ライフサイエンスコーパス: clinical heterogeneity

1 gnostic testing only partially predicts this clinical heterogeneity.

2 d by its pronounced genetic, phenotypic, and clinical heterogeneity.

3 ial DNA (mtDNA) mutations manifest with vast clinical heterogeneity.

4 ught to account for the disorder's prominent clinical heterogeneity.

5 , and probably genes, that contribute to the clinical heterogeneity.

6 tic disease, is characterized by substantial clinical heterogeneity.

7 f biomarkers relevant to AA pathogenesis and clinical heterogeneity.

8 e a group of disorders with wide genetic and clinical heterogeneity.

9 ac disorder, exhibits remarkable genetic and clinical heterogeneity.

10 lasma cell dyscrasias that may explain their clinical heterogeneity.

11 heterogeneity in these reports may be due to clinical heterogeneity.

12 aits and pathomechanisms that translate into clinical heterogeneity.

13 erized by a marked degree of morphologic and clinical heterogeneity.

14 he different transcription factors result in clinical heterogeneity.

15 that exhibits a wide range of biological and clinical heterogeneity.

16 neoplasm in children, is remarkable for its clinical heterogeneity.

17 ion products and the biological basis of the clinical heterogeneity.

18 long periods without medication, indicating clinical heterogeneity.

19 it's marked cytological, immunological, and clinical heterogeneity.

20 D) encompasses considerable pathological and clinical heterogeneity.

21 gnostics do not exist due to ASD genetic and clinical heterogeneity.

22 d N-terminal signatures to immunological and clinical heterogeneity.

23 APOL1 risk genotypes, which may explain some clinical heterogeneity.

24 t GPCR signaling pathways that contribute to clinical heterogeneity.

25 lethal disease characterized by genomic and clinical heterogeneity.

26 ed alpha-synuclein proteins, exhibit notable clinical heterogeneity.

27 ng individual differences that contribute to clinical heterogeneity.

28 s, with varying subtypes proposed to address clinical heterogeneity.

29 certain origins and striking and unexplained clinical heterogeneity.

30 Notably, SCD is characterized by extreme clinical heterogeneity.

31 sarcoma) comprise significant biological and clinical heterogeneity.

32 2D risk, helping to account for the observed clinical heterogeneity.

33 many pathogenetic contributors that parallel clinical heterogeneity.

34 d uncover biologic mechanisms underlying T2D clinical heterogeneity.

35 many organs and systems, having significant clinical heterogeneity.

36 ribute to clinical disease manifestation and clinical heterogeneity.

37 of psychological distress, and accommodates clinical heterogeneity.

38 zed by a high mortality rate and significant clinical heterogeneity.

39 ipt expression, explaining the observed wide clinical heterogeneity.

40 S-C patients, and that IFNy levels delineate clinical heterogeneity.

41 between men and women with HFrEF may explain clinical heterogeneity.

42 main ill-defined in IPEX, across genetic and clinical heterogeneity.

43 genetic risk factor profiles to deconstruct clinical heterogeneity.

44 oducing prenatal as well as later neural and clinical heterogeneity.

45 pes of CD, which contributes to its observed clinical heterogeneity.

46 esults were often limited by low numbers and clinical heterogeneity.

47 cterized by a striking degree of genetic and clinical heterogeneity.

48 d diseases and because there is considerable clinical heterogeneity.

49 ups, which does not appropriately depict the clinical heterogeneity.

50 netic condition characterized by significant clinical heterogeneity.

51 criteria based on biologic, morphologic, and clinical heterogeneity.

52 er predisposition characterized by extensive clinical heterogeneity.

53 tinct monocytic chemokine signature, despite clinical heterogeneity.

54 questions remain about its comorbidities and clinical heterogeneity.

55 ular dystrophies showing extreme genetic and clinical heterogeneity.

56 which has shown considerable etiological and clinical heterogeneity.

57 subject to a high risk of selection bias and clinical heterogeneity.

58 ral dementia, however, there was substantial clinical heterogeneity across the C9ORF72 mutation cohor

59 contributes to a better understanding of the clinical heterogeneity among alpha-synucleinopathies, of

60 protein accounts, at least in part, for the clinical heterogeneity among FA(C) patients.

61 omodulators with NMDARs, which could explain clinical heterogeneity among patients.

62 a group of neurodevelopmental disorders with clinical heterogeneity and a substantial polygenic compo

63 Substantial clinical heterogeneity and comorbidity inherent amongst

64 agnostic and dimensional phenotypes to model clinical heterogeneity and comorbidity.

65 interesting and testable hypothesis for the clinical heterogeneity and differential responsiveness i

66 ding a rich genomic resource to address NPC1 clinical heterogeneity and discover potential biomarkers

67 es in cancer therapy, due to its substantial clinical heterogeneity and divergent therapeutic options

68 Because of clinical heterogeneity and experimental difficulties in

69 its roles in neurodevelopment, the extent of clinical heterogeneity and how this relates to underlyin

70 Because of the presence of high clinical heterogeneity and intransitivity, the potential

71 Neuroblastoma is remarkable for its clinical heterogeneity and is characterized by genomic a

72 % of the global population, with significant clinical heterogeneity and limited information about mol

73 are ongoing, but challenges in trial design, clinical heterogeneity and need for long-term follow-up

74 ion of human neuroblastoma tumors reflecting clinical heterogeneity and outcome.

75 emia and can provide novel insights into the clinical heterogeneity and pathobiology of sickle cell d

76 Given their clinical heterogeneity and potential for significant mor

77 that contribute to the biological basis for clinical heterogeneity and progression of prostate cance

78 tical cellular activities that contribute to clinical heterogeneity and provide diagnostic and therap

79 Clinical heterogeneity and the complex impact of missens

80 Challenges include disease classification, clinical heterogeneity and the establishment of robust b

81 iagnosis of XLP is still difficult given its clinical heterogeneity and the lack of a readily availab

82 largest reported to date and highlights the clinical heterogeneity and the unique phenotypic and fun

83 the relationship between factors influencing clinical heterogeneity and their relationship to brain a

84 he epidemiology, underlying pathomechanisms, clinical heterogeneity and treatment outcomes.

85 changes over time may explain wAIHA's great clinical heterogeneity and unpredictable course.

86 nd provides a basis to understand the marked clinical heterogeneity and variable disease course.

87 use a multisystem disorder that is marked by clinical heterogeneity and variable expressivity and tha

88 Thus, genetic ancestry may contribute to the clinical heterogeneity and variation in disease outcomes

89 CLE subtypes show clinical heterogeneity and varying associations with SLE

90 y red blood cell aplasia, macrocytic anemia, clinical heterogeneity, and increased risk of malignancy

91 of studies, variability in study designs and clinical heterogeneity, and methodological shortcomings

92 ession with better outcome, further suggests clinical heterogeneity, and possible differences in trea

93 methods are challenged by ambiguous labels, clinical heterogeneity, and the inability to utilize mul

94 nto SSc has been hampered by its rarity, its clinical heterogeneity, and the lack of mouse models tha

95 atures of this mouse model suggest that this clinical heterogeneity arises from a cell type-specific,

96 It forces a consideration of clinical heterogeneity as well as variation in study pro

97 The striking clinical heterogeneity associated with C9orf72 repeat ex

98 Their clinical heterogeneity associated with the low number of

99 ing likely disease-causing variants revealed clinical heterogeneity associated with the PROM1 gene.

100 , posing varying challenges in diagnosis and clinical heterogeneity because of the occupation of the

101 features in this disorder and highlights the clinical heterogeneity both within and between families

102 C9orf72 ALS/FTD patients show remarkable clinical heterogeneity, but the complex biology of the r

103 In conclusion, our data confirmed AIMAH's clinical heterogeneity by identifying molecularly distin

104 in cause of morbidity and mortality, and its clinical heterogeneity can be uncovered using genetic da

105 the molecular level that likely reflects the clinical heterogeneity characteristic of breast carcinom

106 es (IRDs), displaying pronounced genetic and clinical heterogeneity, comprise of a broad range of dis

107 kaemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic a

108 ions, the wealth of allelic, non-allelic and clinical heterogeneities determining the phenotypic expr

109 ews and meta-analyses, which had substantial clinical heterogeneity, differing statistical methods, a

110 The large clinical heterogeneity even in individuals with the same

111 nges in the cortex might explain much of the clinical heterogeneity found in HD.

112 ent a new method, CloneSeeker, for inferring clinical heterogeneity from sequencing data, SNP array d

113 young adult rhinitis, like asthma, exhibits clinical heterogeneity identifiable by means of cluster

114 We describe the clinical heterogeneity in 16 patients from 4 unrelated f

115 enging, particularly in light of genetic and clinical heterogeneity in addition to the emergence of n

116 Here we show several genetic links to clinical heterogeneity in ADHD in a case-only study of 1

117 pendent disease mechanisms drive some of the clinical heterogeneity in ALS.

118 Factors associated with clinical heterogeneity in Alzheimer disease (AD) lay alo

119 The factors driving clinical heterogeneity in Alzheimer's disease are not we

120 Clinical heterogeneity in Alzheimer's disease has been w

121 The mechanisms underlying the observed clinical heterogeneity in ARPKD remain incompletely unde

122 Understanding the origins of clinical heterogeneity in bipolar disorder (BD) will inf

123 Age at onset is associated with clinical heterogeneity in bipolar disorder and aggregate

124 s have sufficiently evaluated biological and clinical heterogeneity in CLL.

125 Phenotypic classification has identified clinical heterogeneity in CRS based on endoscopically ob

126 ide the basis for a molecular explanation of clinical heterogeneity in Ewing's sarcoma.

127 Clinical heterogeneity in HbE beta-thalassemia is incomp

128 ent for using transgenic Drosophila to study clinical heterogeneity in human disease.

129 The neuronal physiological correlates of clinical heterogeneity in human essential tremor are unk

130 regarding pathogenetic mechanisms underlying clinical heterogeneity in lupus erythematosus (LE).

131 These findings help explain clinical heterogeneity in lvPPA and suggest that Abeta i

132 , identifies robust genetic contributions to clinical heterogeneity in MDD associated with comorbidit

133 y of applying integrative methods to address clinical heterogeneity in multifactorial multi-ethnic di

134 Clinical heterogeneity in multiple sclerosis is the rule

135 r all these disorders, there is considerable clinical heterogeneity in patients with the same mutatio

136 Our findings suggest that clinical heterogeneity in people with autosomal dominant

137 evance of KCNMA1 mutations and the basis for clinical heterogeneity in PNKD3 has not been established

138 Clinical heterogeneity in protocols for SMBP monitoring,

139 cellular and molecular mechanisms that drive clinical heterogeneity in PsA phenotypes, and detail exi

140 ture utility in understanding biological and clinical heterogeneity in PTSD and potential application

141 Clinical heterogeneity in Staphylococcus aureus bacterem

142 Significant clinical heterogeneity in study populations, interventio

143 strongest association with these features of clinical heterogeneity in synucleinopathies.

144 cificity, 36%-100%) and high statistical and clinical heterogeneity in tests used, eligibility criter

145 The clinical heterogeneity in the datasets was reduced by gr

146 BI provides neurobiological insight into the clinical heterogeneity in the disorder.

147 These studies suggest that the clinical heterogeneity in the HIT immune response may be

148 Although there is significant clinical heterogeneity in the presentation of PN, diseas

149 CD8+ T cell response may in part explain the clinical heterogeneity in the severity of PC pneumonia.

150 Risk of bias and clinical heterogeneity in the studies were high.

151 erns of tau aggregation, which contribute to clinical heterogeneity in these disorders.

152 onmental factors must account for the marked clinical heterogeneity in these families with an abnorma

153 GHMBP2 mutations suggests genetic as well as clinical heterogeneity in these infants.

154 tumours to find out the molecular basis for clinical heterogeneity in these tumours.

155 Because of the varying features and clinical heterogeneity inherent to this disorder, patien

156 Clinical heterogeneity is a hallmark of both diseases.

157 Clinical heterogeneity is a major barrier to effective t

158 Clinical heterogeneity is associated with GRN haploinsuf

159 Clinical heterogeneity is common in Mendelian disease, b

160 We hypothesized that the clinical heterogeneity is explained by genetically disti

161 ogeneous results and it is not clear how the clinical heterogeneity is related to the observed differ

162 To date, the clinical heterogeneity is well matched by an extensive a

163 s of current treatments and within-diagnosis clinical heterogeneity, is articulated.

164 mong sarcomas, as well as their biologic and clinical heterogeneity, is that management guidelines ar

165 d rate of disease progression, with inherent clinical heterogeneity making disease quantitation diffi

166 ts' differences in their genetic background, clinical heterogeneity may be caused by rather diverse s

167 dels identify neither the molecular basis of clinical heterogeneity, nor specific therapeutic targets

168 oproliferative neoplasms, CMML has a complex clinical heterogeneity not reflected by the mutational l

169 y of these tissues to SCO1 mutations and the clinical heterogeneity observed across SCO1 pedigrees re

170 To gain a better understanding of the clinical heterogeneity observed across SCO1 pedigrees, w

171 outbred population likely contribute to the clinical heterogeneity observed across SCO1 pedigrees.

172 e, and nail disease, thus deconstructing the clinical heterogeneity observed among AA patients.

173 microenvironment (TME) result in significant clinical heterogeneity observed both within and across p

174 se findings indicate a genetic basis for the clinical heterogeneity observed for this inflammatory bo

175 molecular stratification associates with the clinical heterogeneity observed in DS, suggesting that i

176 These findings address the clinical heterogeneity observed in EBS, a rare genetic s

177 ight into the molecular mechanism underlying clinical heterogeneity observed in Ewing's sarcoma.

178 Overall, these results may explain the clinical heterogeneity observed in GS patients and may h

179 The molecular basis for the clinical heterogeneity observed in patients with maligna

180 leading to distinct pathologies, akin to the clinical heterogeneity observed in patients with mitocho

181 Overall, our findings explain the clinical heterogeneity observed in sialidosis and may he

182 The clinical heterogeneity observed in STGD1 is reflected in

183 In order to better characterize the clinical heterogeneity observed, we assessed the prognos

184 R repertoires and provides a window into the clinical heterogeneity observed.

185 Marked clinical heterogeneity occurs even among patients carryi

186 ypes that explain much of the pathologic and clinical heterogeneity of AD.

187 The genetic and clinical heterogeneity of ALK-negative ALCL has not been

188 rapies that account for the pathological and clinical heterogeneity of Alzheimer's disease and Tauopa

189 e basis for the overwhelming morphologic and clinical heterogeneity of AMR.

190 the correlation between the pathological and clinical heterogeneity of amyloid diseases.

191 uman inherited disease, expand the locus and clinical heterogeneity of ARS-related clinical phenotype

192 well as adaptive immune responses, with the clinical heterogeneity of asthma perhaps a result of the

193 The genetic and clinical heterogeneity of breast cancer makes the identi

194 onents make an important contribution to the clinical heterogeneity of bvFTD.

195 pathogenic mechanism with the biological and clinical heterogeneity of CLL and offers opportunities f

196 e of the molecular mechanisms to explain the clinical heterogeneity of CLL.

197 review aims to discuss the pathological and clinical heterogeneity of congenital myopathies, and the

198 es of COPD have been recognized, despite the clinical heterogeneity of COPD, it has proved difficult

199 The clinical heterogeneity of CVID has hindered identificati

200 These findings reinforce the clinical heterogeneity of diabetes and highlight the imp

201 on does not fully explain the biological and clinical heterogeneity of DLBCLs.

202 Clinical heterogeneity of ER(-)/PR(-) tumors suggests th

203 As part of the spectrum of clinical heterogeneity of familial TAAD, we recently des

204 with different TnT alleles suggest that the clinical heterogeneity of FHC is at least partially due

205 The clinical heterogeneity of frontotemporal dementia (FTD)

206 The clinical heterogeneity of HCC, and the lack of good diag

207 We posit that reducing the clinical heterogeneity of hiPSC-based studies, by select

208 in rat models suggesting a genetic basis for clinical heterogeneity of human essential hypertension.

209 Considering the biological and clinical heterogeneity of liposarcoma, here, we confirme

210 The biologic and clinical heterogeneity of lymphomas represents the major

211 ne in our progress towards understanding the clinical heterogeneity of multiple sclerosis outcomes, i

212 To decipher and predict the molecular and clinical heterogeneity of NDMM, we assembled a series of

213 Moreover, given the clinical heterogeneity of NIID, we examined the size of

214 ed as core determinants of the molecular and clinical heterogeneity of oncogene-driven lung cancer su

215 d highlight the key role of modifiers in the clinical heterogeneity of PC symptoms.

216 ety of clinical vignettes that highlight the clinical heterogeneity of PNH and the attributes and lim

217 ions in PDSS2 and confirms the molecular and clinical heterogeneity of primary CoQ(10) deficiency.

218 In view of the significant biologic and clinical heterogeneity of prostate cancer, molecular ima

219 y of the neurobiology and the biological and clinical heterogeneity of PTSD have challenged clinician

220 gnificant implications for understanding the clinical heterogeneity of RBC membrane disorders.

221 The genetic, biologic, and clinical heterogeneity of sarcomas poses a challenge for

222 The clinical heterogeneity of schizophrenia has hindered neu

223 In particular, some genes involved in the clinical heterogeneity of SLE and some phenotype-related

224 e, we review insights into the molecular and clinical heterogeneity of SLE from transcriptomics studi

225 To explore mechanisms contributing to the clinical heterogeneity of systemic mastocytosis (SM) and

226 notable yield given the diverse genetics and clinical heterogeneity of the cerebellar ataxias.

227 contribution of cerebellar pathology to the clinical heterogeneity of the condition.

228 cular and biological pathways underlying the clinical heterogeneity of the disease.

229 state cancer biology and explain in part the clinical heterogeneity of the disease.

230 Although the clinical heterogeneity of the included studies was high,

231 Despite the clinical heterogeneity of the schizophrenia phenotype, b

232 The clinical heterogeneity of these disorders alludes to the

233 biological understanding of the substantial clinical heterogeneity of these tumours restricts therap

234 The significant genetic and clinical heterogeneity of this condition have substantia

235 g of pathogenesis and an appreciation of the clinical heterogeneity of this disease, together with th

236 nd genetic factors contributing to the known clinical heterogeneity of this disorder.

237 minant keloid disease is consistent with the clinical heterogeneity of this scarring disorder.

238 ico-basal ganglia networks contribute to the clinical heterogeneity of this syndrome.

239 se and significantly expands the allelic and clinical heterogeneity of YARS-associated human disease.

240 Understanding this clinical heterogeneity offers the prospects to tailor th

241 e clusters could enable better dissection of clinical heterogeneity on the basis of immune cell profi

242 in specialized medical centres, owing to its clinical heterogeneity, overlap with mimicking condition

243 offering insights into mechanisms underlying clinical heterogeneity, pathological propagation and bas

244 Despite genetic and clinical heterogeneity, PKDs have in common defects of c

245 atory bowel disease is marked by significant clinical heterogeneity, posing challenges for accurate d

246 skin condition characterized by substantial clinical heterogeneity, posing significant challenges to

247 Clinical heterogeneity precluded primary outcome meta-an

248 rrelates of schizophrenia is the substantial clinical heterogeneity present in this disorder.

249 We conclude that, despite its clinical heterogeneity, PTC is characterized by consiste

250 logic condition characterized by significant clinical heterogeneity, ranging from malignant cancers t

251 al strategies that accommodate molecular and clinical heterogeneity rather than ignore or reduce it.

252 In this study of BD, clinical heterogeneity reflected the burden of liability

253 The molecular basis for this clinical heterogeneity remains incompletely understood.

254 We dissected the genetic and clinical heterogeneity, revealing distinct polygenic arc

255 However, it is not known whether the clinical heterogeneity seen in the disorder is reflected

256 The dramatic molecular and clinical heterogeneity seen in this tumor has led to att

257 Further investigations on clinical heterogeneity showed that populations with trau

258 Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is

259 arkable biological and genetic variation and clinical heterogeneity, such as spontaneous regression,

260 thic hypersomnia is a rare syndrome in which clinical heterogeneity suggests a variable or multifacto

261 on of 11C-PK-11195 binding related better to clinical heterogeneity than did 18F-AV-1451: distinct sp

262 mphomas (CTCLs), disorders notable for their clinical heterogeneity that can present in skin or perip

263 ase in NMDs is made challenging by the broad clinical heterogeneity that exists among many NMDs and b

264 (DLBCL) exhibits significant biological and clinical heterogeneity that presents challenges for risk

265 ome (LQTS) is characterized by such striking clinical heterogeneity that, even among family members c

266 The condition is characterized by marked clinical heterogeneity, the different phenotypes/modes o

267 Characterized by extreme genetic and clinical heterogeneity, the separate groups share many c

268 strategies must account for both genetic and clinical heterogeneity to identify the genes and pathway

269 delling for understanding the biological and clinical heterogeneity underlying mental disorders.

270 odegenerative disease with poorly understood clinical heterogeneity, underscored by significant diffe

271 Reducing clinical heterogeneity using obesity data and improved e

272 Clinical heterogeneity was observed among the affected i

273 model captures mutational patterns linked to clinical heterogeneity, we anticipate it to be suited as

274 otential molecular variation underlying this clinical heterogeneity, we profiled gene expression in 6

275 The clinical heterogeneity which has long been recognized in

276 tionally, tuberculosis presents with notable clinical heterogeneity, which complicates diagnosis, tre

277 drome with complex pathophysiology and great clinical heterogeneity, which complicates the delivery o

278 ASD has profound etiological and clinical heterogeneity, which has impeded the identifica

279 Prostate cancer shows remarkable clinical heterogeneity, which manifests in spatial and c

280 tifactorial nature and their etiological and clinical heterogeneity will prove more resistant to refi

281 haracterized by a low survival rate and high clinical heterogeneity with current intensive therapies,

282 By integrating clinical heterogeneity with mechanistic insights, we pro

283 Patients with 17p- CLL exhibit clinical heterogeneity, with some patients experiencing

284 tistical approach to identify and adjust for clinical heterogeneity within ACPA(-) RA and observed in

285 Our findings exemplify clinical heterogeneity within BSS and extend the body of

286 (ACPA(-)) RA has been challenging because of clinical heterogeneity within clinical cohorts.

287 ct TME composition, DLBCL ecosystems capture clinical heterogeneity within existing subtypes and exte

288 While emerging evidence suggests clinical heterogeneity within RSV bronchiolitis, little

289 Emerging evidence suggests clinical heterogeneity within RV bronchiolitis.

290 Specific co-mutation patterns account for clinical heterogeneity within SF3B1- and SRSF2-related M

291 Therefore, the clinical heterogeneity within the ARMS category is assoc