ライフサイエンスコーパス: climb

1 ning across multiple modes (e.g., walk, run, climb).

2 ated to STGBs are annihilated by dislocation climb.

3 led just as incarceration rates dramatically climbed.

4 ident rates of end-stage kidney disease have climbed.

5 Lesioning the habenula reduces light-evoked climbing.

6 source additional to that of faster gradient climbing.

7 demonstrate directional control, as well as climbing.

8 e role of adaptation in chemotactic gradient-climbing.

9 d patterns with other legs, as in walking or climbing.

10 in the triad maintains EMF responsiveness in climbing.

11 ican ape-like terrestrial quadrupedalism and climbing.

12 L5 (sweeping the floor for 4 minutes), ADL6 (climbing 1 flight of stairs carrying a load).

13 ts of difficulty walking one-quarter mile or climbing 10 steps during semiannual assessments over 13

14 eed (12.1; 95% CI, 1.4-22.8; P = .03), stair climb (11.4; 95% CI, 1.3-21.5; P = .03), pain (20.7; 95%

15 03; LS mean 0.286 [95% CI 0.104, 0.469]) and climb 4 stairs velocity (p = 0.027; LS mean 0.059 [95% C

16 < 0.001 [95% CI 0.220, 0.491 meters/second]; climb 4 stairs velocity, p = 0.001 [95% CI 0.034, 0.105

17 lows: distance (39.1%), speed (15.6%), stair climb (9.7%), pain (116.9%), VascuQol (41%), EQ-5D (18%)

18 that when the body plane is vertical as rats climb a wall, grid cells produce stable, almost-circular

19 ed exercises (such as standing from a chair, climbing a step) taught by a physical therapist and perf

20 ill compared with those that performed RT by climbing a vertical ladder with weights, despite their s

21 Such a climber-climbing-a-climber phenomenon signals the potential ecol

22 e phenotypes, including decreased flying and climbing abilities, in heterozygous female flies.

23 Indeed, survival, climbing ability and neuronal function were unchanged in

24 ed axonal transport, synapse loss, defective climbing ability and olfactory perception, as well as li

25 anges in lifespan and age-related decline in climbing ability in the Drosophila Genetic Reference Pan

26 ositive response to DR for both lifespan and climbing ability, 14% showed a negative response for one

27 DR extended lifespan and delayed decline in climbing ability, but there was a lack of correlation be

28 diet responsive nor to influence lifespan or climbing ability.

29 s one that influences age-related decline in climbing ability.

30 nce is severely impaired when concentrations climb above 5 muM as a result of effects like self-absor

31 Kinetic Monte Carlo simulations yield a self climb activation energy of 2 (2.5) times the vacancy mig

32 We optimize a hill climbing algorithm and extend the framework to include m

33 We propose a modified hill-climbing algorithm to optimize pattern sets for database

34 The phenotypic network inferred via the Hill-Climbing algorithm was used to estimate SEM parameters.

35 An alternative mechanism, self climb, allows prismatic dislocation loops to move away f

36 , it also deployed specialized branches that climbed along other dendrites to form strong multi-synap

37 nd newborn and child health has continued to climb, although DAH for HIV/AIDS and most other health f

38 r, and loss of stand from supine, four-stair climb, ambulation, full overhead reach, hand-to-mouth fu

39 We propose a climb and drive 0D/2D interaction to explain the underly

40 slocation dynamics simulations allowing self climb and glide show quantitative agreement with transmi

41 Insect fouling during takeoff, climb and landing can result in increased drag and fuel

42 Jurassic of China has skeletal features for climbing and dental characters indicative of an omnivoro

43 ct in grip strength, and repeat the cycle of climbing and falling.

44 resistance physical activity (RPA), such as climbing and fighting, that creates pressure stress on t

45 nt recovery of motor function as assessed by climbing and flight assays.

46 imulations and experiments for commonly used climbing and sailing bends.

47 ng life for strong grasping during locomotor climbing and suspension.

48 potentially suggesting regular bouts of both climbing and terrestrial bipedalism.

49 sitions in hand use: a reduction in arboreal climbing and the manufacture and use of tools.

50 ions in Multiple Sclerosis at Brigham study (CLIMB), and paediatric patients (n = 132) from the US Ne

51 sms associated with their nucleation, glide, climb, and annihilation at elevated temperatures.

52 nd to sustain the colony, workers must walk, climb, and use phototaxis as they move inside and outsid

53 dy the allometry of adhesive pad area in 225 climbing animal species, covering more than seven orders

54 Attachment mechanisms used by climbing animals facilitate their interactions with comp

55 a way that trapped genotypes can repeatedly climb ascending slopes and hence, escape adaptive stasis

56 ity behavior was assessed in flies using the climbing assay.

57 r behavioral phenotypes for these genes, fly climbing assays have been widely used.

58 underlying the grain rotation is dislocation climb at the grain boundary, rather than grain boundary

59 Flies avoid futile climbing attempts by processing parallax-motion vision t

60 ms based on evolutionary algorithms and hill-climbing based techniques.

61 we use the perplexity metric to guide a hill climbing-based search, converging toward the best config

62 We introduce a climbing behavior assay which provides such fine-scale b

63 ted assay to quantitatively characterize the climbing behavior at high parametric resolution in 3 con

64 Second, we study climbing behavior of heterozygous mutants of genes impli

65 The result is a "ratchet-like" gradient climbing behavior with drift speeds that can approach ha

66 over a hitherto unknown sexual dimorphism in climbing behavior.

67 ar junction morphology, bang sensitivity and climbing behaviour in comparison between single and pair

68 One striking class of flies attempts to climb chasms of unsurmountable width; expression analysi

69 e Sclerosis at Brigham and Women's Hospital (CLIMB) cohort study.

70 To identify neuronal substrates of climbing control, we screened a large collection of fly

71 sing the recent advances in this field, pure climb creep controlled by diffusion is identified as the

72 of MgSiO(3) bridgmanite resulting from pure climb creep is consequently evaluated and compared with

73 els and rescue of the shortened lifespan and climbing defects of Abeta-expressing flies.

74 utant) overexpression reverses eye necrosis, climbing deficit, and firing discharge caused by (G4C2)-

75 y exposure length over five minutes produced climbing deficits that lasted for days.

76 osure to 100% CO2, D. melanogaster exhibited climbing deficits up to 24 hours after exposure.

77 st and palm indicate a significant degree of climbing, despite the derived nature of many aspects of

78 allowing different replicate populations to climb different adaptive peaks and explore otherwise-ina

79 e further observed aligned point defects and climb-dissociated dislocations.

80 nge scores on the distance, speed, and stair-climb domains of the Walking Impairment Questionnaire (s

81 15 healthy older adult subjects for 4 wk at climbing dosages of, on average, 9.2, 22.5, 46.3 and 91

82 Viremia gradually climbs during gestation but sometimes declines sharply i

83 Here, we report a climbing fern engaged in left-handed twining around a se

84 ns, but, regardless of activation frequency, climbing fiber (CF) coactivation provides an instructive

85 e transient depolarization associated with a climbing fiber (CF) EPSP activates voltage-gated Ca(2+)

86 mouse cerebellar Purkinje neurons (PNs), the climbing fiber (CF) input provides a signal to parallel

87 ays a predominant role in terminating DSE at climbing fiber (CF) to PC synapses, while both neuronal

88 rom acute cerebellar slices revealed altered climbing fiber (CF)-evoked complex spike generation, as

89 rning, MCS and ZCS cells developed increased climbing fiber (MCS) or parallel fiber (ZCS) input durin

90 Cerebellar climbing fiber activity encodes performance errors durin

91 Climbing fiber activity increased when the monkeys were

92 e cell dendrites faithfully transformed this climbing fiber activity into dendrite-wide Ca(2+) signal

93 This pattern of climbing fiber activity is markedly similar to the respo

94 During VOR-increase training, climbing fiber activity on one trial predicted changes i

95 ng electrical stimulation of mossy fiber and climbing fiber afferents as CS and US, while alternating

96 Comparison between climbing fiber and simple spike activity indicated diffe

97 of the cerebellum: the mossy fibers and the climbing fiber collaterals.

98 rding to the initial membrane potential, the climbing fiber depolarizing transient activates two dist

99 racking task in the monkey (Macaca mulatta), climbing fiber discharge dynamically controls the inform

100 r trains of parallel fiber stimuli and after climbing fiber evoked complex spikes.

101 th types of response were shown to be mainly climbing fiber in origin and therefore evoked by transmi

102 firing provide for a new hypothesis in which climbing fiber input adjusts the encoding of SS informat

103 ts suggest a novel function of CSs, in which climbing fiber input dynamically controls the state of P

104 The climbing fiber input to Purkinje cells acts as a teachin

105 In the present study we examined the climbing fiber input to the medial half of folium IXcd,

106 , determined by coincident activation of the climbing fiber input, underlies cerebellar learning.

107 Purkinje cell synapses under control of the climbing fiber input, which provides an error signal as

108 in simple spike firing can be independent of climbing fiber input.

109 Theories of cerebellar learning assert that climbing fiber inputs control plasticity at synapses ont

110 ng in advance of reward under supervision of climbing fiber inputs signaling reward delivery.

111 Climbing fiber inputs to Purkinje cells are thought to b

112 We probed the role of climbing fiber inputs to Purkinje cells in generating an

113 are: (1) early, fast, acquisition driven by climbing fiber inputs to the cerebellar cortex, with poo

114 Climbing fiber inputs to the cerebellum encode error sig

115 calcium spikes, which was modulated by a non-climbing fiber pathway.

116 in access to the cerebellum is via ascending climbing fiber pathways.

117 We find distinct climbing fiber responses in three lateral cerebellar reg

118 transmission in these pathways controls when climbing fiber signals can modify cerebellar activity.

119 own that Golgi cell activity is regulated by climbing fiber stimulation, yet there is little function

120 f excitation and inhibition following single climbing fiber stimulation.

121 ed of electrically-coupled neurons that make climbing fiber synapses onto Purkinje cells.

122 ficits along with an increased engulfment of climbing fiber synaptic elements by microglia were found

123 s this single isoform, we studied excitatory climbing fiber synaptic function onto PCs in Cacna2d2 KO

124 neuron dendrites.SIGNIFICANCE STATEMENT The climbing fiber synaptic input transiently depolarizes th

125 Moreover, significant climbing fiber synaptic refinement deficits along with a

126 ffect of NPC1 deficiency on microglia and on climbing fiber synaptic refinement during cerebellar pos

127 ligin isoforms differentially contributed to climbing-fiber and basket/stellate-cell synapse function

128 distal climbing-fiber synapses and weakened climbing-fiber but not parallel-fiber synapses, consiste

129 ely depressed in Purkinje cells that receive climbing-fiber inputs from the instruction.

130 tion of pursuit and therefore do not receive climbing-fiber inputs related to the instruction, simple

131 nexpectedly essential for maintaining normal climbing-fiber synapse numbers.

132 ebellar Purkinje cells caused loss of distal climbing-fiber synapses and weakened climbing-fiber but

133 airments in their distribution and function (climbing-fiber synapses) to large decreases in synapse n

134 Climbing-fiber synapses, conversely, were unaffected.

135 llins as neurexin ligands for the excitatory climbing-fiber versus parallel-fiber synapses.

136 ing in the granule cell population, allowing climbing-fiber-driven Purkinje cell learning at arbitrar

137 These results demonstrate that the size of climbing-fiber-evoked Ca(2+) signals in Purkinje cell de

138 f the C1q family of proteins, is provided by climbing fibers (CFs) and serves as a crucial anterograd

139 quired for bursting, activation of AMPARs by climbing fibers (CFs) was sufficient to trigger bursts.

140 o visualize instructional signals carried by climbing fibers across the lateral cerebellum in mice be

141 In addition, we observed that climbing fibers activated by periocular airpuffs also re

142 Here, we show that glutamate released from climbing fibers activates ionotropic and metabotropic re

143 IO neurons excite Purkinje cells via climbing fibers and depress their parallel fiber inputs.

144 or anatomical evidence for synapses between climbing fibers and Golgi cells.

145 uces the magnitude of the teaching signal in climbing fibers and limits learning.

146 sion patterns that suggest a contribution of climbing fibers and their collaterals.

147 oded, we recorded the activity of individual climbing fibers during cerebellum-dependent eyeblink con

148 These results indicate that climbing fibers encode the expected reward size and sugg

149 ayer interneurons, these results reveal that climbing fibers exert control over inhibition at both th

150 ound the following topographic relationship: climbing fibers from the caudal lateral mcIO were locate

151 Climbing fibers from the inferior olive make strong exci

152 ated in lateral P2+ and P2- ZII stripes, and climbing fibers from the middle lateral mcIO were locate

153 e located in P1+ and medial P1- ZII stripes; climbing fibers from the rostral lateral mcIO were locat

154 ng pathways, respectively, that terminate as climbing fibers in the "hindlimb-receiving" parts of the

155 s limits their ability to forward signals to climbing fibers in the cerebellar cortex.

156 g, we analyzed excitatory synapses formed by climbing fibers on Purkinje cells in cerebellum and inhi

157 cal models of cerebellar learning posit that climbing fibers operate according to a supervised learni

158 Following glutamate spillover from climbing fibers or application of CNQX, evoked GABA rele

159 vironment along translational axes and their climbing fibers originate in the lateral half of the med

160 ings of Purkinje cell activity, we show that climbing fibers signal reward expectation, delivery and

161 We found that climbing fibers signaled both the unexpected delivery an

162 stronger influence of the background on the climbing fibers than on learning.

163 are transmitted by mossy/parallel fibers and climbing fibers to cerebellar Purkinje cells that acquir

164 s in inferior olivary (IO) neurons that send climbing fibers to innervate cerebellar Purkinje cells f

165 he next trial, and optogenetic activation of climbing fibers to mimic their encoding of performance e

166 Individual climbing fibers were broadly responsive to different sen

167 nts are encoded, we recorded the activity of climbing fibers when monkeys were engaged in an eye move

168 naptic activity of their axonal projections (climbing fibers) in the cerebellar cortex.

169 al instructive signals carried by cerebellar climbing fibers, but with a stronger influence of the ba

170 fibers to Purkinje cells' synapse guided by climbing fibers, feedforward inhibition of Purkinje cell

171 innervation of Purkinje cells by cerebellar climbing fibers.

172 ns of variability driven by the parallel and climbing fibers.

173 is largely determined by the firing level of climbing fibers.

174 ly robust putative error signals in the same climbing fibers: learned increases and decreases in the

175 In vivo and in vitro data suggest that climbing fibre collateral excitation is weak in adult mi

176 We therefore examined climbing fibre collateral input to large premotor CbN ce

177 res in the cerebellar cortex, implicates the climbing fibre collateral pathway in early postnatal dev

178 Activating climbing fibre collaterals evoked well-timed increases i

179 The convergence of climbing fibre collaterals onto CbN cells decreases from

180 eneration of proximal dendrites, the site of climbing fibre innervation, most pronounced.

181 grating diverse afferent signals to generate climbing fibre inputs to the cerebellar cortex.

182 grating diverse afferent signals to generate climbing fibre inputs to the cerebellar cortex.

183 tive motor signals to the cerebellum via the climbing fibre projection, which sends collaterals direc

184 While it is well established that climbing fibre signals are important for motor coordinat

185 central role in control of olivo-cerebellar climbing fibre signals.

186 jor excitatory inputs to Purkinje cells, and climbing fibre-Purkinje cell connections are essential f

187 These findings suggest that abnormal climbing fibre-Purkinje cell connections could be of imp

188 s to examine the density and distribution of climbing fibre-Purkinje cell synapses using post-mortem

189 into question the widely held view that the climbing-fibre input is an 'all-or-none' event.

190 lex spike (CS) caused in Purkinje cells by a climbing-fibre input.

191 rning relies on movement errors signalled by climbing-fibre inputs to cause long-term depression of s

192 e imaged post-lesion sprouting of cerebellar climbing fibres (CFs) in mice using in vivo time-lapse m

193 ression (LTD) at these synapses is driven by climbing fibres (CFs), which fire continuously about onc

194 Normally, climbing fibres form synapses mainly on the thick, proxi

195 ptic strength coinciding with the pruning of climbing fibres in the cerebellar cortex, implicates the

196 ggest that during learning, longer bursts in climbing fibres lead to longer-duration CS responses in

197 Climbing fibres provide one of the major excitatory inpu

198 Additionally, however, these climbing fibres send collaterals to the cerebellar nucle

199 ected Purkinje cells (PCs), basket cells and climbing fibres, in individuals with ET.

200 r olivary neurons transmit their signals via climbing fibres, which powerfully excite Purkinje cells,

201 reover, developmental elimination of surplus climbing fibres--a model for activity-dependent synaptic

202 olive and therefore may be correlated across climbing fibres.

203 The rock-climbing fish (Beaufortia kweichowensis) adheres to slip

204 , the general skeletal structure of the rock-climbing fish was determined using microtomography.

205 adhesive locomotion system used by the rock-climbing fish was observed with a high speed camera.

206 ations, from shoelaces to the knots used for climbing, fishing and sailing(1).

207 lls in rats as they explored a cubic lattice climbing frame which could be aligned or tilted with res

208 f C2/C3 neurons strongly or mildly decreased climbing frequency.

209 rior to its upper surface, peak temperatures climb from as much as 20 degrees C below to 5 degrees C

210 een 1996/1997 and 2008/2009, the share of LA climbed from 33.1% to 85.8% (P < 0.001).

211 al's percentage of Black patients increased, climbing from 0.6% to 32.5% (lowest vs highest decile),

212 higher risk (determined by the inability to climb >=2 flights of stairs, which is <4 metabolic equiv

213 However, all of these diagnoses of a climbing habit are based upon either indirect morphologi

214 t consume substantial energy for takeoff and climb; hence, their burdens depend critically on trip di

215 on the fitness landscape, with a bias toward climbing hills.

216 wn in Drosophila was associated with drastic climbing impairment.

217 re used to map the energy landscape for self climb in iron and tungsten, finding a simple, material i

218 e influenced by the presence of a support to climb in their vicinity.

219 tures worldwide, resulting in an exponential climb in vapor pressure deficit (VPD).

220 -specific antibody than RD-Ad, which notably climbed in serum and vaginal wash samples over 12 weeks

221 and improved motor coordination during pole climbing in male mice.

222 f exercise on functional muscle power (stair climbing) in middle-aged women.

223 omotor adaptations in docodontans to include climbing, in addition to digging and swimming.

224 firming that this novel form of vacancy-free climb is many orders of magnitude faster than what is pr

225 t that negative geotaxis in flies, scored as climbing, is disrupted by a static EMF, and this is medi

226 study presents dislocation motion, glide and climb, leading to grain boundary migration in a tungsten

227 As mutation rates and burdens climbed, lifespan steadily eroded.

228 In geological history, climbing may have already been present in the first Midd

229 Vacancy-mediated climb models cannot account for the fast, direct coalesc

230 faster than what is predicted by traditional climb models.

231 Inspired by the gradient-climbing nature of chemotaxis, the infotaxis algorithm s

232 of multisecond intervals does not depend on climbing neural activity as indexed by the CNV and that

233 It is often argued that climbing neural activity, as for example reflected by th

234 we investigate the role of adaptation in the climbing of gradients by E. coli.

235 aised surfaces; allowing children to play or climb on furniture; and teaching children safety rules a

236 significantly more likely to have played or climbed on furniture (AOR, 9.25; 95% CI, 1.22-70.07).

237 significantly less likely to have played or climbed on garden furniture (AOR, 0.74; 95% CI, 0.56-0.9

238 ot to have taught their children rules about climbing on kitchen objects (AOR, 1.58; 95% CI, 1.16-2.1

239 re; and teaching children safety rules about climbing on objects.

240 wo conditions: with and without a support to climb onto.

241 0.05), but did not demonstrate slower stair climbing or descent speed.

242 that atmospheric CO2 will likely continue to climb over the next century, a long-term increase in flo

243 When an animal transitioned to climbing over an obstacle, the encoding of movement in t

244 ocomotion during behaviors such as foraging, climbing over barriers, and navigating to memorized loca

245 Climbing over chasms larger than step size is vital to f

246 It comprises a fossil climbing perch (Anabantidae) and a diverse subtropical f

247 8 degrees C) with/without predator cues from climbing perch (Anabas testudineus) for 11 generations (

248 is inferred to be closely related to extant climbing perches from tropical lowlands in south Asia an

249 elates of a labyrinth organ, which in extant climbing perches gives them the ability to breathe air t

250 The observed climbing phenotypes were classified; lines in each group

251 herwise uniform helical structure, such as a climbing plant tendril, refers to a kink that connects t

252 The ability of climbing plants to grow upward along others to reach the

253 lso observed in bioadhesives exuded by other climbing plants, the adhesion mechanisms revealed by Eng

254 smission electron microscopy observations of climbing prismatic loops in iron and tungsten, confirmin

255 driven by a diffusion-controlled dislocation climb process.

256 Old male rats were submitted to RT (ladder climbing, progressive load, 3 times a week for 12 weeks)

257 The firing fields observed in flying bats or climbing rats can be generated by neurons that combine a

258 a physical realization with three autonomous climbing robots limited to onboard sensing.

259 ly generates low-level rules for independent climbing robots that guarantee production of that struct

260 d age at weaning on gross motor, running and climbing scores was strongest among children with the hi

261 substantially reduced probability of T cells climbing sharp-edged ramp-like structures, indicating in

262 Self climb significantly influences the coarsening rate of de

263 ociated with intrusive body pain, difficulty climbing stairs and slower chair rise speed.

264 OA, personal history of knee OA, or pain on climbing stairs or walking up slopes all had LRs of 2.1

265 Difficulty walking one-quarter mile or climbing stairs was measured every 6 mo over 6 y.

266 models of intrusive body pain and difficulty climbing stairs, but for chair rise speed they were full

267 e, fluctuating limb weakness, and difficulty climbing stairs.

268 The twining habit is a climbing strategy that helps slender plants grow upward

269 lerosis at the Brigham and Women's Hospital (CLIMB) study completed a self-administered questionnaire

270 in the Complex Lipids in Mothers and Babies (CLIMB) study in Chongqing, China were included in our st

271 ibilities as professor of biology, including climbing tall trees for her canopy research.

272 re leads to improved team coordination among climbing teams, but impaired psychological safety and in

273 rms) and exploratory outcomes (12-step stair climbing test, 6-min walking distance, fast gait speed,

274 y, and their views affect their decisions to climb the corporate ladder (or not).

275 the rate at which children born into poverty climb the income ladder-varies considerably across the U

276 cted by current social status than those who climbed the social hierarchy.

277 r the intriguing turning behavior of T cells climbing the ramp-like structures.

278 Additionally, the mutant flies fall when climbing the walls of the vials, suggesting a defect in

279 As the prevalence of diabetes continues to climb, the number of individuals living with diabetic co

280 Despite the known importance of self climb, theoretical models require a typically unknown ac

281 Climbing therefore provides a robust and reliable phenot

282 ging gravitational acceleration as the rover climbs through Gale crater.

283 Stair climbing time (four-step and 12-step tests), chair rise

284 mance as secondary outcomes (four-step stair climbing time, usual gait speed, and time to rise five t

285 teau lasting from 5 to 20 min, followed by a climb to within 10% of reference where a second plateau

286 ilities increased, even as arterial pressure climbed to new levels); or altered pulmonary stretch rec

287 on of agents in low scores, while a few ones climb up the social hierarchy and exploit the rest, with

288 ces remained constant prior to 2011 but have climbed up substantially since then, and the chronic lym

289 The accuracies improved to 99.9-100% when climbing up the embryonic tree and classifying cancers a

290 ght and various slopes, and observed T cells climbing up the ramp-like structures.

291 that promotes the capacity of this plant to climb vertical surfaces.

292 By the late Carboniferous, climbing was both more common and diverse - preserved in

293 Gradient climbing was effective because the arena size allowed an

294 lind cavefish Cryptotora thamicola walks and climbs waterfalls with a salamander-like diagonal-couple

295 from DNA to turbulent plasmas, as well as in climbing, weaving, sailing, and surgery.

296 er lines consistently reproduced hyperactive climbing whereas strong or weak artificial depolarizatio

297 ted fin and body movements, allowing them to climb with increasingly stable postures.

298 for closely related groups helps explain how climbing with adhesive pads has evolved in animals varyi

299 eases, chronic kidney disease burden rapidly climbed, with age-standardised YLL and DALY rates increa

300 illustrate the size limits of adhesion-based climbing, with profound implications for large-scale bio