ライフサイエンスコーパス: cleavage product

1 f a previously uncharacterized C-terminal C3 cleavage product.

2 compared with controls and the GrB-EH(ITSN) cleavage product.

3 ated serine (p.S216L) in the 32-kDa enamelin cleavage product.

4 ection, resulting in the previously observed cleavage product.

5 NA cleavage rather than simply stabilize the cleavage product.

6 RNA, full-length protein, and SREBP-2 active cleavage product.

7 caspase-6 also generates a 45-kDa PPARgamma cleavage product.

8 n and solvent dependence) will favor the C-C cleavage product.

9 ible hepatic production of prolactin and its cleavage product.

10 s converted to a normal T in the 3'-fragment cleavage products.

11 ncorporating oxygen from O2 and H2O into its cleavage products.

12 copy analysis of selected immunoprecipitated cleavage products.

13 cation, and a lack of detection of secondary cleavage products.

14 e engulfment proteins or their peptidoglycan cleavage products.

15 s-match observed MS peaks with predicted RNA cleavage products.

16 s have been used for analysis of deaminative cleavage products.

17 was no accumulation of caspase-mediated HuR cleavage products.

18 ts are required to determine the fate of the cleavage products.

19 lution containing the apolactoferrin and its cleavage products.

20 ydroquinone yields a mixture of 1,2- and 1,6-cleavage products.

21 oteins and a decrease in the accumulation of cleavage products.

22 s that generate secretory-stage ameloblastin cleavage products.

23 critical step for determining splicing over cleavage products.

24 e structures of some of the aldehyde-bearing cleavage products.

25 ies controlling stimuli and unknown fates of cleavage products.

26 ctivation by removing siRNA passenger strand cleavage products.

27 e full-length amelogenin and its proteolytic cleavage products.

28 rocessed miRNAs constitute a minority of the cleavage products.

29 but oxidation of 2H-pyrans also gives alkyl cleavage products.

30 proprotein convertase family that match the cleavage products.

31 rix metalloproteinase (MMP)-derived collagen cleavage products.

32 arance of beta-amyloid (Abeta) affecting its cleavage products.

33 ing molecule or via its numerous proteolytic cleavage products.

34 eading to the generation of an unique set of cleavage products.

35 tions are well-known and so are the expected cleavage products.

36 hlorine in the production of dicarbonyl ring cleavage products.

37 le RNAs consisting of the 5' portions of the cleavage products.

38 tibodies against NfH, NfH aggregates and NfH cleavage products.

39 Unexpectedly, the HuR-cleavage product 1 (HuR-CP1) was found to strongly assoc

40 ionizing radiation (IR), determined that HuR cleavage product-1 (HuR-CP1) bound and promoted the expr

41 Further analyses revealed that the HuR cleavage product-1 (HuR-CP1) directly associates and sta

42 amounts of full-length TDP-43 as well as its cleavage products (35 kDa and 25 kDa) in the urea-solubl

43 In addition, the ring cleavage product 4-nitro-2,4,-diazabutanal (NDAB) and a

44 at terminate between residues 90-115, termed cleavage product A or 1 (cp-A/1), form intracellular and

45 cuses on the formation of electrophilic ring cleavage products-a class of compounds that poses potent

46 e studies attribute these changes to the APP cleavage product Abeta, in recent years it became appare

47 nous FPR ligand, annexin A1 (ANXA1), and its cleavage product Ac2-26, which mediate activation of ROS

48 c function and generates a carboxyl-terminal cleavage product, acCED-8, that promotes PS externalizat

49 Because C3 cleavage products act as ligands for CR2, we hypothesize

50 for the formation of small quantities of C-H cleavage products alpha to the chloro substituent.

51 Amyloid precursor protein (APP) and its cleavage product amyloid beta (Abeta) have been thorough

52 cursor protein and its associated neurotoxic cleavage product amyloid-beta*56.

53 iRNA enhanced accumulation of a 100-kDa Dsg2 cleavage product and internalized pool of Dsg2.

54 used: an SDS-PAGE based assay to detect IgG cleavage products and a surface plasmon resonance spectr

55 d to monitor both time-resolved formation of cleavage products and disappearance of full-length RNA.

56 raphy were used to further purify huntingtin cleavage products and enrich for the cp-1/cp-2 fragments

57 ed these smaller fragments to be proteolytic cleavage products and identified a limited number of pro

58 cineurin and immunoblot analysis of spectrin cleavage products and showed that both substrates were c

59 Analysis of cleavage products and the correlation of affinities with

60 mation of products of reactions between ring cleavage products and the model nucleophile N-alpha-acet

61 eased accumulation of precursor proteins and cleavage products and this is attenuated by lysosomal, b

62 rminally truncated species were not the main cleavage products, and calpain I activity present in cel

63 ic intermediates, simple organic acids, ring cleavage products, and inorganic ions.

64 , as varying degrees of heterogeneity of the cleavage products appear to accompany the emergence of t

65 Thus, caspase-derived cleavage products are a sensitive reflection of cell-typ

66 ents from insoluble bacterial cell walls and cleavage products are able to trigger responses typicall

67 To determine whether C3 cleavage products are critical in CR2-dependent Ab produ

68 f the collagen VI alpha3 chain revealed that cleavage products are deposited in tissue and cell cultu

69 TAp73 and some of its cleavage products are localized to mitochondria.

70 RNA with little sequence specificity and the cleavage products are mainly 11 nucleotides (nt) long.

71 The proteasome-independent cleavage products are no longer detected at late times c

72 The expected C-O cleavage products are not formed under the reaction cond

73 However, C-C cleavage products are observed with an aryl group in the

74 However, the resultant cleavage products are poorly defined, and the functional

75 xrn1 yeast cells, wherein mRNA endonuclease cleavage products are stabilized.

76 Deltatau314, the C-terminally-truncated cleavage products, are soluble and present in human brai

77 discussed to explain the variations in bond cleavage products as a function of the driving forces fo

78 otypes, but these fragments are not terminal cleavage products as they are subject to further proteol

79 NaC currents and the appearance of gammaENaC cleavage products at the cell surface.

80 omelanocortin peptide (POMC), and its opioid cleavage product, beta-endorphin, are expressed in the m

81 The esterase cleavage product binds to the zinc active site via the t

82 philized platelets increase the formation of cleavage product by 2-3-fold.

83 observation and quantification of the small cleavage product by SDS-PAGE.

84 xon1 was devoid of polyQ peptides as partial cleavage products by incomplete proteolysis, indicating

85 eating cells with ASOs or siRNA and analyzed cleavage products by RACE.

86 y, which allows for the detection of dimeric cleavage products by TGA/FT-IR/GC/MS.

87 n pathways of complement activation, and its cleavage products C3a and C3b mediate several functions

88 ds the central complement protein C3, the C3 cleavage products C3b and C3d, and C5.

89 Finally, we show that an N-terminal Set-beta cleavage product can induce neuronal death.

90 together, our findings suggest that peptide cleavage products can affect cellular function beyond th

91 The resulting cleavage products can be involved in reverse signaling.

92 thrin is cleaved by thrombin, the C-terminal cleavage product continues to exert prolonged inhibition

93 Moreover, the HER-2 cleavage products cooperate with Noxa to induce apoptosi

94 The cleavage products could be reproduced by incubation of t

95 cleavage of histone pre-mRNA, the downstream cleavage product (DCP) is degraded by the 5'-3' exonucle

96 preciable change in FP, probably because the cleavage product did not have sufficiently increased mob

97 The downstream cleavage products did not appear to be degraded in the 3

98 2a was converted to the C-CN cleavage product (dippe)Ni(CN)(2-thiophenyl) (3) when he

99 This 17 kDa APP cleavage product does not appear to be a substrate for e

100 y, WRN also influences the formation of FEN1 cleavage products during strand displacement on a nontel

101 e concerns about the formation of toxic ring-cleavage products during the initial stage of oxidation

102 he formation mechanisms and identity of ring cleavage products, especially at higher chlorine doses.

103 binds tighter to miRNA targets than its RNAi cleavage product, even though the cleaved product contai

104 single cellular substrate and sequesters the cleavage product, evolutionary pressure has likely selec

105 ures the cleavage kinetics and time-resolved cleavage products for over 10,000 targets containing mis

106 Ring-cleavage products for which quantification was possible

107 -LIF, the assay signal is the peak height of cleavage product formed after a fixed incubation time.

108 Second, the ratio of cleavage products formed by subsequent sequential proteo

109 cells is negatively regulated by prohormone cleavage products formed from plasmin-mediated proteolys

110 , we observed that the CLCA1 C-terminal self-cleavage product forms a disulfide-linked dimer that non

111 In nondiseased mice, the cleavage product from Ac-gamma-Glu-gamma-secretase inhib

112 tide WE14, a naturally occurring proteolytic cleavage product from ChgA.

113 We isolated a 23-kDa ameloblastin cleavage product from developing enamel and determined i

114 redox-mediated release of the antiangiogenic cleavage product from HRG.

115 We found that the cleavage product from this fragmentation event is releas

116 udor domain protein Qin prevents Aubergine's cleavage products from becoming Piwi-bound piRNAs, ensur

117 Cleavage products from the reaction are detected by matr

118 C3 cleavage products function in B cell activation through

119 demonstrate that the C-terminal JunB caspase cleavage product functions as a potent inhibitor of AP-1

120 nsible for the degradation of the downstream cleavage products generated by ASOs or siRNA targeting m

121 In contrast, downstream cleavage products generated by ASOs targeting nuclear lo

122 RNA cleavage products generated by RNase L enhance IL-1beta

123 activity of these hydrolases by sensing the cleavage products generated by these enzymes and modulat

124 Its natural cleavage product GLP-1(9-36)(amide) possesses distinct p

125 Feedback loop disruption by the GLP-1 cleavage product GLP-1(9-36)(amide) reverses the persist

126 275, respectively, to generate an N-terminal cleavage product (GSDMD-NT) that triggers inflammatory d

127 evidence by modified 5'-RACE for a MYB mRNA cleavage product guided by miR828 in Pinus resinosa.

128 Ectopic expression of H3.3 and its cleavage product (H3.3cs1), which lacks the first 21 ami

129 ff after assembly into microfibrils, and the cleavage product has been implicated in tumor angiogenes

130 The N-terminal TUG cleavage product has properties of a novel 18-kDa ubiqui

131 t the matriptase-2 and proprotein convertase-cleavage products have different roles in the regulation

132 The cleavage products, identified through high-resolution ma

133 of full-length D187N gelsolin and its 68-kDa cleavage product in blood-demonstrating the importance o

134 We also identify an additional caspase-5 cleavage product in LPS-stimulated monocytes, which corr

135 nctional form, whereas S-OPA1 is an inactive cleavage product in mammals, and that stress-induced OPA

136 HDV ribozyme transition state resembles the cleavage product in the degree of proton transfer to the

137 oxy-1-arylethanols was developed that yields cleavage products in 62-98% isolated yield.

138 ugh cathepsin L generated the requisite TLR9 cleavage products in a cell-free in vitro system, severa

139 sis greatly reduces the level of undesirable cleavage products in O-glycan analysis and increases the

140 n vitro, and the accumulation of proteolytic cleavage products in SCA7 patients and mouse models has

141 RNAP to elongate the 5'-proximal transcript cleavage products in the presence of substrates.

142 s to exogenous threats, resulting in various cleavage products including anaphylatoxin C3a.

143 lkyl substituents as well as a suite of ring-cleavage products, including acetaldehyde, formic acid,

144 precursors of a unique set of apo-carotenoid cleavage products, including retinoids.

145 absence of O2, the concentration of the ring-cleavage product increased relative to phenol.

146 ration of FVIII (1 nm), the formation of VWF cleavage product increases dramatically as a function of

147 effects of translation on processing the 3' cleavage products into tasiRNAs.

148 sor ion scan experiment, the resulting ozone cleavage product ions were used to determine the positio

149 inetic isotope effect on cleavage; the major cleavage product is an RNA strand terminated by a 5'-ald

150 The degradation of the caspase-7 cleavage product is mediated by macroautophagy in cell c

151 Exclusive formation of the C-N cleavage product is observed for all aziridines with the

152 hat this cholesterol-modified amino-terminal cleavage product is responsible for all HH-dependent sig

153 -terminal fragments, we show that this toxic cleavage product is specific for pathologic inclusions i

154 The NH(2)-terminal cleavage product is the substrate for site-2 protease (S

155 However, the pathway to these cleavage products is complex, initiated by regioselectiv

156 We also find that the accumulation of Pcdh cleavage products is regulated during development.

157 g requires endocytosis and that the level of cleavage products is regulated during neuronal different

158 SAH (a SAM analog) or 5'-dAdo and l-Met (SAM cleavage products) is consistent with the canonical mech

159 (MAPK) activity ratio caused by the GrB/ITSN cleavage products lead to EC proliferation and selection

160 Tth111II methylates cleavage product-like duplex oligos CAAACAN9, but the mo

161 Expression of cyclin E proteolytic cleavage products, low-molecular weight cyclin E (LMW-E)

162 biological effects of each of the resultant cleavage products make ascribing causality much more com

163 utoantibodies against NfH aggregates and NfH cleavage products may explain the variable expression of

164 posed to catalyze the hydrolysis of the meta-cleavage product (MCP) 4,11-dicarboxy-8-hydroxy-9-methox

165 Meta-cleavage product (MCP) hydrolases are members of the alp

166 DxnB2 and BphD are meta-cleavage product (MCP) hydrolases that catalyze C-C bond

167 mbrane injury but an injury-specific calpain-cleavage product, mini-dysferlinC72.

168 ning these proteoforms are stable functional cleavage products, most with unknown functional implicat

169 vage site, but instead produced two unstable cleavage products, neither of which were stabilized by i

170 of its cosubstrate dioxygen into the rubber cleavage product ODTD, and we show that RoxA is isolated

171 tion as only a recombinant analog of a MMP20-cleavage product of amelogenin was capable of guiding ap

172 ls of brain amyloid-beta, a secreted peptide cleavage product of amyloid precursor protein (APP), is

173 The cleavage product of APP, extracellular amyloid-alpha pep

174 neprilysins and Drosophila Abeta (dAbeta), a cleavage product of APPL.

175 lternative translation isoform and a caspase cleavage product of B56epsilon.

176 ed that beta-apo-13-carotenone, an eccentric cleavage product of beta-carotene, antagonizes the activ

177 At baseline, NH2-terminal (NT)-proBNP, a cleavage product of BNP, was inversely associated with a

178 Cpb1 modifies a cleavage product of C3, which binds to and activates C3a

179 C4d, the final cleavage product of C4 activation, is found in the disea

180 ocalization when compared with the caspase-3 cleavage product of caspase-7 (p20).

181 The cleavage product of cathelicidin, LL-37, was assayed by

182 Levels of M30, a cleavage product of cytokeratin-18 caspase, are signific

183 entin phosphoprotein (DPP) is the C-terminal cleavage product of DSPP that binds collagen and induces

184 tention at the cell surface of a proteolytic cleavage product of FH.

185 Moreover, the cleavage product of FVenv generated by SPPL3 serves as a

186 A 35-kDa cleavage product of ISTK retaining key signature sequenc

187 It also circulates as an endoproteolytic cleavage product of mKL (cKL).

188 dies have implicated an N-terminal caspase-6 cleavage product of mutant huntingtin (htt) as an import

189 k, a cytoplasmic, transcriptionally inactive cleavage product of Myc.

190 The presence of increased levels of the cleavage product of PARP indicated apoptosis in response

191 Finally, we show that granulin E, a cleavage product of PGRN, is sufficient to increase cath

192 It is the C-terminal cleavage product of profibrillin, and we name it Asprosi

193 genic hormone named asprosin, the C-terminal cleavage product of profibrillin.

194 on from the precursor peptide (a proteolytic cleavage product of prostatic acid phosphatase, PAP(248-

195 tivity is determined by detecting the unique cleavage product of synthetic oligomer substrates.

196 I) collagen alpha chain, suggesting that the cleavage product of the alpha3(VI) collagen does not eli

197 Amyloid beta-peptide (Abeta), a cleavage product of the amyloid precursor protein (APP),

198 Abeta is a cleavage product of the amyloid precursor protein (APP),

199 The beta-amyloid peptide is a cleavage product of the amyloid precursor protein (APP).

200 nent is the beta-amyloid peptide, which is a cleavage product of the amyloid precursor protein (APP).

201 is of this study is that a carboxyl-terminal cleavage product of the cardiac L-type calcium channel (

202 Here, we have described a cleavage product of the COL6alpha3 chain, endotrophin (E

203 eins of different sizes present, one being a cleavage product of the full-length form.

204 Medin, a 50-amino-acid cleavage product of the milk fat globule-EGF factor 8 pr

205 ract with the membrane bilayer, is a tryptic cleavage product of the outer capsid spike protein, VP4.

206 Only the cleavage product of the third motif of genotype A was ob

207 Abeta is a cleavage product of the ubiquitously expressed amyloid p

208 ontaining AU elements are cleaved and the 5' cleavage product of these RNAs persists for many hours.

209 Soluble TREM2 (sTREM2), a soluble cleavage product of TREM2, is elevated in AD cerebrospin

210 and CTFalpha APP metabolite production, both cleavage products of ADAM10, concordant with increased A

211 The enzymatic cleavage products of beta-endorphin (beta-endorphin1-27

212 Endogenous human IgG cleavage products of comparable size to mAbs with the si

213 The cleavage products of HuR are known to promote cell death

214 are consistent with the hypothesis that the cleavage products of ICP0 function in topologically dist

215 The upstream cleavage products of Malat1 were degraded in the 3' to 5

216 Sequencing cleavage products of modified lambda DNA indicates that

217 fication of cDNA ends, deep sequencing of 3' cleavage products of mRNA and bioinformatic analysis.

218 ormation of oxidation products and oxidative cleavage products of norbixin.

219 We focused on NSP1alpha and NSP1beta (self-cleavage products of NSP1 during virus infection) and NS

220 3, activation of caspase 3 and increases in cleavage products of PARP.

221 specific antibodies and detecting the unique cleavage products of peptide substrates.

222 Cleavage products of plasmin-degraded LL-37 were analyze

223 We show that RNA cleavage products of RNase L activity induce the formati

224 Both cellular and viral RNA cleavage products of RNase L bind pattern recognition re

225 d Delta-peptides, which are small C-terminal cleavage products of sGP secreted by ebolavirus-infected

226 ension to analyze mRNA, small RNAs, and mRNA cleavage products of synchronized BY2 cells at S, G2, M,

227 0-kDa complex that also contained C-terminal cleavage products of TDP-43 linked to neuropathology.

228 ribonuclease followed by RNA-seq) to profile cleavage products of the essential endoribonuclease RNas

229 SPR(159)) motif, and the other two forms are cleavage products of the first ((151)RRDR(154)) and thir

230 und to a protein, followed by separating the cleavage products on a denaturing electrophoresis gel to

231 (PARE) has made it possible to sequence mRNA cleavage products on a large-scale.

232 dence suggesting that the native proteolytic cleavage product P148 may have an important functional r

233 native 20-kDa porcine amelogenin proteolytic cleavage product P148 that is prominent in developing en

234 orcine amelogenin (P173) and its predominant cleavage product (P148) can inhibit spontaneous calcium

235 e nonstructural proteins (NSPs) P200 and its cleavage products, P150 and P90 (N and C terminal within

236 ) is an integral membrane glycoprotein whose cleavage products, particularly amyloid-beta, accumulate

237 3'UTR) are deadenylated and cleaved, but the cleavage products persist for hours, in contrast to the

238 is part of the amyloid-beta (Abeta) peptide cleavage product (position 2 of Abeta).

239 O atom into either of its carbon-carbon bond cleavage products, pregnenolone and isocaproaldehyde .

240 res in the bacterial surface with Perforin-2 cleavage products present in bacteria.

241 Levels of the cross-linked fibrin cleavage product protein, d-dimer, were significantly de

242 ating APP in neurons and its processing into cleavage products remain incompletely understood.

243 the differential effects of individual notch cleavage products remain to be elucidated.

244 The major C-terminal GrB cleavage product, residues 28-337, had no enzymatic acti

245 A POLYMERASE 6 (RDR6) to ARGONAUTE 1-derived cleavage products, resulting in more efficient amplifica

246 The concurrent expression of the two cleavage products results in a high p38/Erk1/2(MAPK) act

247 ases by transcriptome-wide profiling of mRNA cleavage products retaining 5' phosphate groups in mouse

248 Analysis of the FH cleavage products revealed that they lack cofactor activ

249 atly facilitates direct visualization of the cleavage product, revealing important characteristics of

250 t amelogenin (rP172), a homolog of its major cleavage product (rP148), and a native amelogenin lackin

251 sed secretion of the soluble alpha-secretase cleavage product sAPPalpha.

252 The 47- and 25-kDa HER-2 cleavage products share a functional BH3-like domain, wh

253 higher macrophage MerTK, lower levels of the cleavage product soluble Mer, improved efferocytosis, sm

254 y and levels of the matrix metalloproteinase cleavage product soluble receptor for advanced glycation

255 eolysis of STEP(61), producing the truncated cleavage product STEP(33) and activation of p38.

256 Additionally, these cleavage products stimulate NLRP3 complex formation with

257 cohol and o-dihydroxybenzene as well as ring-cleavage products such as glyoxal were also identified a

258 tion of tasiRNAs and over-accumulation of 3' cleavage products, suggesting positive effects of transl

259 nous caspase, calpain, and metalloproteinase cleavage products, terminating between residues 400-600,

260 The remaining products included a ring-cleavage product that appeared to contain an alpha,beta-

261 mes process amelogenin to generate the major cleavage products that accumulate during the secretory s

262 These cleavages generate all of the major cleavage products that accumulate in porcine secretory-s

263 ting protein fibrinogen, yielding fibrinogen cleavage products that acted as TLR4 ligands on airway e

264 68R forms increased amounts of intracellular cleavage products that are also present in expression me

265 Similar considerations apply to cleavage products that are formed during laser-assisted

266 is impaired on such substrates, resulting in cleavage products that do not allow direct religation.

267 tously expressed transmembrane protein whose cleavage product, the amyloid-beta (Abeta) protein, is d

268 gth protein and its major Deltapsi-dependent cleavage product to the cytosolic face of the outer mito

269 Addition of purified C3 cleavage products to cultured neurons suggested that C3b

270 Dichloromethane, however, gives only C-Cl cleavage product Tp'Rh(CNR)(CH(2)Cl)Cl.

271 nant VWF-A2 as determined by quantifying the cleavage products using Western-blotting, enhanced cleav

272 We report that the cleavage products vary from regiospecific alkyl cleavage

273 The formation of the ring-cleavage product warrants further studies of its toxicit

274 generation of the calpain-specific spectrin cleavage product was not observed in lens tissue from ca

275 -secretase within the endosome; however, the cleavage product was proteasome-sensitive and failed to

276 The final CG cleavage product was RMAD-4((55-94)), and P3 produced bo

277 In hippocampal slices, this increase in cleavage products was accompanied by a significant reduc

278 The processing of APP into its cleavage products was also increased in hippocampi and c

279 alization of both MMTV-SP and the C-terminal cleavage product, we prepared plasmids expressing green

280 raphy and mass spectrometric analysis of the cleavage products, we report the ability to demonstrate

281 han full-length NEMO, whereas all other NEMO cleavage products were abrogated for the IFN-beta-induci

282 Cleavage products were analyzed with reversed-phase high

283 alyzed by SDS-PAGE and Western blotting, and cleavage products were characterized by N-terminal seque

284 ldolase, HpaI, in complex with substrate and cleavage products were determined to 1.8-2.0 A resolutio

285 miRNA-mediated-cleavage products were easily discerned from an extensiv

286 lation reaction is indicative that authentic cleavage products were generated.

287 cyclin D1, whereas caspase activity and PARP cleavage products were increased in tumors of drug-treat

288 rity and dynamic range for detection of BoNT cleavage products were initially examined, including the

289 ctivated by LPS; vanillin and other putative cleavage products were negligible.

290 nown to hydrolyze Abeta1-40 and the expected cleavage products were observed.

291 tion limits obtained by monitoring the ether cleavage products were somewhat higher (between 100 and

292 In contrast, the 3' and 5' cleavage products were stabilized by the deletion of the

293 osphorylated PRH produces a stable truncated cleavage product which we have termed PRHDeltaC (HhexDel

294 ull-length 315-kDa and a 190-kDa proteolytic cleavage product), which are type I single-pass membrane

295 ilbenes and flavonoids to muconoid-type ring-cleavage products, which are likely the first steps in t

296 ficking of the full-length UL37 glycoprotein cleavage products, which divergently traffic either thro

297 Other ring-cleavage products, which were most likely aldehydes and

298 or cytoplasmic Dis3L1 degraded mRNA upstream cleavage products, which were not bound by the 5'-cap bi

299 nvert to two forms of a ferryl heme O-O bond-cleavage product, whose nu(Fe horizontal lineO) frequenc

300 V ribozymes appear to be similar, generating cleavage products with 5'-hydroxyl and 2',3'-cyclic phos