ライフサイエンスコーパス: claustrum

1 located in the posterior-ventral part of the claustrum.

2 projections to either ipsi- or contralateral claustrum.

3 supporting a core/shell organization of the claustrum.

4 o contribute to broad integration within the claustrum.

5 o determine the cellular organization of the claustrum.

6 the contralateral neostriatum, thalamus, and claustrum.

7 right frontoparietal cortex and in the left claustrum.

8 key cerebral cortex (layers I-II) and in the claustrum.

9 s area, superior temporal gyrus, insula, and claustrum.

10 a perisylvian division travelling within the claustrum.

11 trosplenial and perirhinal cortices, and the claustrum.

12 striatum, lateral neocortex, or endopiriform claustrum.

13 layer 6, suggesting that they project to the claustrum.

14 s to suppress cortical signaling through the claustrum.

15 ergence of hyperactivation in the insula and claustrum.

16 ces send projections only to the ipsilateral claustrum.

17 zation of these projections within the mouse claustrum.

18 stral cells, enabling a clear delineation of claustrum.

19 ore intrinsic excitatory connectivity of the claustrum.

20 d and more evenly distributed throughout the claustrum.

21 , the ventral pulvinar nucleus (Pv), and the claustrum.

22 , and hypocretin (Hcrt) in the region of the claustrum.

23 tivity between a given cortical area and the claustrum.

24 (0.94 +/- 0.08 mum(2) ), intermediate in the claustrum (0.34 +/- 0.02 mum(2) ), and smallest in the d

25 common in the Pv (39%), intermediate in the claustrum (15%), and least common in the dLGN (12%).

26 Significance statement: The function of the claustrum, a brain nucleus found in mammals, remains poo

27 Here, we studied the role of claustrum, a key vSub input, in this incubation.

28 The human claustrum, a major hub of widespread neocortical connect

29 reas of the neocortex are connected with the claustrum, a nucleus located between the neocortex and t

30 The claustrum, a poorly understood subcortical structure loc

31 Non-human studies suggest that the claustrum, a small subcortical nucleus, coordinates slow

32 Here, we report that the claustrum, a subcortical nucleus implicated in cognitive

33 Claustrum activity during reward acquisition was also en

34 Sensory-evoked claustrum activity is thought to modulate the neocortex'

35 Using fiber photometry, we found elevated claustrum activity prior to an expected cue during corre

36 hat recurrent excitatory circuits within the claustrum alone are unlikely to integrate across multipl

37 the bed nucleus of the stria terminalis, the claustrum (alpha1G), the olfactory tubercles (alpha1H an

38 The entire claustrum also receives a serotonergic input.

39 Tracer injections in the claustrum also revealed hundreds of labeled neurons thro

40 anterior and middle cingulate gyrus, insula/claustrum, amygdala/periamygdala, lingual and middle tem

41 ntred around the left putamen, including the claustrum, amygdalostriatal transition area and other ad

42 er, we discover pathological activity of the claustrum and a region near the posterior inferior front

43 nal capsule and the surrounding gray matter (claustrum and amygdala).

44 frontal eye fields, dysfunctional pulvinar, claustrum and amygdaloid subnuclei of the amygdala, the

45 the piriform lobe, such as the endopiriform claustrum and basolateral amygdala.

46 nction of the neural projections between the claustrum and cortical areas remain largely unknown.

47 ne expression profiles akin to the mammalian claustrum and deep cortical layers, while certain nidopa

48 Latexin was detected in the claustrum and dorsal endopiriform nucleus, but not in co

49 ibited highly concentrated expression in the claustrum and endopiriform nucleus, as well as in a subp

50 Moreover, the birthdates of the claustrum and Layer 6b are similarly precocious in mice.

51 module exhibits a unique position within the claustrum and overlaps substantially with other modules

52 the interhemispheric connections between the claustrum and primary motor (MI) cortex, anterograde tra

53 reased relative [14C]AA incorporation in the claustrum and pyramidal cell layer of the hippocampus co

54 enetic unit gives rise to the insular cortex/claustrum and should therefore be considered a most vent

55 evolutionary origin of the cells that become claustrum and subplate, a likely scenario that is shared

56 death of the neurons that contribute to the claustrum and subplate.

57 MC regions also receive projections from the claustrum and the basal forebrain and project to the cau

58 The connections between the claustrum and the cortex in mouse are systematically inv

59 5-HT2A-mediated network coupling between the claustrum and the cortex, leading to attenuation of cano

60 sms underlying the communication between the claustrum and the cortex.

61 regulation of the communication between the claustrum and the cortical modalities.

62 developmental and evolutionary origin of the claustrum and the subplate.

63 nectivity with the right ventral putamen and claustrum and the temporoparietal junction.

64 ood extinction rats in select regions of the claustrum and ventral hippocampus.

65 terior insula" that may arise, in part, from claustrum and/or peri-insular projections to the anterio

66 three subcortical structures (the pulvinar, claustrum, and amygdala).

67 veral subcortical regions (external capsule, claustrum, and amygdala).

68 pic organizations have been described in the claustrum, and anatomical studies in cats, monkeys, and

69 parvalbumin-positive interneurons within the claustrum, and cortical afferents is also consistent wit

70 x, alpha5 mRNA was detected in the subplate, claustrum, and endopiriform nucleus at embryonic day 18

71 stinct subregions of the thalamus, striatum, claustrum, and hippocampus showed a varied pattern of ec

72 nally comparable to the mammalian neocortex, claustrum, and pallial amygdala (all of which derive fro

73 by the hypothalamus and basal forebrain, the claustrum, and the brainstem.

74 ons of the pulvinar, two subdivisions of the claustrum, and the interlaminar portions of the lateral

75 IPCG bilaterally, the right anterior insula/claustrum, and the left cerebellum.

76 n involving the ventral lateral putamen, the claustrum, and the white matter underneath the frontal l

77 Thus, the gene set required for the claustrum appears to be broadly conserved across species

78 ent sizes in bat claustrum compared with rat claustrum are consistent with events occurring in popula

79 ogical data suggested that most cells in the claustrum are large neurons that both receive cortical i

80 eral claustrum, but those to the ipsilateral claustrum are less numerous.

81 trinsic and extrinsic connections of the rat claustrum are structured for rapid, interhemispheric tra

82 hemical-based approaches typically treat the claustrum as a relatively narrow anatomical region that

83 ingled populations of labeled neurons in the claustrum, as well as many double-labeled neurons.

84 inuously distributed across the dorsoventral claustrum axis.

85 Finally, we performed claustrum axon silencing experiments which revealed that

86 In vivo imaging of claustrum axons revealed responses to both unimodal and

87 ital, and perirhinal cortices as well as the claustrum, basal forebrain, thalamus, epithalamus, hypot

88 y and the three-dimensional structure of the claustrum based on a variety of molecular and anatomical

89 include accumbens nucleus, caudate putamen, claustrum, bed nucleus of the stria terminalis, amygdalo

90 OS expression increased significantly in the claustrum, bed nucleus of the stria terminalis, medial p

91 Inactivation of claustrum but not areas dorsolateral to claustrum decrea

92 sends dense projections to the contralateral claustrum, but those to the ipsilateral claustrum are le

93 as a very early developmental marker of the claustrum (CL) proper in the mouse.

94 However, the function of the claustrum (CLA) and its neural projections remains large

95 e of the basolateral amygdala complex (BLC), claustrum (CLA) and PIR.

96 re we show that the principal neurons of the claustrum, claustrocortical (ClaC) projection neurons, r

97 efrontal cortex), emotional aspects of pain (claustrum, closely connected to amygdala) and motor cont

98 The smaller event sizes in bat claustrum compared with rat claustrum are consistent wit

99 The claustrum complex is viewed as fundamental for higher-or

100 nd dorsal-ventral topographic arrangement of claustrum connections and clear rostral-caudal topograph

101 The claustrum connects with a broad range of cortical areas

102 ive anatomical studies demonstrated that the claustrum connects with many cortical areas, the functio

103 cortex is at the extreme caudal limit of the claustrum, consistent with classical definitions of insu

104 The claustrum contains a significant projection by MCH axons

105 Carollia's claustrum contains cells whose intrinsic connectivity an

106 Here, we report that the claustrum coordinates neocortical SW generation.

107 The claustrum core projects predominantly to frontal-midline

108 Functional connectivity changes in claustrum-cortical circuits during electric barrier-indu

109 ks, this may explain the manifold effects of claustrum damage on brain and behaviour.

110 n of claustrum but not areas dorsolateral to claustrum decreased incubation of oxycodone seeking afte

111 cal areas and should be considered part of a claustrum-DEn complex.

112 ly regulating impulsivity, activation of the claustrum disrupted attention in the 5-CSRTT.

113 dicate that the synaptic organization of the claustrum does not correspond to a driver/modulator fram

114 ubercle, nucleus accumbens, caudate-putamen, claustrum, dorsal endopiriform nucleus, and cingulate co

115 The Claustrum/dorsal endopiriform cortex complex (CLA) is an

116 The claustrum/endopiriform nucleus is a unique structure tha

117 Tmem163 genes were both concentrated in the claustrum/endopiriform nucleus, as reported in mice, but

118 GNG2 was expressed strongly in the claustrum/endopiriform nucleus, but was abundant across

119 ion in the upper layers (layers 2-4) and the claustrum/endopiriform nucleus.

120 ation histochemistry was performed for such "claustrum-enriched" genes in the marmoset brain.

121 In this model, we propose that the claustrum entrains canonical cortical network states, an

122 edge about the origin and development of the claustrum, especially in primates, is still limited.

123 ense, widespread connections from the dorsal claustrum, extending along its entire rostral-caudal len

124 together are a ventromedial extension of the claustrum for major regions of the temporal and frontal

125 lating the concentration of serotonin in the claustrum, for example, caused a matching modulation of

126 Here, we review the varied models of claustrum function and synthesize them with developments

127 Early hypotheses of claustrum function were fueled by neuroanatomical data a

128 The claustrum has been the subject of intense research inter

129 Our quantitative results show that the claustrum has strong reciprocal and bilateral connection

130 och's primary interest in the claustrum: the claustrum has widespread extensive connectivity with the

131 (DEn), which lies immediately ventral to the claustrum, has connections with limbic cortical areas an

132 By showing that DEn and claustrum have parallel sets of connections, these resul

133 Here we report that a homologue of the claustrum, identified by single-cell transcriptomics and

134 ditioned stimulus, suggesting a role for the claustrum in associative learning.

135 cussed mainly with regard to the role of the claustrum in cognitive functions and that of MCH in REM

136 t with more recent proposals implicating the claustrum in detecting sensory novelty or in amplifying

137 isphere, whereas wSI does not project to the claustrum in either hemisphere.

138 ons are the dominant interneuron type in the claustrum in fetal macaque, and their maturation is inde

139 late cortex and orbitofrontal cortex) to the claustrum in mice.

140 The role of the claustrum in Pavlovian heart rate (HR) conditioning was

141 The role of the claustrum in processing limbic information, however, is

142 Our study identified a novel role of claustrum in relapse to opioid drugs after abstinence in

143 showed that wMI projects most densely to the claustrum in the contralateral hemisphere, whereas wSI d

144 nscriptomic approaches, we also identified a claustrum in the turtle Trachemys scripta, a distant rep

145 Each class was found throughout the entire claustrum, in all functionally defined subdivisions.

146 nd mainly located in the dorsal and anterior claustrum, in regions known to project to frontal, motor

147 We find that the claustrum, in turn, sends widespread projections prefere

148 g after electric barrier-induced abstinence; claustrum inactivation had no effect on incubation after

149 task, we found that neurons in the anterior claustrum, including putative optotagged claustrocortica

150 In vitro optogenetic stimulation of the claustrum induced excitatory postsynaptic responses in m

151 Claustrum inhibitory cells containing parvalbumin, somat

152 wake mice, we demonstrate that the effect of claustrum input to the cortex differs depending on brain

153 rphanol produced a bilateral deactivation of claustrum, insula, and putamen, areas activated during i

154 oming-specific interactions within the right claustrum/insula extending inferiorly into the amygdala

155 whereas auditory-specific imagery recruited claustrum/insula.

156 in the ipsilateral hemisphere including the claustrum, insular and perirhinal cortices; (4) unexpect

157 atomical tracers to map projections from the claustrum-insular region to the medial prefrontal and an

158 atomical data, it has been proposed that the claustrum integrates activity across sensory modalities.

159 Recent evidence indicates that the rat claustrum interconnects the motor cortical areas in both

160 c region, stria terminalis, medial amygdala, claustrum, internal capsule, and globus pallidus.

161 The claustrum is a brain region that has been investigated f

162 The claustrum is a densely interconnected structure involved

163 The claustrum is a functionally and structurally complex bra

164 The function of the claustrum is a fundamental issue in neuroscience.

165 The claustrum is a gray-matter structure that underlies neoc

166 The claustrum is a small subcortical structure with widespre

167 The claustrum is a small, elongated nucleus close to the ext

168 The claustrum is a subcortical structure reciprocally and to

169 The claustrum is a telencephalic gray matter structure with

170 The claustrum is an intriguing brain structure, featuring th

171 emerging picture is one in which the rodent claustrum is closely tied to frontal/limbic regions and

172 The claustrum is connected with the cerebral cortex.

173 The claustrum is densely connected to the cortex and partici

174 In lower mammals, the claustrum is directly adjacent to neocortex, making the

175 Altogether, our data indicate that the claustrum is integrated into higher-order premotor circu

176 omical data and yielded suggestions that the claustrum is involved in processes ranging from salience

177 Finally, our study reveals that the claustrum is likely not a continuance of subplate neuron

178 The claustrum is made up of distinct deep (subplate-like) an

179 al, and functional studies indicate that the claustrum is most highly interconnected with prefrontal

180 as drug addiction.SIGNIFICANCE STATEMENT The claustrum is one of the most mysterious brain regions.

181 The claustrum is one of the most widely connected regions of

182 Anatomical data indicate that the rat claustrum is part of an interhemispheric circuit that co

183 We have previously shown that the claustrum is part of an interhemispheric circuit that in

184 Although the rodent claustrum is probably involved in the interhemispheric c

185 The claustrum is proposed to mediate a variety of functions

186 The claustrum is therefore an ancient structure that was pro

187 The claustrum is thus not involved in the generation of the

188 The overall size of claustrum, its pronounced vascularity, and its more comp

189 ation signal was also seen in the neocortex, claustrum, lateral amygdala, ventral cochlear nucleus, r

190 led neurons were abundant in the allocortex, claustrum, lateral septum, bed nucleus of the stria term

191 ulum of the hippocampus, dorsal tenia tecta, claustrum, lateral septum, dorsal striatum, nucleus accu

192 inent in the neocortex endopiriform nucleus, claustrum, lateral septum, ventral forebrain, hypothalam

193 in the right subinsular region including the claustrum, left caudate and putamen, right middle occipi

194 Here, we systematically review claustrum lesion studies and discuss their functional im

195 During this time, the claustrum, like many other brain regions, has been studi

196 rminals, suggesting that many neurons of the claustrum make extensive intraclaustral connections.

197 lfactory bulb, the endopiriform nucleus, the claustrum, many parts of retrohippocampal allocortex, an

198 ilencing experiments which revealed that the claustrum may operate bidirectionally to maintain enhanc

199 This connectivity pattern suggests that the claustrum may preferentially subserve executive function

200 ersistent subplate cells in Layer 6b and the claustrum might have similar origins.

201 The possibility that the claustrum might mediate a more "global" function has bee

202 egions of cortex are innervated by different claustrum modules.

203 ulation, producing approximately 1 spike per claustrum neuron, affects many fast spiking (FS; putativ

204 Therefore, the details underlying how claustrum neurons broadcast information to cortical netw

205 Furthermore, we found that claustrum neurons encoded upcoming movement during inter

206 uring intertrial intervals and that pairs of claustrum neurons exhibiting synchronous firing were enr

207 ty, connectivity, and activity of identified claustrum neurons in Mus musculus to understand how the

208 ity of specific ensembles of similarly tuned claustrum neurons may modulate cortical activity.

209 eased as a function of processing hierarchy; claustrum neurons projecting to primary sensory cortices

210 Claustrum neurons projecting to vSub were activated duri

211 egions receive common input from a subset of claustrum neurons shared by neighboring modules, whereas

212 Individual claustrum neurons were responsive to inputs from more th

213 Recording from claustrum neurons while mice performed a tactile-visual

214 types, including striatal, hypothalamic, and claustrum neurons.

215 In the claustrum, non-GABAergic terminals (0.34 +/- 0.01 mum(2)

216 ere the medial striatum, olfactory tubercle, claustrum, nucleus accumbens, septum, substantia innomin

217 g around retrogradely labeled neurons in the claustrum of both hemispheres.

218 e-dependent subjects and the lateral putamen/claustrum of control subjects were observed at a weaker

219 he MI-Fp region has few connections with the claustrum of either hemisphere, both whisker regions pro

220 forepaw region sends few projections to the claustrum of either hemisphere.

221 substrate for information processing in the claustrum of the cat by analyzing the patterns of immuno

222 amidal neurons, the endopiriform nucleus and claustrum of the insular cortex, the globus pallidus, th

223 Studies on gene expression in the developing claustrum of the mouse have clarified the relationships

224 ling suggests a directional influence of the claustrum on activity in this piDLPFC region, and diffus

225 However, the impact of the claustrum on cortical activity is not fully understood,

226 ntiated parts of the traditional cortex, the claustrum, or the striatum, and these parts belong to fo

227 nd inhibitory cell types may enable parallel claustrum outputs to independently coordinate distinct c

228 The mammalian claustrum, owing to its widespread connectivity with oth

229 ft caudate nucleus and right lateral putamen/claustrum (p < 0.05, determined by threshold-free cluste

230 nections, these results suggest that DEn and claustrum perform similar functions in processing limbic

231 ons of Y1 immunoreactivity were found in the claustrum, piriform cortex (superficial layer), arcuate

232 so consistent with recent proposals that the claustrum plays a role in detecting salient stimuli or a

233 Carollia claustrum possesses intrinsic excitatory connectivity su

234 Interestingly, the claustrum-prefrontal cortex pathway also regulates metha

235 The claustrum-prefrontal cortex pathway may be a novel targe

236 sults provided preclinical evidence that the claustrum-prefrontal cortex regulates impulsivity.

237 Here, we show that neurons of rhesus macaque claustrum primordium are generated between embryonic day

238 The cells of the claustrum primordium express Nr4a2; they are formed in c

239 positive) are formed in the deep part of the claustrum primordium in the lateral pallium, but they mi

240 Furthermore, optogenetically inhibiting the claustrum prior to the onset of the cue reduced choice a

241 n mice to selectively monitor and manipulate claustrum projection neurons during 1-choice versus 5-ch

242 The present results suggest that the claustrum projections may help coordinate the activity o

243 eported the widely divergent organization of claustrum projections, others describe parallel claustro

244 This indicates that the same part of the claustrum projects to the whisker representations in bot

245 Tract tracing revealed that the reptilian claustrum projects widely to a variety of forebrain area

246 rified the relationships and identity of the claustrum proper and related endopiriform nuclei.

247 neurons (WMNs), peri-claustral WMNs, and the claustrum proper project to the putamen.

248 rior parietal lobule, and hippocampus; right claustrum/putamen, lateral prefrontal gyrus, and middle

249 d with increased activity in the ipsilateral claustrum (r = 0.51, P < 0.05), cerebellum (r = 0.43, P

250 reciprocal connections with the pulvinar and claustrum; received afferents from the locus coeruleus,

251 rcuit-based approaches can suggest a broader claustrum region containing projections to the neocortex

252 ions studies support the hypothesis that the claustrum regulates cortical excitability.

253 ermine if functional connectivity changes in claustrum-related circuits predict incubation of oxycodo

254 Though the claustrum remained relatively obscure throughout the las

255 rimental studies, the functional role of the claustrum remains unknown.

256 Other FEF connections were with the claustrum, reticular nucleus, zona incerta, lateral post

257 neus, right anterior cingulate cortex, right claustrum, right middle and inferior frontal gyri, and r

258 d function that will permit unique access to claustrum's processing capabilities.

259 Hence, the claustrum should not be universally regarded as an integ

260 Finally, chronic claustrum silencing specifically reduced animals' sensit

261 Prolonged claustrum stimulation affects many more cortical neurons

262 Our findings reveal that claustrum stimulation increased single-cell variability

263 Brief claustrum stimulation, producing approximately 1 spike p

264 ful (in aMCC) and non-painful (contralateral claustrum) stimulation, while similar habituation for bo

265 In addition, EphA5 protein was found in the claustrum, stria terminalis, barrel cortex, and striatal

266 Instead, the circuitry of the claustrum suggests an integration of convergent cortical

267 These results suggest that the claustrum supports a cognitive control function necessar

268 Unilateral or bilateral lesions of the claustrum suppress the production of sharp-wave ripples

269 nial cortices; CA1/subiculum of hippocampus; claustrum, tania tecta, lateral septum, substantia innom

270 uced more labeled neurons in the ipsilateral claustrum than retrograde tracer injections in the MI-Re

271 send denser projections to the contralateral claustrum than to the ipsilateral one.

272 substrate for information processing in the claustrum that may allow integration of information acro

273 en retrograde tracers were injected into the claustrum, the highest density of labeled neurons in MI

274 ical areas send bilateral projections to the claustrum, the majority being denser on the ipsilateral

275 rts Crick and Koch's primary interest in the claustrum: the claustrum has widespread extensive connec

276 ve enabled the anatomy and physiology of the claustrum to be studied with the spatiotemporal and cell

277 showed that the neural projections from the claustrum to the prefrontal cortex regulates impulsivity

278 distribution of neurons projecting from the claustrum to these areas.

279 hich are Nr4a2-negative, migrate through the claustrum toward the pial surface to form layers (2-6a)

280 In Pogona, the claustrum underlies the generation of sharp waves during

281 iate cortex projections to the dLGN, Pv, and claustrum, using anterograde tracing and electron micros

282 psilateral and contralateral inactivation of claustrum-vSub projections decreased incubation after el

283 overlap of labeled terminals and soma in the claustrum was greatest when both tracers were injected i

284 ancis Crick, written with Christof Koch, the claustrum was suggested to be critically linked to consc

285 To provide clues to the function of the claustrum, we compare the synaptic arrangements of stria

286 Given its proportionately large claustrum, we hypothesized that the short-tailed fruit b

287 ilar patterns of cortical connections as the claustrum, we used anterograde and retrograde tracing te

288 Since some WMNsST were located adjoining the claustrum, we wanted to compare results for density and

289 The largest terminals in the claustrum were GABAergic (0.51 +/- 0.02 mum(2) ), and th

290 Many neurons in the claustrum were surrounded by parvalbumin, calretinin, GA

291 rojections to the neostriatum, thalamus, and claustrum when the whisker regions were injected, but no

292 projections from the sensory cortices to the claustrum, whereas frontal inputs are more extensive and

293 nt and restricted in distribution across the claustrum, whereas neurons projecting to the cingulate c

294 l inputs from a posterior-dorsal part of the claustrum, which has been previously reported to project

295 input from an anterior-ventral region of the claustrum, which has been reported to project to the vis

296 ncepts is the reciprocal connectivity of the claustrum with most, if not all, areas of the cortex.

297 tudy was to elucidate the connections of the claustrum with respect to the whisker representations in

298 ial strip located in the rostral half of the claustrum, with a second, smaller patch of cells in the

299 nterpreted to imply a relay function for the claustrum, with information from different functional co

300 whisker regions project to the contralateral claustrum, with those from the MI-RW region being denser