ライフサイエンスコーパス: clearance

1 RI binding and enhanced CD23-dependent serum clearance.

2 in CKD is maintained despite lower diuretic clearance.

3 Body size had no effect on clearance.

4 l response that persists well after parasite clearance.

5 ot required for in vitro or in vivo leukemia clearance.

6 antimicrobial peptides involved in pathogen clearance.

7 and either early or late survival, or fungal clearance.

8 role in initial viral infection, spread and clearance.

9 of proteins or target misfolded proteins for clearance.

10 e-displaying cells and drive efficient viral clearance.

11 t of two existing models for augmented renal clearance.

12 ut those constructed with CD28 exhibit rapid clearance.

13 g an IL-1beta functional significance in SaB clearance.

14 pithelial repair at the expense of bacterial clearance.

15 ntial for intestinal remodeling and helminth clearance.

16 n 90-day mortality or in faster MERS-CoV RNA clearance.

17 host inflammatory response but not bacterial clearance.

18 define age-specific changes that predict AD clearance.

19 iseases, are altered by the rate of nicotine clearance.

20 expressed in cancer cells, facilitates their clearance.

21 14% had a VLVL and 17% had spontaneous viral clearance.

22 tissue hypoperfusion as well as decreased LA clearance.

23 nism that plays an essential role in protein clearance.

24 chimeric receptor that improved solid tumor clearance.

25 intruding pathogens and dying host cells for clearance.

26 at are characterized by impaired mucociliary clearance.

27 ression, implicating mechanisms beyond renal clearance.

28 underlying fibrin(ogen)-dependent bacterial clearance.

29 d good oral bioavailability but high in vivo clearance.

30 ult host through increased hepatic bacterial clearance.

31 testinal inflammation and impaired bacterial clearance.

32 complete responders achieving mIDH1 mutation clearance.

33 (S protein) associated with rapid virologic clearance.

34 ain itself to prevent secretion and initiate clearance.

35 Biodistribution showed fast renal clearance.

36 to and cope with oxidative damage and immune clearance.

37 (19)F/(177)Lu-rhPSMA-7.3 revealed fast blood clearance (0.63 %ID/g at 1 h after injection), and the h

38 neurological deficits, and improved hematoma clearance, a function that normally requires microglia/m

39 T scores for both disease severity and viral clearance, a standardised HRCT score system for COVID-19

40 4]; P = .87) or with more rapid MERS-CoV RNA clearance (adjusted hazard ratio, 0.65 [95% CI, .30-1.44

41 e proinflammatory T cells promoted bacterial clearance after infection with Staphylococcus aureus and

42 Improved understanding of myelin clearance allows for the identification of pathways that

43 isodes during chronic HSV-2 infection; viral clearance always predominated within 24 hours of detecti

44 load in bronchial aspirates and faster viral clearance and a higher IFN-lambda to type I IFN ratio co

45 Clearance and adaptation to reactive oxygen species (ROS

46 e evolved in the airways such as mucociliary clearance and cough.

47 binding capacity, allowing increased splenic clearance and enabling several months of subclinical par

48 gnition receptor that opsonizes bacteria for clearance and functions as a damage-associated molecular

49 CD8 T cell response, preventing early viral clearance and immunopathology associated with CD8 T cell

50 re potentially accessible to increase myelin clearance and improve remyelination and recovery.

51 7 cells and synergized with antibody for RNA clearance and improved cell survival.

52 Slower plasma clearance and increased drug exposure over time of ALDC1

53 identified compounds with reduced metabolic clearance and increased in vivo half-life.

54 levant impact of IVIg on monoclonal antibody clearance and indirectly hint at an IVIg mechanism of ac

55 phage activation, which favored bactericidal clearance and led to a better survival rate.

56 Forest clearance and maize cultivation were initiated during pe

57 f muscle tissue followed by relatively rapid clearance and only slight increases in intracellular acc

58 atment regimen successfully attained sterile clearance and prevented disease reactivation.

59 h a contribution of antibodies to both viral clearance and progression to severe disease.

60 lting coupled behavior between toxic protein clearance and proteopathic phenomenology.

61 the healthy ecostate, coinciding with viral clearance and recovery.

62 sponsible for efficient myelin stripping and clearance and resident MPs being involved in axonal regr

63 mechanisms of neurofilament degradation and clearance and review new methods for future elucidation

64 2 nM and a solubility of 9 muM, showed lower clearance and seems better suited for in vivo studies.

65 raining profound improved whole-body glucose clearance and skeletal muscle insulin sensitivity along

66 Notably, we also observed complete tumor clearance and subsequent full protection against tumor r

67 r understanding of mechanisms of early viral clearance and the development of approaches to induce cl

68 mposed by plasmablasts and enhanced parasite clearance and the formation of protective humoral immune

69 ignaling and abrogates AM-dependent bacteria clearance and thereby causes extreme susceptibility to p

70 vestigate the mechanisms of LB formation and clearance and to screen and evaluate therapeutics target

71 of its localization, structure, aggregation, clearance and toxicity.

72 euticals are small molecules with fast blood clearance and urinary excretion.

73 (glymphatic) system facilitates brain fluid clearance and waste removal during sleep via glia-suppor

74 2 excretion correlated with lower free water clearance, and four patients developed mild hyponatremia

75 l migration, anoikis resistance, mesothelial clearance, and peritoneal metastasis in vitro and in viv

76 ial burden in the FRT, accelerated Chlamydia clearance, and reduced hydrosalpinx pathology.

77 After the initial viral clearance, animals were rechallenged with SARS-CoV-2 and

78 are chain-length dependent, impair pathogen clearance, antagonize phagocyte recruitment, diminish ph

79 On the other hand, mucociliary clearance appeared to play a less prominent role in the

80 on (day 7), abscess resolution and bacterial clearance are hindered in DeltafakA mutant-infected mice

81 al management of SAB should target bacterial clearance as soon as possible to minimize incremental ri

82 earlier observations of impaired glymphatic clearance associated with AD in humans.

83 chondrial dysfunction, impairment of protein clearance (associated with deficient ubiquitin-proteasom

84 ortical accumulation at 2 h followed by fast clearance at 24 h.

85 Secondary endpoints were Mf clearance at 6, 12, and 24 months; inactivation of adult

86 gnificant increase in electrolyte-free water clearance at week 6 (mean difference, 312 mL [95% CI, 26

87 e found minor fever resolution and virologic clearance benefits with chloroquine.

88 ance), inhaled ETX001 was able to accelerate clearance both when CFTR function was reduced by adminis

89 y and is implicated in protein secretion and clearance, but its role in alphasyn spread has yet to be

90 Rifapentine-isoniazid increased dolutegravir clearance by 36% (relative standard error 13%) resulting

91 ced colitis, loss of MHCII reduces bacterial clearance by decreasing binding of IgA to commensal and

92 BMN apoptosis, FasL and CD36 expression, and clearance by macrophages.

93 report that PKR regulates misfolded protein clearance by preventing it release through exosomes and

94 presenting cells and evades effective immune clearance by the adaptive response through (i) manipulat

95 and, has evolved several mechanisms to evade clearance by the host immune system.

96 onstrated significantly increased creatinine clearance calculated on POD3 (63.6 +/- 19.0 mL/min) comp

97 ge, defective mitochondrial biosynthesis and clearance, cell growth retardation, and cellular senesce

98 ed mice showed inefficient and delayed viral clearance compared with H1N1-infected mice.

99 ncreased, suggesting that increased blood TG clearance contributes to the decreased blood TG concentr

100 The kidney furosemide clearance correlated with iGFR (r=0.84) and the summary

101 e (SQOR) catalyzes the first step in sulfide clearance, coupling H(2)S oxidation to coenzyme Q reduct

102 osing in rats/NHPs and compared to the human clearance data (n = 18/27).

103 Preclinical clearance data were generated following intravenous dosi

104 However, infection clearance does not happen once infection is established,

105 migraine type 2 (FHM2) mutation have slower clearance during sensory processing, as well as previous

106 By virtue of their ideal renal clearance efficiency (60% injected doses at 24 h postinj

107 If not, latency strongly decreased clearance even at low latent cell frequencies.

108 rtemisinin resistance (delayed P. falciparum clearance following artemisinin-based combination therap

109 ting plumes are a consequence of inefficient clearance following synaptic release.

110 Prospective predictions of human hepatic clearance for anionic/zwitterionic compounds, which are

111 hich ultimately supported first-in-class FDA clearance for extragenital assays.

112 study to compare GFR with tubular secretory clearance for predicting kidney drug elimination, we eva

113 d in rats and monkeys and exhibited the slow clearance from circulation and tissue biodistribution ty

114 mmune responses and promotes effective virus clearance from infected lungs when apoptosis is absent.

115 Single-cell longitudinal estimates of HCV clearance from liver have never been reported previously

116 nonneutralizing antibody functions in viral clearance from neurons.

117 ity, aggregation, photodegradation, and slow clearance from the body.

118 The potential benefit of beta-amyloid clearance from the circulation via CR1-mediated mechanis

119 have generally been hampered by their rapid clearance from tumors, thus diminishing tumor-to-nontarg

120 ne with persistence: 2.48 mg/dL vs 1.65 with clearance, geometric means, P = .018).

121 80 mg compared to those administered 40 mg (clearance half-life 5.5 hours [95% confidence interval {

122 The parasite clearance half-life following artemether-lumefantrine tr

123 Surprisingly, we found that serum HBsAg clearance has only a minimal effect on the expansion of

124 ass spectrometry and measured GFR by iohexol clearance (iGFR).

125 e relationship to disease severity and viral clearance in COVID-19 patients.

126 TM inhibitor enhances isoniazid mediated Mtb clearance in macrophages as well as in murine infection

127 (99m)Tc-AGA-2 displayed faster blood clearance in mice and better radiochemical stability com

128 manner in vitro and attenuated Abeta uptake/clearance in mouse AD brain xenotransplants.

129 a novel therapeutic strategy to improve heme clearance in patients with hemolytic disorders.

130 An important mechanism of Abeta clearance in the brain is uptake and degradation by micr

131 Accelerated fungal clearance in the combination treatment group was associa

132 e group had a higher rate of microbiological clearance in the first follow-up blood cultures (92.3% v

133 ins, may result in reduced hepatic bacterial clearance in the juvenile host with septic shock.

134 tment because of the larger degree of tracer clearance in this early phase.

135 ated antigen-specific phagocytosis and tumor clearance in vitro.

136 5 nM and a solubility of 33 muM, showed high clearance in vivo but is a preferred tool in vitro.

137 Mean tesidolumab exposure decreased 34%, clearance increased 63%, and half-life decreased 41% com

138 pithelial fluid secretion and enhances mucus clearance independent of CFTR function.

139 nce (tracheal mucus velocity and mucociliary clearance), inhaled ETX001 was able to accelerate cleara

140 Effective clearance is critical, as mice with an aged platelet pop

141 d illness in healthy adults, as timely viral clearance is mediated by the functions of cytotoxic T ce

142 cokinetic measurements, we show that 25(OH)D clearance is reduced in CKD and may differ by race.

143 he presence of mechanisms dedicated to Abeta clearance is still lacking.

144 evealed high tumor uptake, sufficiently fast clearance kinetics from blood, low hepatobiliary excreti

145 in ARISTOTLE without severe renal (creatine clearance <=30 mL/min) or liver disease were included in

146 ureus (MSSA) bacteremia, including immediate clearance (<=24 hours) in 8 cases.

147 manipulating antimicrobial immunity and Mtb clearance may potentially serve in more effective therap

148 e cytochrome P450 (CYP) 2B11 as an important clearance mechanism for these drugs and suggest Greyhoun

149 patients supported CR4 as an active alphaSN clearance mechanism in this disease.

150 ation studies suggest that an enhancement of clearance mechanisms and/or promotion of an anti-inflamm

151 re standard practice, but dynamic influx and clearance mechanisms prevent delivery of a uniform dose

152 didate selection: (1) What are the important clearance mechanisms that mediate the disposition of my

153 lls encode several RNA polymerase and R-loop clearance mechanisms to limit replisome exposure to thes

154 n epithelial fluid secretion and mucociliary clearance.Methods: The effects of a novel low-molecular-

155 acity is critical to understanding how viral clearance might be mediated by memory cells and what fun

156 Mf clearance occurred within 2 days of initiation of DEC in

157 ay revealed high stability and low intrinsic clearance of 17d (T(1/2) > 145 min and CL(int(mic)) < 9.

158 Clearance of 25-hydroxyvitamin D in Chronic Kidney Disea

159 Chronic Kidney Disease (CLEAR), NCT02937350; Clearance of 25-hydroxyvitamin D3 During Vitamin D3 Supp

160 n capacity of less than 80%, or a creatinine clearance of 30 mL/min or more but less than 60 mL/min,

161 ss rating scale greater than 6, a creatinine clearance of 30-69 mL/min, or both.

162 f this vasomotion may contribute to impaired clearance of Abeta.

163 rticles, suggesting a phagocytic role in the clearance of AMFs.

164 y role of the glymphatic-lymphatic system in clearance of amyloid-beta and other proteins.

165 ote PS receptor-mediated virus infection and clearance of apoptotic cells.

166 In addition, the phagocytic clearance of apoptotic tumor cells (efferocytosis) enhan

167 c from the CNS into the periphery; following clearance of ATRT xenografts, B7-H3.BB.z-CAR T cells adm

168 RvD1 at the peak of inflammation accelerates clearance of bacteria, blunts PMN accumulation, and prom

169 atory immune responses of macrophages during clearance of blood-based pathogens.

170 rived immunosuppression were reversible upon clearance of brain insults.

171 Phagocytes are essential for clearance of CDC-producing bacteria; however, the mechan

172 utralizing antibodies that are essential for clearance of challenging pathogens.

173 mprove CD8(+) T cell immune surveillance and clearance of CHIKV infection could be a strategy for mit

174 8(+) T cells prior to infection enhanced the clearance of CHIKV infection in the spleen but had a min

175 successive rounds of alphaCD20 mAb-dependent clearance of circulating B cells.

176 nical implications for CNS drug delivery and clearance of CNS waste products, including Abeta, and fo

177 al administration overcomes the rapid ductal clearance of CPX, prolongs mammary tissue persistence, i

178 n the CNS, which potentially could overwhelm clearance of cytotoxic alphaSN species.

179 s of CD68 and F480 macrophages and increased clearance of damaged hepatocytes.

180 function that can be used to accelerate the clearance of drugs, metabolites, or toxins and reverse t

181 owever, about the mechanisms responsible for clearance of extracellular alphaSN.

182 nal change in the receptor regulated tightly clearance of fibrillar alphaSN by human monocytes.

183 expansion reduces lymph stasis and increases clearance of fluid and cells, including profibrotic macr

184 Vasomotion correlated with paravascular clearance of fluorescent dextran from the interstitial f

185 improvements in the prediction of the kidney clearance of furosemide and penciclovir.

186 ted mice displayed progressive physiological clearance of gold, with >85% elimination from the liver

187 infected mice, suggesting that delayed viral clearance of H5N1 (2:6) was due to the suppression of T

188 The functional mechanisms that lead to their clearance of harmful substances involve phagocytosis, en

189 Clearance of hepatitis C virus (HCV) results in rapid ch

190 dependent PLWH.IMPORTANCE Identification and clearance of HIV reservoirs is a major challenge in achi

191 inhibition of Nef to enhance immune-mediated clearance of HIV-infected cells.

192 s MHC-I is needed to promote immune-mediated clearance of HIV-infected cells.

193 TOLLIP mediates clearance of Huntington's disease-linked polyQ protein a

194 latency reversal followed by immune-mediated clearance of infected cells.

195 ains of pathogenic bacteria and promoted the clearance of intracellular Shigella within macrophages.

196 e associations may be explained by defective clearance of intraorgan microthrombi that have been prop

197 lly, we found that TIMP-3 can facilitate the clearance of its target metalloproteinases by bridging t

198 Clearance of low-level viremia that persists in most HIV

199 We hypothesized that clearance of medroxyprogesterone acetate (MPA) would inc

200 , which activates autophagy and enhances the clearance of misfolded proteins.

201 8-mediated degradation pathway to facilitate clearance of misfolded proteins.

202 , we sought to assess 3HP treatment-mediated clearance of Mtb infection in latently infected macaques

203 ising pH or apical perfusion did not improve clearance of mucus strands from CF airways.

204 on" (SDG 13) and "life on land" (SDG 15) via clearance of natural vegetation.

205 Loss of BLT1 signaling led to defective clearance of neutrophils from the inflamed joint and fai

206 to annual treatment for achieving sustained clearance of Onchocerca volvulus MF from the skin (P = .

207 ere collected to monitor the development and clearance of parasitemia, and plasma artefenomel concent

208 Clearance of pathogens by Kupffer cells is an important

209 LTBI, experimental evidence for 3HP-mediated clearance of persistent Mtb infection in human lungs has

210 (mice and dogs), and the biodistribution and clearance of pHLIP ICG in mice.

211 urnover of the endoplasmic reticulum and the clearance of protein aggregates.

212 the adult brain for the autophagy-dependent clearance of proteinaceous deposits, and its depletion i

213 eins: OPTN, NBR1, p62, NDP52, and TAX1BP1 in clearance of proteotoxic aggregates.

214 ults: PCN treatment resulted in an increased clearance of radioactivity from the brain as reflected b

215 trength of activation of indiscriminate host clearance of red blood cells while increasing the half-l

216 nd/or T cells are not only important for the clearance of SARS-CoV-2 but also play an early role in p

217 This suggests that tubular clearance of secretory solutes provides additional infor

218 on of exosomal degradation and could include clearance of stalled ribosomes from mRNA, poising mRNA f

219 However, the rapid clearance of Sunb-malate eye drops administered through

220 is a key E3 ligase in the autophagy-mediated clearance of SV proteins.

221 rotein scaffold manifested by the more rapid clearance of the Active ADC, while exhibiting minimal de

222 also has a role in proteostasis, influencing clearance of the amyloid beta peptide and phosphorylatio

223 ranscriptional factor T-bet only delayed the clearance of the bacterial mutant without fully rescuing

224 8%) in group II, IVA was given with complete clearance of the hemorrhage.

225 capability to track tissue distribution and clearance of the injected polymer over time.

226 ed mechanism of cytoprotection involving the clearance of the lethal excess of ROS molecules through

227 YP) enzymes is responsible for the intrinsic clearance of the majority of therapeutic drugs in humans

228 Clearance of the maternal protein dowry thus appears to

229 l size of Cu(5.4)O USNPs enables rapid renal clearance of the nanomaterial, guaranteeing the biocompa

230 on, reduced lung inflammation, and the rapid clearance of the Pneumocystis organisms.

231 om the LC-MRM assay were used to monitor the clearance of these lipases during biologics process deve

232 e ubiquitin-proteasome system, and defective clearance of these protein aggregates results in proteot

233 rring hours earlier, egg activation mediates clearance of these proteins through the Pan Gu kinase, w

234 o eliminate S. aureus deficient in vWbp, but clearance of these same microbes in WT mice was restored

235 ppeared to play a less prominent role in the clearance of those proteins after pulmonary delivery.

236 Rapid clearance of thrombolytics from blood following intraven

237 r, the clinical significance of the kidney's clearance of tubular secretory solutes is uncertain.

238 the pathogenesis of malaria by inducing the clearance of uninfected erythrocytes.

239 ependent on type III IFN for the control and clearance of virus infection, but the physiological basi

240 te cells of the immune system to trigger the clearance of viruses and subsequent killing of infected

241 Clearance of VT serotypes was consistent across differen

242 and the chemotherapy drug tamoxifen promoted clearance of Zika virus and multiple viruses in vitro or

243 rresponding to a pretreatment production and clearance of ~10(8) [10(7.7)-10(8.3)] IU/day.

244 We found lower kidney clearances of endogenous secretory solutes to be associa

245 to penciclovir), we calculated their kidney clearances on the basis of sequential plasma and timed u

246 ioimpedance sensor named EPA would score the clearance or malignancy involvement of dissected tumor m

247 he multifunctional Tc1 clone did not enhance clearance or significantly alter immunopathology.

248 re constructed to examine median time to HPV clearance overall, and by selected risk factors.

249 xpression (P = 2.1 x 10-3), and MTX systemic clearance (P = 4.4 x 10-2) explained 42% of the variatio

250 Haptoglobin and the Hb clearance pathway are therapeutic targets after aSAH.

251 utophagy is a highly conserved intracellular clearance pathway in which cytoplasmic contents are traf

252 Blockade of this Nedd8 clearance pathway with MLN4924 causes accumulation of mi

253 nvasively evaluate strategies to enhance the clearance properties of the BBB.

254 72 h of physiologic hyperglycemia, metabolic clearance rate of insulin was markedly reduced (P < 0.01

255 insulin resistance, and 3) reduces metabolic clearance rate of insulin.

256 ogression to high-grade SILs (HSILs) and the clearance rate were estimated at the lesion level.

257 e cell body is stronger, leading to a higher clearance rate.

258 evelopment, and Evaluation, ++--) and lesion clearance rates (risk ratio, 2.97; 95% confidence interv

259 gery showed the highest participant complete clearance rates (risk ratio, 7.73; 95% confidence interv

260 ance and disappearance, as well as metabolic clearance rates, were lower in the MHD group at 30 and 6

261 mice with CAA, which corresponded to slower clearance rates.

262 Early identification of augmented renal clearance remains challenging for the ICU physician.

263 However, the major driving force for clearance remains largely unknown.

264 testinal bleeding had the fastest eculizumab clearance, required the highest number of eculizumab dos

265 erplay among CO release kinetics, CO prodrug clearance, route of administration, and CO delivery effi

266 diated innate immune gene expression, and Ag clearance, so low parasitemia in comparison with haploty

267 cient immune phenotype that connects symptom clearance speed to differential antibody durability dyna

268 rk level), their immunocompetence (bacterial clearance tests) and their chemosensory specialization (

269 drier conditions coincided with renewed land clearance, the establishment of a permanent village and

270 Mucociliary clearance, the physiological process by which mammalian

271 Microglia and macrophages carry out hematoma clearance, thereby facilitating functional recovery afte

272 The primary endpoint was fever clearance time (FCT); secondary endpoints were treatment

273 d by viability criteria based on the lactate clearance to levels <=2.5 mmol/L within 4 h.

274 to multiple outcomes ranging from bacterial clearance to progressive or latent infection.

275 In ovine models of mucus clearance (tracheal mucus velocity and mucociliary clear

276 s associated with reticuloendothelial system clearance, tumor heterogeneity, and complexity of the tu

277 rpose [GFR measurement by urinary Creatinine Clearance (uCrCl) versus GFR estimation (eGFR) by the CK

278 n that neutrophils are crucial for S. aureus clearance, understanding the mechanism(s) driving the in

279 therwise lethal sepsis by enhancing pathogen clearance via the restoration of host immunity in an int

280 tween iGFR-predicted and measured furosemide clearance was 30.0%.

281 rs, 55.5% were men, mean baseline creatinine clearance was 87.8 ml/min, and mean duration of hospital

282 posite nanoparticles were injected and joint clearance was assessed via IVIS.

283 association of age with viral load and viral clearance was examined by determining the area under the

284 The rate of parasite clearance was greater in subjects administered 80 mg com

285 CMV clearance was observed after 17.7 +/- 12.6 weeks despite

286 ecame transfusion independent. IDH1 mutation clearance was seen in 9/14 patients achieving CR+CRh (5/

287 of integrated virus, the degree of reservoir clearance was still insufficient to achieve viral contro

288 Serum clearance was typically biexponential and dependent on t

289 in viral RNA associated with immune-mediated clearance we developed recombinant strains of SINV that

290 Although IFN-gamma typically helps microbial clearance, we found that increased plasma IFN-gamma in e

291 heir receptors, in S. aureus recognition and clearance, we investigated their contribution to the enh

292 iated lysosomal exocytosis promotes cellular clearance, we show that reduced ISF tau in the absence o

293 Lactate and catecholamine clearance were also significantly enhanced in patients t

294 Mean 25(OH)D clearances were 360 ml/d, 313 ml/d, and 263 ml/d in part

295 ts infection spread and accelerates pathogen clearance when compared to populations with longer-lived

296 conditions, tenofovir dramatically increased clearance while atazanavir did not.

297 and the development of approaches to induce clearance will be important for cancer prevention and th

298 We derived a model for infection clearance with inputs being drug effects on ongoing vira

299 ion to test associations of secretory-solute clearances with CKD progression and mortality, adjusting

300 se, leading to clinical resolution and viral clearance, with no evidence of acquired drug resistance.