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1 r growth rate as effectively as the standard clinical dose.
2 than that observed in humans at the maximal clinical dose.
3 tion dose to one half and one quarter of the clinical dose.
4 nistrations at 4 times the anticipated human clinical dose.
5 PV4 effectively in patients from a low daily clinical dose.
6 duce immune activation at safe and tolerable clinical doses.
7 ut did not resolve renal injury at practical clinical doses.
8 and bupivacaine) were added to solutions in clinical doses.
9 ial for renal and hepatic OAT2 inhibition at clinical doses.
10 their correct syntenic murine loci to model clinical dosing.
11 ncy CAR-T cell products meeting criteria for clinical dosing.
14 fasted or normally fed mice at the standard clinical dose 30 micromol/kg, both 3,4,3-LI(1,2-HOPO) an
16 ia social dosing was nearly 4 fold that from clinical dosing alone and did not vary by delivery mode.
17 absorbed based on solubility at an expected clinical dose and represents a valuable parameter to the
19 om the haemopoietic properties that occur at clinical doses and which, at the highest doses, might le
20 cing adverse effects in the normal organs at clinical doses, and optimal clinical doses balancing eff
21 normal organs at clinical doses, and optimal clinical doses balancing efficacy/safety as determined b
22 ting disorders, the drug was administered at clinical doses, both in vivo and in vitro, to rat dorsal
23 wever, the time requirement for synthesis of clinical doses can hinder patient throughput because of
24 coadministration of lapatinib or imatinib at clinical doses could result in a significant increase in
26 STAR-guided ML models can directly predict clinical dose/efficacy/safety from five features to desi
28 (ADR) and informed predictions about optimal clinical doses, expected performance of standard doses a
29 openic murine pneumonia model with simulated clinical dosing exposures was used to validate our quant
30 tween 1991 and 2006 and classified them into clinical (dose-finding trials) and statistical trials (m
32 nt susceptible sub-population (S1) with this clinical dose given (i) over 24 h for mcr-negative isola
41 aging was performed once after 1 week with a clinical dose of a macrophage-specific iron oxide-based
42 ination of Intralipid with half the standard clinical dose of Abraxane reduces the tumor growth rate
44 ays starting after the final dose of CCl(4) (clinical dose of gadoxetate disodium is 0.25 mmol/kg).
45 monstrate that in vivo HA degradation with a clinical dose of hyaluronidase impairs mCRC tumorigenesi
46 Treatments with GSK-3 inhibitors including a clinical dose of lithium to rats with thoracic spinal co
48 ered in SAB synthesis for the preparation of clinical doses of (211)At-labeled radiopharmaceuticals.
49 or appropriate formulations and dilutions of clinical doses of 90Y immunopharmaceuticals immediately
51 behavioural effects of fetal treatment with clinical doses of betamethasone and dexamethasone; (2) d
53 enfluramine (DF) in human subjects receiving clinical doses of DF and to determine whether human brai
54 a mouse model to investigate the effects of clinical doses of etoposide on the induction of chromoso
56 ial drug amodiaquine inhibited infection but clinical doses of hydroxychloroquine and other antiviral
57 a basic science finding (acute tolerance to clinical doses of methylphenidate) into clinical applica
58 e data indicate that while mothers receiving clinical doses of sertraline experience substantial bloc
59 l studies, nearly half of those who received clinical "doses" of the HealtheRx shared their informati
60 ff-targets determining efficacy in tumors at clinical doses, on/off-target-driven tissue/cell selecti
63 ation, causing more embolus dissolution than clinical-dose r-tPA alone (P<0.001) or alpha2-antiplasmi
66 T 719 treatment was compared with a standard clinical dose regimen of 25 mg/kg/day 5-FU/leucovorin gi
67 ltiple-dose ADC regime, which replicates the clinical dose regimen standard, with a single-dose regim
68 models to evaluate the effects of long-term, clinical dosing regimens of these drugs on the relative
69 d can be studied over longer timescales with clinical dosing regimens that are more relevant to human
70 P and adenosine beyond currently recommended clinical doses resulted in a significant increase in cor
74 ug residence and transit times, important to clinical dose scheduling, have not yet been defined.
75 paramagnetic ion concentration in a typical clinical dose) showed persistent (up to at least 2 hours
76 ntibiotic concentrations (when available) in clinical dosing software, which uses pharmacokinetic/pha
80 nical trial simulations are used to identify clinical doses that achieve these kill rates in children
81 d mice that, when delivered at the same high clinical dose, the human IFN-alpha14 subtype has very po
82 uantify information spread via social versus clinical dosing then conducted information diffusion exp
83 opioid use, which prevents understanding the clinical dose threshold level that increases the risk of
84 es of these predictions relative to measured clinical doses to ease translation of new PET radiotrace
85 The computer software is applicable as a clinical dosing tool to optimize tacrolimus exposure and
86 l LNP that delivers mRNA to Kupffer cells at clinical doses; unlike most LNPs, this LNP does not pref
88 and vinorelbine seem to correlate with their clinical doses, where vincristine with the highest overa