ライフサイエンスコーパス: cleavage

1 527, 528, and 530, which are crucial for S1P cleavage.

2 s of the transmembrane portion of pro-TNF on cleavage.

3 sly triggers high-molecular-weight kininogen cleavage.

4 fficient to produce a large effect on CA-SP1 cleavage.

5 d version of the essential gene resistant to cleavage.

6 he neighboring phenyl ring, leading to rapid cleavage.

7 or C-rich PAM sequence triggers dsDNA target cleavage.

8 mbination intermediates may drive biased DNA cleavage.

9 -end 3' processing complex, blocking mRNA 3' cleavage.

10 s to states competent for stable binding and cleavage.

11 al forces that specifically select S-C5' for cleavage.

12 nuclease motif (RphiXXXH) important for RNA cleavage.

13 d transcription factor (TF) released by self-cleavage.

14 S-C antibond, which undergoes regioselective cleavage.

15 for C3b binding, preventing FI-mediated C3b cleavage.

16 while simultaneously incorporating substrate cleavage.

17 post-translational modification and peptide cleavage.

18 information regarding substrate binding and cleavage.

19 oning the DNase active site for first-strand cleavage.

20 competent for non-specific double-strand DNA cleavage.

21 nt, 30% of quinoin is resistant to enzymatic cleavage.

22 eration of reactive oxygen species, and PARP cleavage.

23 e inadvertently altered by nuclease-mediated cleavage.

24 tion of resistance alleles that prevent Cas9 cleavage.

25 longer susceptible to proteinase K-mediated cleavage.

26 of murine proteases facilitate H3 and IBV HA cleavages.

27 oII poisons that enhance enzyme-mediated DNA cleavage, a mechanism that is linked to the development

28 evelopment and optimization of this chemical cleavage acDrug PK assay, resulting in robust accuracy a

29 With the introduction of CRISPR cleavage activity into the E-DNA sensor, a more apparent

30 cation has been suggested to control its DNA cleavage activity through flexibility of the catalytic H

31 sDNA binding is a good predictor for RNA/DNA cleavage activity.

32 A recent study suggested that tau cleavage after amino acid 368 by asparagine endopeptidas

33 exhibits a strict substrate specificity for cleavage after asparagine and aspartic acid residues dur

34 al electrode assembly and treated in the DNA cleavage agent formed by the Fenton type reaction.

35 mutants of agcA and aphC, encoding the meta-cleavage alkylcatechol dioxygenase, grew on guaiacol but

36 Cleavage allows the N-terminal fragment to function inde

37 arious paths of reductive catalytic C-O bond cleavage among functionalized aryl ethers relevant to en

38 e adult substantia nigra of mice induces DCC cleavage and a significant loss of dopamine neurons, res

39 ed, phosphorylated NCC levels decreased, and cleavage and apical localization of gamma-ENaC increased

40 uclease Csx1, and showed that subsequent RNA cleavage and dissociation acts as an 'off-switch' for th

41 redict the percentages of success for zygote cleavage and embryo blastocyst formation.

42 s that all three mutations alter ASPRV1 auto-cleavage and filaggrin processing, a function vital to e

43 The second strand cleavage and formation of a hairpin-DNA product requires

44 s well as all other methods for the C-C bond cleavage and functionalization of cyclopropanols, includ

45 understanding the mechanisms for HA protein cleavage and how they may differ depending on the biolog

46 prior to administration minimized premature cleavage and instability of the drug in plasma and enabl

47 ty-fold faster compared to the rates of sn-2 cleavage and isomerization, respectively.

48 tellite ribozyme catalyses site-specific RNA cleavage and ligation, and serves as an important model

49 l hydroxylation of the ring followed by ring cleavage and mineralization of the resulting products-do

50 Generated by 3' end cleavage and polyadenylation at alternative polyadenylat

51 R of the target gene, resulted in rapid self-cleavage and subsequent decay of the mRNA.

52 In plants, this typically results in cleavage and subsequent degradation of the mRNA.

53 ) instead promote binding of inosine without cleavage and thus enable high affinity capture of inosin

54 ied on precious-metal catalysts for C-H bond cleavage and, as a result, display high selectivity for

55 erature dependence, staggered-end DNA target cleavage, and a requirement for long stretches of homolo

56 o more hydrophilic pendant groups via linker cleavage, and as this drug release proceeds, the polymer

57 cluding alkynyl cyclotrimerization, C-O bond cleavage, and C-H bond activation, are triggered on dema

58 s involving immunoaffinity capture, chemical cleavage, and LC-MS/MS.

59 et, the inhibitor C-terminal residue Ser(33) cleavage, and the cyclization of ToPI1 via a peptide bon

60 wherein either the cis-interaction or alpha-cleavage are selectively prevented.

61 molecular dynamics simulations and a DNase I cleavage assay we found that the wild type hTERT core pr

62 reconstituted in vitro in tandem with a LexA cleavage assay, we studied LexA cleavage during DNA repl

63 Here, in vitro cleavage assays with recombinant proteins confirmed that

64 uggests that caspase-2 (Casp2)-catalyzed tau cleavage at aspartate 314 mediates synaptic dysfunction

65 erful genome engineering tools, but unwanted cleavage at off-target and previously edited sites remai

66 in Rrp9 to Ala (R289A) specifically reduced cleavage at sites A1 and A2.

67 Many secretory proteins are activated by cleavage at specific sites.

68 well as peptide bond isosteres resist KLKB1 cleavage but that only the PEG-extended analogues signif

69 s Fpr with an enhanced selectivity toward HJ cleavage but with a target sequence preference distinct

70 ene attack involving allenic C(sp(3))-H bond cleavage, but it also induces a face-selective reaction

71 on and diminished protein half-life, whereas cleavage by ADAM proteases was not modified.

72 protein (APP) through sequential proteolytic cleavage by BACE1 and gamma-secretase.

73 mechanisms to protect their genomes from R-M cleavage by covalent modifications, such as the hydroxym

74 of in vivo RNA secondary structure in miRNA cleavage by developing the new CAP-STRUCTURE-seq method

75 ations alter amyloid precursor protein (APP) cleavage by gamma-secretase, increasing the proportion o

76 za virus hemagglutinin (HA) glycoprotein via cleavage by host cell proteases is essential for viral i

77 1-kDa fragment (TCP96), are produced through cleavage by human neutrophil elastase and aggregate lipo

78 based reporters that become fluorescent upon cleavage by recombinant DENV-2/ZIKV proteases in vitro A

79 ease-targeted chimeras, RIBOTACs) and direct cleavage by small molecules have also been developed.

80 ATP level was not necessary for Pro-sigma(K) cleavage by SpoIVFB, based on analysis of mutants that b

81 Premature termination requires RNA cleavage by the endonuclease subunit of Integrator, but

82 In analyzing site-specific DNA cleavage by the mammalian RAG1-RAG2 recombinase, which i

83 d TA-dinucleotide repeats are susceptible to cleavage by the MUS81 nuclease, leading to massive chrom

84 MutSgamma directly stimulates DNA cleavage by the MutLgamma endonuclease.

85 the amyloid-beta precursor protein (APP) via cleavages by beta- and gamma-secretase.

86 uct in mammals, and that stress-induced OPA1 cleavage causes mitochondrial fragmentation and sensitiz

87 increased discrimination against off-target cleavage compared with wild-type Streptococcus pyogenes

88 re we show that topoisomerase 1-DNA covalent cleavage complex (TOP1cc) is both necessary and sufficie

89 d TOP2 DNA-protein intermediate, termed TOP2 cleavage complex (TOP2cc).

90 dation, including stabilized topoisomerase-1 cleavage complexes (Top1ccs).

91 In Atm(-/-) spermatocytes, trapped SPO11 cleavage complexes accumulate due to defective MRE11 ini

92 As proteolytic cleavage contributes to the activation of the SARS-CoV-2

93 A series of strong bond (C-C and C-H) cleavages convert the C5 gem-dimethyl group to the C15 l

94 ells to determine rate constants of the AGO2 cleavage cycle in vivo.

95 development, precisely orchestrated nuclear cleavages, cytoskeletal rearrangements, and directed mem

96 Whereas cleavage-dependent transpeptidase activity has been repo

97 biosynthetic genes DWARF27 (D27), CAROTENOID CLEAVAGE DIOXYGENASE 7 (CCD7) and CCD8 revealed that the

98 carotenoids through the action of carotenoid cleavage dioxygenases (CCDs).

99 spase-8 (CASP8)-mediated gasdermin D (GSDMD) cleavage drives pyroptotic cell death.

100 with a LexA cleavage assay, we studied LexA cleavage during DNA replication of both undamaged and ba

101 atalytic activity specificity (SEAM-seq) and cleavage efficiency of RGEs.

102 d over; the latter process is mediated by PG cleavage enzymes, for example, the endopeptidases (EPs).

103 t in addition to the well-described GPS/GAIN cleavage event in PC1 at 3048 aa and the proprotein conv

104 This cleavage event is required for and results in destabiliz

105 The physiological relevance of this cleavage event remains unclear, although it is thought t

106 ocystin at 3616 aa, there are multiple other cleavage events in these proteins.

107 transmembrane portion of PC1 undergoes three cleavage events in vivo.

108 Calpain cleavage exposes a region that is recognized by the prot

109 ontains two functionally distinct modules: a cleavage factor (mCF) and a polyadenylation specificity

110 We find that the rate-limiting step in mRNA cleavage frequently involves unmasking of target sites b

111 n a sequence-specific manner, with up to 90% cleavage from 5-nt bulge-loops (BC5-alpha and BC5L-beta

112 opy of Myrf-V679A or Myrf-R695H for its auto-cleavage function, indicating that V679A and R695H are n

113 ransiently at the division plane just before cleavage furrow ingression, suggesting that these calciu

114 hown an association of microtubules with the cleavage furrow, and we used a fluorescently tagged EB1

115 s organelle lies directly in the path of the cleavage furrow, this delay may explain, at least in par

116 data suggested the inhibition of the glycine cleavage (GCV) system caused the synthetic lethality.

117 nctionalization, in many cases, the C-F bond cleavage has been shown to occur on fluorinated substrat

118 t the role of ATP in regulating Pro-sigma(K) cleavage has been unclear, as has the impact of the chan

119 The third step, C-C bond cleavage, has been proposed to involve either compound I

120 oes not affect classical pathway-mediated C3 cleavage, hC3Nb3 inhibits classical pathway-driven hemol

121 the omegaB97X-D functional, of a rapid amide cleavage in 2-carboxyphthalanilic acid (2CPA), where the

122 ricacies of Rh(I)-catalyzed cyclobutanol C-C cleavage in a complex molecule setting are described.

123 uccessfully be used for the detection of TNF cleavage in flow cytometry and live-cell imaging applica

124 binding are suggested to be inhibition of HS cleavage in MDA-MB-231 triple-negative breast cancer (TN

125 f the cut site and increases the rate of DNA cleavage in modified versus unmodified junctions.

126 unlike O-O bond cleavage, reductive C-O bond cleavage in peroxides using the Pd catalyst and H(2) is

127 lecular borylation and sequential B-Mes bond cleavage in the presence of BBr(3) .

128 Here, we report on C-F bond cleavage in two C(6) per- and polyfluorinated compounds

129 ld-derived African mosquitoes do not prevent cleavage in vitro by the Cas9/guide RNA complex.

130 hat mutants perturbing ATP hydrolysis or DNA cleavage in vitro impair P2 OLD-mediated killing of recB

131 rally accessible for miRISC binding prior to cleavage in vivo.

132 -12 and provided protection from proteolytic cleavage in-vitro.

133 its physiological substrate involve multiple cleavages in the linker domain upon activation by Ca(2+)

134 nd robust poly(ADP-ribose) polymerase (PARP) cleavage indicative of DNA damage and apoptosis.

135 the product of which generates a stabilized cleavage intermediate in vitro.

136 nock-in (KI) mice, demonstrating that L-OPA1 cleavage is a novel mechanism for cristae abnormalities

137 GAIN domain-mediated self-cleavage is constitutive and produces two-fragment holor

138 Determining the site of cell cleavage is crucial for cytokinesis and involves precise

139 tenoid product demonstrated that the site of cleavage is defined by interactions along the substrate

140 calculations demonstrate that this C-C bond cleavage is energetically feasible and thermodynamically

141 MicroRNA (miRNA)-mediated cleavage is involved in numerous essential cellular path

142 Syndecan-1 cleavage is mediated by upregulation of matrix metallopr

143 l intermediates and that carbon-halogen bond cleavage is not involved in the rate-determining step.

144 The second cleavage is prevented by Pro hydroxylation, resulting in

145 ch indicated that the gamma-C(sp(3) )-H bond cleavage is the rate-limiting step during the reaction p

146 assively parallel platform that measures the cleavage kinetics and time-resolved cleavage products fo

147 and other catalysts have hinted at different cleavage mechanisms for the C-O ether bonds in alpha-ket

148 The endonuclease and the entire cleavage module undergo extensive rearrangements for act

149 The cleavage motif of MuV F is highly conserved among all st

150 ABA is derived from the cleavage of 9-cis-isomers of violaxanthin and neoxanthin

151 etic partitioning favors release rather than cleavage of a bound off-target substrate only because th

152 corresponding organic halides via selective cleavage of a carbon-carbon bond between the skeleton of

153 al utility was demonstrated by the selective cleavage of a tetrazine-linked antibody-drug conjugate b

154 ns originate from the metal (via heterolytic cleavage of an M-H bond).

155 or for a "therapeutic" function, namely, the cleavage of another RNA sequence.

156 trafficking results in an increase in BACE1 cleavage of APP and increased production of both Abeta40

157 A and the Polycomb protein, EZH2, results in cleavage of B2 RNA, release of B2 RNA from chromatin, an

158 t developments in transition-metal-catalyzed cleavage of C-C bonds in unstrained alcohols via beta-ca

159 Transition-metal-mediated cleavage of C-C single bonds can enable entirely new ret

160 des with high selectivity over the oxidative cleavage of C=C bond that usually forms the ketone of an

161 )-CH(2)-B compound, the product of reductive cleavage of carbon monoxide.

162 ression of pro-IL-1beta and NLRP3 as well as cleavage of caspase-1 and pro-IL-1beta, indicating infla

163 xpression of Bcl2 family of proteins and the cleavage of caspases 7 and 8.

164 ), an enrichment strategy that uses targeted cleavage of chromosomal DNA with Cas9 to ligate adapters

165 s its MIDAS motif to bind to and inhibit the cleavage of complement C3, and small-angle X-ray scatter

166 ion/intramolecular cyclization/[1,5]-H shift/cleavage of CS(2)/aromatization/nucleophilic acyl substi

167 The carbon-carbon (C-C) bond cleavage of cyclopropanols is a wide area of research wi

168 ADR induces enzymatic cleavage of DAF from podocyte surfaces, leading to compl

169 te molecular oxygen for subsequent oxidative cleavage of glycosidic bonds.

170 Strikingly large entropy associated with cleavage of H(2) results in a strong temperature depende

171 ncy ~1500-fold lower than that of kallikrein cleavage of HK.

172 anism to induce ribosome degradation and H69 cleavage of host ribosomes.

173 release via HS removal, it also facilitates cleavage of HS-containing ectodomains of syndecan-1, the

174 Cleavage of human and mouse RIPK1 after residues D324 an

175 4 (DPP4) modulates inflammation by enzymatic cleavage of immunoregulatory peptides and through its so

176 isms to catalyse collagen unwinding prior to cleavage of individual collagen chains.

177 Cleavage of isoseramox produced a native peptide N-termi

178 We show that the activation of AtMC4 and cleavage of its physiological substrate involve multiple

179 the transmembrane region and is generated by cleavage of L-OPA1.

180 ms a homo-trimer, which carries out the auto-cleavage of Myrf.

181 ydrogels), affects both the mode and rate of cleavage of NB moieties, leading to unpredictable limita

182 synthesis pathway based upon the promiscuous cleavage of O-succinyl-L-homoserine by cystathionine gam

183 e S3 that mediates constitutive and complete cleavage of OPA1.

184 The distinct tethered ligands formed through cleavage of PAR1 by thrombin versus APC result in unique

185 vivo, with Plk1-targeting siRNNs results in cleavage of Plk1 mRNA.

186 rprisingly, the aptamer enhanced proteolytic cleavage of precursor p66/p66 by HIV-1 protease, suggest

187 Cleavage of prelamin A variants was assessed using an in

188 Cleavage of pro-interleukin (IL)-1beta, pro-IL-18, and g

189 d in both the trimming of prespacers and the cleavage of protospacer adjacent motif (PAM) in several

190 Furthermore, ATR prevents excessive cleavage of reversed forks by MUS81, revealing a MUS81-t

191 cin and/or neomycin analogues, we describe a cleavage of ring I from paromomycin that proceeds in the

192 al importance of blocking caspase-8-mediated cleavage of RIPK1 on RIPK1 activation in humans is unkno

193 Cleavage of S generates a polybasic Arg-Arg-Ala-Arg carb

194 he truncated protein is generated by trypsin cleavage of soluble HttEx1 fusion protein, which we anal

195 icals through energetically uphill reductive cleavage of strong Si-Cl bonds.

196 siRNAs direct cleavage of target RNAs by guiding Argonaute2 (AGO2) to

197 The hydrolytic cleavage of TGs generates free fatty acids (FFAs), which

198 Modification of approved drugs, facile cleavage of the benzazole auxiliary, and tolerance of am

199 The experimental studies showed that cleavage of the C-H bond is rate-limiting and formation

200 Proteolytic cleavage of the cell adhesion molecule L1 (L1) in brain

201 apping") units at the tethers and subsequent cleavage of the covalent ring/thread ester linkages.

202 During catalysis, homolytic cleavage of the Fe-C5' bond liberates 5'-dAdo(*) for rea

203 While the cleavage of the hairpins by the constituents associated

204 This 2,3-dioxygenative cleavage of the indole ring of tryptophan with dioxygen

205 Fab fragment with an anti-idiotypic mask and cleavage of the mask by tumor-specific proteases can be

206 igands were found to be key in assisting the cleavage of the meta-C-H bond in the concerted metalatio

207 ated or activated (i.e., partial or complete cleavage of the N(2) triple bond in the observed product

208 The RVP domain is probably responsible for cleavage of the precursor of the transcription factor Nr

209 y Criegee ozonolysis of an alkene, reductive cleavage of the resulting alpha-alkoxy hydroperoxide, tr

210 y structure modeling and analysis of RNase E cleavage of the rimO-crhR transcript in vitro suggested

211 catalytic bimetallic site for the hydrolytic cleavage of the RNA model substrate HPNP, whose reactivi

212 undergoes regioselective homolytic reductive cleavage of the S-C5' bond to generate the 5'-dAdo. radi

213 Following cleavage of the signal peptide upon entry into the endop

214 e activity, and 28-bp hybridization promotes cleavage of the target strand.

215 addition, reduction of the azo group led to cleavage of the triazapentalene core.

216 Cleavage of these proteins in a proline-rich region betw

217 Cleavage of this probe by the secreted S. aureus enzyme

218 exposure of a second proteolytic site (S2'), cleavage of which is required for the release of the fus

219 g how piRNA sequences are defined during the cleavages of piRNA precursors remain elusive.

220 betaFurKO cells show impaired cleavage or shedding of vacuolar-type ATPase (V-ATPase)

221 elongation factor S-II (TFIIS)-dependent RNA cleavage, or as drastic as premature transcription termi

222 nd systematic comparisons of specificity and cleavage outcomes across engineered and natural nuclease

223 understanding their fidelity, mechanisms and cleavage outcomes requires systematic profiling across m

224 HEPN nucleases participate in diverse RNA cleavage pathways and share a short HEPN nuclease motif

225 arboxylates that operate by heterolytic H(2) cleavage pathways.

226 tion of apoptosis, and prevention of amyloid cleavage pathways.

227 DNA gap was sufficient to modulate RNase H1 cleavage patterns and combining these designs with simpl

228 ntrolling PS chirality can modulate RNase H1 cleavage patterns, ASO sequence and design are the prima

229 tors, including susceptibility to proteasome cleavage, peptide transport into the endoplasmic reticul

230 PC1 at 3048 aa and the proprotein convertase cleavage (PPC) event in fibrocystin at 3616 aa, there ar

231 We found that the cleavage product from this fragmentation event is releas

232 nctional form, whereas S-OPA1 is an inactive cleavage product in mammals, and that stress-induced OPA

233 Soluble TREM2 (sTREM2), a soluble cleavage product of TREM2, is elevated in AD cerebrospin

234 mation of products of reactions between ring cleavage products and the model nucleophile N-alpha-acet

235 e concerns about the formation of toxic ring-cleavage products during the initial stage of oxidation

236 ures the cleavage kinetics and time-resolved cleavage products for over 10,000 targets containing mis

237 Ring-cleavage products for which quantification was possible

238 However, the pathway to these cleavage products is complex, initiated by regioselectiv

239 he formation mechanisms and identity of ring cleavage products, especially at higher chlorine doses.

240 cuses on the formation of electrophilic ring cleavage products-a class of compounds that poses potent

241 hlorine in the production of dicarbonyl ring cleavage products.

242 Determining the off-target cleavage profile of programmable nucleases is an importa

243 ons, the custom design of the cell cycle and cleavage properties, the protein number partitioning upo

244 magnesium-catalyzed regiodivergent C-O bond cleavage protocol is presented.

245 bound off-target substrate only because the cleavage rate is so low.

246 sus sequence is driven by maintenance of the cleavage rate.

247 It was established that flavonol oxidative cleavage reaction and oxidative polymerization are main

248 inverse-electron-demand Diels-Alder (IEDDA) cleavage reaction between tetrazine and trans-cycloocten

249 The alpha-chymotrypsin-based cleavage reaction is necessary for manufacturing peptide

250 rpin ribozyme, pressure slowed down the self-cleavage reaction on the basis that the formation of the

251 mediated chemistry to encompass the C-C bond cleavage reaction.

252 For the first time, unlike O-O bond cleavage, reductive C-O bond cleavage in peroxides using

253 sulfur into the microbial food web, whereas cleavage releases sulfur into the atmosphere.

254 gulating this cellular characterization with cleavage signatures of 178 proteases highlights proteoly

255 ) precursor with alterations in the protease cleavage site (R508S/R511S) or by introducing a disulfid

256 express a TEVp (tobacco etch virus protease) cleavage site and a SpyTag (st) between cMyBP-C domains

257 of the SARS-CoV-2 S glycoprotein, the furin cleavage site and D614G, have evolved to balance virus i

258 protease, activates PAR1 through a distinct cleavage site and promotes anti-inflammatory responses,

259 introduced a previously developed enzymatic-cleavage site between helices E and F and pulled from th

260 ave an Arg residue at the P4 position of the cleavage site between the nonstructural protein P1 (nsP1

261 transcription termination downstream of the cleavage site in an XRN2-dependent manner.

262 golins, SARS-CoV-2 harbors a polybasic furin cleavage site in its spike (S) glycoprotein.

263 The absence of the polybasic cleavage site in SARS-CoV-2 did not affect virus replica

264 We found that the cleavage site in this 1192-amino-acid-long fragment is l

265 2 that either directly affect the furin-like cleavage site itself (NSPRRAR) or a flanking sequence (Q

266 ensor containing the flavivirus internal NS3 cleavage site linker reported the highest fluorescence a

267 esidue at position 8 (P8) of the proteolytic cleavage site of MuV F, because this amino acid residue

268 le the Icelandic APP mutation near the BACE1-cleavage site protects from sporadic dementia, emphasizi

269 The cleavage site within the S2 subunit responsible for acti

270 ospacer-adjacent motif (PAM) near the target cleavage site, constraining the sequences accessible for

271 ognizes HS substrate and selects a favorable cleavage site.

272 es a pri-miRNA and accurately identifies the cleavage site.

273 ructure of the BMV capsid shows four trypsin cleavage sites (K(65), R(103), K(111), and K(165) on the

274 Broad identification of optimal cleavage sites and natural substrates of proteases is cr

275 ion strategy to introduce artificial tryptic cleavage sites at Cys29 and Cys33 in rhEPO.

276 esulting in a set of 55 high-confidence gRNA cleavage sites identified by both methods.

277 ural explanation of accessibility of the RNA cleavage sites to the peptide with adoption of an 'in-li

278 locus no longer produces transcripts with S2 cleavage sites, we generated a simplified system to iden

279 redictor of protease-specific substrates and cleavage sites.

280 d by Dux, a multicopy retrogene defining the cleavage-specific transcriptional program in placental m

281 Gldc functions in the glycine cleavage system, a mitochondrial component of folate met

282 In photolytic cleavage those forces act through control of the ribose

283 al pyroptotic function to inhibiting caspase cleavage to disrupting oligomerization and pore formatio

284 e GPs displayed reduced thermostability upon cleavage to GP conformers (GP(CL)).

285 ine residues reduced the number of enzymatic cleavages to the protein and retained large molecular we

286 tion involving a sigma complex and oxidative cleavage transition state.

287 and cohered replicated chromosomes until its cleavage triggered the metaphase-to-anaphase transition.

288 idation and amidation via oxidative C-C bond cleavage under an O(2) atmosphere to deliver the target

289 , in bulk experiments we observe promiscuous cleavage under physiological negative supercoiling.

290 hylation and Ni-catalyzed benzalkyl C-N bond cleavage under reductive conditions.

291 lease of annexin A5 owing to diselenide-bond cleavage under the oxidizing conditions of the tumour mi

292 s confirm that these aryl ethers undergo C-O cleavage via distinct paths.

293 The relative risk for cleavage was 2.36 times lower in the embryos derived fro

294 Pro-IL1beta cleavage was only moderately enhanced by similar substit

295 ding of the molecular mechanism of substrate cleavage, we have solved the crystal structures of human

296 tory to prothrombinase- or thrombin-mediated cleavage, we observed variant affinities between ~1 and

297 e, applying oxidant insult that induces OPA1 cleavage, we show that cells unable to generate S-OPA1 a

298 While Mg(2+) enables eEndoV to catalyze RNA cleavage, we show that similar levels of Ca(2+) instead

299 e PK assay strategies for these ADCs involve cleavage with cathepsin B or papain to release and measu

300 SBT6.1-mediated cleavage within the variable domain allows for continued