ライフサイエンスコーパス: clearing

1 due to degraded conditions (e.g., vegetation clearing).

2 biodiversity losses (unregulated vegetation clearing).

3 tisfactorily compared for suitability to LNs clearing.

4 Tomato and then imaged following brain slice clearing.

5 rical woody alien plant densities 30 y after clearing.

6 STED super-resolution microscopy upon tissue clearing.

7 bear the higher private costs of mechanical clearing.

8 ortionately impacted by these linear habitat clearings.

9 We combined tissue clearing, 3D-immunofluorescence, and electron tomography

10 might decrease the efficacy of vancomycin in clearing a S. aureus infection.

11 While successful in clearing Abeta and improving cognition in mice, anti-Abe

12 nt macrophages and play an important role in clearing accumulated amyloid and tau from neurons.

13 esses haematopoietic stem-cell metabolism by clearing active, healthy mitochondria to maintain quiesc

14 olar concentrations in vitro, have aggregate-clearing activity in a cellular model of Huntington's di

15 Piperaquine possesses rapid parasite-clearing activity, but monotherapy is followed by the ap

16 d responses may also have a systemic effect, clearing additional tumors throughout the body.

17 e present a new, convenient, aqueous optical clearing agent, termed UbasM: Urea-Based Amino-Sugar Mix

18 using the appropriate temperature for tissue clearing, all of which contributed to the superiority of

19 nt a simple and reliable protocol for tissue clearing along with a quantitative assessment of the eff

20 results show that macrophages are capable of clearing alphaS, but that high levels of exogenous or en

21 Because microglia are involved in clearing amyloid and tau pathology from the central nerv

22 tural preexisting immunity is ineffective at clearing an HCMV infection, and an incomplete understand

23 Although inflammation is beneficial for clearing an infection, in some cases, the infection can

24 This technique combines tissue clearing and 3D microscopy with machine learning-based i

25 we describe a novel approach, using optical clearing and a novel staining procedure with confocal mi

26 Here, we use optical tissue clearing and a TAM-targeting injectable fluorescent nano

27 ent coronary angiography after optical organ clearing and by cardiac magnetic resonance imaging.

28 Using tissue clearing and confocal microscopy, we examined thick (up

29 ween 2002 and 2005 on contemporaneous forest clearing and disturbance.

30 ern retains strong fluorescence after tissue clearing and expansion microscopy, thereby facilitating

31 forts to increase crop yields, minimize land clearing and habitat fragmentation, and protect natural

32 earing organs were processed by using tissue clearing and imaged with confocal microscopy and MRI.

33 ing of cleared tissues, thus enabling tissue clearing and imaging in a wide variety of settings.

34 DS)-based clearing protocol for the chemical clearing and imaging of brain tissue containing transgen

35 Clearing and immunolabeling take ~1-2 weeks, depending o

36 have used whole-mount immunostaining, tissue clearing and light-sheet fluorescent microscopy to study

37 We used tissue clearing and light-sheet microscopy for 3-dimensional (3

38 Tissue clearing and light-sheet microscopy have a 100-year-plus

39 Recent advances in optical clearing and light-sheet microscopy have provided unprec

40 Recent developments in optical tissue clearing and microscopic imaging have advanced three-dim

41 1-Cre mice combined with whole-brain optical clearing and multiple-label immunofluorescence to create

42 n the same cuvette from seeding to fixation, clearing and observation, without the need to remove or

43 ycle, oxidative stress, caused by imbalanced clearing and production of reactive oxygen species (ROS)

44 rsal column sensory and corticospinal axons; clearing and staining of unsectioned spinal cord; visual

45 Clearing and subsequent 3D reconstruction of entire orga

46 lution without labeling by leveraging tissue clearing and the scattering contrast of optical frequenc

47 en, as was previously found for women: "slow-clearing" and "fast-clearing." Only 68% (57%-78%) (poste

48 d rapid immunofluorescence staining, optical clearing, and confocal microscope imaging.

49 the use of a transgenic mouse line, optical clearing, and imaging techniques, combined with electrop

50 or sonication treatment, antibody staining, clearing, and mounting.

51 activate Pak4, which in turn activates NMII, clearing apical junctions.

52 Mer) signaling maintains immune tolerance by clearing apoptotic cells (ACs) and inducing immunoregula

53 Defects in clearing apoptotic debris disrupt tissue and immunologic

54 sed by satellite glia in the DRG involved in clearing apoptotic neurons during development.

55 Here, we developed a sample clearing approach for FISH measurements.

56 ouse brain using this matrix-imprinting and -clearing approach.

57 Unfortunately, existing optical clearing approaches present a compromise between maximiz

58 ndogenous fluorescent reporter where typical clearing approaches render such structures difficult to

59 demonstrate a high-speed approach, termed as Clearing Assisted Scattering Tomography (CAST), where in

60 ions to take one of 1, 2, or 3 courses, each clearing at a different rate.

61 tein receptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein

62 bleaching-augmented solvent-based non-toxic clearing (BALANCE) using ethyl cinnamate (ECi) with ligh

63 ing technique, current available methods for clearing bones and teeth, general principles of 3-dimens

64 Several methods have been developed for clearing bones.

65 tching local energetic demand and supply and clearing brain metabolites.

66 scape-related tick control measures, such as clearing brush, trimming branches, and having a dry barr

67 urbances-processes that occur without forest clearing but are increasingly important drivers of bioma

68 raints in crossing biological membranes, and clearing by enterohepatic circulation.

69 Our results indicate that titling reduces clearing by more than three-quarters and forest disturba

70 chicken and shows antibody is ineffective in clearing C. jejuni from the ceca within the production l

71 Microglia lose their amyloid-beta-clearing capabilities with age and as AD progresses.

72 ches present a compromise between maximizing clearing capability, the preservation of fluorescent pro

73 to enteric pathogens, but capable of rapidly clearing causative and coinfecting pathogens.

74 Tissue clearing caused tissue swelling (compared to conventiona

75 microglia respond, microglia are the debris-clearing cell.

76 eveal that these processes are important for clearing chemically modified mRNA and the resulting aber

77 In addition, tissue-clearing chemistry allows whole-organ antibody labelling

78 nstrated a critical role for Th1 immunity in clearing Chlamydia from the small intestine but not the

79 more, exogenous IFN-gamma was sufficient for clearing Chlamydia from the small intestine but not the

80 cating a critical role for CD4(+) T cells in clearing Chlamydia from the small intestine.

81 n cell division, co-ordinating division with clearing chromosomal DNA from the site of septation and

82 ng lamin A on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulu

83 ficacy similar to that of valganciclovir for clearing CMV viremia among recipients of hematopoietic-c

84 antigen "bystander" tumors while efficiently clearing combinatorial antigen "disease" tumors.

85 Tissue clearing combined with confocal and light sheet fluoresc

86 imensional (3D) view of the AVN using tissue clearing combined with confocal microscopy.

87 is of entire transparent rodent bodies after clearing could provide holistic biological information i

88 e hypothesized that Cyp26b1 is the main atRA clearing Cyp in postnatal mammals.

89 e and elevation of Trem2, both necessary for clearing damaged myelin, were markedly reduced in GALC +

90 ucial to maintaining cellular homeostasis by clearing damaged organelles, pathogens, and unwanted pro

91 embryogenesis and daily in adult organisms, clearing dead cells and associated cellular debris is im

92 m tissue regeneration and synapse pruning to clearing debris and controlling tumor cell progression.

93 Non-clearing debris was the most significant long-term compl

94 TREM2 variant has been linked to human-Abeta-clearing deficits.

95 ly during the first 20 years following stand-clearing disturbance, with slower accumulation following

96 microenvironment, especially macrophages in clearing dying hepatocytes.

97 al compartments maintain cellular fitness by clearing dysfunctional organelles and proteins from cell

98 d the feasibility of the regional mapping of clearing efficacy and correlating optical transparency a

99 been developed, quantitative assessments on clearing efficacy depending on tissue properties are rar

100 This novel quantitative mapping of clearing efficacy depending on tissue types and clearing

101 veloped the quantitative mapping of regional clearing efficacy using mean free path in optical cohere

102 -based simple immersion), we observed lowest clearing efficiency in the white matter as well as poor

103 and PACT (hydrogel embedding) showed higher clearing efficiency in white matter than gray matter in

104 We recently developed clearing-enhanced 3D (Ce3D), a simple and effective meth

105 Here we report an easy to use method, clearing-enhanced 3D (Ce3D), which generates excellent t

106 Compared with the standard SRS, the clearing-enhanced SRS achieves greater than 10-times dep

107 Global knockouts of the atRA clearing enzymes Cyp26a1 or Cyp26b1 are embryonic lethal

108 prices for the ecosystems service: a market-clearing equilibrium.

109 mechanisms, requires forecasting the market-clearing equilibrium.

110 -/-) T cells to be intrinsically superior at clearing established tumors that secrete TGFbeta.

111 em to utilize blood protein to develop eggs: clearing excess fluid, digesting protein, and egg matura

112 09 and 2013, both the efficacy of IPTp-SP at clearing existing peripheral malaria infections and the

113 icroglia in regulating synaptic formation by clearing extracellular matrix proteins that embed neuron

114 7 cells secrete IL-17A and are important for clearing extracellular pathogens, but inappropriate sign

115 whether meningeal lymphatics are involved in clearing extravasated erythrocytes in CSF after SAH rema

116 transcription machinery and define HelD as a clearing factor that releases RNAP from nonfunctional co

117 ersatile Free-of-Acrylamide SDS-based Tissue Clearing (FASTClear) protocol specifically designed for

118 results suggest a key role for autophagy in clearing fibrillar alpha-synuclein pathologies in human

119 duced habitat alteration (urbanization, land clearing for agriculture) or a suite of ecological facto

120 We find that clearing for oil palm plantations using mechanical metho

121 m abrupt and total losses of biomass in land clearing, forest fires and clear cuts are easy to measur

122 gram at 4 h after injection, respectively), clearing from background predominantly via the kidneys.

123 This was associated with impaired F-actin clearing from the center of the cellular interface, redu

124 airway neutrophil responses are critical for clearing fungal conidia from the host airways prior to e

125 C1A2 is a trimeric transporter essential for clearing glutamate from neuronal synapses.

126 toms, recurrent sore throat, frequent throat clearing, halithosis and dental erosion among others.

127 Tissue clearing has become an essential tool for neuroscientist

128 Tissue clearing has become an important tool for the investigat

129 Tissue clearing has gained attention as a pioneering research t

130 Optical tissue clearing has revolutionized researchers' ability to perf

131 cal imaging technologies and chemical tissue clearing have facilitated the acquisition of whole-organ

132 ) protects the host from oxidative damage by clearing hemoglobin that has leaked from red blood cells

133 sal cavity of inoculated pigs, with all pigs clearing HS069Deltacap by 5 days postchallenge.

134 By combining the most powerful labelling, clearing, imaging and data-analysis tools, scientists ar

135 Here, we develop a clearing-imaging-analysis pipeline to visualize innervat

136 , we developed a method that combines tissue clearing, immunohistochemistry, confocal microscopy, and

137 eep elicit arousal, which facilitates airway clearing in the case of obstruction and reinstates norma

138 that the DART molecules were not capable of clearing infected cells in vivo, attributed to the lack

139 V remission by halting viral replication and clearing infected cells.

140 t defense, monocytes play important roles in clearing infected microbes.

141 intain latency has been a major challenge to clearing infection and preventing KS development.

142 Slow-clearing infections with longer parasite clearance half-

143 intains the majority of its effectiveness in clearing infections.

144 that seals the wound and facilitates debris clearing, inflammatory containment and matrix compaction

145 These cells play an important role in clearing inhaled pathogens and regulating the inflammato

146 oad on the heart, and relieves congestion by clearing interstitial fluid without excessively reducing

147 tial metabolic program that is also used for clearing intracellular pathogens.

148 are specialized phagocytic cells involved in clearing invading pathogens.

149 BABB (solvent-based clearing), involving both refractive index matching and

150 Modified BABB tissue clearing is a reliable technique to clear skin and soft

151 Ce3D clearing is fast, achieving robust transparency of most

152 ogress has been made with intact methods for clearing, labeling, and imaging whole organs such as the

153 lm plantations under different scenarios for clearing land and controlling fires.

154 to propose a new paradigm of LSEC and HDL in clearing LPS with a potential to avoid inflammation duri

155 licits a Th17 response that is necessary for clearing many fungal pathogens.

156 dium, compatibility with aqueous and organic clearing media, quick specimen mounting without hydrogel

157 inally, samples are immersed in a designated clearing medium to achieve a uniform refractive index an

158 nged Acrylamide Tissue hYdrogel) is a tissue clearing method that has enabled successful 3-dimensiona

159 s to the BABB (Benzoic Acid Benzyl Benzoate) clearing methodology, preservation of fluorophore expres

160 re, we review the state of the art of tissue-clearing methods and light-sheet microscopy and discuss

161 de a brief overview of the different optical clearing methods as well as different imaging modalities

162 Optical clearing methods can facilitate deep optical imaging in

163 pproaches to image analysis, existing tissue-clearing methods can speed up and may reduce the cost of

164 In this Review, we discuss how tissue-clearing methods could provide an unbiased, system-level

165 y be helpful in the development of optimized clearing methods for different biological samples.

166 Next-generation clearing methods have been (re)designed with a better un

167 Different optical clearing methods have been developed recently, making it

168 Many tissue-clearing methods have been developed, and they all follo

169 Recently, tissue clearing methods have enabled the investigation of a ful

170 aring efficacy depending on tissue types and clearing methods may be helpful in the development of op

171 State-of-the-art tissue-clearing methods provide subcellular-level optical acces

172 Since tissue-clearing methods were first combined with modernized lig

173 he methods and application of various tissue-clearing methods.

174 At 6 and 12 months IDA was superior to IA in clearing Mf (89% [77-99%] and 71% [56-85%]), respectivel

175 At 6 and 12 months IDA was superior to IA in clearing Mf (89%, CI 77-99, and 71%, CI 56-85) respectiv

176 Thus, UBQLN1 plays an important role in clearing mislocalized mitochondrial proteins upon cell s

177 om the contralateral control, with particles clearing more slowly from 15-month old rats than from 5-

178 Without tissue staining or clearing, mPAM generates micrometer-resolution 3D images

179 revir and pibrentasvir was also effective in clearing multidrug-resistant HCV replication in mice.

180 ce cytokines or counteract neuronal death by clearing myelin debris.

181 double-edged players in neurodegeneration-by clearing neurotoxic protein aggregates, but also providi

182 evealed a role for UIM-directed autophagy in clearing non-functional CDC48/p97 complexes, including s

183 oil palm concessions in the tropics, and the clearing of abundant forest as a result.

184 promoting a rapid response to infection and clearing of apoptotic cells.

185 ent of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be preven

186 Optical clearing of brain tissue using hydrogel-based methods (e

187 critical for hearing and requires continuous clearing of cellular debris, but little is known about h

188 observed light-dependent redistribution and clearing of CRY2-tethered proteins within the nucleus.

189 Lack of proliferation at the rim and/or over-clearing of epithelial cells in the center of the pouch

190 This suggests that the clearing of FMDV infection is associated with an enhance

191 (+) T cell responses, resulting in efficient clearing of FVC-infected cells.

192 ial sojourn in resident macrophages promoted clearing of infection.

193 Optical clearing of intact T. gondii-infected brains using iDISC

194 associated with P23H rhodopsin and promoted clearing of mutant rhodopsin from photoreceptors.

195 ck-out (ApoE(-/-)) mice, which show impaired clearing of plasma lipoproteins and spontaneously develo

196 meticulous dissection of arterial planes and clearing of retropancreatic tissue in an attempt to achi

197 Efficient methods to obtain optical clearing of the tissue for 3D visualisation are therefor

198 eatures within large tissue sections.Optical clearing of tissue has enabled optical imaging deeper in

199 and data processing, applications of tissue clearing on studying biological processes within bones a

200 y found for women: "slow-clearing" and "fast-clearing." Only 68% (57%-78%) (posterior median and 95%

201 Using wholemount tissue staining and clearing, or retrograde tracing in a MET(EGFP) transgeni

202 viding nutrients and signaling molecules and clearing out toxic by-products from the brain.

203 The compound was also capable of clearing parasites in established infections at 50 mg kg

204 ng and lipid removal, exhibited best optical clearing performance with the highest proton density red

205 ting the role of IFNs and innate immunity in clearing persistent viral infection, and discussing the

206 The nuclear clearing phenotype was dependent on the presence of a di

207 s display broad columnar mesophases and high clearing points and self-associate in solution to form d

208 role of the mitochondrial protease YME1L in clearing poly(GR), revealing mitochondria as major sites

209 malaria burden significantly reduces forest clearing, possibly mediated by human behavior or economi

210 benefit-cost assessment and forecast market-clearing prices and quantities for ecological infrastruc

211 10-15 times shorter and less intensive lens clearing procedures compared with an untreated endoscope

212 Tissue clearing procedures overcome this challenge by rendering

213 Our enhanced clearing process allowed us to fluorescently image and m

214 During the tissue-clearing process, chemical or physical treatments are ap

215 ostasis by monitoring neuronal function, and clearing protein aggregates across the lifespan.

216 ing confocal microscope and (ii) an improved clearing protocol compatible with lipophilic dyes that h

217 is a new sodium dodecyl sulfate (SDS)-based clearing protocol for the chemical clearing and imaging

218 we also established EyeDISCO, a novel tissue clearing protocol that removes melanin allowing 3D imagi

219 ng of coronaries with a CLARITY-based tissue clearing protocol.

220 We systematically compared seven clearing protocols with the FACT protocol, using transge

221 ltiple specimens processed with a variety of clearing protocols, which will facilitate wide adoption

222 of specimens, and compatibility with various clearing protocols.

223 importance of an intact complement system in clearing Pseudomonas infection during phage therapy.

224 ethyl cinnamate) as a nontoxic solvent-based clearing reagent that can be handled without specific sa

225 ion with serum amyloid P, is responsible for clearing residual hyaluronan and cellular debris).

226 express FOXO3a and play an important role in clearing rhinovirus (RV) by mounting antiviral type I an

227 Additionally, neutrophils, essential for clearing S. aureus, demonstrated sex-specific S. aureus

228 s) are constantly exposed to the blood flow, clearing senescent red blood cells (RBCs) and recycling

229 n) is unique as its activity is required for clearing short RNA fragments, which is important for cel

230 ITY technique) tissue hydrogel embedding and clearing, smHCR can detect single mRNAs deep within thic

231 We observed blotched flowers and a vein-clearing symptom in aged petunia plants.

232 (DAT) controls dopamine neurotransmission by clearing synaptically released dopamine.

233 Application of tissue-clearing technique on dental research remains limited.

234 e covered: general principles for the tissue-clearing technique, current available methods for cleari

235 abeling of endothelial cells, a novel tissue-clearing technique, lightsheet microscopy, and automated

236 led advances in fluorescence-friendly tissue clearing technique, our cardiac LSFM enables dual-sided

237 in the brain sample with four representative clearing techniques (benzyl alcohol and benzyl benzoate

238 Other than neural science research, tissue-clearing techniques also have applications for bone rese

239 Recent advances in tissue clearing techniques and microscopy make it possible to o

240 Optical clearing techniques can alleviate these mismatches, but

241 However, most tissue clearing techniques do not satisfactorily preserve expre

242 Although various clearing techniques have been developed, quantitative as

243 Tissue-clearing techniques have emerged in recent years in the

244 Recently, a series of tissue-clearing techniques have emerged to allow significant de

245 epithelial markers, an obstacle for previous clearing techniques, can be achieved with FLASH.

246 anges using OCT and MRI from existing tissue clearing techniques.

247 rtoli cells and to test novel antivirals for clearing testicular ZIKV infection.

248 D), a simple and effective method for tissue clearing that achieves excellent transparency; preserves

249 on, and reset proteostasis by enveloping and clearing the aggregates.

250 After clearing the allergic bronchial inflammation, post-AAI m

251 vealed the protective effect of # 5175552 in clearing the bacilli inside murine macrophages.

252 s, as a reflection of their dominant role in clearing the bulk of apoptotic cells.

253 at P. carabi mites assist burying beetles in clearing the carcass of bacteria as a side-effect of gra

254 ions in reward learning and decision-making, clearing the course for future empirical work.

255 ance is excessive, Mfd dissociates the RNAP, clearing the DNA for other processes.

256 nly ubiquitous cellular checkpoint known for clearing the error.

257 inflammatory responses that are directed at clearing the infection, but if not controlled, these res

258 The inflammatory response is ineffective in clearing the infection, leading to disease progression t

259 tly in parasite killing by encapsulating and clearing the infection.

260 te immune system appear to be ineffective at clearing the material; however, human light chain amyloi

261 eplacing a thought with a different one, and clearing the mind of all thought.

262 immune responses capable of recognizing and clearing the rare cells in which HIV latency has been re

263 type-1 (GLT-1), which plays a vital role in clearing the released glutamate from synapses and drug s

264 gy into the interstellar medium, potentially clearing the surrounding gas.

265 Patients clearing the virus within 6 days (early resolvers) had a

266 hough NLRC5-deficient mice were defective at clearing the virus, they did not show an increase in mor

267 optimal gene expression depends on enhancers clearing this repressive mark.

268 linked receptors shows selectivity in vivo, clearing three-antigen tumors while ignoring related two

269 luorescent signal was achieved by decreasing clearing time, adjusting the pH of the SDS solution, and

270 imensions of the workflow, including reduced clearing time, improved efficiency of fluorescent signal

271 Fast Free-of-Acrylamide Clearing Tissue (FACT) is a new sodium dodecyl sulfate (

272 chnique of multiphoton microscopy (MPM) with clearing to a new mouse model of cisplatin-induced CKD,

273 We used immunolabeling and tissue clearing to image the vascular network of adult mouse br

274 We adapted iDISCO tissue clearing to process large, whole-body specimens for an u

275 Recently, tissue optical clearing (TOC) techniques were established to bypass thi

276 riate regulation of autophagy is crucial for clearing toxic proteins from cells.

277 Clearing treatment enables 3-dimensional imaging of bone

278 in lipase (LPL) is an enzyme responsible for clearing triglycerides from circulation, and its activit

279 s to quantitatively understand HK functions, clearing up several open questions and providing a new s

280 Clearing up these conceptual confusions is a necessary f

281 ntitative assessment of the effect of tissue clearing upon morphology.

282 e, we provide detailed procedures for tissue clearing using Ce3D, including optimized workflows for t

283 tes higher social net benefits compared with clearing using fires.

284 use eye is feasible, with and without tissue clearing, using light-sheet fluorescent microscopy (LSFM

285 vement of VE-cadherin and may play a role in clearing VE-cadherin from the site of TEM.

286 ation (aOR 1.89, 95% CI 1.07-3.35, p=0.028), clearing vegetation (1.89, 1.11-3.22, p=0.020), and havi

287 inable approach, "slash and clear", involves clearing vegetation from breeding areas, and recent fiel

288 cated MAVS, STING and TLR3 are important for clearing viral infections.

289 ies show that T cell functions important for clearing virally infected cells are impaired by higher n

290 Clearing viremia was associated with detectable BKPyV-sp

291 Clearing viremia was associated with detectable BKPyV-sp

292 n an endogenous pararetrovirus, petunia vein clearing virus (PVCV), because this virus may have a sup

293 rI]) of incident infections in men were slow-clearing, vs 77% (69%-84%) in women.

294 ng lineage tracing combined with whole brain clearing, we provide new insight into timing of generati

295 or >/=6,000 y and that only small, temporary clearings were made to build the geoglyphs; however, con

296 Clearing wild forests to grow food, fibre, and fuel prod

297 estions, the effectiveness of neutrophils in clearing wild-type (wt) M1T1 GAS strain MGAS2221 from th

298 By combining optical clearing with a novel scatter-based optical coherence to

299 technique that couples Raman-tailored tissue-clearing with stimulated Raman scattering (SRS) microsco

300 tic activity associated with prolonged wake, clearing worn components of heavily used synapses.