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1 BMI change was not related to the risk of cleft lip.
2 tin cre transgenic line resulted in isolated cleft lip.
3 tic attenuation results in failed fusion and cleft lip.
4 number of realistic facial images depicting cleft lip.
5 that disruption of this sequence results in cleft lip.
6 been identified in both mice and humans with cleft lip.
7 ed by persistence of the epithelial seam and cleft lip.
8 tches in the upper beak or the equivalent of cleft lip.
9 outgrowth, epithelial seam persistence, and cleft lip.
10 Cases were infants with isolated defects--cleft lip alone (n = 334), cleft lip and palate (n = 494
12 beta2-agonists were found for spina bifida, cleft lip, anal atresia, severe congenital heart defects
13 ndwork for understanding the causes of human cleft lip and analyzing the mechanism of action of growt
20 the molecular pathogenesis of the bilateral cleft lip and cleft palate that results from mutation of
23 ork has focused on the molecular etiology of cleft lip and clefts of the hard palate, but study of th
24 surgical outcome assessment in patients with cleft lip and for the rehabilitation of patients with fa
28 also observed wider de novo deletions among cleft lip and palate (CLP) cases than seen among cleft p
29 notypic spectrum - including cleft lip (CL), cleft lip and palate (CLP), or cleft palate (CP) - and c
31 isolated defects--cleft lip alone (n = 334), cleft lip and palate (n = 494), or cleft palate alone (n
33 shortened fifth fingers (one), microtia with cleft lip and palate (one), microtia alone (one), and ne
34 ormations (RR, 1.52; 95% CI, 1.02-2.25), and cleft lip and palate (RR, 3.23; 95% CI, 1.44-7.22) compa
35 patients with surgically repaired unilateral cleft lip and palate (UCLP) undergoing orthodontic corre
36 amilies with autosomal dominant nonsyndromic cleft lip and palate and 3 families with autosomal domin
38 syndrome (VWS) is a common form of syndromic cleft lip and palate and accounts for approximately 2% o
41 ere craniofacial defects including bilateral cleft lip and palate and tongue agenesis, following the
42 r teeth alignment; Group 3 had patients with cleft lip and palate but no treatment for teeth alignmen
47 y drain saliva, and patients with the common cleft lip and palate have a higher prevalence of dental
48 ions (p = 0.001), and with SNP rs3923086 and cleft lip and palate in Asian populations (p = 0.004).
49 signaling pathway have been associated with cleft lip and palate in humans and mice, the mechanisms
53 Recently, we identified a family in which cleft lip and palate segregated in two of three generati
54 surgery such as ophthalmology (88, 28%) and cleft lip and palate surgery (70, 22%) were also frequen
62 health and microbial flora in patients with cleft lip and palate undergoing treatment with fixed bra
63 alformation, other cardiac malformation, and cleft lip and palate was higher for infants exposed to T
65 he disorder is an autosomal dominant form of cleft lip and palate with lip pits, and is the most comm
66 a positive dose response among infants with cleft lip and palate+ (for light smokers, odds ratio (OR
67 ditional malformations: cleft lip+ (n = 58), cleft lip and palate+ (n = 140), or cleft palate+ (n = 2
68 aking and aid in treating conditions such as cleft lip and palate, among other congenital craniofacia
69 tations in several candidate genes may cause cleft lip and palate, but definitive evidence regarding
70 been shown to be an important contributor to cleft lip and palate, but the functional variant leading
71 s are candidate genes for genetic disorders (cleft lip and palate, certain forms of cancer) or solute
72 ed with syndromic and non-syndromic forms of cleft lip and palate, consistent with a role for Irf6 in
74 es a constellation of abnormalities, such as cleft lip and palate, pigmentary retinopathy, and multip
75 petitive urinary tract infections, bilateral cleft lip and palate, retinopathy, and gut malrotation.
78 ily of three affected siblings with isolated cleft lip and palate, we discovered that they share a no
91 upracondylar fracture of humerus: ICC, 0.25; cleft lip and palate: ICC, 0.24; acute appendicitis with
93 detected in the DNA of 74 unrelated cases of cleft lip and/or cleft palate; no variants associated si
97 In Ethiopia, more than 70% of infants with cleft lip and/or palate (CL/P) lack access to surgery.
99 lex aetiology and the variable penetrance of cleft lip and/or palate (CL/P), understanding the molecu
105 l and known candidate genes for nonsyndromic cleft lip and/or palate through genome-wide linkage anal
106 tes the genetic contribution to nonsyndromic cleft lip and/or palate through the analysis of family p
107 by bilateral choanal atresia, hearing loss, cleft lip and/or palate, and other craniofacial dysmorph
108 r because of abnormal development (including cleft lip and/or palate, craniosynostosis and facial dys
109 including characteristic facial dysmorphism, cleft lip and/or palate, craniosynostosis, learning disa
110 857 806 newborns included, 1197 (0.1%) had a cleft lip and/or palate, including 170 (14.2%) with a cl
111 expression of genes previously implicated in cleft lip and/or palate, including components of multipl
114 l tube defects to neurocristopathies such as cleft-lip and cleft-palate, cardiac septal defects, and
115 ults obtained using phenytoin (which induces cleft lip) and 6-aminonicotinamide (which induces cleft
118 rther investigated the mechanisms leading to cleft lip as well as cleft palate in both existing and n
121 others of limb deficiency, cleft palate, and cleft lip cases were, respectively, 1.8 (95% CI: 1.1, 3.
122 We named this new Mendelian syndrome CATIFA (cleft lip, cataract, tooth abnormality, intellectual dis
124 cur across a phenotypic spectrum - including cleft lip (CL), cleft lip and palate (CLP), or cleft pal
125 s who consumed alcohol tended to be near to (cleft lip, cleft lip with cleft palate) or to exceed (cl
127 tralogy of Fallot, coarctation of the aorta, cleft lip, cleft palate, anorectal atresia/stenosis, and
130 uced by the method of Farrall and Holder for cleft lip/cleft palate data is not consistent with the p
132 t disorders characterized by combinations of cleft lip, CLP, lip pits, skin-folds, syndactyly and ora
133 showcase DOT by analyzing breast cancer and cleft lip data, in which our method strengthened levels
135 rs of unique faces depicting a wide range of cleft lip deformity with variation of ethnic background.
136 rter snout, expansion of the facial midline, cleft lip, extensive exencephaly, and microphthalmia or
137 t MSX1 mutations could increase the risk for cleft lip formation by interacting with an impaired morp
138 uals with isolated cleft palate (ie, without cleft lip) had increased mortality (hazard ratio, 3.4; 9
139 interesting because the occurrence of fetal cleft lip has been demonstrated to increase with materna
141 f a large multi-ethnic human population with cleft lip identified clusters of single-nucleotide polym
145 l defects, middle-ear defects, cleft palate, cleft lip, limb defects, limb-reduction defects, polydac
146 th clefts plus (+) additional malformations: cleft lip+ (n = 58), cleft lip and palate+ (n = 140), or
147 ct of the A allele, with a relative risk for cleft lip of 1.68 for the AG genotype and 2.40 for the A
148 , 8q24, KIAA1598-VAX1, and MAFB and isolated cleft lip only (CLO) and cleft lip and palate (CLP).
149 c orofacial clefts (NSOFCs) are nonsyndromic cleft lip only (NSCLO), nonsyndromic cleft lip with pala
150 as greater for cleft lip and palate than for cleft lip only (odds ratio=2.4 vs. 1.8, p<0.001 for diff
152 ce: Young adults who were born with isolated cleft lip only did not differ significantly from unaffec
154 GEF19 (cleft lip with/without palate), FBN2 (cleft lip only), SLC35B3 (cleft palate only), CASC20 (Pi
155 and/or palate, including 170 (14.2%) with a cleft lip only, 493 (41.2%) with a cleft palate only, an
161 ), hypospadias (0.6%), hydrocephalus (0.6%), cleft lip or palate (0%), and obstetric fistula (0%).
163 or 12 percent of the genetic contribution to cleft lip or palate and tripled the risk of recurrence i
167 contribution of variants in single genes to cleft lip or palate is an important consideration in gen
169 During the 2-year follow-up, children with a cleft lip or palate showed higher incidence rate ratios
170 control analyses, and determined the risk of cleft lip or palate that is associated with genetic vari
171 his nationwide cohort study, the presence of cleft lip or palate was associated with increased hospit
177 enesis is commonly found in individuals with cleft lip/palate (CL/P), we used four large cohorts to e
181 hem, ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome is caused by single poin
182 from ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome patients with p63 mutati
184 ns found in ectrodactylyectodermal dysplasia-cleft lip/palate (EEC), Limb-mammary syndrome (LMS) and
185 example ectrodactyly--ectodermal dysplasia--cleft lip/palate (EEC; OMIM 604292), limb--mammary syndr
188 yposmia; and (iii) Q680X in a nIHH male with cleft lip/palate and missing teeth, his brother with nIH
189 dence of the involvement of chromosome 6q in cleft lip/palate and suggest PRSS35 as a novel candidate
192 association of PRSS35 and SNAP91 genes with cleft lip/palate in the case-control cohort and in Cauca
195 p revision surgery in patients with repaired cleft lip/palate is based on surgeons' subjective evalua
198 escended testes, hypospadias, hydrocephalus, cleft lip/palate, and clubfoot) was determined by physic
199 lts in defects analogous to hypotelorism and cleft lip/palate, characteristics of the mild forms of h
200 urgically treatable conditions (breast mass, cleft lip/palate, club foot, hernia or hydrocele [adult
202 e been associated with cognitive defects and cleft lip/palate, its role in mammalian development and
203 representing 14 specialties (ophthalmology, cleft lip/palate, multidisciplinary teams, orthopaedics,
204 fferent surgical specialties (ophthalmology, cleft lip/palate, multidisciplinary teams, orthopaedics,
205 syndrome (ADULT; OMIM 103285) and recessive cleft lip/palate--ectodermal dysplasia (CLPED1; OMIM 225
210 with the cellular mechanism demonstrated for cleft lip pathogenesis, we found that either SHH ligand
213 of the defect, epidemiologic assessments of cleft lip should, when possible, include separate analys
214 e identify CDH3 variants in individuals with cleft lip, supporting the relevance of this mechanism in
216 e remain a limited number of mouse models of cleft lip that can be leveraged to characterize the gene
217 tributes to the etiology and pathogenesis of cleft lip through antagonistic interactions with other g
219 formation, Msx1-deficient embryos develop a cleft lip when the mother is transiently exposed to redu
221 th cleft lip who had revision, patients with cleft lip who did not, and non-cleft control individuals
222 d clinical trial that included patients with cleft lip who had revision, patients with cleft lip who
223 ear two genes not previously associated with cleft lip with and without cleft palate (MAFB, most sign
225 GI, the authors identified associations with cleft lip with cleft palate (aOR = 1.23) and anorectal a
226 een 1967 and 1998, there were 1,572 cases of cleft lip with cleft palate and 1,122 cases with cleft l
230 med alcohol tended to be near to (cleft lip, cleft lip with cleft palate) or to exceed (cleft palate)
233 2%), encephalocele (83%), cleft palate (0%), cleft lip with or without cleft palate (14%), omphalocel
234 hree or more occasions: odds ratio = 3.2 for cleft lip with or without cleft palate (95% confidence i
235 vitamins or liver consumption would decrease cleft lip with or without cleft palate (CL +/- P) risk a
236 udies suggest that the risks of nonsyndromic cleft lip with or without cleft palate (CL+/-P) and isol
237 tudies suggest that the risk of nonsyndromic cleft lip with or without cleft palate (CL+/-P) and isol
238 g mutations by screening 33 individuals with cleft lip with or without cleft palate (CL/P) and 19 ind
240 de linkage scan discovered a novel locus for cleft lip with or without cleft palate (CL/P) at 9q22-q3
248 a gene (TGFA) polymorphisms with the risk of cleft lip with or without cleft palate (CL/P) or cleft p
249 authors genotyped 244 infants with isolated cleft lip with or without cleft palate (CL/P), 99 with i
251 l clefts (OFCs), which include non-syndromic cleft lip with or without cleft palate (CL/P), are among
254 f delivering infants with cleft palate (CP), cleft lip with or without cleft palate (CLP), conotrunca
255 increased risk of anencephaly, spina bifida, cleft lip with or without cleft palate (CLP), or cleft p
258 ndidate gene in the etiology of nonsyndromic cleft lip with or without cleft palate (NS-CL/P) and of
260 n implicated in the etiology of nonsyndromic cleft lip with or without cleft palate (NSCL/P) in popul
265 Previously we have shown that nonsyndromic cleft lip with or without cleft palate (NSCL/P) is stron
270 ing) were more likely to have an infant with cleft lip with or without cleft palate (odds ratio = 2.2
271 separated into two different phenotypes: (1) cleft lip with or without cleft palate and (2) cleft pal
272 ,019 nonsyndromic orofacial cleft cases (814 cleft lip with or without cleft palate and 205 cleft pal
277 rnal smoking were most elevated for isolated cleft lip with or without cleft palate, (odds ratio 2.1
278 .7), cleft palate, 0.9 (95% CI 0.5-1.6), and cleft lip with or without cleft palate, 1.3 (95% CI 0.8-
283 common birth defects, including hypospadias, cleft lip with or without cleft palate, or hydrocephalus
284 toward understanding the genetic etiology of cleft lip with or without cleft palate, relatively littl
285 d into two groups, isolated cleft palate and cleft lip with or without cleft palate, representing a h
288 ion analyses for cleft palate only (CPO) and cleft lip with or without palate (CL/P) with ~17 million
292 ndromic cleft lip only (NSCLO), nonsyndromic cleft lip with palate (NSCLP), and nonsyndromic cleft pa
293 alysis, cleft lip with/without cleft palate, cleft lip with palate plus cleft palate only, and all da
296 h transmission disequilibrium test analysis, cleft lip with/without cleft palate, cleft lip with pala
297 focused on subtypes other than non-syndromic cleft lip with/without cleft palate, or investigated sub
298 P1 (combined clefts), ARHGEF18 and ARHGEF19 (cleft lip with/without palate), FBN2 (cleft lip only), S