ライフサイエンスコーパス: clinical endpoint

1 ction between ischemia and treatment for any clinical endpoint.

2 s awaiting all patients to reach the primary clinical endpoint.

3 are intended to predict the true, meaningful clinical endpoint.

4 nths, and disease recurrence was used as the clinical endpoint.

5 output and give rise to freezing of gait as clinical endpoint.

6 clinical outcomes at 1 year using a combined clinical endpoint.

7 linical outcomes at 5 years using a combined clinical endpoint.

8 sociation of drug targets with the patient's clinical endpoint.

9 of all-cause mortality were identified as a clinical endpoint.

10 935 (13%) participants reached the composite clinical endpoint.

11 ty, it is important to harmonize the primary clinical endpoint.

12 not the NPPB variant, was associated with a clinical endpoint.

13 andomized PCV13 pediatric trial has included clinical endpoints.

14 roups of patients and varying definitions of clinical endpoints.

15 nimal studies and Phase IIB/III studies with clinical endpoints.

16 d of measuring adherence without reliance on clinical endpoints.

17 easily correlate with measureable objective clinical endpoints.

18 s limit the contemporary utility of standard clinical endpoints.

19 orizing them as biomarkers, and surrogate or clinical endpoints.

20 (26%) had reached one of the pre-established clinical endpoints.

21 ment protocols; and measurement of different clinical endpoints.

22 early biomarkers for subsequent conventional clinical endpoints.

23 prior treatment, CD4(+) T cell response, and clinical endpoints.

24 by surgery as well as long-term trials with clinical endpoints.

25 ce antigens of S. aureus have failed to meet clinical endpoints.

26 rovement in MADRS and SHAPS scores and other clinical endpoints.

27 talisation for heart failure (HHF) served as clinical endpoints.

28 imaging, cerebrospinal fluid parameters, and clinical endpoints.

29 nd were evaluable for both immunological and clinical endpoints.

30 erved retinal area), surgical techniques and clinical endpoints.

31 findings but have not attempted to determine clinical endpoints.

32 atinine (eGFRcrea) is associated with severe clinical endpoints.

33 tify patient characteristics associated with clinical endpoints.

34 eatment was significant on several secondary clinical endpoints.

35 their clinical value was tested against hard clinical endpoints.

36 may scale up to and contribute to cognitive clinical endpoints.

37 s), with no evidence of differences in other clinical endpoints.

38 obiology for the mapping of dose response to clinical endpoints.

39 n, and give specific examples pertinent to 8 clinical endpoints.

40 imaging, cerebrospinal fluid parameters and clinical endpoints.

41 pnea treatment on cardiovascular disease and clinical endpoints.

42 s in SUVmax between 0, 5, and 10 wk for both clinical endpoints.

43 al wound infection but failed to reach their clinical endpoints.

44 data are available correlating viraemia with clinical endpoints.

45 nt immunodeficiency leading to AIDS-defining clinical endpoints.

46 but the other loci were not associated with clinical endpoints.

47 lowering by B-vitamins improves only certain clinical endpoints.

48 d+ lesions and showed a beneficial effect on clinical endpoints.

49 discordant results between neuroimaging and clinical endpoints.

50 with an average of 19% lower hazard for the clinical endpoint (95% Bayesian credible interval (BCI):

51 ted with an average 27% lower hazard for the clinical endpoint (95% BCI 5-45%; median R(2) 0.47, 95%

52 tment effects on GFR slope with those on the clinical endpoint across all studies and by disease grou

53 tment effects on albuminuria to those on the clinical endpoint across studies and developed a predict

54 erformance of commonly reported intermediate clinical endpoints across all randomised trials in local

55 and the achievement of a stable periodontal clinical endpoint after 10 years of periodontal maintena

56 o demonstrate the reproducibility of defined clinical endpoints after AEC house dust mite (HDM) chall

57 d to evaluate the effect of cardioversion on clinical endpoints (all cause mortality, non-haemorrhagi

58 d inflammatory biomarkers, but its impact on clinical endpoints among treated human immunodeficiency

59 es high correlation between the intermediate clinical endpoint and overall survival at the patient le

60 of the treatment effect of the intermediate clinical endpoint and overall survival), using R(2) weig

61 asure that fulfils the criteria for an ideal clinical endpoint and that is meaningful to patient and

62 een the treatment effect on the intermediate clinical endpoint and the treatment effect on overall su

63 at there is a rational linkage to the drug's clinical endpoint and/or site of action.

64 10, was intended to (i) identify appropriate clinical endpoints and (ii) standardize definitions of t

65 We also assessed multiple clinical endpoints and identified features associated wi

66 dies are needed to develop novel biomarkers, clinical endpoints and interventions for young children

67 g and facilitates robust comparisons between clinical endpoints and intravascular results.

68 o test for associations between metabolic or clinical endpoints and overall survival (OS), progressio

69 lating treatment effects of the intermediate clinical endpoints and overall survival, the composite e

70 antly improved endoscopic, radiographic, and clinical endpoints and patient-reported outcomes.

71 o test for associations between metabolic or clinical endpoints and progression-free survival (PFS) o

72 ed in a phase III trial it failed to achieve clinical endpoints and revealed neurotoxicity.

73 nges in albuminuria and treatment effects on clinical endpoints and surrograte endpoints, to inform t

74 We examined clinical endpoints and the safety of sacubitril-valsarta

75 e survival (EFS, primary endpoint) and other clinical endpoints and toxicities were assessed.

76 ing negative trials; and incorporating novel clinical endpoints and trial designs.

77 ween multiple covariates as they relate to a clinical endpoint, and to provide a more intuitive and p

78 erall survival and at least one intermediate clinical endpoint, and with a sample size of at least 70

79 eeks to provide core principles, appropriate clinical endpoints, and endpoint definitions to be used

80 d bioactive metabolites, effects on specific clinical endpoints, and existing dietary guidelines.

81 e, the doses of study drug used, insensitive clinical endpoints, and the patient population selected

82 ed biomarkers, inefficient physiological and clinical endpoints, and variable regulatory review world

83 onverting a genome discovery into a tangible clinical endpoint are numerous and formidable.

84 The underlying clinical endpoints are analysed in seasonal time periods

85 with GA lesions or progression, alternative clinical endpoints are being sought.

86 Molecular imaging and clinical endpoints are frequently discordant in Parkinso

87 associations between virological markers and clinical endpoints are lacking.METHODSWe performed CMV D

88 with adequate control groups and predefined clinical endpoints are necessary to determine the true r

89 Clinical endpoints are reported according to the Mitral

90 ized silymarin is dosed to identify specific clinical endpoints are urgently needed.

91 The utility of specific measures as clinical endpoints, as well as benefits and limitations

92 Clinical endpoints assessed to allergen exposure in the

93 Xience stent for a device-oriented composite clinical endpoint at 12 months in an all-comer populatio

94 olymer stent for a device-oriented composite clinical endpoint at 12 months in an all-comer populatio

95 receiver operating characteristic curve) the clinical endpoint at 12 weeks.

96 ons, ulcerations, or granulation tissue) and clinical endpoints at the end of induction (week 8 and 1

97 Intermediate clinical endpoints based on biochemical and local failur

98 aphy and intravascular ultrasound; composite clinical endpoints based on death, myocardial infarction

99 portant research questions, such as defining clinical endpoints, biomarkers of patient selection and

100 are being applied to predict preclinical and clinical endpoints, but the reliability of these predict

101 severity grade, HIV co-infection status, and clinical endpoints by 3 months were recorded.

102 severity grade, HIV coinfection status, and clinical endpoints by 3 months were recorded.

103 Clinical endpoints (cardiac death, myocardial infarction

104 uestions about rare diseases and "harmonize" clinical endpoints collected from administrative records

105 rs and subsequently adjudicated by a blinded Clinical Endpoint Committee (CEC) according to a prespec

106 in a group of expert reviewers, known as the clinical endpoint committee (CEC), verify potential endp

107 nvestigators (physicians, investigators, and clinical endpoint committee members) were masked to trea

108 n the blinded adjudication of an independent clinical endpoint committee.

109 The combined clinical endpoint consisted of death, reinfarction, targ

110 ITNs and IRS using this framework instead of clinical endpoints could support policy and expedite the

111 e data, including phase 3 controlled trials, clinical endpoint data, virologic and immunologic endpoi

112 Biochemical parameters, clinical endpoints, death and liver transplantation were

113 Clinical endpoints defined as hepatic decompensation (as

114 or study using strict inclusion criteria and clinical endpoint definition.

115 t provides an update of the most appropriate clinical endpoint definitions to be used in the conduct

116 update, and (iii) review and revise specific clinical endpoint definitions.

117 at 3 months after randomization, and on the clinical endpoint (doubling of serum creatinine, GFR < 1

118 A majority (12 out of 16) of the clinical endpoint estimates showed similar outcomes betw

119 as host response to vaccine, virus type, and clinical endpoint evaluated.

120 raditional randomized controlled trials with clinical endpoints, experimental medicine studies are fo

121 ctralis, and each OCT scan was linked to EMR clinical endpoints extracted from EPIC.

122 subsequent decompensation are accepted hard clinical endpoints, fibrosis and fibrosis progression al

123 the suitability of viral load as a surrogate clinical endpoint for clinical trials for cytomegaloviru

124 ochondrial efficiency and could be used as a clinical endpoint for mitochondrial function in vivo, al

125 vere disease or dysentery may be a pragmatic clinical endpoint for severe shigellosis in vaccine tria

126 and nine patients (36%) in TG2 achieved the clinical endpoint for treatment (less than or equal to f

127 entification and validation of biomarkers as clinical endpoints for clinical trials, and the definiti

128 r devices, and defining single and composite clinical endpoints for clinical trials.

129 tional outcomes; and provide suggestions for clinical endpoints for future clinical trials on GA.

130 In addition, clinical endpoints for studies and care remain poorly de

131 ints are summarised, with recommendations on clinical endpoints for the different phase trials, inclu

132 disease monitoring, prognostic research, and clinical endpoints for therapy development.

133 f metastatic infection represents a distinct clinical endpoint from death due to Staphylococcus aureu

134 then the resulting HD COURSE MAP to forecast clinical endpoints from the baseline data of 11,510 part

135 imaging database was performed and linked to clinical endpoints from the EMR.

136 a causal relationship between NT-proBNP and clinical endpoints has not been established.

137 ultrasound, but no clinical trials assessing clinical endpoints have yet been completed.

138 the inverse variance of the log intermediate clinical endpoint hazard ratio.

139 rs, resting PVRI was not associated with the clinical endpoint (hazard ratio [HR] 0.95 per WU.m2, 95%

140 Clinical endpoints (i.e. Ki67 dynamics and pathological

141 Patients with SAB experience distinct clinical endpoints: (i) early death, associated with mul

142 ave gradually shifted away from conventional clinical endpoints (ie, patient and graft survival) to s

143 ial design is hampered by lack of a feasible clinical endpoint in this population.

144 ification of biomarkers as a surrogate for a clinical endpoint in tuberculosis is very challenging, a

145 Standardization and harmonization of clinical endpoints in AIT trials as well as current know

146 ntinuous cardiometabolic markers and RRs for clinical endpoints in association with ASB intake both d

147 Prior work from the Intermediate Clinical Endpoints in Cancer of the Prostate (ICECaP) co

148 The international Intermediate Clinical Endpoints in Cancer of the Prostate working gro

149 ent data from trials within the Intermediate Clinical Endpoints in Cancer of the Prostate-ICECaP-data

150 te the effect of SGLT2 inhibitors on various clinical endpoints in heart failure The primary endpoint

151 gression models to test their association to clinical endpoints in lung carcinoma.

152 dization of the methodology and reporting of clinical endpoints in MIGS investigations enhances inter

153 s study aimed to correlate the assessment of clinical endpoints in patients with allergic rhinitis se

154 tested without delay on both virological and clinical endpoints in patients with or at risk of severe

155 nificant immunodeficiency, and AIDS-defining clinical endpoints in some animals.

156 ED) to predict deterioration to one of three clinical endpoints in the remainder of the hospital stay

157 resonance (CMR) and its association with key clinical endpoints in the SEQUOIA-HCM (Safety, Efficacy,

158 illance of the impact of <3 vaccine doses on clinical endpoints in the targeted age group is warrante

159 A more standardised choice of clinical endpoints in these studies, as well as the appl

160 We sought to evaluate candidate intermediate clinical endpoints in trials assessing definitive treatm

161 Intermediate clinical endpoints included biochemical failure, local f

162 Clinical endpoints included constipation to age 3 years

163 Clinical endpoints included in-hospital mortality, one-y

164 as safety/tolerability; pharmacodynamic (PD)/clinical endpoints included serum tryptase, plasma SCF,

165 We observed modest changes in clinical endpoints including circulating levels of F.IX

166 ers, the panel recommended a set of standard clinical endpoints including growth, response to vaccina

167 New terminology is proposed for clinical endpoints, including sustained control to repla

168 nd clinically meaningful improvements across clinical endpoints, including the coprimary endpoints of

169 with real microarray datasets, one where the clinical endpoint is disease group and another where it

170 hways in HFrEF and T2DM and their effects on clinical endpoints is important.

171 efficacy of these vaccines, a general set of clinical endpoints is proposed, along with consideration

172 f donor, rather than recipient, genotypes on clinical endpoints is unknown.

173 positive cells at relapse and, using several clinical endpoints, KRT80 expression associates with poo

174 te cancer patients for two post-radiotherapy clinical endpoints: late rectal bleeding and erectile dy

175 received IFNalpha-based therapies developed clinical endpoints less frequently than those treated wi

176 esses, but it is unclear if rhythms exist in clinical endpoints like vaccine protection.

177 Clinical endpoints (liver-related death, liver transplan

178 Supplemental oxygen-free days as a clinical endpoint may allow smaller sample sizes for tri

179 Clinical endpoints measured in terms of duration, such a

180 cer research that correlates biomarkers with clinical endpoints, methods are needed to ascertain outc

181 espiratory rates until day 180, and the main clinical endpoints (mortality until day 28 and day 180,

182 groups were assigned to define the following clinical endpoints: mortality, stroke, myocardial infarc

183 However, PFS and other clinical endpoints numerically favored lasofoxifene: cli

184 provide an average hazard ratio (HR) for the clinical endpoint of 0.68, and 95% of sufficiently large

185 The composite clinical endpoint of death, myocardial infarction, and i

186 edictive ability of nGA for the conventional clinical endpoint of geographic atrophy (GA) as defined

187 n 2.0 assay reports fewer subjects below the clinical endpoint of HIV-1 RNA <50 copies/mL in HIV clin

188 nine ratio (UACR) change and the established clinical endpoint of kidney failure or doubling of serum

189 uscle samples, suggesting its potential as a clinical endpoint of mitochondrial function.

190 sured either as mortality or as the combined clinical endpoint of mortality or severe renal failure w

191 The primary endpoint was the device-oriented clinical endpoint of target lesion failure at 12 months

192 The 30-day primary clinical endpoint of target lesion failure occurred in 0

193 The primary clinical endpoint of the study was mortality at Day 28.

194 The primary clinical endpoint of the study was the occurrence of maj

195 onth change in albuminuria and the composite clinical endpoint of treated end-stage kidney disease, e

196 It also raises the question whether the clinical endpoint of wound closure should include re-est

197 surfaces, but no significant improvements in clinical endpoints of defect resolution were observed.

198 tients (n = 9) in the UDCA group who reached clinical endpoints of disease progression (the developme

199 ed between the patient groups divided by the clinical endpoints of histological grade, histological t

200 ns and newer calcium antagonists have on the clinical endpoints of myocardial infarction and death is

201 The secondary clinical endpoints of overall survival, distant brain fa

202 logical studies been initiated, with defined clinical endpoints of periodontal disease, to address th

203 iction of risk, detection, and prediction of clinical endpoints of prostate cancer (PCa).

204 ets and develop 360 predictive models on six clinical endpoints of varying predictability.

205 iction model for the treatment effect on the clinical endpoint on the basis of the treatment effect o

206 measured by immunological, virological, and clinical endpoints over a 15-month period.

207 nths revealed no differences in the combined clinical endpoints (p = 0.22).

208 classifiers in this MAQC-III/SEQC study for clinical endpoint prediction using neuroblastoma as a mo

209 n cancer research to identify biomarkers for clinical endpoint prediction.

210 microarray-based models perform similarly in clinical endpoint prediction.

211 spective Observation of Fibrosis in the Lung Clinical Endpoints (PROFILE) study.

212 A-specific immunity, and impact on surrogate clinical endpoints provides a scientific rationale for f

213 The mean time in seconds to reach the clinical endpoint ranged from HAND 289 +/- 193, US 194 +

214 MeTIL signature scores were correlated with clinical endpoints reflecting overall or disease-free su

215 t set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness o

216 reas Px and isoprenaline separately produced clinical endpoints related to diabetic cardiomyopathy, t

217 nd statistically correlated with a composite clinical endpoint (renal function, biopsy-proved acute r

218 chance of not achieving a stable periodontal clinical endpoint, respectively.

219 one therapy over another using gold standard clinical endpoints, since it is often not clear how much

220 Large trials with clinical endpoints, some already in progress, are needed

221 Numerous large clinical endpoint studies are under way to investigate t

222 ation of the guidelines, data from two large clinical endpoint studies have been presented that show

223 However, design and conduct of clinical endpoint studies may be hampered by low inciden

224 Because PEPI was not designed to assess clinical endpoints, studies of the impact of hormone-med

225 spective Observation of Fibrosis in the Lung Clinical Endpoints) study and tested against a further U

226 epresent a more tractable genetic trait than clinical endpoints such as schizophrenia.

227 as shown that PROs can be prognostic of hard clinical endpoints such as survival time (time from stud

228 east cancer therapy is ultimately defined by clinical endpoints such as survival.

229 ce and prolonged time-to-event for important clinical endpoints such as thrombosis, progression, and

230 has less definitive evidence tying it to the clinical endpoint (such as death or liver transplant) bu

231 or in combination with other drugs, on hard clinical endpoints, such as decompensation of cirrhosis,

232 Furthermore, the impact of RFA on secondary clinical endpoints, such as renal function outcomes, has

233 ions with transcriptomics, metabolomics, and clinical endpoints suggest implication of processes rela

234 el demonstrated an improvement in meaningful clinical endpoints, suggesting axi-cel addresses an impo

235 sitizing versus insulin-providing therapy on clinical endpoints, symptom relief, and perceived health

236 nues to be debate about the most appropriate clinical endpoint that should be used in future randomiz

237 e main diagnostic systems in use and discuss clinical endpoints that represent meaningful clinical be

238 ns that are even more effective in achieving clinical endpoints, that are not hampered by resistance,

239 For some clinical endpoints, the combined use of molecular analys

240 e radiomics has been associated with several clinical endpoints, the complex relationships of radiomi

241 aimed to assess the effect of vericiguat on clinical endpoints through pooled analyses of patient-le

242 ed to develop evidence-based definitions and clinical endpoints through which the pathophysiology can

243 aim of this work was to reach a consensus on clinical endpoints to consider in future clinical trials

244 anscatheter aortic valve implantation (TAVI) clinical endpoints to make them more suitable to the pre

245 AmB dose is being taken forward to a phase 3 clinical endpoint trial.

246 omozygous familial hypercholesterolaemia and clinical endpoint trials will be needed for PCSK9 and CE

247 Results of major clinical endpoint trials with fibrates, although not uni

248 have been increasingly highlighted in large clinical endpoint trials with lipid therapy.

249 age data, vaccine efficacy against different clinical endpoints, waning of immunity, different antivi

250 The primary clinical endpoint was 2-year target-vessel failure (TVF)

251 The secondary clinical endpoint was a composite of cardiac death, myoc

252 The clinical endpoint was a composite of death or transplant

253 The primary clinical endpoint was change in SBP at 6 months.

254 Our primary clinical endpoint was clinical response to surgery, adju

255 The primary clinical endpoint was confirmed >/= 50% PSA decline vers

256 The intermediate clinical endpoint was deemed to be a surrogate for overa

257 The secondary clinical endpoint was good functional outcome, defined a

258 The primary clinical endpoint was lesion healing (ie, full epithelia

259 Our primary clinical endpoint was progression-free survival, analyse

260 8.1% to 17.2% (p < 0.001), and the composite clinical endpoint was significantly reduced from 50.0% t

261 The clinical endpoint was the 12-month rate of major adverse

262 The primary clinical endpoint was the 30-day rate of target lesion f

263 The clinical endpoint was the occurrence of ischemic stroke.

264 ournal, the case for the use of a variety of clinical endpoints was analyzed, and the article conclud

265 The primary analysis for clinical endpoints was by modified intention to treat (e

266 sion following prostatectomy as the relevant clinical endpoint, we found that ensemble tree classifie

267 For clinical endpoints, we defined eligibility criteria as r

268 eq and microarray-based models in predicting clinical endpoints, we divide the cohort randomly into t

269 Treatment effects on the clinical endpoint were strongly associated with treatmen

270 Clinical endpoints were all-cause mortality or hospitali

271 Adjudicated clinical endpoints were analyzed through the end of foll

272 Clinical endpoints were assessed by intention to treat d

273 Eight intermediate clinical endpoints were considered as potential surrogat

274 Several clinical endpoints were explored to assess whether intra

275 ing to patient and study characteristics and clinical endpoints were extracted.

276 Clinical endpoints were gingival bleeding (papillary ble

277 sing 6MWD in patients with PAH and reporting clinical endpoints were included in a meta-analysis.

278 atment effects on the remaining intermediate clinical endpoints were less strongly correlated with ov

279 Standard clinical endpoints were modeled to evaluate efficacy, in

280 Because clinical endpoints were not assessed for the new antigen

281 r this novel agent, although other objective clinical endpoints were not different from those of cont

282 The clinical endpoints were overall survival (OS) and cancer

283 lammation (including cytokines), and 3-month clinical endpoints were performed in active S. stercoral

284 ost strongly influenced by the nature of the clinical endpoint, whereas technological platforms (RNA-

285 fully from early clinical data and predicted clinical endpoints with high accuracy, the best model ac

286 irst condition, correlating the intermediate clinical endpoints with overall survival at the individu

287 B remained significantly associated with all clinical endpoints with pembrolizumab after adjusting fo