavy chain (Chc), a major constituent of coate

61 exhibited increased association of Egfr with clathrin heavy chain (CHC), Gab1, and p85alpha, the regu

62 The ubiquitous clathrin heavy chain (CHC), the main component of clathr

63 nduced phagocytosis requires GULP binding to clathrin heavy chain (CHC).

64 stmitotic Golgi reassembly that requires the clathrin heavy chain (CHC).

65 , composed of clathrin light chain (Clc) and clathrin heavy chain (Chc).

66 Here, we report that clathrin heavy chain (CHC-1), a membrane coat protein we

67 ull allele is also synthetically lethal with clathrin heavy chain (chc1) temperature-sensitive allele

68 In humans, there are two isoforms each of clathrin heavy chain (CHC17 and CHC22) and light chain (

69 tion and function compared with conventional clathrin heavy chain (CHC17), encoded on chromosome 17.

70 was shown to bind to two proteins, including clathrin heavy chain, Chc1p.

71 The muscle isoform of clathrin heavy chain, CHC22, has 85% sequence identity t

72 We examined clathrin heavy chain (ClaH-GFP) which localized to three

73 elium cell line revealed important roles for clathrin heavy chain (clathrin) in endocytosis, secretio

74 ted hits included Rab GTPases Rab1 and Rab4, Clathrin heavy chain, clathrin adaptor protein genes AP-

75 c1p displayed no defects in Clc1p binding to clathrin heavy chain, clathrin trimer stability, sorting

76 have previously shown that mESCs lacking the clathrin heavy chain (Cltc), an essential component for

77 mples from a variety of cancers, we identify Clathrin Heavy Chain (CLTC), Ezrin, (EZR), Talin-1 (TLN1

78 hal screen identified DRS2/SWA3 along with a clathrin heavy-chain conditional allele (chc1-5/swa5-1)

79 The clathrin heavy chains continue inwards under the vertice

80 In the current study, fusion of ALK with the clathrin heavy chain (CTLC) gene localized to 17q23 was

81 uppressors that can rescue lethal strains of clathrin heavy chain-deficient yeast (Chc - scd1-i) to v

82 otillin had no effect on ATP7A localization, clathrin heavy chain depletion or expression of AP180 do

83 ntigen 1) and clathrin-mediated endocytosis (clathrin heavy chain) during entry into RFs.

84 shed roles in clathrin-mediated endocytosis (clathrin heavy chain, dynamin-2, heat shock 70-kDa prote

85 as well as treatment with Torin 1, degrades clathrin heavy chain expression in a hepatoma cell line.

86 ly 70% in B cells conditionally deficient in clathrin heavy chain expression.

87 , to inhibit endocytic pathways regulated by clathrin heavy chain, flotillin-1, caveolin-1, dynamin-2

88 concept by demonstrating that acute loss of clathrin heavy chain function in the fly eye leads to sy

89 An interesting characteristic of the yeast clathrin heavy chain gene (CHC1) is that in some strains

90 m and site-directed mutagenesis of the yeast clathrin heavy chain gene (CHC1) to characterize regions

91 hat carry a multicopy plasmid containing the clathrin heavy chain gene (CHC1), resulting in levels of

92 is a new temperature-sensitive allele of the clathrin heavy chain gene (chc1-5), which carries a fram

93 d with a temperature-sensitive allele of the clathrin heavy chain gene (chc1-521) in Saccharomyces ce

94 An exon representing a novel clathrin heavy chain gene (CLTCL) was isolated during ge

95 not identical to the ubiquitously expressed clathrin heavy chain gene.

96 rrying a temperature-sensitive allele of the clathrin heavy chain gene.

97 We report the cloning of a novel clathrin heavy-chain gene (CLTC)-TFE3 gene fusion result

98 In contrast, inactivation of the clathrin heavy-chain gene CHC1 results in transport of K

99 genetics, we sequenced parts of two unlinked clathrin heavy chain genes (CLTC and CLTCL1).

100 id sequence of this gene product to those of clathrin heavy chain genes of other species.

101 alpha(q) on Kir4.1, whereas knockdown of the clathrin heavy chain had no effect.

102 recruitment to membranes is mediated by the clathrin heavy chain (HC) N-terminal domain (TD), which

103 LC binding to clathrin heavy chain (HC) was characterized by genetic a

104 hVam6p binds through its clathrin heavy chain homology domain to a unique region

105 We investigate how the deletion of clathrin heavy chain impairs the dynamics and the morpho

106 STAT3 was constitutively associated with clathrin heavy chain in membrane and in the 1- to 2-MDa

107 ane is significantly less than the number of clathrin heavy chains in the assembly.

108 was strongly inhibited by siRNA depletion of clathrin heavy chain, indicating that CAT-1-HA-GFP inter

109 amin, or a dominant-negative hub fragment of clathrin heavy chain, indicating that it is mediated by

110 n triskelia but not the N-terminal domain of clathrin heavy chain, indicating that stabilization of k

111 coimmunoprecipitation demonstrated that the clathrin heavy chain is the major binding partner of CAL

112 ntracellular trafficking, and in humans, the clathrin heavy-chain isoform CHC22 is highly expressed i

113 A triskelion comprises three clathrin heavy chains joined at their C-termini, extendi

114 romised if clathrin levels fall by 20% after clathrin heavy chain knock down using RNAi.

115 Clathrin heavy chain knockdown and dileucine mutation of

116 anslocation and shown that it interrupts the clathrin heavy chain-like gene (CLTCL) within the MDGCR.

117 to the cytokinesis failure of Dictyostelium clathrin heavy-chain mutants.

118 -NT in yeast suppresses endocytic defects of clathrin heavy-chain mutants.

119 Combination of suppressor mutations with a clathrin heavy chain mutation (chc1-ts) confers no synth

120 when combined with a conditional mutation in clathrin heavy chain or deletion of GGA genes, accentuat

121 Transient silencing of NbCHC, encoding clathrin heavy chain, or the endosome marker gene NbAra6

122 r annexins I, II, IV, and VI; alpha-adaptin; clathrin heavy chain; or beta-coatomer protein.

123 ssense mutation in CLTCL1 encoding the CHC22 clathrin heavy chain, p.E330K, which we demonstrate to h

124 ly kinase activity is required for inducible clathrin heavy chain phosphorylation, BCR colocalization

125 Clathrin (heavy-chain) plaques and pits, expression of a

126 ,210-1,516 involved in mediating spontaneous clathrin heavy-chain polymerization and light-chain asso

127 other fundamental cellular processes (e.g., clathrin heavy-chain polypeptide, culreticulin, and Ras-

128 ion at a site at the N-terminal hooks of the clathrin heavy chains, presumably via the J domain of C5

129 re involved and deletion analysis mapped the clathrin heavy-chain regions participating in their form

130 and that its self-assembly is mediated by a clathrin heavy chain repeat domain in the middle of the

131 Both the CNH and clathrin heavy chain repeat domains are required for ind

132 conserved N-terminal domain and a C-terminal clathrin heavy-chain repeat (CHCR) domain.

133 ptor protein complex) interaction domain and clathrin heavy-chain repeat domain are required for prot

134 predicted protein contains six WD repeats, a clathrin heavy-chain repeat, and three transmembrane dom

135 lso shares structural features with HEAT and clathrin heavy chain repeats.

136 ith an inducible short hairpin RNA targeting clathrin heavy chain, resulting in approximately 85% pro

137 in cells expressing a temperature-sensitive clathrin heavy chain results in accentuated growth and a

138 her alpha adaptin (AP-2 clathrin adaptor) or clathrin heavy chain, revealing that Kir2.3 is internali

139 hree-dimensional framework for understanding clathrin heavy-chain self-assembly, light-chain binding

140 Knockdown of endogenous clathrin heavy chain showed that the Golgi apparatus fai

141 rimeric CHC22 protein does not interact with clathrin heavy chain subunits nor bind significantly to

142 s of clathrin-coated membranes, we expressed clathrin heavy chain tagged with green fluorescent prote

143 ity correlates with expression levels of the clathrin heavy chain TbCLH, and additional evidence sugg

144 bind weakly to the N-terminal domain of the clathrin heavy chain (TD).

145 uted to direct interaction of kindlin-2 with clathrin heavy chain, thereby controlling endocytosis an

146 have found that ACK2 directly interacts with clathrin heavy chain through a clathrin-binding motif th

147 rence to knock down the AP-2 mu2 subunit and clathrin heavy chain to undetectable levels in HeLaM cel

148 ty salt bridges which would otherwise induce clathrin heavy chains to assemble at physiological pH.

149 Depletion of clathrin heavy chain using RNA interference prolonged mi

150 After inactivation of clathrin heavy chain, vacuolar protease-dependent degrad

151 We present evidence for two clathrin heavy chain variants in the photoreceptor termi

152 centrated at clathrin-coated pits, and binds clathrin heavy chain via two clathrin boxes.

153 r ros sequences identified cellular RNA 7SL, clathrin heavy chain, visinin-like protein-1, and three

154 ies of ERICH3 interacting proteins including clathrin heavy chain which are known to play a role in v

155 he vertex may correspond to the C-termini of clathrin heavy chains which form a protrusion on free tr

156 assembly of recombinant hub fragments of the clathrin heavy chain, which bind clathrin light-chain su

157 ly, we further demonstrate that knockdown of clathrin heavy chain, which blocks clathrin-mediated end

158 The amino-terminal domain of the clathrin heavy chain, which folds into a seven-bladed be

159 ankyrin(R) binds to the N-terminal domain of clathrin heavy chain with high affinity.