ライフサイエンスコーパス: cleavable

1 vage at the target site and are thus termed 'cleavable'.

2 ly dimeric and conclude that LexA dimers are cleavable.

3 >20 nucleolar proteins were identified as C1 cleavable.

4 and then linked to Ad via a single reduction-cleavable 5kDa PEG.

5 ional moieties to the polysaccharide through cleavable acetal linkages.

6 Probe variants incorporating enzyme-cleavable acetomethoxy ester groups are processed by int

7 inhibitor as a single, macrocyclic esterase-cleavable (acyloxy)alkoxy prodrug.

8 cess using randomized splint ligation with a cleavable adapter, a design which resolves previous chal

9 re we demonstrate that photo-activation of a cleavable air-stable dimeric dopant can result in kineti

10 s spectrometry due to the presence of easily cleavable alkoxyamine bonds formed in step (ii).

11 Compared with the non-cleavable alpha7 chain, the cleaved form enhances cell a

12 This report mechanistically describes a new cleavable amide bond in 4-aminopyrazolyloxy acetamide pe

13 The readily cleavable amide group has been utilized as a directing g

14 yrins and prodrug models, attached via (1)O2-cleavable amino-acrylate linker, to the SCPNs, we show t

15 mbretastatin A-4 (CA4) with a singlet oxygen-cleavable aminoacrylate linker, and a biotin moiety as a

16 njugating photosensitizer via singlet oxygen-cleavable aminoacrylate linker.

17 ize reactive macromers that contain protease-cleavable and fluorescent peptides and are able to form

18 By comparison of cleavable and non-cleavable cysteine-cysteine crosslinke

19 tility of this connection with both protease-cleavable and reductively cleavable antibody-drug conjug

20 etic analyses reveal extensive clustering of cleavable and uncleavable motifs in sequence space.

21 with both protease-cleavable and reductively cleavable antibody-drug conjugates that were effective a

22 prenylated peptides using mass spectrometry-cleavable approaches was developed.

23 c peptide fragment through the attachment of cleavable arginine tags.

24 Introducing the cleavable arginine-alanine peptide into the NAc attenuat

25 or as antibody-drug conjugate containing non-cleavable auristatin drug payload (033-F).

26 action with a phosphine group to form a self-cleavable azaylide intermediate.

27 on of the purines (A and G) via a chemically cleavable azido-based linker, with different length link

28 acid as the source of stereoinduction, and a cleavable bidentate directing group appended to the alke

29 ivated alkenes has been developed, wherein a cleavable bidentate directing group is used to control t

30 To realize this transformation, a cleavable bidentate directing group is used to control t

31 oped, wherein selectivity is controlled by a cleavable bidentate directing group.

32 dition to the previously described aspartase-cleavable biosensors, we report development of granzyme

33 Five cleavable biotin probes are described for use in labelin

34 and evaluation of a novel set of chemically cleavable biotinylated dideoxynucleotides, ddNTPs-N(3)-b

35 an acid-sensitive bond (1) or a cathepsin B cleavable bond (3) for ensuring an effective release of

36 ese findings reveal that optimization of the cleavable bond location can be used as a design principl

37 to anticancer drug doxorubicin (Dox) by a pH-cleavable bond that is physically loaded onto the exosom

38 genomic viral RNA with VPg linked via a 'non-cleavable' bond.

39 ge, redox-cleavable bonds, and enzymatically-cleavable bonds are also thoroughly described.

40 system, we show that when a small number of cleavable bonds are selectively installed within the str

41 The cross-linker was designed to contain cleavable bonds such as geminal diol, disulfide, and ace

42 nd pH-degradable bonds, amide linkage, redox-cleavable bonds, and enzymatically-cleavable bonds are a

43 the end-groups of the dendron through enzyme-cleavable bonds.

44 rove the selection of residues that are less cleavable by aminopeptidases predominantly at N-flanking

45 7 cleavage site (30)DETD(33) in ORF57 is not cleavable by caspase-3, although both enzymes use DEXD a

46 To sense protease release, peptides cleavable by MMP9 were designed to contain a donor/accep

47 yproline (Dyp) is a typical protecting group cleavable by traces of TFA.

48 o a VPg-triazole-RNA construct that was 'non-cleavable' by TDP2.

49 S, ATPase but not ACOT was stimulated by non-cleavable C14 ether-CoA.

50 ent Caspase-8(F122GL123G/F122GL123G) and non-cleavable Caspase-8(D387A/D387A) mutant mice with defect

51 by a near-infrared imaging approach using a cleavable cathepsin-selective probe.

52 tudy, we report the generation of a protease-cleavable CD1d variant with a similar trafficking patter

53 technology that couples a mass spectrometric-cleavable chemical cross-linker with high-resolution mas

54 Peptides crosslinked with cleavable chemical crosslinkers are identified with mass

55 N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide, a cleavable chromogen, were conjugated to primary amines o

56 not affect etoposide-stabilized topo II-DNA cleavable complex formation.

57 d measuring the formation of the topo II-DNA cleavable complex.

58 y disabling the formation of the topo II-DNA cleavable complex.

59 ormation of etoposide-stabilized topo II-DNA cleavable complex.

60 ormation of etoposide stabilized topo II-DNA cleavable complex.

61 izing the Top1-DNA intermediate or cleavage (cleavable) complex.

62 IIalpha inhibitors are unable to induce DNA-cleavable complexes and cell death.

63 the hairpin cleavage rate and to form active cleavable complexes with Rnt1p.

64 ross-links (including topoisomerase I and II cleavable complexes) produce stalling and collapse of re

65 concentrations ranging from non-cleavable to cleavable concentrations obtained from in vitro cleavage

66 this significant problem to be addressed, a cleavable conjugate of the antibiotic kanamycin and a no

67 amide directing group plays a dual role as a cleavable coordinating moiety as well as an essential co

68 the polymer poloxamer 407 (P407) via a photo-cleavable coumarin linkage (CM).

69 be the synthesis of a thin glutathione (GSH)-cleavable covalently crosslinked polymer coating, called

70 on as amine-reactive sulfoxide-containing MS-cleavable cross-linked peptides, thus permitting their s

71 he use of a tandem mass spectrometry (MS/MS) cleavable cross-linker (containing a 1,3-bis-(4-oxo-buty

72 Second, the homobifunctional thiol-cleavable cross-linker 3,3'-dithiobis(sulfosuccinimidylp

73 the commercially available mass spectrometry-cleavable cross-linker disuccinimidyl dibutyric urea and

74 The strength of our cleavable cross-linker is that characteristic patterns o

75 The introduction of a cleavable cross-linker makes this process reversible and

76 Using the MS-cleavable cross-linker, disuccinimidyl sulfoxide, inter-

77 e present the use of novel mass spectrometry cleavable cross-linkers and tags to stabilize intact pro

78 er demonstrates that sulfoxide-containing MS-cleavable cross-linkers offer robust and predictable MS2

79 eveloped a series of sulfoxide-containing MS-cleavable cross-linkers to facilitate the detection and

80 y approach enabled by three mass spectometry-cleavable cross-linkers to generate highly reliable cros

81 cross (X)-linked peptides) by integrating MS-cleavable cross-linkers with isobaric labeling reagents.

82 rther development of sulfoxide-containing MS-cleavable cross-linkers with new functionalities.

83 The use of MS-cleavable cross-linkers, including protein interaction r

84 es of amine-reactive sulfoxide-containing MS-cleavable cross-linkers.

85 ility of sulfoxide chemistry in designing MS-cleavable cross-linkers.

86 rry a short-lived, indiscriminately reactive cleavable crosslinker that marks contacts close to ligan

87 By contrast, installation of cleavable crosslinks, even at much higher loadings, does

88 oc159 in reverse orientation functioned as a cleavable cTP that guided the fluorescent protein to the

89 By comparison of cleavable and non-cleavable cysteine-cysteine crosslinked samples, capilla

90 Leveraging the benefits of an acid-cleavable detergent, RapiGest SF Surfactant (Waters Corp

91 the discovery of new transformations and new cleavable DGs.

92 NA'), and have modified them using the photo-cleavable di-methoxy nitro phenyl ethyl group (DMNPE) gr

93 ipening, and the encoded enzyme converts the cleavable diglycosides of the smoky-related phenylpropan

94 -silylation reactions of alkenes containing cleavable directing groups.

95 olyurethane nanoparticles (GPUs) using a GSH-cleavable disulfide bond containing polyurethane that re

96 l or energetic role, but a growing subset of cleavable disulfide bonds has been shown to control the

97 ted to a PEGylated protein therapeutic via a cleavable disulfide linker.

98 material with an optimal ratio of an enzyme-cleavable drug or immunotherapy (effector elements) and

99 hylene oxide block copolymer, which was made cleavable due to the intervening disulfide bond.

100 n 3 (nsP3) or insertion of the reporter as a cleavable element between the capsid and PE2 structural

101 Also, ADCs with a nonprotease-cleavable enantiomer, the VC(R) isomer, mediated effecti

102 ores (fluorescein and Cy3) through an Fe(II)-cleavable endoperoxide bridge, where Fe(II)-triggered pe

103 The polymerization of vinyl monomers with cleavable enzymatic substrates has been shown to lead to

104 ry prodrug pyrene-aspirin (P-aspirin) with a cleavable ester bond and also facilitate loading the pro

105 ed polyethylene glycol chains on SWNTs via a cleavable ester bond to obtain a water-soluble SWNT-PTX

106 an alcohol derivative of thapsigargin via a cleavable ester linkage.

107 a recombinant NDV (rNDV) whose F protein is cleavable exclusively by prostate-specific antigen (PSA)

108 nalysis approach that is based on chemically cleavable fluorescent antibodies.

109 rnal reflection fluorescence microscopy of a cleavable fluorescent calpain substrate.

110 sis, we have determined the structure of the cleavable form of Escherichia coli maltose-binding prote

111 n vivo in comparison with cells expressing a cleavable form of HuR.

112 wever, determination of the structure of the cleavable form, which is populated only transiently, rem

113 erminal helices in MBP are unfolded in their cleavable form.

114 ematic approach to determining structures of cleavable forms by protein engineering and native-state

115 accessibilities of partially unfolded forms (cleavable forms) under native conditions.

116 ed which enables the facile incorporation of cleavable functional groups, i.e., esters, thioesters, a

117 ne-disruptive chains that are masked by acid-cleavable galactose residues.

118 to HPMA copolymer side chains via an enzyme-cleavable GFLG linker.

119 f cytotoxic gemcitabine by introducing Pd(0)-cleavable groups in positions that are mechanistically r

120 l degradable polymer is typically enabled by cleavable groups on the backbone, which can be attacked

121 Here, we present a cleavable hairpin beacon (CHB)-enhanced fluorescence det

122 The auto-cleavable hairpin structure can be activated on site at

123 Thus, the ATXalpha insertion constitutes a cleavable heparin-binding domain that mediates interacti

124 ogeneity on a 10-100 mg scale using protease-cleavable His(10)-tagged constructs.

125 ted using a trimerization domain linked to a cleavable histidine tag.

126 ic residue-targeting sulfoxide-containing MS-cleavable homobifunctional cross-linker, dihydrazide sul

127 here the development of new isotope-coded MS-cleavable homobifunctional cross-linkers: d0- and d10-la

128 Our results indicated that, cellular non-cleavable HuR controls COX-2 mRNA expression and enzymat

129 orifices surrounding the nanopores contained cleavable imine double bonds.

130 essing wild-type or mutant SOD1 containing a cleavable IMS targeting signal to directly investigate t

131 nder a variety of conditions and selectively cleavable in the presence of a low-oxidation-state trans

132 Only one predicted off-target site is cleavable in vitro, with negligible deletions observed i

133 immunoassay platform that adopts stable and cleavable ionic probes as mass reporter; these probes ma

134 Overexpression of a non-cleavable isoform, HuR-D226A, revealed a potent dominant

135 Cleavable isoforms of ErbB4 release a soluble intracellu

136 we used T cells expressing cleavable or non-cleavable L-selectin and determined the impact of L-sele

137 e-3 or ectopic expression of a caspase-3 non-cleavable lamin B mutant blocks nuclear opening formatio

138 et of fifteen ORs to examine the effect of a cleavable leucine-rich signal peptide sequence (Lucy tag

139 ield binding specificity motifs and identify cleavable LHE targets using a combination of bioinformat

140 y, Tf-containing nanoparticles with the acid-cleavable linkage avoid major endothelium retention by s

141 ining, 80-nm gold nanoparticles with an acid-cleavable linkage between the Tf and the nanoparticle co

142 With the Abs, the addition of the acid-cleavable linkage provided no improvement to in vivo bra

143 h small gold nanoparticles (Au NPs) via acid-cleavable linkages in order to explore the possibility o

144 ll as their development for incorporation of cleavable linkages into the network of micro- and nanoge

145 This can be achieved by introducing stimuli-cleavable linkages into the scaffold structures.

146 We also describe the synthesis of chemically cleavable linked conjugates designed to enable mild elut

147 in prodrug whereby the PEG is attached via a cleavable linker (col-aaPEG) introducing an acetic acid

148 to fluorophores through a novel azide-based cleavable linker are utilized to detect their protein ta

149 h incorporation of a boronic acid-containing cleavable linker between polycationic cell-penetrating p

150 ptamer sensors through the installation of a cleavable linker between the two DNA fragments that comp

151 A stable or cleavable linker connects the two modules of a chimera.

152 e group that is appended to a drug through a cleavable linker is achieved by organocatalyzed ring-ope

153 ing from which to develop this near-IR light cleavable linker strategy.

154 (CuAAC), is applied to generate a gas-phase cleavable linker suitable for the formation of reporter

155 view summarises the advances in the field of cleavable linker technologies for ADCs.

156 al antibody (cAC10) conjugated by a protease-cleavable linker to a microtubule-disrupting agent, mono

157 l-penetrating peptide (CPP) is coupled via a cleavable linker to a neutralizing peptide.

158 -gpNMB monoclonal antibody, conjugated via a cleavable linker to monomethyl auristatin E.

159 a functionalized biotin reagent containing a cleavable linker via Cu(I)-catalyzed azide-alkyne cycloa

160 nucleobase protecting groups and a UV-light cleavable linker were used.

161 odules of an anticancer agent (taxoid with a cleavable linker) that is activated to its cytotoxic for

162 olobenzodiazepine (PBD) dimer via a protease-cleavable linker, against acute myeloid leukemia (AML) c

163 anised antibody against HER2, a novel enzyme-cleavable linker, and a topoisomerase I inhibitor payloa

164 -terminal fibrinogen-like domain (FLD) via a cleavable linker, and both full-length Angptl4 and its i

165 (L-glutamic acid) by means of a pH-sensitive cleavable linker, and load the polymeric drug (pDox) int

166 mer, protein scaffold, or antibody), spacer, cleavable linker, and therapeutic warhead, criteria for

167 The optimal ADC bears a non-cleavable linker, auristatin as payload at DAR = 4 and a

168 was conjugated to trastuzumab by a protease-cleavable linker, maleimido-caproyl-valine-citruline-p-a

169 30-specific monoclonal antibody by an enzyme-cleavable linker, producing the antibody-drug conjugate

170 ed to hyperbranched polyglycerol (PG-M) by a cleavable linker.

171 eyond a removable backbone modification to a cleavable linker.

172 the C terminus of CSF1R, separated by a T2A-cleavable linker.

173 g pyrrolobenzodiazepine dimer via a protease-cleavable linker.

174 s covalently linked to the carrier through a cleavable linker.

175 ngineered cysteines (THIOMABs) by a protease cleavable linker.

176 to the anti-CD3 Fab through a tumor protease-cleavable linker.

177 Bicycles with the potent cytotoxin DM1 via a cleavable linker.

178 38, which is conjugated to the antibody by a cleavable linker.

179 lene glycol (PEG)ylated lipids with esterase-cleavable linkers (e.g., ME42) to promote intracellular

180 These results suggest that protease-cleavable linkers are unlikely to increase the therapeut

181 NDCs generated with protease-cleavable linkers demonstrated that the site of conjugat

182 Here, we describe cleavable linkers designed for the traceless release of

183 l protective groups in organic chemistry and cleavable linkers for solid phase synthesis, to more mod

184 ADCs with cleavable linkers mediated in vivo efficacy via all thes

185 elivery system that utilizes enzyme assisted cleavable linkers to release conjugated cargo within the

186 Thus, our data suggest that ADCs with cleavable linkers work on a broad range of targets, and

187 munoproteasome-selective inhibitor via light-cleavable linkers, yielding peptide epoxyketone-doxorubi

188 conjugated with a chemodrug through hypoxia-cleavable linkers.

189 uch less important for R-sshRNAs that have a cleavable loop.

190 We recently demonstrated that protease-cleavable luciferase biosensors detect granzyme B and pr

191 e aryl phthalate esters were conjugated with cleavable masking groups sensitive to light and hydrogen

192 CYP27, which contains a canonical cleavable mitochondrial signal, required all of the peri

193 These isoforms differ by their cleavable mitochondrial targeting peptides, whereas the

194 However, deactivation of photo-cleavable MO activity has remained elusive.

195 Here, we describe photo-cleavable MOs with which it is possible to activate or d

196 As a broader approach for the use of photo-cleavable MOs, we show temporal control over gal4 functi

197 combines ciprofloxacin with a beta-lactamase-cleavable motif.

198 at flanking mutations producing more or less cleavable motifs can increase or decrease epitope produc

199 In combination with dedicated MS-cleavable MS(n) software, UVPD-MS(n) therefore provides

200 However, a non-cleavable mutant, N570T, undergoes the transition revers

201 n in the gut, blood, and tissues by removing cleavable N- and C-termini and by shielding components f

202 The sole exception is cytochrome f, whose cleavable N-terminal cpSecA-dependent signal sequence en

203 we demonstrate that L27 variants with an un-cleavable N-terminal extension, or lacking the extension

204 Different human BCO2 isoforms possess cleavable N-terminal leader sequences critical for mitoc

205 n cytosolic ribosomes as a preprotein with a cleavable N-terminal presequence that is the mitochondri

206 These modular proteins, comprising a cleavable N-terminal signal peptide, a surface-exposed c

207 Est55, which lacks a classical, cleavable N-terminal signal sequence, was found to be se

208 The activity of CADA maps to the cleavable N-terminal SP of hCD4.

209 ly expressed Tm as alpha.beta dimers using a cleavable N-terminal tag on one of the two chains.

210 These LAADs employ a non-cleavable N-terminal twin-arginine translocation (Tat) p

211 Also, PSA-cleavable NDV failed to replicate in chicken embryos, in

212 of-of-concept of PODs, by fusion of protease cleavable oligomers of glucagon-like peptide-1, a type-2

213 nditions, the Id-carrier protein linkage was cleavable only after maleimide conjugation.

214 In this study, we used T cells expressing cleavable or non-cleavable L-selectin and determined the

215 monomethyl auristatin D with either protease-cleavable or noncleavable linkers.

216 A brief stimulation of myocytes expressing cleavable or uncleavable pro-BDNF elicits synaptic poten

217 gated to an auristatin through a stable, non-cleavable oxime linkage to afford a chemically homogeneo

218 PA-L1 (5.98 +/- 0.62 %ID/g) but not by furin-cleavable PA-WT (1.05 +/- 0.21 %ID/g) or a noncleavable

219 Beads displaying photochemically cleavable pepstatin A were distributed into droplets and

220 ith human serum albumin (HSA) via a thrombin-cleavable peptide (GFPRGFPAGGCtPA).

221 We found that a negatively charged, enzyme cleavable peptide (MitoFlag) enables the trafficking of

222 information to automatically validate XL-MS cleavable peptide crosslinks.

223 Moreover, a cleavable peptide linker successfully reduced kidney upt

224 tested with endosomal furin- and cathepsin B-cleavable peptide linkers located between the integrin-b

225 tics and therapeutics that leverage protease-cleavable peptide linkers to enhance their specificity f

226 n the striking mimicry of an identical FURIN-cleavable peptide on the human epithelial sodium channel

227 als containing an alternate and non-protease-cleavable peptide sequence are stable in both in vitro a

228 actamase modified by insertion of a protease cleavable peptide sequence.

229 njugate with a humanised anti-HER2 antibody, cleavable peptide-based linker, and potent topoisomerase

230 njugate with a humanised anti-HER2 antibody, cleavable peptide-based linker, and topoisomerase I inhi

231 alpha-chymotrypsin (Cht) (a protease) and a cleavable peptide-chromogen (pro-drug) covalently incorp

232 roof-of-concept for the use of a cathepsin K cleavable peptide-linked conjugate for targeting of bisp

233 photosensitizer (Ce6) through a Cathepsin B-cleavable peptide.

234 made of a PEG core conjugated with protease-cleavable peptides, we explore a vast design space and i

235 ting conformational transitions shifting the cleavable phosphate by one step.

236 Using HJs containing non-cleavable phosphorothioate-containing linkages in one st

237 ture-sensitive properties, as well as enzyme-cleavable polysaccharides for targeted bioactive deliver

238 article (TBN) comprising of an enzymatically cleavable porous gelatin nanocore encapsulated with gefi

239 M23 complex) sorts precursor proteins with a cleavable presequence either into the matrix or into the

240 d mass spectrometry, it is convenient to use cleavable probes that allow release of labeled biomolecu

241 ion that was restored by the addition of non-cleavable proNGF.

242 zes simple chemistry on the prenyl group and cleavable properties of a sulfoxide group in the gas pha

243 interlayer coupling gives rise to the highly cleavable property of the single crystal specimens.

244 The acid-cleavable protecting groups for secondary alcohol and ur

245 CRAC performed using cleavable proteins (split-CRAC) revealed that Rrp44 endo

246 ation was enhanced by inclusion of the photo-cleavable radical initiator di-tert-butyl peroxide (DTBP

247 ur previously developed sulfhydryl-reactive, cleavable, radioiodinated photocross-linking reagent: me

248 verall, our results reveal a new metal-based cleavable reaction that expands the application of plati

249 These MS-cleavable reagents have allowed us to establish a common

250 To date, studies have utilized non-cleavable rhodopsin (Rho) tags and/or chaperones (i.e. R

251 Together, these data suggest that human non-cleavable RIPK1 variants promote activation of RIPK1, an

252 The RNAi-microsponges consist entirely of cleavable RNA strands, and are processed by the cell's R

253 Further, PSA-cleavable rNDV caused specific lysis of androgen-indepen

254 Functional analysis of the cleavable RTKs indicated that proliferation promoted by

255 PEGylated, cleavable RTN formulations offer prospects for tumor-spe

256 Transfection efficiency by PEG-modified, cleavable RTNs improved approximately 2-fold in 4 differ

257 Assembling a peptide-based Cathepsin B cleavable sensor over a large array of nano-needles allo

258 t residue 306 and forced expression of a non-cleavable Septin-2 restored cytokinesis, suggesting a di

259 -drug conjugates which contain enzymatically cleavable sequences (GFLG) in both polymeric backbone an

260 An amphiphilic polymer with cleavable side chain and main chain functional groups ha

261 otein by 69 amino acids, reveals a predicted cleavable signal peptide, and suggests structural homolo

262 achment inhibits processing of a potentially cleavable signal peptide.

263 to the ER by the first 31 aa which act as a cleavable signal sequence.

264 an in-house created (18)O-labeled peptide, a cleavable SIL peptide, and an internal standard created

265 ate the lack of commutability of tryptic and cleavable SIL peptides as internal calibrators across va

266 isotopically labeled (SIL) tryptic peptides, cleavable SIL peptides, and a full-length SIL protein we

267 an a peptide that models a potential but non-cleavable site just 2-triplets away and NMR studies show

268 Use of the acid-cleavable solubility tag strategy should facilitate synt

269 Here we adopted an acid-cleavable solubility tag strategy that facilitated synth

270 ree HNs exhibited similar affinities for all cleavable soluble substrates, their activities were 5- t

271 sox10 function after deactivation of a photo-cleavable sox10-MO at different time points.

272 g a disulfide bifunctional initiator lead to cleavable structures, underlining the role of initiator

273 A cathepsin B-specific cleavable substrate (KGRR) conjugated with triacetylated

274 rally designed by placing fluorochromes on a cleavable substrate in close proximity to one another, s

275 BoNT-cleavable substrates contain a C-terminal Nle, while BoN

276 ining peptide linkers that are enzymatically cleavable, such as MC-ValCit-PAB.

277 re chemically conjugated with T3 using a non-cleavable sulfo-SMCC linker.

278 surfactants including stimuli-responsive and cleavable surfactants.

279 Single doses of the liver-targeted, enzyme-cleavable tafenoquine polymer were found to be as effica

280 ity, stability, and simplicity of the enzyme-cleavable taurine motif promise new ways to promote the

281 ed on our previous work with photochemically cleavable terminators.

282 d in the design: a lysosomally (cathepsin B) cleavable tetrapeptide GFLG spacer conjugated doxorubici

283 d down using magnetic beads decorated with a cleavable tetrazine-modified linker.

284 Although ADC linkers can be 'non-cleavable', the vast majority of ADCs in clinical develo

285 ly attaching lactic acid to 8-arm PEG-SH via cleavable thioester bonds.

286 at different concentrations ranging from non-cleavable to cleavable concentrations obtained from in v

287 The released pro-IL-1beta was cleavable to mature bioactive IL-1beta in the extracellu

288 Notably, the crystal has naturally cleavable top and side planes-stacked via van der Waals

289 sistance and that the attachment of multiple cleavable toxophores enhances the efficiency of this sma

290 eveal that distinct type-III effectors use a cleavable transit peptide to localize to chloroplasts, a

291 de while AtCML30 utilizes an N-terminal, non-cleavable transit peptide.

292 other, hydrophobic membrane proteins lacking cleavable transit sequences into the inner mitochondrial

293 They lack a cleavable trigger in the linker and consist of a maleimi

294 e the 3-iodopropyl acetal moiety as a simple cleavable unit that undergoes acid catalyzed hydrolysis

295 hat installs a S-Se bond in peptides that is cleavable upon 266 nm ultraviolet photodissociation (UVP

296 Here, we examine the effect of the protease-cleavable valine-citrulline [VC(S)] linker on ADC effica

297 nglioside (FucGM1) antibodies using lysosome-cleavable valine-citrulline dipeptide linkers via hetero

298 f-immolative hydrolytic linkers or cathepsin-cleavable valine-citrulline peptide linkers.

299 ll, phosphatidyl choline, while the protease cleavable version of CD1d contains bound sphingomyelin a

300 Similarly, linker chemistry (cleavable versus stable) altered activity, but not accum