ライフサイエンスコーパス: cleavage at

1 Ph(3), which was capable of heterolytic H(2) cleavage at 1 atm and room temperature, representing, fo

2 from 1-bromoethylbenzene undergoes NO-C bond cleavage at 120 degrees C with an activation energy of E

3 othrombin to thrombin by specific sequential cleavage at 2 sites.

4 of transcription suggested that endonuclease cleavage at 3'-proximal sites was an early step in turno

5 However, H5' abstraction can lead DNA cleavage at 5' end through the formation of C5'=O5' keto

6 After cleavage at a canonical proprotein convertase cleavage s

7 h guide strand into RISC with resultant mRNA cleavage at a defined site.

8 binding repeat region, which can result from cleavage at a furin cleavage site present in some apoER2

9 The latter is more active and generated by cleavage at a furin-like site.

10 ssed in cilia that undergoes autoproteolytic cleavage at a G protein-coupled receptor proteolytic sit

11 oth MAbs increased HA sensitivity to trypsin cleavage at a higher pH range, suggesting MAb-induced co

12 sing peptidase and Oct1 and an autocatalytic cleavage at a highly conserved LGST motif yielding the a

13 tory region (NRR) that enables ADAM protease cleavage at a juxtamembrane site that otherwise lies bur

14 mong the mildest conditions reported for C-H cleavage at a Ni center.

15 VEGF-C specifically and efficiently through cleavage at a novel N-terminal site.

16 ated region (UTR) sites, or miR-122-mediated cleavage at a perfectly complementary site.

17 endonuclease domain of the RdRp for specific cleavage at a precise length from the 5' cap.

18 (C)) is subjected to the physiological alpha-cleavage at a region critical for both PrP toxicity and

19 SBT-mediated cleavage at a second site within the mature peptide atte

20 Cleavage at a serine residue near the C terminus was a m

21 bond can undergo an electrochemically driven cleavage at a significantly more anodic-yet accessible-p

22 ing experiments, (2) selective monitoring of cleavage at a single site in a peptide with multiple pro

23 e isoacceptor tRNA, tRNA(Lys43-UUU), through cleavage at a single site within its anticodon (UU U).

24 ids within the loop is necessary rather than cleavage at a single site.

25 der RNA has been shown to depend on RNase J1 cleavage at a single-stranded, AU-rich region just upstr

26 spase-3, an enzyme that is required for SipA cleavage at a specific recognition motif that divided th

27 14, snR30, and snR10, which are required for cleavage at A0-A2.

28 yltransferase that is required for efficient cleavage at A2.

29 Ecm16 is also required for cleavage at A2.

30 Peptides requiring cleavage at acidic and hydrophobic sites, which involve

31 tly, it has been postulated that proteolytic cleavage at Ala(1800) and protein kinase A phosphorylati

32 Notably, we found that this non-canonical cleavage at Ala-470-Asn-471 is instrumental for the onse

33 namics of dCas9-based binding and Cas9-based cleavage at all DNA sites with both canonical and non-ca

34 nd DNA cleavage by independent single-strand cleavages at all five sites.

35 n of proteins leads to reproducible backbone cleavage at almost every inter-residue position, and in

36 Here we report a carbon-carbon bond cleavage at ambient conditions by a Au(i) complex that g

37 Further, cleavage at amino acid 45/47 of caspase-7 by calpain res

38 he presence of Htt fragments consistent with cleavage at amino acid Asp-586 of Htt in the BACHD Casp6

39 yclic amine at C2 on the nucleobase promotes cleavage at an alternative site and it has a negative im

40 cal structural role in poising chromatin for cleavage at an early stage of neutrophil cell death.

41 complex that is subsequently dissociated by cleavage at an upstream site.

42 ient all sister chromatids prior to cohesion cleavage at anaphase.

43 ometric analyses of CF mucins revealed mucin cleavage at antibody recognition sites.

44 tives generated by spermine-catalyzed strand cleavage at Ap sites in duplex DNA can react with adenin

45 activation where Lnk2 presents the sites of cleavage at Arg(271) and Arg(320) to factor Xa in differ

46 without preference along the prethrombin-2 (cleavage at Arg(271) first) or meizothrombin (cleavage a

47 20) and a surprising increase in the rate of cleavage at Arg(271).

48 this region with an abrupt shift toward slow cleavage at Arg(271).

49 substrate leads to a decrease in the rate of cleavage at Arg(320) and a surprising increase in the ra

50 leavage at Arg(271) first) or meizothrombin (cleavage at Arg(320) first) pathways.

51 or cleavage is implied by essentially normal cleavage at Arg(320) in recombinant prothrombin variants

52 ity for FXa to activate FVIII variants where cleavage at Arg(336) was accelerated due to flanking seq

53 estern blotting and correlated with rates of cleavage at Arg(372) and Arg(1689), respectively.

54 Rates of thrombin cleavage at Arg(372) were increased ~10- and ~3-fold com

55 r two sites is relatively fast compared with cleavage at Arg(372), which appears to be rate-limiting.

56 king Arg(372) abrogated the need for initial cleavage at Arg(740) to facilitate this step.

57 cleavage at Arg-740, we investigated whether cleavage at Arg-1689 influences catalysis at this step.

58 ve intermediate prethrombin-2 via an initial cleavage at Arg-271 followed by cleavage at Arg-320.

59 thrombin activation proceeds with an initial cleavage at Arg-320 yielding the catalytically active, y

60 a an initial cleavage at Arg-271 followed by cleavage at Arg-320.

61 Because cleavage at Arg-372 appears rate-limiting and dependent

62 The catalytic efficiency for thrombin cleavage at Arg-740 is greater than at either Arg-1689 o

63 ars rate-limiting and dependent upon initial cleavage at Arg-740, we investigated whether cleavage at

64 s citrullinated host peptides by proteolytic cleavage at Arg-X peptide bonds by arginine gingipains,

65 can be activated to FVIIIa by FXa following cleavages at Arg(372), Arg(740), and Arg(1689).

66 embrane-bound PC7 can directly shed hTfR1 by cleavage at Arg100 downward arrow.

67 Group E mAbs inhibited fVIII light-chain cleavage at Arg1689.

68 Whereas initial cleavage at Arg271 generates the inactive intermediate p

69 inactive intermediate prethrombin-2, initial cleavage at Arg320 generates the enzymatically active in

70 h alpha-thrombin formation quickly after via cleavage at Arg320.

71 fVIII by interfering with thrombin-catalyzed cleavage at Arg372 at the A1-A2 domain junction.

72 Inhibition of cleavages at Arg372 and Arg1689 represent novel mechanis

73 That PAR1 cleavage at Arg46 can occur on cells was supported by AP

74 can target/disarm cell surface PAR1 through cleavage at Arg46 downward arrow.

75 at residue Asn47, which is generated by APC cleavage at Arg46, mediates APC's cytoprotective signali

76 licate donor T-cell APC-induced noncanonical cleavage at Arg46-PAR1, which is known to confer cytopro

77 ither site, cleavage must occur at Arg12, as cleavage at Arg5 alone is insufficient for successful in

78 or no inhibitory activity despite inhibiting cleavage at Arg740 at the A2-B domain junction.

79 Intramolecular self-cleavage at Asp-193 evoked higher solvent exposure in th

80 omplex and inducing selective intramolecular cleavage at Asp-315.

81 uggests that caspase-2 (Casp2)-catalyzed tau cleavage at aspartate 314 mediates synaptic dysfunction

82 Markedly reduced cleavage at beta'-site exhibited by BACE1-GPI was cell t

83 Increased caspase 3 cleavage at both early (transient) and late times of inf

84 le N-TBDPS aziridine but caused nucleophilic cleavage at C(1) as well as C(10) without cleavage of th

85 Initial C-H cleavage at C2 led to 7% C2 hydroxylation and 19% 3-hydr

86 rgonaute 2-loaded miRNAs via endonucleolytic cleavage at CA and UA dinucleotides, preferentially at s

87 containing MmeI sites at its ends, allowing cleavage at chromosomal sites 16-17 bp from the inserted

88 mately 40% of observed synapses resulting in cleavage at consensus RSS binding sites.

89 oteolysis, with complete blockade of peptide cleavage at constrained sites in the immediate vicinity

90 The cleavage at D285 blocks expression of LC3-II, Nrf2 and s

91 During ribosomal RNA (rRNA) maturation, cleavages at defined sites separate the mature rRNAs fro

92 The kinetic profile of peptide bond cleavage at different regions of lambdaN was first detec

93 Hi-C read pairs to estimate the fractions of cleavages at different possible targets.

94 nterferases that selectively target mRNA for cleavage at distinct consensus sequences.

95 at trypsin IV and trypsin I activate ENaC by cleavage at distinct sites.

96 ctivation by cleaving at the furin site, and cleavage at downstream sites is accomplished by membrane

97 Thus, NEMO cleavage at E349 alone may not be sufficient to complete

98 as shown to undergo autocatalytic C-terminal cleavage at E946, removing 15 residues, both in vitro an

99 urate estimates of DeltaS(double dagger) for cleavage at each C-C bond.

100 ity deriving from tighter binding and faster cleavage at EcoRI* sites (one incorrect base pair).

101 tion process involving triflate-assisted C-H cleavage at either a Ni(IV) or a Ni(III) intermediate.

102 process that is primed by an initial epsilon-cleavage at either T48 or L49, resulting in subsequent p

103 on and unsuitable for applications requiring cleavage at elevated temperatures.

104 rmophilus (GeoCas9) catalyzes RNA-guided DNA cleavage at elevated temperatures.

105 be directed by short RNAs to induce precise cleavage at endogenous genomic loci in human and mouse c

106 The increased cleavage at endosomal pH also has implications for other

107 e R(max) change, combined with the increased cleavage at endosomal pH, indicates greater accessibilit

108 d that both HP21 and PAP3 activate proHP5 by cleavage at ESDR(176)*IIGG.

109 Both hairpin DNAs underwent double-strand cleavage at five sites within or near the original rando

110 Each underwent double-strand cleavage at five sites within, or near, an eight base pa

111 ence supports the mechanism of autocatalytic cleavage at FlhB residue N269.

112 n bond, results in a substantial decrease in cleavage at G and U of the triple.

113 Top1 cleavage at genomic ribonucleotides can produce ribonucl

114 dentified a semitryptic peptide arising from cleavage at Gly(2196)-Leu(2197) We noted that this sciss

115 ee DNA binding suppresses Top1-catalyzed DNA cleavage at high drug concentrations, whereas DNA cleava

116 ctivity was detected and increased total RNA cleavage at high Mg(2+) concentrations sufficient to fol

117 esidues on this receptor allow productive S2 cleavage at high temperatures and thereby serve as a buf

118 NP1 suppresses polyadenylation and cleavage at its internal site, termed the proximal polya

119 3S), and its activation requires proteolytic cleavages at its C terminus, involving proteases involve

120 consensus motifs and the second showing slow cleavage at largely unique sites with low-scoring motifs

121 ut this role appears to be independent of HJ cleavage, at least in mouse cells.

122 siloxycarbyne/CO species undergoes C-O bond cleavage at lower temperatures, indicating that monosily

123 Processing at Arg(162) was not required for cleavage at Lys(158) or regulation of chemerin bioactivi

124 Endopeptidase cleavage at Lys(91) generates a cleaved globular gCTRP12

125 Cleavage at Lys(91) is context-dependent: mutation of th

126 nd ADAM17 have also been implicated in alpha-cleavage at Lys-109 downward arrowHis-110; however, we o

127 rotease cleavage site revealed that specific cleavage at Met(369) inhibited NCX1 activity (both forwa

128 Each of the DNAs underwent double-strand cleavage at more than one site, and all of the cleavage

129 ed Nup98 with 2A(pro) results in proteolytic cleavage at multiple sites in vitro, indicating that 2A(

130 intolerant to change and caused inefficient cleavage at NC-p2.

131 at altered the 5' proximal AUG abolished Vhs cleavage at nearby sites, while mutations that changed s

132 of Fe(2+) in supporting the catalysis of RNA cleavage at neutral pH, but not at lower pH.

133 m triflate followed by triflate-assisted C-H cleavage at Ni(IV) to yield the products.

134 In some cases, however, there can be cleavage at nonspecific sites, giving rise to heterogene

135 erful genome engineering tools, but unwanted cleavage at off-target and previously edited sites remai

136 To investigate how nucleosomes affect Cas9 cleavage at off-target sites in vitro, we used a single

137 site, specificity of cleavage (i.e. rate of cleavage at 'off-target' sites), and efficient/facile me

138 phorylation at several sites and proteolytic cleavage at one of these sites, resulting in nuclear tra

139 ites, held together by a resolvase tetramer; cleavage at one site stimulates cleavage at the partner

140 t in the sequence of HHM, strictly selective cleavage at only 6 solvent accessible aspartate residues

141 tRNA(Ala2), tRNA(Ser26) and tRNA(Ser24)) for cleavage at, or adjacent to, their anticodons, resulting

142 late sequential strand displacement and flap cleavage at other genomic sites.

143 YpeB cleavage sites reduced proteolysis, but cleavage at other sites still resulted in loss of full-l

144 prisingly differed in its ability to inhibit cleavage at other sites, a phenomenon attributed to long

145 A physiologically relevant cleavage at PC1's G protein-coupled receptor proteolytic

146 h a 5'-terminal uridine (U) demonstrated cis-cleavage at PHAS precursors, and these cis-acting sites

147 two leader peptides that undergo sequential cleavage at positions G17/G18 and G35/A36 during export

148 strong DNA sequence specificity that favors cleavage at promoters and terminators and accounts for s

149 encing and deep sequencing of iodine-induced cleavage at PT (ICDS).

150 3C(pro) mediates TRIF cleavage at Q312 and Q653, which are sites in the amino-

151 d fV activation were almost doubled, whereas cleavage at R(306) was equivalent.

152 sed rates of factor Va (fVa) inactivation by cleavages at R(506) and R(306).

153 n that both FHC mutants increase the rate of cleavage at R133, ~45 residues N-terminal to the mutatio

154 sidues C-terminal to E180G, in parallel with cleavage at R133.

155 -like proteases is the result of proteolytic cleavage at R15 followed by an ionic interaction that en

156 ombin pathway, whilst the open form promotes cleavage at R271 and initiates activation along the alte

157 sed equilibrium and exposure of the sites of cleavage at R271 and R320.

158 rombin, which is generated by two sequential cleavages at R271 and R320 by the prothrombinase complex

159 cifically, the dominant closed form promotes cleavage at R320 and initiates activation along the meiz

160 s active form meizothrombin desF1 carrying a cleavage at R320.

161 Initial cleavage at R74 is proposed in a distal ubiquitin to pro

162 ant, suggesting little dependence upon prior cleavage at residue 1689 as compared with thrombin.

163 , G409R and E410V, render LPL susceptible to cleavage at residue 297 (a known furin cleavage site).

164 ro-PanD, which undergoes an auto-proteolytic cleavage at residue Ser25 to yield the catalytic pyruvoy

165 at H2 activation at 2 proceeds via oxidative cleavage at Ru with concomitant hydride transfer to Zn.

166 t NLRP1 activity is dependent upon autolytic cleavage at Ser(1213) within the FIIND.

167 mation on the exact timing and extent of TNF cleavage at single-cell resolution and they do not allow

168 Nucleolar cleavage at site A(2) excises this sequence element, lea

169 3 and the pseudoknot, placing Utp24 close to cleavage at site A1.

170 Cleavage at site A2 liberates the pre-40S subunit.

171 omain (CTD) of Rrp5 is required for pre-rRNA cleavage at sites A0-A2 on the pathway of 18S rRNA synth

172 in Rrp9 to Ala (R289A) specifically reduced cleavage at sites A1 and A2.

173 asses of sites for TFs, one displaying rapid cleavage at sites with robust consensus motifs and the s

174 5' end appears to increase the likelihood of cleavage at sites within the 5' untranslated region.

175 ain in human UTP24 was required for accurate cleavages at sites 1 and 2a in vivo, whereas mutation of

176 U3 and Rrp9 are required for early pre-rRNA cleavages at sites A0, A1 and A2, but the mechanism rema

177 are essential for early pre-ribosomal (r)RNA cleavages at sites A0, A1/1 and A2/2a in yeast and human

178 ed rapid degradation of mRNAs beginning with cleavages at sites in the first 250 nucleotides, includi

179 r and how PAM binding activates Cas9 for DNA cleavage at spatially distant sites.

180 2+), but not Mg(2+), and Ca(2+), can enhance cleavage at specific nucleotides in UTR1.

181 Many secretory proteins are activated by cleavage at specific sites.

182 tuate the entire structure through enzymatic cleavage at specific sites.

183 ations through either bond formation or bond cleavage at sulfur.

184 In order to achieve efficient and specific cleavage at target sites, a high degree of target site d

185 of the adsorbed complexes underwent C-H bond cleavage at temperatures as low as 150 kelvin (K).

186 ass spectrometry (LC-MS/MS) method to detect cleavage at the (374)ARGS site and the (1820)AGEG site.

187 positions the nuclease Nob1 for cytoplasmic cleavage at the 3'-end of 18S rRNA and is required for t

188 Thus, Nob1 is poised for cleavage at the 3'-end of 18S rRNA.

189 at these enzymes introduce a double-stranded cleavage at the 3'-side away from the recognized modifie

190 eudorevertant (termed EG) partially restored cleavage at the 3B-3C cleavage site.

191 involve prenylation of the cysteine residue, cleavage at the AAX tripeptide and methylation of the ca

192 5)H(10)), slowly undergoes a second N-H bond cleavage at the alpha-N-H bond and elimination of hydrog

193 uctural microheterogeneity of signal peptide cleavage at the amino terminus of FGF2, whereas IGF1 dis

194 )J recombination entails double-stranded DNA cleavage at the antigen receptor loci by the RAG1/2 prot

195 We found extensive cleavage at the beginning of the coding region of five t

196 mutation, we demonstrate efficient targeted cleavage at the beta-globin locus with minimal off-targe

197 CE1-GPI is mainly attributed to preferential cleavage at the beta-site and failure to detect +11 Abet

198 peptide by trypsin yields two fragments from cleavage at the C terminus of the L-Arg residue.

199 in the spinal cord that in turn causes KCC2 cleavage at the C terminus.

200 63alpha occurs during apoptotic signaling by cleavage at the C terminus.

201 Selective backbone cleavage at the C(alpha)-C bond is observed to yield a a

202 mass spectrometric analysis, consistent with cleavage at the C-1'' position.

203 arboxypeptidases is initiated by proteolytic cleavage at the C-terminal end of the propeptide by tryp

204 This analysis confirmed cleavage at the C-terminal side of Pro residues.

205 ed LysC proteolysis leads to high efficiency cleavage at the C-terminal side of the hinge lysine 222

206 SP1 lattice, whereas mutational abolition of cleavage at the CA-SP1 site results in virions in which

207 CA5 particles, which exhibit no cleavage at the CA-SP1 site, have spheroidal shells with

208 rnative site and it has a negative impact on cleavage at the canonical site.

209 apsid junction occurs five times faster than cleavage at the capsid|spacer peptide 1 junction.

210 ceptor CD44 undergoes sequential proteolytic cleavage at the cell surface.

211 these factors may lead to either ineffective cleavage at the cognate restriction site or relaxed spec

212 t the crucial role of Sae2 in activating MRX cleavage at the correct cell cycle stage.

213 hown to direct the Cas9 nuclease for precise cleavage at the desired sites and introduce mutation (in

214 y for therapeutic application: efficiency of cleavage at the desired target site, specificity of clea

215 nts obtained from Chloe mice that resist MMP cleavage at the DIPEN downward arrowFFGVG site in the in

216 previously shown to efficiently direct Cas9 cleavage at the edge of the strongly positioned 601 nucl

217 Cytokinesis is the process of physical cleavage at the end of cell division; it proceeds by ing

218 Moreover, we detect Cas9 cleavage at the fourth nucleotide on the non-complementa

219 These observations suggest that cleavage at the furin-cleavage site decreases the overal

220 Polycystin-1 (Pc1) cleavage at the G protein-coupled receptor (GPCR) proteo

221 ey phenotype in mice by markedly suppressing cleavage at the G protein-coupled receptor proteolysis s

222 or DNA, enzyme and drug contributions to DNA cleavage at the gate, suggest a mechanism for DNA discri

223 dification of versican is a prerequisite for cleavage at the Glu(441)-Ala(442) site, as demonstrated

224 and PC2 first interact in the ER before PC1 cleavage at the GPS/GAIN site and determined that PC2 ac

225 emperatures were partially resistant to LysC cleavage at the hinge and resulted in a species where on

226 Cleavage at the initial site was followed by RT dissocia

227 Inhibition of RIP1 cleavage at the KD suppresses NF-kappaB activation and c

228 Cleavage at the latter two sites is relatively fast comp

229 In a previous study, a mutation inhibiting cleavage at the MA-CA junction was observed to potently

230 A mutation that blocks cleavage at the MA/CA processing site (Y132I) displayed

231 ficient cleavage at the Shadow site requires cleavage at the Main site, and remarkably, none of the s

232 cleavage at the Shadow site is dependent on cleavage at the Main site.

233 cally disordered coil to a beta-hairpin upon cleavage at the matrix|capsid junction occurs five times

234 igand binding, the Notch4 receptor undergoes cleavage at the membrane and the Notch4-intracellular do

235 sociation with 266 nm light yields homolytic cleavage at the modification site, generating a beta rad

236 argeted to mitochondria by sequence-specific cleavage at the N terminus by a cytosolic Ser protease (

237 Self-cleavage at the N terminus of HIV-1 protease from the Ga

238 Cleavage at the N terminus of the cyclotide domain occur

239 ation of expected products from DEA-mediated cleavage at the N-glycosidic bond.

240 ly studied atypical KlbA Ala(1) inteins: (a) cleavage at the N-terminal splice junction in the absenc

241 Cleavage at the NS2/3 junction is a rate-limiting step i

242 tered the stability of the NS4B protein, and cleavage at the NS4B/5A junction was significantly delay

243 in occurs in a highly regulated manner, with cleavage at the P2/3 junction influencing RNA template u

244 se tetramer; cleavage at one site stimulates cleavage at the partner site.

245 sts that the prodomain undergoes intradomain cleavage at the PGD downward arrow L(50) site followed b

246 ergoes nonamyloidogenic processing via alpha-cleavage at the plasma membrane, amyloidogenic beta- and

247 ne the basal mechanism of PADT and show that cleavage at the poly(A) site is not required for PADT.

248 , in the absence of extract, nucleotides, or cleavage at the poly(A) site.

249 nd that loss of EF-RNA interactions upon RNA cleavage at the polyadenylation site triggers disassembl

250 d the neoepitope generated after proteolytic cleavage at the prostasin/kallikrein cleavage site (K181

251 he common pre-rRNA transcript by stimulating cleavage at the proximal site in ITS1.

252 cleavage, and proteinuria is associated with cleavage at the putative prostasin/kallikrein site and r

253 Cleavage at the S1 or atypical S0 site in Gbb produces G

254 of the wing and leg imaginal discs, whereas cleavage at the S1 site is sufficient to rescue Dpp func

255 s we demonstrate, by dpp mutant rescue, that cleavage at the S2 site of proDpp is required for develo

256 Cleavage at the S2 site, which appears to occur in a tis

257 joining (NHEJ) DNA repair following repeated cleavage at the same critical site may permanently disru

258 hich prevents the repaired RNA from repeated cleavage at the same site.

259 e ends to form a circular mRNA inhibited Vhs cleavage at the same sites at which it cuts capped linea

260 Cleavage at the second site regulates the stability of m

261 tes in Scw can be cleaved independently, but cleavage at the Shadow site is dependent on cleavage at

262 be cleaved independently, although efficient cleavage at the Shadow site requires cleavage at the Mai

263 ormational flexibility required for specific cleavage at the single-strand/double-strand DNA junction

264 Cleavage at the sites of the lesions was also observed b

265 n spectra of [PC - CH3](-) suggest favorable cleavage at the sn-2 position over the sn-1 due to disti

266 Mutations that interfered with cleavage at the SP-NC junction disrupted CA-SP processin

267 HIV-1 isolate Envs is not caused by aberrant cleavage at the tandem gp120/gp41 cleavage sites, which

268 elease mechanisms to allow controlled linker cleavage at the target site and are thus termed 'cleavab

269 he approach relies on dual-RNA:Cas9-directed cleavage at the targeted genomic site to kill unmutated

270 nted, and electron capture caused a specific cleavage at the terminal butyl-trithiocarbonate group, w

271 aled a delay between first and second strand cleavage at the transposon end.

272 e to different degrees of phosphorus-LG bond cleavage at the TS for different substrates, the LG is s

273 exchange DNA strands after double-strand DNA cleavage at the two recombining att sites, and that many

274 he cognate dNTP enhanced DNA 3' end-directed cleavages at the 17th and 18th nucleotides.

275 ngdoms of life, responsible for the specific cleavages at the second phosphodiester bond 3' to inosin

276 Several unique cleavages at the sphingoid base and the fatty acid chain

277 n-coupled receptors activated by proteolytic cleavage at their amino termini by serine proteases.

278 Cleavage at these positions results in the selective rem

279 at DNA bubbles induce off-target binding and cleavage at these sites, even with ten mismatches, as we

280 The preference for cleavage at these two positions depends upon the seconda

281 We also found that the cleavage at these two sites is independent of each other

282 Enhanced double-strand cleavages at these sites appear to be a consequence of t

283 Further repositioning leads to a loss in cleavage at this region with an abrupt shift toward slow

284 psbN gene is not transcribed suggesting that cleavage at this site is dependent on the formation of s

285 ngineering mutant viruses, we showed caspase cleavage at this site was not required for productive in

286 the peptide bond joining Asp(80) and Pro(81) Cleavage at this site was predicted to separate the firs

287 lphaC region blocked plasmin-mediated fibrin cleavage at this site, resulting in the generation of in

288 the R1689Q variant was resistant to thrombin cleavage at this site.

289 active site docking by Arg(320) and initial cleavage at this site.

290 activated by thrombin or factor Xa-catalyzed cleavage at three P1 residues: Arg-372, Arg-740, and Arg

291 Heterodimeric factor Va is produced by cleavage at three sites in the middle of factor V by thr

292 domain protein Utp24 is essential for early cleavages at three pre-rRNA sites in yeast (A0, A1 and A

293 pecific RAG endonuclease, which mediates DNA cleavage at two recombining gene segments and their flan

294 reaction involves DNA binding, synapsis, and cleavage at two RSSs located on the same DNA molecule an

295 Cleavage at U exhibits a large 5' deuterium kinetic isot

296 lytic core that preferentially catalyzes RNA cleavage at UN dinucleotide junctions (k(obs) = 0.9 h(-1

297 However, off-target DNA cleavages at unknown sites can lead to mutations that ar

298 find substantial differences in UDG-directed cleavage at uracils rotationally positioned toward (U-In

299 plotting the initial rates of the C-OMe bond cleavage at varying concentrations.

300 While HPLC studies confirm ligand cleavage at very high protein concentrations, they indic