ライフサイエンスコーパス: clinical implication

1 diseases and has important translational and clinical implications.

2 different trajectories could have important clinical implications.

3 ping using diverse cohorts and insights into clinical implications.

4 These considerations have profound clinical implications.

5 ge mammalian model, a finding with potential clinical implications.

6 s are key to studying tumorigenesis and have clinical implications.

7 genomic landscape of childhood ALL and their clinical implications.

8 ween neurons and glioma cells with potential clinical implications.

9 T cell interactions in vivo, with important clinical implications.

10 f carcinogenesis and fusions that could have clinical implications.

11 of NK cell functions and may have important clinical implications.

12 gram in the kidney: molecular mechanisms and clinical implications.

13 ths of therapy, which could have substantial clinical implications.

14 This finding has both mechanistic and clinical implications.

15 veries in the field, which are having direct clinical implications.

16 obesity have potential short- and long-term clinical implications.

17 g loss of function (LoF) of human genes have clinical implications.

18 basic biological principles and has profound clinical implications.

19 dopamine-serotonin opponency with potential clinical implications.

20 diated pulmonary inflammation with important clinical implications.

21 ks in different cancer types, with potential clinical implications.

22 c disorders and may consequently have direct clinical implications.

23 ress susceptibility, these insights may have clinical implications.

24 romote IL-17A production with as yet unknown clinical implications.

25 the inhibition of glutaminolysis could have clinical implications.

26 xtracorporeal gas exchange and highlight the clinical implications.

27 nate the hematopoietic system have important clinical implications.

28 t knowledge of CTC biology and the potential clinical implications.

29 sted acceleration of healing has significant clinical implications.

30 tile area for future research with important clinical implications.

31 sease perception or diagnosis with potential clinical implications.

32 potential therapeutic drug target with broad clinical implications.

33 cific conditions, which likely has important clinical implications.

34 of chronic immunosuppression with potential clinical implications.

35 e DEGs and the pathways may potentially have clinical implications.

36 o our understanding of tumor biology and its clinical implications.

37 can help to inform their interpretations and clinical implications.

38 pathologic conditions with equally different clinical implications.

39 bclinical, THV thrombosis may have important clinical implications.

40 ecture is a central biological question with clinical implications.

41 i for acute coronary syndrome with effective clinical implications.

42 cation, is of public health significance and clinical implications.

43 hat modulation of miRNA export has potential clinical implications.

44 brain activity would have enormous basic and clinical implications.

45 regulation of tumorigenesis, with important clinical implications.

46 important role of central plasticity and its clinical implications.

47 ticular focus on the functional and possible clinical implications.

48 umour metabolism and epigenetics and outline clinical implications.

49 y genomic alterations in ILBC with potential clinical implications.

50 control may have significant theoretical and clinical implications.

51 g to assess their potential consequences and clinical implications.

52 This technology has clinical implications.

53 revalence, location, associated factors, and clinical implications.

54 ed individuals and therefore bears important clinical implications.

55 ated metastatic pattern in CRC and has great clinical implications.

56 he regulation of HR and TLS with significant clinical implications.

57 ding a unique framework to identify relevant clinical implications.

58 the MAS may have important physiological and clinical implications.

59 nificance of histone modifications and their clinical implications.

60 Our findings have important clinical implications.

61 agnostic criteria for BE that have important clinical implications.

62 iac ultrastructure, a finding with important clinical implications.

63 aneous inflammatory responses with important clinical implications.

64 e long-term outcomes of DBS and consider the clinical implications.

65 n this tubal paradigm and its biological and clinical implications, alongside the promise and challen

66 logical, and diagnostic issues, and identify clinical implications and areas for future research.

67 findings of recent clinical trials and their clinical implications and describes ongoing trials and f

68 This study has important clinical implications and highlights the role of individ

69 this resistance mechanism may have important clinical implications and lead to the development of mor

70 The present data have far-reaching clinical implications and raise the hypothesis that path

71 We also discuss the clinical implications and review concepts of targeted tr

72 Our study has important clinical implications and transformative potential as ou

73 idine CCBs on diverticulosis risk could have clinical implications and warrants further investigation

74 ular hypertension at 10 years have important clinical implications, and as such this information shou

75 nderpinning mutant CALR-driven MPNs, discuss clinical implications, and highlight future therapeutic

76 er age, with special emphasis on etiologies, clinical implications, and innovative concepts in the ma

77 rial drainage of the right SVC has important clinical implications, and knowledge of its imaging appe

78 We discuss pathophysiological mechanisms, clinical implications, and pharmacological and non-pharm

79 There are limited data on the incidence, clinical implications, and predisposing factors of trans

80 ferent RAS mutations and the tissue-specific clinical implications are complex and nuanced.

81 These are reviewed and their clinical implications are discussed in this article.

82 ation was the result of routine RBC storage; clinical implications are discussed.

83 to the sex disparity in ASD incidence, whose clinical implications are significant.

84 Clinical implications are yet to be determined.

85 ow these genes function in vivo and what the clinical implications are.

86 of in vivo lipid peroxidation with important clinical implications as a breath biomarker of bacterial

87 This has potentially meaningful clinical implications as the accuracy of the measurement

88 These findings have important clinical implications as VO2 peak is highly predictive o

89 this new PV/CEL-overlap MPN has significant clinical implications, as both PV and CEL patients are a

90 These findings have clinical implications, as high levels of HBP were detect

91 This finding has important clinical implications, as stochastic expression of resis

92 This finding may have clinical implications because microvascular dysfunction

93 This may have clinical implications because mutations in some spliceos

94 force of microbial community structure, have clinical implications because of the frequent occurrence

95 This finding has important clinical implications because of the risk of additional

96 These results have important clinical implications, because topical therapies that ta

97 t tumors within the same organism have major clinical implications, especially in the context of surg

98 tand the biological mechanism, pathways, and clinical implication for risk management.

99 catenin and PKM2 inhibition which would have clinical implication for the cancer development and new

100 We end by considering the clinical implications for adaptive deep-brain stimulatio

101 d survival of CD8(+) T cells, with potential clinical implications for adoptive cell transfer and vac

102 of Parkinson's disease, these findings have clinical implications for behavioural symptoms and cogni

103 These findings could have broad clinical implications for cancer patients.

104 w it functions in DSB repair, with potential clinical implications for cancer therapy.

105 hts into TOPBP1's role in HR, with potential clinical implications for cancer treatment.

106 These results have important clinical implications for CNS drug delivery and clearanc

107 of the circulating and CSF compartments with clinical implications for cryptococcal disease outcome,

108 These findings may have important clinical implications for decision-making based on risk

109 Our results have clinical implications for diagnosis and cerebellar neuro

110 to Li-Fraumeni Syndrome (LFS) has important clinical implications for diagnosis, surveillance, and t

111 ption/maladaptation to hypoxia has potential clinical implications for disease featuring low oxygen d

112 isuse-driven neuronal atrophy which may have clinical implications for disease management, including

113 ic variation between bvFTD and FTD-ALS, have clinical implications for early detection of FTD-ALS and

114 opsychological phenotype in ALS-FTD may have clinical implications for early diagnosis, disease manag

115 ully protect against GvHD and have important clinical implications for future clinical trials testing

116 , their underlying molecular mechanisms, and clinical implications for future innovative therapeutic

117 The inferred haplotypes may have clinical implications for genetic disease predisposition

118 in future in vivo experiments to clarify the clinical implications for hemostat use in post-surgical

119 tic) effects of scopolamine could have great clinical implications for humans; however, rats and mice

120 These results may have clinical implications for immunosuppressive therapy usin

121 The results may have clinical implications for improving access to mental hea

122 between host and pathogen and has important clinical implications for infection outcome.

123 1 may enhance cytosolic retention, which has clinical implications for inflammation-associated neopla

124 These results have significant clinical implications for liver development in infants e

125 HPS and POPH have major clinical implications for liver transplantation.

126 lveolar macrophages and might have important clinical implications for local immunity and immunopatho

127 These findings have clinical implications for lung vascular function and can

128 The efficacy of the cHBI design has valuable clinical implications for many allergen-specific respons

129 These finding have clinical implications for mechanisms of seizure-induced

130 cell lines provides mechanistic insights and clinical implications for metastatic dissemination of IL

131 ions to enable immune attack on tumors, with clinical implications for molecular markers to modify em

132 mechanism of acquired MEKi resistance, with clinical implications for MPNST patients harboring NF1 a

133 This may have clinical implications for pathologies associated with ce

134 These observations have immediate clinical implications for patients with ERBB2/HER2-negat

135 Our findings have significant clinical implications for people with GBM.

136 cell population in the JE and have potential clinical implications for prevention and treatment of pe

137 Our findings have clinical implications for rehabilitation of patients wit

138 onal restart, a process that has significant clinical implications for relapsed staphylococcal infect

139 de insight into disease biology and may have clinical implications for risk assessment.

140 mTORC1-dependent granulomatous disease with clinical implications for sarcoidosis.

141 We then discuss their clinical implications for tauopathies and synucleinopath

142 Our observations have clinical implications for the development of successful

143 he host immunologic response, and has direct clinical implications for the management and follow-up o

144 1 are strong predictors of ESRD, indicating clinical implications for the management of chronic HCV.

145 These results may have relevant clinical implications for the management of CNV and lead

146 rception of airway obstruction has important clinical implications for the management of patients wit

147 subtypes in prostate cancer, with important clinical implications for the management of patients.

148 genic process, with important functional and clinical implications for the origins of genomic remodel

149 Our findings may have clinical implications for the prediction and clinical ma

150 aling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxici

151 properties of transgelin-2 and discuss their clinical implications for the treatment of immune, oncog

152 in, destination and duration, which may have clinical implications for the understanding and treatmen

153 l helminths to reduce DTH responses may have clinical implications for the use of skin test-based dia

154 isms underlying walking adaptation, and have clinical implications for treating walking impairments a

155 tween stressors and drug use, and we discuss clinical implications for treatment development.

156 on of functional brain networks and may have clinical implications for understanding the actions of a

157 These results have direct clinical implications for understanding tolerance induct

158 Our findings have immediate clinical implications given the potential of the identif

159 teps following HMPV entry and have important clinical implications.IMPORTANCE Human metapneumovirus (

160 However, OmpA clinical implication in hospital-acquired infections rem

161 tional neural network (CNN) to elucidate its clinical implication in oncological perspectives.

162 bring new focus to SMOC2 by highlighting its clinical implications in both human and veterinary medic

163 and MAGEA1-FBXW7 interactions have potential clinical implications in breast and ovarian cancer treat

164 anism of action of B7-H1 in T cells and have clinical implications in cancer immunotherapy when anti-

165 nscripts may have significant biological and clinical implications in cancer patient management.

166 1A expression with potential mechanistic and clinical implications in GC.

167 L-6- and IL-10-producing monocytes, may have clinical implications in HIV-infected patients that are

168 s seem to exert immunological effects, their clinical implications in human immunodeficiency virus (H

169 sively detected myocardial fibrosis (MF) has clinical implications in hypertrophic cardiomyopathy, th

170 mor-infiltrating B cells and their potential clinical implications in NSCLC.

171 block RpoN consensus promoters has potential clinical implications in reducing virulence and improvin

172 rmal serotonergic synapse may have important clinical implications in sensory dysfunctions, such as t

173 These results have potential clinical implications in the active field of anthracycli

174 the differentiation of Tregs, with potential clinical implications in the alteration of the immune la

175 borate these findings, they may have further clinical implications in the laboratory workup of uveiti

176 er, the results of this study have potential clinical implications in the prevention of AKI in at-ris

177 Furthermore, our findings suggest potential clinical implications in the use of steroid drugs.

178 us spatiotemporal MDSC infiltration may have clinical implications in tumour progression.

179 breast cancer subtypes is proposed, and the clinical implications include a need for combinatorial t

180 Clinical implications include targeted monitoring for SC

181 tanding of human CSF flux and open important clinical implications, including concepts for drug deliv

182 Despite its important clinical implications, little is known about ECM changes

183 The clinical implication of applying LCA to CDI is to report

184 We herein examine the assessment and clinical implication of sarcopenia in liver transplantat

185 We aimed to investigate the clinical implication of suspended scattering particles i

186 n of the natural fluctuation of disease, the clinical implication of the chosen primary endpoint, and

187 g for disease-related entity, but not on the clinical implication of the feature itself.

188 es with early hippocampal insult, and on the clinical implication of the hippocampus in developmental

189 Clinical implication of the NAC1-HDAC4-HIF-1alpha pathwa

190 Future studies are required to assess the clinical implication of these findings.

191 n murine, canine, and human NK cells and the clinical implication of these findings.

192 purpose of this study is to investigate the clinical implication of these markers in clinical-radiol

193 R, and ascertain factors associated with and clinical implications of a lack of improvement in exerci

194 ively evaluated the incidence, cost, and the clinical implications of actionable arrhythmia alarms on

195 BN, the authors have further illuminated the clinical implications of albuminuria.

196 Clinical implications of complete left-sided reverse rem

197 m detailed clinical data were available, the clinical implications of diagnostic and other medically

198 however, the epidemiology, risk factors, and clinical implications of difficult bag-mask ventilation

199 ders to reference in order to understand the clinical implications of each patient's genetic makeup.

200 monitoring and its level of evidence or the clinical implications of early detection of serious diso

201 ls in an attempt to define the incidence and clinical implications of EMD.

202 spective presents these current concepts and clinical implications of epigenetic ITH, and the experim

203 ecificity vs. sensitivity by considering the clinical implications of false positive and false negati

204 uncertainty in key parameters (including the clinical implications of false-negative results), the ex

205 pecificity vs sensitivity by considering the clinical implications of false-positive and false-negati

206 However, the intrinsic clinical implications of FTR are not fully understood.

207 This study further establishes the important clinical implications of genetic and epigenetic ITH in L

208 To illustrate the clinical implications of genetic variants with large eff

209 The clinical implications of HDL-cholesterol changes associa

210 uld stimulate a careful re-evaluation of the clinical implications of HPV mutation rates, transmissio

211 useful tool to elucidate the degree and the clinical implications of immune system failure in indivi

212 ardial injury based on pathogenesis, but the clinical implications of implementing this guideline are

213 To determine the proportion and potential clinical implications of inherited variants detected usi

214 as our perspective on future directions and clinical implications of iPSC technology.

215 To date, clinical implications of iron deficiency and high EPO le

216 cal underpinnings of this model and point to clinical implications of it.

217 is study provides insight into the potential clinical implications of lncRNAs in breast cancer.

218 ticle by Tayari et al that suggests studying clinical implications of long noncoding RNAs as possible

219 the article by Hara et al that discusses the clinical implications of mitotic catastrophe in podocyte

220 Follow-up for potential clinical implications of mutation detection was through

221 nowledge gaps remain in the epidemiology and clinical implications of myocardial injury in coronaviru

222 The current study sought to investigate the clinical implications of OPN expression in NSCLC and the

223 Given the significant clinical implications of optical imaging, there is an ur

224 Further studies are needed to evaluate the clinical implications of our findings.

225 rm risk and severity of TA, highlighting the clinical implications of our findings.

226 The universality and clinical implications of our observations require furthe

227 Clinical implications of our results are discussed.

228 Potential clinical implications of our study are illustrated by an

229 ny subphenotypes of sickle cell disease; (3) clinical implications of person-to-person variation in t

230 To examine the clinical implications of positive or negative direct imm

231 ore investigation is necessary, examines the clinical implications of randomized and observational cl

232 Further research is needed on the clinical implications of residual immune dysregulation.

233 g different MDRO species, with the potential clinical implications of such interactions remaining lar

234 The clinical implications of switching from the existing Xpe

235 on AR expression and signaling, and address clinical implications of targeting DDX3 by assessing sen

236 onal, and clinical scientists to address the clinical implications of the AGI, with a particular emph

237 In this Personal View, we discuss the clinical implications of the CREATE-X and KATHERINE tria

238 Future perspectives, including clinical implications of the findings from metagenomic i

239 In order to evaluate the clinical implications of the findings, we classified CRC

240 This review also addresses the clinical implications of the newly proposed cell of orig

241 The clinical implications of the peripheral PRL/PRLR system

242 The clinical implications of the proposed flowchart includin

243 le addressing pertinent technical issues and clinical implications of the results.

244 We conclude by discussing clinical implications of the studies reviewed.

245 There are significant differences in use and clinical implications of the test on the basis of race,

246 We also address the clinical implications of therapeutic strategies to remov

247 nger follow-up is required to understand the clinical implications of these abnormalities.

248 The incidence and clinical implications of these findings remain unclear.

249 We discuss the clinical implications of these findings.

250 nts with metastatic prostate cancer, but the clinical implications of these genes remain unclear.

251 of recurrent/intermittent rectal CT and the clinical implications of these infections require furthe

252 ss some of the most important biological and clinical implications of these novel findings, with a sp

253 itional research is needed to understand the clinical implications of these parameters related to pro

254 ylation, regulation of Fc glycosylation, and clinical implications of these pathways.

255 The clinical implications of these pharmacodynamic findings

256 To assess the clinical implications of these physiologic findings, we

257 muscular and cardiac manifestations, but the clinical implications of these signs are not well unders

258 ng impacts on protein function and potential clinical implications of these variants in cardiovascula

259 However, the clinical implications of this decoupling remain unclear.

260 raining immunity and highlight the potential clinical implications of this discovery.

261 iated with an early decline in eGFR, and the clinical implications of this early decline are unclear.

262 We address the clinical implications of this emerging field and highlig

263 Larger studies are needed to understand the clinical implications of this finding.

264 enetic alterations over the past decade, the clinical implications of this knowledge have so far been

265 c definition of chronic pain and discuss the clinical implications of this new definition as well as

266 rimentally confirmed at 7 Tesla (T), and the clinical implications of this new paradigm are illustrat

267 e prevalence, natural history, and potential clinical implications of this nonfamilial subgroup of HC

268 the underlying molecular mechanisms and the clinical implications of this pharmacogenetic associatio

269 ng anti-TNF-driven IL-17A expression and the clinical implications of this phenomenon.

270 damental principles, recent discoveries, and clinical implications of this promising field of researc

271 risk of skeletal muscle dysfunction, but the clinical implications of this remain uncertain.

272 Clinical implications of this research include discussio

273 and consider ethical questions and potential clinical implications of this technology.

274 nce, and offering a fresh perspective on the clinical implications of this work.

275 sed the incidence, potential predictors, and clinical implications of THV thrombosis as determined by

276 e knowledge regarding the occurrence and the clinical implications of tick-borne infections in immuno

277 However, the biological and clinical implications of TP53 allelic state have not bee

278 of events and to situate and understand the clinical implications of various data.

279 However, the clinical implications of viremia below this threshold ar

280 healthy controls and investigated long-term clinical implications of vitamin B-6 deficiency in stabl

281 d encourage shared decision making about the clinical implications of whether to pursue transplantati

282 by homologous recombination and the possible clinical implication on malignant melanoma therapy with

283 diabetic wound microenvironment has a direct clinical implication on the efficacy and safety of vario

284 differentiation by CBP/p300, with potential clinical implications on alteration of the immune landsc

285 nt with lived experience and may have future clinical implications pending further research.

286 Clinical implications range from improved diagnosis and

287 ate tumor heterogeneity, which in turn carry clinical implications regarding the classification and t

288 ation and functions of hDBR1, with immediate clinical implications regarding the regulation of hDBR1

289 ough tumor-associated B cells with important clinical implications.Resistance to BRAFV600E inhibitors

290 Our findings have potential clinical implications since they demonstrate that inheri

291 This has important clinical implications since titration of antihypertensiv

292 9-10-year-old children-might have important clinical implications, suggesting that cognitive dysfunc

293 ntributes to the pathogenesis of ACS and the clinical implications that arise from these new pathogen

294 These mechanisms have clinical implications that relate to the increasing use

295 e samples sequenced from a tumor, and due to clinical implications, this has attracted great interest

296 lizing fibrin networks with potential future clinical implications to reduce bleeding risk.

297 The clinical implication was studied in blood samples of pat

298 CLINICAL IMPLICATIONS: We here evaluate allergen immunot

299 hedule, and tumor models, and describe their clinical implications with an emphasis on approaches and

300 s in patients with ASD may thus have further clinical implications with regard to monitoring for (lat