ライフサイエンスコーパス: cleave

1 anism where mismatches can be bound, but not cleaved.

2 In vitro assays indicated that Sl-LIP8 can cleave 18:2 and 18:3 acyl groups from glycerolipids.

3 ends on host mRNA, because viral polymerases cleave 5'-m7G-capped host transcripts to prime viral mRN

4 , responds to 365 nm light to simultaneously cleave a central nitroveratryl linker and a peripheral d

5 irus resolvase (Fpr) is an endonuclease that cleaves a broad range of branched DNA structures, includ

6 rototype for a gene therapy DNA machine that cleaves a housekeeping gene only in the presence of a ca

7 e inhibition reaction of serpins, a protease cleaves a peptide bond in a solvent-exposed reactive cen

8 INF2 is proteolytically cleaved, a process mediated by cathepsin proteases, libe

9 lly compose the gamma-secretase complex that cleaves Abeta from amyloid precursor protein fragments.

10 The self-cleaving activity of the hammerhead ribozyme is also slo

11 i (PfLCAT-PLA) and castor (RcLCAT-PLA) could cleave acyl chains at both the sn-1 and sn-2 positions o

12 We report that FAMIN phosphorolytically cleaves adenosine into adenine and ribose-1-phosphate.

13 egradation requires two enzymes: LapG, which cleaves adhesins, and RbmB, which digests matrix polysac

14 Legumain cannot cleave after glycosylated Asn residues, which enabled th

15 Furthermore, Dicer cleaves all satellite RNAs in conjunction with MIWI.

16 The SARS-CoV-2 main protease (M(pro) ) cleaves along the two viral polypeptides to release non-

17 on to escalating delta-secretase activity to cleave alpha-Syn and promotes its neurotoxicity.

18 blot hybridization and reverse-transcription cleaved amplified polymorphic sequence analysis), genomi

19 Developing lymphocytes of jawed vertebrates cleave and combine distinct gene segments to assemble an

20 rilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within

21 al NF-kappaB machinery and (b) a protease to cleave and inactivate specific substrates, including neg

22 PAR4 is a member of this family that is cleaved and activated by serine proteinases such as thro

23 CaCu[Formula: see text]O[Formula: see text], cleaved and annealed in ozone to increase the doping all

24 igma3 is proteolytically degraded and mu1 is cleaved and exposed to form infectious subvirion particl

25 lation (pA) sites at which precursor mRNA is cleaved and polyadenylated, allows cells to quickly resp

26 secretory component (SC), is proteolytically cleaved and released either unbound (free SC) or bound t

27 an acidic environment, the acetal groups are cleaved and the gold nanoparticles become highly water-s

28 M structures for RaTG13 S and for both furin-cleaved and uncleaved SARS-CoV-2 S; we compared these wi

29 HP8 activates proSpatzle-1, whereas PAP1 cleaves and activates proPO.

30 Thrombin, a procoagulant protease, cleaves and activates protease-activated receptor-1 (PAR

31 Caspase-1 cleaves and activates the pro-inflammatory cytokines suc

32 this engineered chimeric toxin irreversibly cleaves and inactivates intracellular RAS at low picomol

33 In the nucleus, caspase-8 cleaves and inactivates the ubiquitin-specific peptidase

34 egrading the extracellular matrix as well as cleaving and activating downstream targets.

35 Using non-cleaving antisense oligonucleotides (ASOs), we selective

36 , followed by beta1-3,4 galactosidase, which cleaved any terminal alpha2-3-linked sialic acid and und

37 It exhibited an unusual regiospecificity, cleaving apocarotenoids solely at the C14'-C13' alkene b

38 ilisin-like serine proteases, seven of which cleave at specific basic residues within the trans-Golgi

39 most influenza A and B (IAV/IBV) viruses is cleaved at a monobasic motif by trypsin-like proteases.

40 hey fold up into a hairpin structure that is cleaved at its base by an enzyme complex known as the Mi

41 replication-dependent histone pre-mRNAs are cleaved at the 3' end by U7 snRNP consisting of two core

42 he RAG1-RAG2 protein complex which binds and cleaves at discrete gene segments in the antigen recepto

43 Enzymes that cleave ATP to activate carboxylic acids play essential r

44 ring encloses the transmembrane anchors for cleaved ATP6AP1/Ac45 and ATP6AP2/PRR, the latter of whic

45 In this study, we demonstrated that S1P cleaves BBF2H7 just before the RXXL S1P recognition moti

46 ctive toward beta-apocarotenoids but did not cleave bicyclic carotenoids.

47 crRNP effector complexes become activated to cleave both target RNA (via Cas7) and target DNA (via Ca

48 biochemical theme, but how one nuclease site cleaves both DNA strands of a double helix has not been

49 s during the unfolding of five helices of EF-cleaved bR.

50 e-forming activity of its N-terminal domain, cleaved by activated caspases associated with the releas

51 During apoptosis, the C-terminal tail is cleaved by caspase, allowing the release of ATP through

52 GSDMC is specifically cleaved by caspase-8 with TNFalpha treatment, generating

53 ferrocene label as the peptide molecules are cleaved by cathepsin B.

54 nstrated that the peptide-cargo conjugate is cleaved by cells in the epithelium at the site of a two-

55 owing endocytosis of EBOV, the GP1 domain is cleaved by cellular cathepsins in acidic endosomes, remo

56 Notably, both TrkB and APP are robustly cleaved by delta-secretase in AD brains, accompanied by

57 In this study, N-glycans were sequentially cleaved by enzymes at the head of the separation capilla

58 though the S1-S2 linker of WT Kv1.5 could be cleaved by extracellularly applied proteinase K (PK), an

59 irions traffic to late endosomes where GP is cleaved by host cysteine proteases.

60 e carrying a mutated p85alpha that cannot be cleaved by LF show a greater resistance to anthrax toxin

61 was important for its antiviral activity and cleaved by MCPIP1 in the cell-free system.

62 lectively quantify other endogenous peptides cleaved by peptidases whose concentrations are below 1 p

63 stabilization of the carboxylate group being cleaved by the enzyme.

64 Since PACAP peptide is cleaved by the human membrane neprilysin hNEP, we search

65 only activating receptor on NK cells that is cleaved by the metalloprotease a disintegrin and metallo

66 five continuous ribonucleotides which can be cleaved by the ribonuclease to specifically initiate DNA

67 oluene alters which C-O bonds in a sugar are cleaved by the tris(pentafluorophenyl)borane/HSiR(3) cat

68 ide, S16, that was robustly and specifically cleaved by tumor-associated metalloproteinases in the Hi

69 -chlorobenzoyloxy radical derived from mCPBA cleaves C-H bonds in the alkane to form an alkyl radical

70 in the initiation of viral transcription by cleaving capped mRNA bound to PB2.

71 Unlike inhibitors of DNA-cleaving Cas nucleases, which cause limited immunosuppre

72 DRG neurons showed accumulation of cleaved caspase 3 (apoptosis) and nuclear-localized acti

73 TTC7A-KO cells contained cleaved caspase 3 and had reduced levels of phosphorylat

74 mediated dUTP nick-end labeling staining and cleaved caspase 3 expression.

75 ergic neurons predominantly colocalized with cleaved caspase 3 staining.

76 horylated AKT and XIAP and reduced levels of cleaved caspase 3.

77 also increased expression of Bax as well as cleaved caspase-3 and -PARP in colon cancer cells by dow

78 Immunohistochemical analysis of Ki67 and cleaved caspase-3 confirm these findings from in vivo im

79 ated animals showed significantly lower ROS, cleaved caspase-3, and cytochrome c activities, leading

80 age in tumors, shown by strong expression of cleaved caspase-3, and leads to a prolonged median survi

81 DNA fragmentation, TUNEL-positive neurons, cleaved caspase-3-positive neurons, translocation of mit

82 numbers of monocytes positive for TUNEL and cleaved caspase-3.

83 PRL also reduced active cleaved-caspase-1 levels independent of pannexin-1 activ

84 Levels of cleaved CCN3, an antifibrotic protein, were lowered in H

85 Cleaved CDCP1 isoform (70 kDa) was expressed to a varyin

86 A cut is achieved using TEVp which cleaves cMyBP-C to create a soluble N'-terminal gammaC0C

87 sensor itself or a specialized enzyme) that cleaves cOA and mitigates dormancy or death induction.

88 gation of the magnetism of micromechanically cleaved CrCl(3) flakes with thickness >10 nm is performe

89 The ATP citrate lyase (ACLY) enzyme cleaves cytosolic citrate to generate acetyl-CoA, and is

90 e system utilizes highly selective split RNA-cleaving deoxyribozyme (sDz) sensors.

91 proved that the HpSGN system can efficiently cleave different RNA targets in vitro.

92 an A1A2A3 tridomain fragment of VWF, plasmin-cleaved dimers of VWF, multimeric recombinant VWF, and n

93 or the first time the ability to efficiently cleave disulfide bonds linking heavy and light chains of

94 While ETD retains modifications and cleaves disulfide bonds-making it attractive for mAb cha

95 how these multisubunit complexes target and cleave DNA and RNA and how regulatory molecules control

96 c Argonaute proteins use small DNA guides to cleave DNA, a process known as DNA interference(6-10).

97 l for its ability to programmably target and cleave DNA.

98 Activation of the transposase simultaneously cleaves DNA and adds adapters ('tagmentation') for paire

99 It cleaves DNA with a 5'-NNNCC-3' Protospacer Adjacent Moti

100 O1-RFC-PCNA nuclease ensemble preferentially cleaves DNA with Holliday junctions, but shows no canoni

101 -specific 10-23 or Zn(2+) -specific 8-17 RNA-cleaving DNAzymes to regulate the expression of FPs as a

102 ns, where the corresponding homolog (SAMHD1) cleaves dNTPs.

103 Being guided by an RNA to cleave double-stranded (ds) DNA targets near a short seq

104 II alone, in specific complex with partially cleaved dsDNA, and in scanning complex with an RNA/DNA h

105 The RNase L-cleaved dsRNAs signal to Rig-like helicases to amplify I

106 nt, also produces a self-cleaving RNA and is cleaved during T-cell activation as well as thermal and

107 hesized as a precursor (pre-proSP-B) that is cleaved during trafficking into three related proteins.

108 aining of DCLK1 and active beta-catenin, and cleaved E-cadherin.

109 CTSV had been predicted to cleave ECM proteins in the AMR glomeruli.

110 Thus, in the presence of BMS-806, the cleaved Env on the surface of cells and virus-like parti

111 cessing enzymes, including beta-site amyloid cleaving enzyme (Bace1), A disintegrin and metalloprotei

112 n, we find increased expression of beta-site cleaving enzyme (BACE1), APP, and Abeta in human primary

113 eta precursor protein (APP) by beta-site APP-cleaving enzyme 1 (BACE1) and the gamma-secretase comple

114 g enzyme beta-site amyloid precursor protein cleaving enzyme 1, and both total and hyperphosphorylate

115 from deficiency of the oligodendroglial NAA-cleaving enzyme aspartoacylase.

116 hia coli Endonuclease V (eEndoV), an inosine-cleaving enzyme, can be repurposed to bind and isolate A

117 e, beta-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE-1), and Abeta42 and tau aggregat

118 protein (APP), APP metabolites, and key APP cleaving enzymes were identified in association with EVs

119 gulatory mechanism of Robo and show that the cleaved extracellular fragment of Robo can function as a

120 on molecule SYG-1/Neph as a receptor for the cleaved extracellular Robo fragment to mediate glial mig

121 ted to less conformational constrains of the cleaved form comparedtointact, as suggested by the 2-fol

122 This cleaved form of RILP promotes the movement of multivesic

123 e latter occurring mainly in proteolytically cleaved form, as membrane-spanning C-terminal fragments

124 ) and fully reduced (all disulfide bonds are cleaved) forms.

125 The 2-phenylisopropyl group can be cleaved from carboxyl with 2-3% (v/v) of TFA in acetonit

126 soluble chemokine, CX3CL1 (fractalkine), is cleaved from membrane-bound CX3CL1 by proteases includin

127 ggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death.

128 t proteins confirmed that caspase-11 prefers cleaving gasdermin D over the pro-ILs.

129 The HpSGN system cleaved genomic DNA at an efficiency of ~40% and ~20% in

130 We show that the cryogenic IR spectra of the cleaved glycans are highly structured and virtually iden

131 Cleaved GP then binds its cellular receptor, Niemann-Pic

132 Cleaved GSDMD forms membrane pores, leading to cytokine

133 ndent pyroptosis in target cells by directly cleaving GSDME at the same site as caspase 3.

134 dies suggest that MT2 suppresses hepcidin by cleaving hemojuvelin and other components of the bone mo

135 re, we observe reduced plasma prekallikrein, cleaved high molecular weight kininogen and elevated pla

136 Plasma concentrations of cleaved high-molecular-weight kininogen (cHK), vascular

137 to the single-chain precursor form, PK-R371A cleaves high-molecular-weight kininogen (HK) to release

138 rties as endogenous U7 snRNP, and accurately cleaves histone pre-mRNAs in a reconstituted in vitro pr

139 A recent study has revealed that Dbr1 cleaves HIV-1 gRNA lariats that form early after viral e

140 duced by the presence of a portal complex in cleaved HK97 proheads.

141 on on a wide scale but that also potentially cleaves host cell proteins during colonization.

142 lloprotease virulence factor responsible for cleaving host IgA1, yet the molecular mechanism has rema

143 acilitates the release of viral particles by cleaving HS.

144 tides, and confirmed that the protease could cleave in all domains of lubricin, including the mucin d

145 three SAM S-C bonds can be regioselectively cleaved in an RS enzyme.

146 ence that the C-terminal tail of PC2 is also cleaved in ELVs.

147 We found that full-length APP is cleaved in EVs incubated in the absence of cells.

148 After SREBP2 is cleaved in Golgi, its CTD remains bound to Scap and retu

149 When PCBP2 is cleaved in its linker region by viral proteinase 3CD, tr

150 que rupture and identify substrates that are cleaved in ruptured plaques.

151 We found that mesotrypsin cleaved in the autolysis loop by CTRC exhibited catalyti

152 s, the spike protein is post-translationally cleaved, in this case by furin, into the S1 and S2 compo

153 The functionalization of molecules by cleaving inert carbon-carbon single bonds is regarded as

154 The GPC fails to cleave into its G1 and G2 subunits and is targeted for d

155 Interestingly, the SORLA ectodomain is cleaved into a soluble form, sSORLA, which has been show

156 ic biosensing peptide on the surface that is cleaved into a urinary reporter upon exposure to specifi

157 The dimer is cleaved into its parent radicals when exposed to ultravi

158 The full-length Slit (Slit-FL) is cleaved into Slit-N and Slit-C fragments, which have pot

159 is predicted to be a lipoprotein and that is cleaved into two discrete fragments by a clostripain-lik

160 ated PD-L1 transcription in part through its cleaved intracytoplasmic domain (ICD), which bound to a

161 when it specifically binds to target DNA and cleaves it.

162 HL5, a proteasome-associated deubiquitinase, cleaves K48 branched chains.

163 d high hydrolytic activity on kappa-caseins, cleaving kappa-casein at four main sites, one of which b

164 like plasma protease kallikrein (PKa), which cleaves kininogens to release bradykinin and converts th

165 e-associated zinc metallopeptidase OMA1 that cleaves L-OPA1, causing S-OPA1 accumulation.

166 NA switches that are highly efficient at cis-cleaving mammalian mRNAs and showed that they can be tig

167 As a carboxypeptidase, ACE2 cleaves many biological substrates besides angiotensin I

168 t that pi6 piRNAs repress gene expression by cleaving messenger RNAs encoding proteins required for s

169 Although LF is known to cleave mitogen-activated protein kinase kinases (MEKs/MK

170 Equipping this molecule with a bleomycin A5 cleaving module converts the simple binding compound int

171 gh-throughput technique developed to capture cleaved mRNA fragments and thus can be used to support m

172 present a panel of bacterial proteases that cleave mucin domains via distinct peptide- and glycan-ba

173 Strikingly, when titin-cleaved muscles contract, myosin-containing A-bands beco

174 ondary cleavage of GSDMD to an alternatively cleaved N-GSDMD product.

175 show that human methylpurine DNA glycosylase cleaves N-glycosidic bonds on RNA and that human apurini

176 te that the catalytic activity of Integrator cleaves nascent capped piRNA precursors associated with

177 The complex cleaves nascent peptidoglycan internally to produce free

178 metric G-quadruplex or fluorescent substrate cleaving NAzymes.

179 r NET formation) or DNase 1 treatment (which cleaves NETs) also prolonged allograft survival.

180 We show that DDI2 is indeed capable of cleaving NRF1 in vitro but only when NRF1 protein is hig

181 The premise of CRISPR/Cas centers on the cleaving of one or both DNA strands by a Cas protein, an

182 ach PCAT contains two peptidase domains that cleave off the secretion signal, two transmembrane domai

183 to mitochondria, these targeting signals are cleaved off by the mitochondrial processing peptidase (M

184 ivity, however, we conclusively show that it cleaves only beta-mannose linkages.

185 nt chemical bonds that can also be reversed, cleaved or exchanged are the subject of so-called dynami

186 The LF(W271A) mutant cleaves p85alpha with lower efficiency and is non-toxic

187 siRNA loading into Argonaute, degradation of cleaved passenger strand and degradation of sliced targe

188 s behave as synthetic nanonucleases, able to cleave pBR322 plasmid DNA with the highest efficiency re

189 ability to distinguish between an intact and cleaved peptide was investigated in detail using LL37(FR

190 a divisome-localized glycosyl hydrolase that cleaves peptide-free PG glycans.

191 n using a CAG promoter, Magnets, and 2A self-cleaving peptide.

192 erminase for both classes of PG synthases by cleaving PG glycans as they are being actively synthesiz

193 Both recognize and cleave phage DNA at specific sites while protecting thei

194 CED-3 counters this function by directly cleaving PMK-1 to promote development.

195 LPMOs modify biomass by oxidatively cleaving polysaccharides, thereby enhancing the efficien

196 over ubiquitin-like proteins and efficiently cleaves polyubiquitin chains of three or more ubiquitins

197 proteases play a key role in this process by cleaving polyubiquitin chains to monomers, their functio

198 and enable identification of functional self-cleaving poxins in RNA-virus polyproteins.

199 iquitinated substrates, which allows DupA to cleave PR ubiquitin from substrates.

200 n of SpoIVFB, an intramembrane protease that cleaves Pro-sigma(K) , releasing sigma(K) into the MC.

201 In this study, we obtained evidence that Fpn cleaves proBFT following its transport across the outer

202 It shows that the C-terminal cleaved product of apple RIN4 (MdRIN4) but not AtRIN4 is

203 y stabilizing the folded ground state or the cleaved product.

204 , while uncleaved proheads without portal or cleaved proheads with portal did not bind.

205 HP5 then cleaves proHP6 at a unique site of LDLH(112)*ILGG.

206 We report that legumain (Lgmn) cleaves protease-activated receptor-2 (PAR(2)) in the ac

207 Proteases are enzymes that cleave proteins and are crucial to physiological process

208 developed plaques highly enriched in ADAM10-cleaved PrP and heparan sulfate (HS).

209 , bovine IgG2 and human IgG1 antibodies were cleaved rapidly into Fab and smaller fragments, pointing

210 s action by another protease, calpain, which cleaves Rb after Lys 810.

211 this work, we demonstrated that the C-H bond cleaving reactivity of 1 can be further enhanced by intr

212 As Robo, the cleaved region of Robo, and SYG-1/Neph are all highly co

213 "nanostar" particles, interacted with a DNA-cleaving restriction enzyme, SmaI, whose activity degrad

214 nder gamma-radiation, the hydrogen bonds are cleaved, resulting in the release of pemetrexed.

215 e results obtained in the case of small self-cleaving ribozymes containing adenine bulges are consist

216 mall minority of these enzymes that can also cleave RNA/DNA heteroduplexes and that may therefore be

217 ically active, whereas all Type 2 conjugates cleaved RNA target in a sequence-specific manner, with u

218 Here, we show that (i) Fe2+ cleaves RNA by in-line cleavage, a non-oxidative mechani

219 the human ALU element, also produces a self-cleaving RNA and is cleaved during T-cell activation as

220 se a role during viral infection for RNase L-cleaved RNAs in inducing avSGs containing antiviral prot

221 e only slicer while Argonaute3 (AGO3) barely cleaves RNAs.

222 bozymes constitute a new class of small self-cleaving RNAs.

223 A [4Fe-4S](+) cluster reductively cleaves SAM to form the Omega organometallic intermediat

224 , after which fructose-bisphosphate aldolase cleaves SBP into dihydroxyacetone phosphate and erythros

225 activated complex thereafter nonspecifically cleaves single-stranded DNA reporter probes labeled with

226 hat is activated in virus-infected cells and cleaves single-stranded viral and cellular RNAs.

227 aving a high thermal stability, 2 is able to cleave sp(3) C-H bonds up to 87 kcal/mol to afford rate

228 d a scalable system of reporter enzymes that cleave specific DNA sequences in solution, which results

229 TtAgo cleaves specifically guide-complementary DNA and RNA wit

230 t the HpSGN system required less nuclease to cleave ssDNA substrates than the SGN system we reported

231 nt motifs (PAM); is a multi-turnover enzyme; cleaves ssDNA, dsDNA and RNA targets in a single assay;

232 ngstrom, including an apo state, a caspase-7-cleaved state and a carbenoxolone-bound state.

233 radical-boron 'ate' complex that selectively cleaves sterically unhindered C-H bonds.

234 er kinetic rate constants and the ability to cleave stronger C-H bonds compared to 1.

235 di1 is a ubiquitin-dependent protease, which cleaves substrate proteins only when they are tagged wit

236 CGEP specifically cleaved substrates on the C-terminal side of Glu irrespe

237 hat neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2

238 enabled us to determine the structure of the cleaved synaptic complex intasome, which is the direct t

239 sed as a single transcript, and subsequently cleave target DNA.

240 The use of readily cleaved tert-butoxycarbonyl (Boc) or carboxybenzyl (Cbz)

241 gamma-(AB)-d4TTPs are faster cleaved than gamma-(ACB)-d4TTPs.

242 olves laminarinase enzymes that specifically cleave the algal glycan laminarin into readily analyzabl

243 hat Ni-DBA-2D-COF can be used to reductively cleave the aryl C-S bonds of several organosulfur compou

244 dical chain mechanism shows that Ni does not cleave the C(sp(3))-H bonds as previously proposed; rath

245 lyst following metathesis of enol ethers and cleave the catalyst off the resulting polymers using H(2

246 m/z 1446) using on-tissue acid hydrolysis to cleave the glycosidic linkage between the polysaccharide

247 constituents exhibit catalytic properties to cleave the hairpins in the library.

248 position the N-terminal domains to bind and cleave the opposite strand in the relaxation reaction.

249 o the catalytic site enabling this enzyme to cleave the recognition sequence at a different position.

250 ed Escherichia coli-expressed Lpro unable to cleave the synthetic substrate pro-ISG15 while preservin

251 act as dimers with two catalytic sites, and cleave the two strands of duplex DNA simultaneously, in

252 Accordingly, NleD cleaved the flexible loops of JNK and p38 but not the ri

253 We found that Mt2 specifically cleaved the key components of the hepcidin-induction pat

254 reover, we showed that FEN1 also efficiently cleaved the RNA strand, facilitating pol beta loop/hairp

255 This enzyme cleaved the tripeptide aldehyde protease inhibitors, lea

256 RNA lariat debranching enzyme (Dbr1), which cleaves the 2'-5' bond of branched and lariat RNAs.

257 Specifically, PARN cleaves the 3'-end of immature, polyadenylated hTR to fo

258 ternal processing is performed by MPP, which cleaves the Arg5,6 precursor at its N-terminus and at an

259 nt to lytN, which specifies a hydrolase that cleaves the bond between the fifth glycine of cross-brid

260 a monomer with only one catalytic site, and cleaves the DNA strands sequentially, one after the othe

261 Interestingly, the dimer-bleomycin conjugate cleaves the entire pri-miR-17-92 cluster and hence funct

262 s a "molecular scissor" that proteolytically cleaves the extracellular region from >100 substrates, i

263 A protease on the mitochondria cleaves the Flag from the MitoFlag/H2B complex to form a

264 The host protease furin cleaves the full-length precursor S glycoprotein into tw

265 we reveal a lysosome-dependent reaction that cleaves the GLUT8 protein and releases the carboxy-termi

266 V CRISPR-Cas endonuclease that predominantly cleaves the non-target strand of a double-stranded DNA s

267 to lysostaphin, a secreted bacteriocin that cleaves the pentaglycine cross-bridge.

268 Exposure to proteases cleaves the peptides off the capsid, activating or "swit

269 80, Met381, and Leu385), indicating that S2P cleaves the substrates at variable sites or via a multis

270 e was uncovered, which could suggest that it cleaves the ubiquitylated protein itself.

271 a deoxyribozyme, VMC10, which preferentially cleaves the unmodified RNA.

272 PLP2 acts as a protease that cleaves the viral replicase polyprotein and as a deubiqu

273 2) domain possesses protease activity, which cleaves the viral replicase polyprotein, and also DUB ac

274 ive Rh(-I) species, which is responsible for cleaving the Ar-F bond and is ultimately regenerated usi

275 igates the harmful effects of mesotrypsin by cleaving the autolysis loop.

276 the hydrolase to orient its active site for cleaving the glycan strand.

277 Clover2, a variant of the green FP (GFP), by cleaving the mRNA of Clover2, while the expression of Ru

278 key" to specifically open the DNA/RNA NFs by cleaving the RNA in the DNA/RNA hybrid, releasing high a

279 By cleaving the short 5' tails generated during strand disp

280 oxyurea prevents the endonuclease Mus81 from cleaving the stalled replication fork inappropriately.

281 s such as Oryza sativa twister spontaneously cleave their own RNA when the ribozyme folds into its ac

282 tease that inactivates MAPKs by specifically cleaving their activation loop.

283 undance and function of membrane proteins by cleaving their substrate's extracellular domain (ectodom

284 ally, and a conserved active site to rapidly cleave this signalling molecule, allowing viruses to neu

285 We isolated Env (fully cleaved to gp120 and gp41) from the surface of expressin

286 cifically, RARRES1, which is proteolytically cleaved to release the extracellular domain, was endocyt

287 ailed insight on how pIgR can be potentially cleaved to release the SC.

288 hydroxyethyl) terephthalate (MHET), which is cleaved to terephthalic acid and ethylene glycol by MHET

289 etric sequence 5'-GCG C-3' in duplex DNA and cleaves (' ') to produce fragments with 2-base, 3'-overh

290 We show that a WHO protein cleaves Torulaspora delbrueckii FBA1 efficiently and in

291 Hence, delta-secretase cleaves TrkB and blunts its phosphorylation of APP, faci

292 Delta-secretase cleaves TrkB at N365 and N486/489 residues and abolishes

293 rt with these E3 ligases, PDIA3 was shown to cleave ubiquitinated HC molecules to accelerate HC dislo

294 of its N-acetyl functionality, which can be cleaved under mild conditions using the enzyme family of

295 trategy that allows Cas9 to bind DNA but not cleave until light-induced activation.

296 stability and can be rapidly and completely cleaved with functionalized alkyl-, aryl-, and H-tetrazi

297 Both linkers are quantitatively cleaved within minutes under NaIO(4) treatment.

298 Under acidified conditions, Lgmn cleaved within the extracellular N terminus of PAR(2) at

299 tion as endo-acting lytic transglycosylases, cleaving within the peptidoglycan backbone.

300 single RNA stem; this stem forms only in the cleaved xbp-1 ncRNA fragment.