ライフサイエンスコーパス: clinical efficacy

1 enues to harness them in support of superior clinical efficacy.

2 afe and immunogenic profile and demonstrated clinical efficacy.

3 avenous amphotericin B, while optimizing its clinical efficacy.

4 pared to neurosurgical treatment targets and clinical efficacy.

5 ut as yet there is no convincing evidence of clinical efficacy.

6 ed models of PDAC underscoring the potential clinical efficacy.

7 to reduce plaque load have not demonstrated clinical efficacy.

8 ty-score-matched (1:1) analysis to determine clinical efficacy.

9 ment; however, the study was not powered for clinical efficacy.

10 ls, leading to very different predictions of clinical efficacy.

11 or T-cell receptors (TCRs) has demonstrated clinical efficacy.

12 cificity, "off-target" toxicity, and limited clinical efficacy.

13 ve been developed and demonstrate remarkable clinical efficacy.

14 ical trials, however, drug resistance limits clinical efficacy.

15 easibility, safety and strong indications of clinical efficacy.

16 therapeutics, substantially improving their clinical efficacy.

17 novel long-acting A2A agonists with improved clinical efficacy.

18 often translating into major improvements in clinical efficacy.

19 er long-term studies are warranted to assess clinical efficacy.

20 wed considerable variability that may impact clinical efficacy.

21 ion and antinociceptive tolerance, limit its clinical efficacy.

22 table T cell targets and may help to predict clinical efficacy.

23 ayers, which may explain the incomplete cDCS clinical efficacy.

24 eric antigen receptor (CAR) shows remarkable clinical efficacy.

25 received regulatory approval or demonstrated clinical efficacy.

26 ntended mechanism of action, and encouraging clinical efficacy.

27 eting IL-23 and IL-17 have shown significant clinical efficacy.

28 activating RET gene alterations with modest clinical efficacy.

29 Phase 3 trials are needed to assess clinical efficacy.

30 y lower doses of naltrexone can have greater clinical efficacy.

31 ing IgG antibodies have been associated with clinical efficacy.

32 ctive composites are evaluated for potential clinical efficacy.

33 demonstrated promising preclinical and even clinical efficacy.

34 nt of resistant cancer cells can limit their clinical efficacy.

35 challenges that limiting its feasibility and clinical efficacy.

36 ting, novel mechanisms of action, and higher clinical efficacies.

37 was suspended in 136 cases (mostly owing to clinical efficacy [38.2%], inefficacy [26.5%], and ADRs

38 Twenty-five of the 38 (66%) examined clinical efficacy, 7 (18%) evaluated longer follow-up, a

39 The clinical efficacy (99.2% vs 98.8%) and serious adverse e

40 checkpoint blockade has provided significant clinical efficacy across various types of cancer by unle

41 r design that compared the pharmacokinetics, clinical efficacy, adverse events, or immunogenicity of

42 etrics to capture the totality of alirocumab clinical efficacy after acute coronary syndrome.

43 lls) targeting human CD19 (hCD19) have shown clinical efficacy against B cell malignancies(1,2).

44 or (CAR)-T cell therapy has shown remarkable clinical efficacy against B-cell malignancies, yet marke

45 t promise in hematological malignancies, but clinical efficacy against many common solid epithelial c

46 e is one of the handful of drugs with proven clinical efficacy against the important opportunistic hu

47 The evidence for their clinical efficacy, although limited, is favourable, with

48 Few differences were found in clinical efficacy and acceptability between the differen

49 s we speculate that it may indicate a better clinical efficacy and be a better choice than current tr

50 action of crisaborole through evaluation of clinical efficacy and changes in skin biomarkers in adul

51 Clinical efficacy and cost-effectiveness were examined f

52 vo cellular kinetic analyses to characterize clinical efficacy and CRS severity associated with CTL01

53 roth microdilution MIC of 1 mg/L) to achieve clinical efficacy and ensure safety for patients being t

54 The clinical efficacy and generalizability of this low-cost

55 mum inhibitory concentration (MIC) to ensure clinical efficacy and minimize toxicity in methicillin-r

56 However, evidence for clinical efficacy and optimal management of therapy is l

57 current antimetastatic strategies that show clinical efficacy and review nanotechnology-based approa

58 terol concentrations achieved at 4 weeks and clinical efficacy and safety in the FOURIER trial of evo

59 We assessed the clinical efficacy and safety of a Russian-backbone live

60 During 2010 to 2015, the clinical efficacy and safety of a weight-based regimen o

61 Here, we investigate the clinical efficacy and safety of AM in the treatment of a

62 ional research is necessary to determine the clinical efficacy and safety of CMV suppression in this

63 ation may be a promising strategy to improve clinical efficacy and safety of current BMP therapeutics

64 harmacokinetics (PK), pharmacodynamics (PD), clinical efficacy and safety of edoxaban versus warfarin

65 LDL-C lowering and relative clinical efficacy and safety of evolocumab versus placeb

66 We sought to investigate the clinical efficacy and safety of mepolizumab versus place

67 Conclusion The durable clinical efficacy and safety of MR imaging-guided HIFU w

68 We studied clinical efficacy and safety of pediatric sublingual imm

69 Evidence exists on the clinical efficacy and safety of periodontally accelerate

70 The aim of this study was to evaluate the clinical efficacy and safety of Phleum pratense subcutan

71 nd clarify the biological mechanisms driving clinical efficacy and side effects of a compound.

72 imer's disease and examines the evidence for clinical efficacy and the major problems with safety-i.e

73 To evaluate the clinical efficacy and tolerability of intravenous (i.v.)

74 tic products can affect the bioavailability, clinical efficacy and toxicity of a wide array of drugs

75 in lung transplant recipients, evaluates the clinical efficacy and toxicity of the various antifungal

76 Many studies have elucidated the clinical efficacy and underlying mechanisms of MSCs in i

77 pathways but have variable and unpredictable clinical efficacy, and none is curative.

78 System performance, clinical efficacy, and safety events were assessed out t

79 nce and public health relevance, evidence of clinical efficacy, and safety, as well as comparative co

80 eceptor (A2A) agonists is critical for their clinical efficacy, and we sought to better understand ho

81 ns with CSC marker follow-up as a measure of clinical efficacy are needed to turn the "hype" into the

82 d toxicity studies-which, in addition to pre-clinical efficacy, are critical for partnering with Big

83 these pharmaceuticals demonstrate a limited clinical efficacy as multiple Gq-coupled receptor subtyp

84 PYY, which is believed to contribute to the clinical efficacy associated with the procedure.

85 However, crucial concerns regarding safety, clinical efficacy, best setting, and cost-effectiveness

86 Despite promising clinical efficacy, both innate and acquired resistance o

87 roxyurea provides SCA-related laboratory and clinical efficacy, but optimal dosing and monitoring reg

88 Trimethoprim-sulfamethoxazole retains clinical efficacy, but resistance rates are increasing i

89 tive value of cell chemosensitivity test for clinical efficacy, cancer cells were suggested to be enc

90 To increase their clinical efficacy, checkpoint inhibitors are now being t

91 oplatin added to cabazitaxel showed improved clinical efficacy compared with cabazitaxel alone for me

92 EX did not demonstrate additional benefit in clinical efficacy compared with placebo in subjects with

93 Despite the remarkable clinical efficacy demonstrated by molecularly targeted c

94 ould be developed using standard measures of clinical efficacy demonstrated with non-inferiority or s

95 inase inhibitors of EGFR, which display poor clinical efficacy despite overexpression and/or mutation

96 The clinical efficacy displayed by ibrutinib in chronic lymp

97 sunitinib treatment breaks are feasible and clinical efficacy does not seem to be compromised.

98 , but they are, in general, limited in their clinical efficacy due to high toxicity and lack of selec

99 In contrast, evidence for clinical efficacy emerged only in the threat-related att

100 tin sulfate preservative free showed similar clinical efficacy, evaluated with OSDI score, TBUT and S

101 Three BKIs were then selected for safety and clinical efficacy evaluation in the calf model for crypt

102 hlight AIT-related aspects of public health, clinical efficacy evaluation, mechanisms, development of

103 These results provide clinical efficacy evidence for the first FDA-cleared NAA

104 These results provide clinical-efficacy evidence for two in vitro diagnostic N

105 n of alirocumab versus placebo and, based on clinical efficacy findings from the trial, was stratifie

106 implicated in OCD, has resulted in improved clinical efficacy for an array of ablative and non-ablat

107 remained the only systemic agent with proven clinical efficacy for patients with advanced HCC.

108 There are no antiviral drugs with proven clinical efficacy for the treatment of COVID-19, nor are

109 al sympathetic denervation (RDN) have proven clinical efficacy for the treatment of hypertension.

110 D20 on B lymphoma and leukemia cells exhibit clinical efficacy for treating these malignancies, but a

111 Bispecific T cell engagers have demonstrated clinical efficacy; however, their use can be accompanied

112 of viral replication and limited reports on clinical efficacy, hydroxychloroquine is being considere

113 s allergens for the optimum dose in terms of clinical efficacy, immunogenicity and safety.

114 We compared the clinical efficacy in 2016, of 133 SLIT with 46 SCIT, 351

115 We compared the clinical efficacy in 2017, of 112 SLIT in the third trea

116 le immune-checkpoint inhibition (ICI) proved clinical efficacy in a variety of malignancies, data on

117 to develop architectures that enable robust clinical efficacy in additional tissues.

118 10, and this action is associated with their clinical efficacy in asthmatics.

119 or (CAR) T-cell therapy has shown remarkable clinical efficacy in B-cell cancers.

120 PARP inhibitors (PARPis) have clinical efficacy in BRCA-deficient cancers, but not BRC

121 ional immune suppressive agents have limited clinical efficacy in chronic GVHD, and prolonged immune

122 ly antagonize the AR may contribute to their clinical efficacy in CRPC.

123 echanisms of Dupilumab action and survey its clinical efficacy in different allergic disorders.

124 he function of immune cells have significant clinical efficacy in diseases such as cancer and autoimm

125 TA versus FDA-approved MS drug Tecfidera for clinical efficacy in EAE; characterized key safety/toxic

126 of the CDK4/6 cell-cycle kinases have shown clinical efficacy in estrogen receptor (ER)-positive met

127 adoptive T-cell therapy has shown remarkable clinical efficacy in haematological malignancies, its su

128 combining MEK and EGFR inhibitors to enhance clinical efficacy in HNSCC.

129 different costimulation domains have proven clinical efficacy in leukemia and lymphoma but have diff

130 Despite its impressive clinical efficacy in many patients, intrinsic and acquir

131 ls, and anti-PD1 therapies have demonstrated clinical efficacy in multiple cancers.

132 ide is an immunomodulatory drug (IMiDs) with clinical efficacy in multiple myeloma (MM) and other lat

133 Both agents have demonstrated clinical efficacy in nonalcoholic steatohepatitis (NASH)

134 proteasome inhibitor bortezomib demonstrated clinical efficacy in off-label trials of Systemic Lupus

135 checkpoint blockade, which have demonstrated clinical efficacy in other tumor types, have been less p

136 ing therapy but did not significantly affect clinical efficacy in participants with experimental RSV

137 r p 5, Der p 7, and Der p 21, showing better clinical efficacy in patients sensitized only to Der p 1

138 r the ligand or receptor, have shown notable clinical efficacy in patients with a variety of cancers,

139 sly reported that CTL019 achieved impressive clinical efficacy in patients with relapsed/refractory B

140 nerinetide are the only compounds tested for clinical efficacy in randomised controlled trials (RCTs)

141 ising, have not been rigorously assessed for clinical efficacy in randomised trials.

142 The Ranibizumab AMD Clinical Efficacy in Real-world practice (RACER) study a

143 tric to capture the totality of atorvastatin clinical efficacy in reducing disease burden after strok

144 SLIT in the second treated year showed good clinical efficacy in reducing symptoms and SMS of JCP, a

145 SLIT in the third treated year showed good clinical efficacy in reducing symptoms and TNSMS of JCP,

146 ssessed safety outcomes for all patients and clinical efficacy in the largest patient subgroup, those

147 the faecal microbiota, which may explain its clinical efficacy in the management of hepatic encephalo

148 Ueq/ml showed both immunological effects and clinical efficacy in the TNPT compared with placebo.

149 eceptors (CAR-T cells) have shown impressive clinical efficacy in the treatment of B cell malignancie

150 Cladribine has moderate clinical efficacy in the treatment of ECD and can be con

151 apy and/or radiation have shown only limited clinical efficacy in the treatment of recurrent or metas

152 une checkpoint inhibitors, have demonstrated clinical efficacy in the treatment of squamous cell carc

153 nsic resistance mechanisms have demonstrated clinical efficacy in these regards, thus highlighting th

154 Viral immunotherapy has shown clinical efficacy in treating cancers (e.g., melanoma).

155 Abatacept has shown clinical efficacy in treating some autoimmune diseases b

156 ibitory receptor blockade, have demonstrated clinical efficacy in treating tumors refractory to conve

157 IASD at 6 months, together with measures of clinical efficacy, including functional capacity and cli

158 pf) in a Phase 2a setting using in vitro pre-clinical efficacy information, would be almost 3 days lo

159 rily cytostatic, not cytotoxic, the observed clinical efficacy is a reflection of disease stabilizati

160 Clinical efficacy is associated with improvement of baso

161 While conceptually attractive, clinical efficacy is lacking given several key challenge

162 and both result in DNA damage, however, the clinical efficacy is limited due to therapeutic resistan

163 Although demonstration of clinical efficacy is still well behind the gene therapy

164 pereosinophilic syndrome (HES), although its clinical efficacy is unclear.

165 A larger trial, powered to detect clinical efficacy, is underway, along with trials of oth

166 To improve the clinical efficacy, it is important to understand the cel

167 er function, with associated improvements in clinical efficacy measures, highlighting the therapeutic

168 g IL-23, IL-17A, or IL-17RA, consistent with clinical efficacy observed in psoriasis patients.

169 The clinical efficacies of long-acting GLP-1 derivatives str

170 of HEXIM1 protein, and may contribute to the clinical efficacy of 5-AzadC.

171 This study does not support clinical efficacy of a bradykinin B2 receptor antagonist

172 The demonstrated clinical efficacy of a recombinant vesicular stomatitis

173 Finally, the clinical efficacy of a suppository formulation containin

174 To assess the safety and clinical efficacy of achieving a very low (<30 mg/dL) le

175 Our data may explain the poor clinical efficacy of anti-myostatin approaches in severa

176 Given the clinical efficacy of anti-NGF monoclonal antibody (mAb)

177 Taken together, we show the pre-clinical efficacy of ASHW in reducing RA associated symp

178 luded is a summary of studies evaluating the clinical efficacy of aspirin therapy after desensitizati

179 rmine the extra costs associated with or the clinical efficacy of biological mesh materials for the r

180 s become the gold standard for assessing pre-clinical efficacy of cancer drugs, yet direct visualizat

181 w and readily available means to enhance the clinical efficacy of CB HCT.

182 Clinical efficacy of CC-115 was demonstrated in 8 patien

183 We studied clinical efficacy of Cedarcure((R)) in the first year.

184 These data rationalize the observed clinical efficacy of ceftazidime/avibactam plus aztreona

185 However, the clinical efficacy of checkpoint blockade depends upon in

186 that this activity might underlie the unique clinical efficacy of clozapine.

187 The findings do not support a clinical efficacy of CRF1 blockade in stress-induced alc

188 indicates favorable side effect profiles and clinical efficacy of deoxynucleoside monophosphate and d

189 t EMMA is a feasible platform for estimating clinical efficacy of drugs and inclusion criteria screen

190 bers play in human disease and we review the clinical efficacy of drugs that block CD28 ligands.

191 iding another factor that contributes to the clinical efficacy of drugs that target this organelle.

192 Clinical trials have demonstrated the clinical efficacy of early ART; however, these trials ma

193 Acquired resistance compromises the clinical efficacy of EGFR inhibitors during long-term tr

194 f resistance remains the key obstacle to the clinical efficacy of EGFR tyrosine kinase inhibitors (TK

195 blasts, not cytotoxicity, seems to drive the clinical efficacy of enasidenib.

196 To assess the clinical efficacy of FOLFOXIRI-Bev, including outcomes a

197 ate protocol development) will determine the clinical efficacy of fosfomycin as step-down oral therap

198 These benefits might underlie the clinical efficacy of HFNC.

199 fore, we aimed to prospectively evaluate the clinical efficacy of high-titre immune plasma compared w

200 to explore possible reasons for the limited clinical efficacy of IL-17A blockade in RA, and what we

201 However, the clinical efficacy of immune checkpoint therapy is limite

202 The clinical efficacy of immune cytokines used for cancer th

203 umor microenvironment, which correlates with clinical efficacy of immunotherapies.

204 verse tumor immunosuppression and to restore clinical efficacy of immunotherapy in cancer patients.

205 verse tumor immunosuppression and to restore clinical efficacy of immunotherapy in patients with canc

206 regulated kinase 1/2 signaling; however, the clinical efficacy of inhibitors to this pathway is limit

207 The main prerequisite for clinical efficacy of L-asparaginases is micromolar KM fo

208 We assessed the clinical efficacy of MCT compared to current best psycho

209 between baseline blood eosinophil count and clinical efficacy of mepolizumab in patients with severe

210 However, more recent studies failed to show clinical efficacy of mGlu2/3 receptor agonism in schizop

211 nward clinical investigations to examine the clinical efficacy of minocycline treatment regimens agai

212 The aim of the study was to analyze the clinical efficacy of nasolacrimal duct probing among pat

213 Furthermore, clinical efficacy of nicotinic agents in relieving neuro

214 overing a potential explanation for the poor clinical efficacy of Notch inhibitors observed in this s

215 Best evidence of the clinical efficacy of novel immunologic approaches using

216 Athough the clinical efficacy of oncolytic viruses has been demonstr

217 The clinical efficacy of oral and intranasal gepants and the

218 This work uncovers the mechanism behind the clinical efficacy of PARPi in patients with both BRCA-wi

219 Randomized, controlled trials evaluating the clinical efficacy of PCCs in patients with factor Xa inh

220 Clinical efficacy of PD-1/PD-L1 targeting relies upon th

221 Clinical efficacy of pollen allergen immunotherapy (AIT)

222 to research that could provide evidence for clinical efficacy of probiotic products.

223 Any RCT comparing mortality or clinical efficacy of prolonged (continuous or >/=3 h) ve

224 adly have the same end-goal - to predict the clinical efficacy of prophylactic and therapeutic interv

225 g of the mechanisms underlying the potential clinical efficacy of psychedelics.

226 rial activities that could contribute to the clinical efficacy of roflumilast in COPD.

227 ction is a poor prognostic indicator for the clinical efficacy of secondary hormone therapies, we con

228 To evaluate the clinical efficacy of single- and double- bundle individu

229 We reported the clinical efficacy of SLIT in the first and the second tr

230 The purpose of this study is to clear the clinical efficacy of SLIT in the second treated year by

231 The purpose of this study is to clear the clinical efficacy of SLIT in the third treated year by c

232 provides class I evidence of the safety and clinical efficacy of subthalamic nucleus DBS with a nove

233 ue, which may be important in monitoring the clinical efficacy of supporting therapy.

234 Additionally, the paper reviews clinical efficacy of targeting with these novel MRI tech

235 Despite the evidence showing the safety and clinical efficacy of TCV in endemic populations in devel

236 mized, controlled, double-blind trial of the clinical efficacy of TCV, 28 000 children 9 months throu

237 , as well as investigations of the potential clinical efficacy of tDCS.

238 ebo-controlled REVEAL trial demonstrated the clinical efficacy of the CETP inhibitor anacetrapib amon

239 D2-like receptor blockade is necessary for clinical efficacy of the drugs, and may be responsible f

240 review and meta-analysis was to compare the clinical efficacy of the early dental implant placement

241 The available evidence supports the clinical efficacy of the early implant placement protoco

242 e of plasmid-mediated Tet(X4) challenges the clinical efficacy of the entire family of tetracycline a

243 Recently, the moderate clinical efficacy of the Plasmodium falciparum circumspo

244 conducted to determine the optimal dose for clinical efficacy of the SQ tree SLIT-tablet.

245 atform to improve the antitumor activity and clinical efficacy of therapeutic antibodies.

246 However, the clinical efficacy of these inhibitors can be improved by

247 qualified for a strong rating supporting the clinical efficacy of these materials for periodontics an

248 is crucial to facilitate improvements in the clinical efficacy of these therapies.

249 The clinical efficacy of these two treatment modalities appe

250 The field has seen major strides in the clinical efficacy of this class of molecules, largely du

251 tivation kinetics that may contribute to the clinical efficacy of this compound series.

252 an emphasis on the biological rationale and clinical efficacy of this new class of asthma therapeuti

253 To evaluate the clinical efficacy of this reporting, all adult patients

254 T cell biology and approaches to enhance the clinical efficacy of this therapy.

255 Taken together, the observed clinical efficacy of treatment with pCer provides a deep

256 We investigated the clinical efficacy of vandetanib when used in combination

257 t to provide insights into the dependence of clinical efficacy on device properties and the interplay

258 Because IL-22 blockade showed clinical efficacy only in patients with severe AD, we us

259 r of sufficiently long duration to establish clinical efficacy or assess safety.

260 efficacy to either established correlates of clinical efficacy or surrogate endpoints, they remain cr

261 gh our algorithm cannot be used to determine clinical efficacy, our work provides an approach for sug

262 For the clinical efficacy outcomes (change in NIHSS score at 24

263 SAPIEN 3 device in terms of early safety and clinical efficacy outcomes.

264 However, the decline in clinical efficacy over time in many patients suggests th

265 eir predictive power and demonstrate limited clinical efficacy, possibly due to the lack of functiona

266 ly efficacy in the human laboratory predicts clinical efficacy remains unclear.

267 This review summarizes the clinical efficacy, safety and tolerability of pitolisant

268 d adolescents 12 years of age and older, the clinical efficacy, safety, and tolerability of omalizuma

269 frequent doses of antibiotic than usual for clinical efficacy; second, whether an antimicrobial is l

270 Clinical efficacy studies of uncomplicated P. vivax trea

271 gram typically culminates with a comparative clinical efficacy study.

272 ass of therapeutic modalities with promising clinical efficacy that requires modification or formulat

273 of identification of robust targets and poor clinical efficacy-that hamper cancer drug development.

274 is Review, we describe the available data on clinical efficacy, the emerging evidence regarding bioma

275 ibodies (mAbs) have demonstrated significant clinical efficacy, there is also the potential for sever

276 d clinical use of AGs strongly reduced their clinical efficacy through the selection of resistant bac

277 ydroxyurea with dose escalation had superior clinical efficacy to that of fixed-dose hydroxyurea, wit

278 of of concept supporting the initiation of a clinical efficacy trial in patients with platinum-sensit

279 Several vaccine clinical efficacy trials are approaching completion, and

280 Clinical efficacy trials of drugs targeting these protei

281 vs 586.40, P = 0.039) Although comparable in clinical efficacy, utilization of PS at index ERCP may r

282 Clinical efficacy was evaluated at baseline and weekly i

283 The clinical efficacy was evaluated by assessing symptom sco

284 The clinical efficacy was evaluated by assessing symptom sco

285 The clinical efficacy was evaluated with symptom scores, tot

286 d significant brain penetration, the lack of clinical efficacy was explained by incomplete blockade o

287 al therapeutic agents, however their in vivo clinical efficacy was limited.

288 Clinical efficacy was maintained at 24 weeks in 0% and 4

289 ve pan-Aurora kinase inhibitor; however, its clinical efficacy was not satisfying.

290 Preliminary clinical efficacy was noted in five patients (two partia

291 rms were not the same, neither mortality nor clinical efficacy was reported, only pharmacokinetic or

292 Clinical efficacy was the most frequent cause for ISD di

293 and safety were confirmed and indications of clinical efficacy were identified.

294 ologic hurdles that must be addressed before clinical efficacy will be known.

295 INTERPRETATION: On the basis of the improved clinical efficacy with a manageable safety profile, the

296 omib and dexamethasone has shown encouraging clinical efficacy with acceptable safety and tolerabilit

297 This regimen has shown promising clinical efficacy with acceptable tolerability in chemot

298 Both SCIT and SLIT showed good clinical efficacy without significant difference in ever

299 However, clinical efficacy would require highly effective in vivo

300 ort follow-up duration, and determination of clinical efficacy would require larger randomized trials